TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00169 XX ID T00169 XX DT 15.10.1992 (created); ewi. DT 25.06.2014 (updated); pos. CO Copyright (C), QIAGEN. XX FA c-Rel XX SY c-Rel; HIVEN86A; p68; p82(hc-rel). XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G009127 Rel. XX CL C0020; Rel; XX SF c-Rel heterodimers with NF-kappaB1 (p50) prevail in mature B cells in contrast to pre-B cells, where p50/RelA heterodimers predominate [2]; SF c-Rel/p50 dimers bind 20-fold more stably to the intronic kappaB site of the Igkappa gene than p50/RelA dimers [2]; SF the potent C-terminal trans-activation domain is not found in v-Rel and is masked in the whole molecule [6]; SF trans-activation requires physical interaction with TBP [8]; XX CP Nrf2 (F2) knockout mouse fibroblasts [10]. XX FF potent activator [6] [7]; FF early growth response gene [5]; FF may substitute RelA (p65) during B-cell maturation thus contributing to the constitutive expression of immunoglobulin genes [2]; FF c-rel expression is augmented in mature B cells [2]; XX IN T00169 c-Rel; mouse, Mus musculus. IN T00416 IkappaB-beta; chick, Gallus gallus. IN T00971 IkappaB-beta; mouse, Mus musculus. IN T22436 IkappaB-epsilon-xxb2; human, Homo sapiens. IN T00593 NF-kappaB1-p50; human, Homo sapiens. IN T01925 NF-kappaB1; human, Homo sapiens. IN T00796 TBP; mouse, Mus musculus. IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T). XX MX M00053 V$CREL_01. MX M03545 V$CREL_Q6. XX BS R04704. BS R00699. BS R02173. BS R24519. BS R14486. BS R14492. BS R26903. BS R26286. BS R72490. BS R72342. BS R14483. BS R26192. BS R27473. BS R28386. BS R28670. BS R25624. BS R24514. BS R24177. BS R01058. BS R08126. BS R14616. BS R61241. BS R14784. BS R25731. BS R25734. BS R26590. XX DR TRANSPATH: MO000019369. DR TRANSCOMPEL: C00570. DR UniProtKB: P15307; REL_MOUSE. XX RN [1]; RE0002477. RX PUBMED: 2023921. RA Inoue J.-I., Kerr L. D., Ransone L. J., Bengal E., Hunter T., Verma I. M. RT c-rel activates but v-rel suppresses transcription from kappaB sites RL Proc. Natl. Acad. Sci. USA 88:3715-3719 (1991). RN [2]; RE0004531. RX PUBMED: 8197184. RA Miyamoto S., Schmitt M. J., Verma I. M. RT Qualitative changes in the subunit composition of kappa-binding complexes during murine B-cell differentiation RL Proc. Natl. Acad. Sci. USA 91:5056-5060 (1994). RN [3]; RE0004570. RX PUBMED: 2654811. RA Grumont R. J., Gerondakis S. RT Structure of a mammalian c-rel protein deduced from the nucleotide sequence of murine cDNA clones RL Oncogene Res. 4:1-8 (1989). RN [4]; RE0004571. RX PUBMED: 8241021. RA Grumont R. J., Richardson I. B., Gaff C., Gerondakis S. RT rel/NF-kappa B nuclear complexes that bind kB sites in the murine c-rel promoter are required for constitutive c-rel transcription in B-cells RL Cell Growth Differ. 4:731-743 (1993). RN [5]; RE0004572. RX PUBMED: 2601720. RA Bull P., Hunter T., Verma I. M. RT Transcriptional induction of the murine c-rel gene with serum and phorbol-12-myristate-13-acetate in fibroblasts RL Mol. Cell. Biol. 9:5239-5243 (1989). RN [6]; RE0004573. RX PUBMED: 2204816. RA Bull P., Morley K. L., Hoekstra M. F., Hunter T., Verma I. M. RT The mouse c-rel protein has an N-terminal regulatory domain and a C-terminal transcriptional transactivation domain RL Mol. Cell. Biol. 10:5473-5485 (1990). RN [7]; RE0004574. RX PUBMED: 1903456. RA Richardson P. M., Gilmore T. D. RT vRel is an inactive member of the Rel family of transcriptional activating proteins RL J. Virol. 65:3122-3130 (1991). RN [8]; RE0004577. RX PUBMED: 8413585. RA Kerr L. D., Ransone L. J., Wamsley P., Schmitt M. J., Boyer T. G., Zhou Q., Berk A. J., Verma I. M. RT Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-kappaB RL Nature 365:412-419 (1993). RN [9]; RE0013471. RX PUBMED: 9135156. RA Whiteside S. T., Epinat J. C., Rice N. R., Israel A. RT I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity. RL EMBO J. 16:1413-1426 (1997). RN [10]; RE0051710. RX PUBMED: 15988009. RA Yang H., Magilnick N., Lee C., Kalmaz D., Ou X., Chan J. Y., Lu S. C. RT Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1. RL Mol. Cell. Biol. 25:5933-5946 (2005). RN [11]; RE0054100. RX PUBMED: 15858576. RA Lawrence T., Bebien M., Liu G. Y., Nizet V., Karin M. RT IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. RL Nature 434:1138-1143 (2005). RN [12]; RE0068092. RX PUBMED: 18200499. RA Dennehy K. M., Ferwerda G., Faro-Trindade I., Pyz E., Willment J. A., Taylor P. R., Kerrigan A., Tsoni S. V., Gordon S., Meyer-Wentrup F., Adema G. J., Kullberg B. J., Schweighoffer E., Tybulewicz V., Mora-Montes H. M., Gow N. A., Williams D. L., Netea M. G., Brown G. D. RT Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors. RL Eur. J. Immunol. 38:500-506 (2008). XX //