AC T00169
XX
ID T00169
XX
DT 15.10.1992 (created); ewi.
DT 25.06.2014 (updated); pos.
CO Copyright (C), QIAGEN.
XX
FA c-Rel
XX
SY c-Rel; HIVEN86A; p68; p82(hc-rel).
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G009127 Rel.
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CL C0020; Rel; 6.1.1.2.3.
XX
SF c-Rel heterodimers with NF-kappaB1 (p50) prevail in mature B cells in contrast to pre-B cells, where p50/RelA heterodimers predominate [2];
SF c-Rel/p50 dimers bind 20-fold more stably to the intronic kappaB site of the Igkappa gene than p50/RelA dimers [2];
SF the potent C-terminal trans-activation domain is not found in v-Rel and is masked in the whole molecule [6];
SF trans-activation requires physical interaction with TBP [8];
XX
CP Nrf2 (F2) knockout mouse fibroblasts [10].
XX
FF potent activator [6] [7];
FF early growth response gene [5];
FF may substitute RelA (p65) during B-cell maturation thus contributing to the constitutive expression of immunoglobulin genes [2];
FF c-rel expression is augmented in mature B cells [2];
XX
IN T00169 c-Rel; mouse, Mus musculus.
IN T00416 IkappaB-beta; chick, Gallus gallus.
IN T00971 IkappaB-beta; mouse, Mus musculus.
IN T22436 IkappaB-epsilon-xxb2; human, Homo sapiens.
IN T00593 NF-kappaB1-p50; human, Homo sapiens.
IN T01925 NF-kappaB1; human, Homo sapiens.
IN T00796 TBP; mouse, Mus musculus.
IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T).
XX
MX M00053 V$CREL_01.
MX M03545 V$CREL_Q6.
XX
BS R04704.
BS R00699.
BS R02173.
BS R24519.
BS R14486.
BS R14492.
BS R26903.
BS R26286.
BS R72490.
BS R72342.
BS R14483.
BS R26192.
BS R27473.
BS R28386.
BS R28670.
BS R25624.
BS R24514.
BS R24177.
BS R01058.
BS R08126.
BS R14616.
BS R61241.
BS R14784.
BS R25731.
BS R25734.
BS R26590.
XX
DR TRANSPATH: MO000019369.
DR TRANSCOMPEL: C00570.
DR UniProtKB: P15307; REL_MOUSE.
XX
RN [1]; RE0002477.
RX PUBMED: 2023921.
RA Inoue J.-I., Kerr L. D., Ransone L. J., Bengal E., Hunter T., Verma I. M.
RT c-rel activates but v-rel suppresses transcription from kappaB sites
RL Proc. Natl. Acad. Sci. USA 88:3715-3719 (1991).
RN [2]; RE0004531.
RX PUBMED: 8197184.
RA Miyamoto S., Schmitt M. J., Verma I. M.
RT Qualitative changes in the subunit composition of kappa-binding complexes during murine B-cell differentiation
RL Proc. Natl. Acad. Sci. USA 91:5056-5060 (1994).
RN [3]; RE0004570.
RX PUBMED: 2654811.
RA Grumont R. J., Gerondakis S.
RT Structure of a mammalian c-rel protein deduced from the nucleotide sequence of murine cDNA clones
RL Oncogene Res. 4:1-8 (1989).
RN [4]; RE0004571.
RX PUBMED: 8241021.
RA Grumont R. J., Richardson I. B., Gaff C., Gerondakis S.
RT rel/NF-kappa B nuclear complexes that bind kB sites in the murine c-rel promoter are required for constitutive c-rel transcription in B-cells
RL Cell Growth Differ. 4:731-743 (1993).
RN [5]; RE0004572.
RX PUBMED: 2601720.
RA Bull P., Hunter T., Verma I. M.
RT Transcriptional induction of the murine c-rel gene with serum and phorbol-12-myristate-13-acetate in fibroblasts
RL Mol. Cell. Biol. 9:5239-5243 (1989).
RN [6]; RE0004573.
RX PUBMED: 2204816.
RA Bull P., Morley K. L., Hoekstra M. F., Hunter T., Verma I. M.
RT The mouse c-rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain
RL Mol. Cell. Biol. 10:5473-5485 (1990).
RN [7]; RE0004574.
RX PUBMED: 1903456.
RA Richardson P. M., Gilmore T. D.
RT vRel is an inactive member of the Rel family of transcriptional activating proteins
RL J. Virol. 65:3122-3130 (1991).
RN [8]; RE0004577.
RX PUBMED: 8413585.
RA Kerr L. D., Ransone L. J., Wamsley P., Schmitt M. J., Boyer T. G., Zhou Q., Berk A. J., Verma I. M.
RT Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-kappaB
RL Nature 365:412-419 (1993).
RN [9]; RE0013471.
RX PUBMED: 9135156.
RA Whiteside S. T., Epinat J. C., Rice N. R., Israel A.
RT I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
RL EMBO J. 16:1413-1426 (1997).
RN [10]; RE0051710.
RX PUBMED: 15988009.
RA Yang H., Magilnick N., Lee C., Kalmaz D., Ou X., Chan J. Y., Lu S. C.
RT Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1.
RL Mol. Cell. Biol. 25:5933-5946 (2005).
RN [11]; RE0054100.
RX PUBMED: 15858576.
RA Lawrence T., Bebien M., Liu G. Y., Nizet V., Karin M.
RT IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation.
RL Nature 434:1138-1143 (2005).
RN [12]; RE0068092.
RX PUBMED: 18200499.
RA Dennehy K. M., Ferwerda G., Faro-Trindade I., Pyz E., Willment J. A., Taylor P. R., Kerrigan A., Tsoni S. V., Gordon S., Meyer-Wentrup F., Adema G. J., Kullberg B. J., Schweighoffer E., Tybulewicz V., Mora-Montes H. M., Gow N. A., Williams D. L., Netea M. G., Brown G. D.
RT Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors.
RL Eur. J. Immunol. 38:500-506 (2008).
XX
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