AC T01925
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ID T01925
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DT 04.11.1996 (created); ewi.
DT 26.06.2015 (updated); sup.
CO Copyright (C), QIAGEN.
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FA NF-kappaB1
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SY EBP-1; KBF1; MGC54151; NF-kappa-B; NF-kappaB (p50); NF-kappaB1 (p105); NFkappaB1 precursor (p105); NFKB-p105; NFKB-p50; NFKB1; Nuclear factor NF-kappa-B p105 subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105); p105; p50.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G000356 NFKB1; HGNC: NFKB1.
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CL C0020; Rel; 6.1.1.1.1.
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SF 105 kDa precursor of the mature transcription factor NF-kappaB-p50 subunit T00593 [2];
SF the precursor interacts with processed NF-kappaB1-p50 through its ankyrin repeats and inhibits its nuclear translocation by masking the NLS signal intra- and intermolecularly [9] [13];
SF inhibition of nuclear translocation of NF-kappaB1 is abolished by phosphorylation of NF-kappaB1 in response to, e. g., TNF-alpha or reactive oxygen intermediates [11];
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CP ubiquitous.
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FF inducible by a variety of inducers;
FF C-terminal sequences comprising the ankyrin repeats can act as IkappaB-like inhibitor: IkappaB-gamma [12];
FF nuclear translocation of NF-kappaB1-p50 or p65 may be controlled by heterodimerization with the NF-kappaB1precursor (p105) [13];
FF cellular ATP-dependent proteases or HIV-1 protease can clip NF-kappaB1 to release NF-kappaB1-p50 [3] [5];
FF the cellular processing proceeds via a ubiquitin-proteasome pathway, also leading to rapid degradation of the C-terminal sequences [17];
FF preceded and forced by phosphorylation [8] [11];
FF the NFkappaB1 gene is regulated through AP-1 and NF-kappaB sites [16];
FF HIV-1-infected T-cells exhibit self-activation of the NFkappaB1 gene which occurs through the kappaB site [15] [16];
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IN T00168 c-Rel; human, Homo sapiens.
IN T00169 c-Rel; mouse, Mus musculus.
IN T01154 c-Rel; chick, Gallus gallus.
IN T00950 IkappaB-alpha; human, Homo sapiens.
IN T00414 IkappaB-beta; human, Homo sapiens.
IN T00416 IkappaB-beta; chick, Gallus gallus.
IN T00971 IkappaB-beta; mouse, Mus musculus.
IN T22503 IkappaBzeta; human, Homo sapiens.
IN T00593 NF-kappaB1-p50; human, Homo sapiens.
IN T14940 NF-kappaB2; human, Homo sapiens.
IN T02767 Nur77; human, Homo sapiens.
IN T14055 PARP; human, Homo sapiens.
IN T06377 PML; human, Homo sapiens.
IN T08711 RelA-p65; human, Homo sapiens.
IN T01931 RelB; human, Homo sapiens.
IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T).
IN T08660 YY1; human, Homo sapiens.
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MX M07221 V$NFKB1_03.
MX M08952 V$NFKB1_04.
MX M00194 V$NFKB_Q6.
MX M00774 V$NFKB_Q6_01.
MX M03557 V$P50_Q6.
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BS R20825.
BS R29232.
BS R29238.
BS R29912.
BS R66040.
BS R30655.
BS R30369.
BS R30650.
BS R30143.
BS R32656.
BS R71710.
BS R21544.
BS R29147.
BS R29148.
BS R29149.
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DR TRANSPATH: MO000019359.
DR UniProtKB: P19838; KBF1_HUMAN.
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RN [1]; RE0000172.
RX PUBMED: 2203531.
RA Kieran M., Blank V., Logeat F., Vandekerckhove J., Lottspeich F., Le Bail O., Urban M. B., Kourilsky P., Baeuerle B. A., Israel A.
RT The DNA binding subunit of NF-kappaB is identical to factor KBF1 and homologous to the rel oncogene product
RL Cell 62:1007-1018 (1990).
RN [2]; RE0001870.
RX PUBMED: 2234062.
RA Bours V., Villalobos J., Burd P. R., Kelly K., Siebenlist U.
RT Cloning of a mitogen-inducible gene encoding a kappaB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs
RL Nature 348:76-80 (1990).
RN [3]; RE0001872.
RX PUBMED: 2017258.
RA Riviere Y., Blank V., Kourilsky P., Israel A.
RT Processing of the precursor of NF-kappaB by the HIV-1 protease during acute infection
RL Nature 350:625-626 (1991).
RN [4]; RE0001873.
RX PUBMED: 1876189.
RA Schmid R. M., Perkins N. D., Duckett C. S., Andrews P. C., Nabel G. J.
RT Cloning of an NF-kappaB subunit which stimulates HIV transcription in synergy with p65
RL Nature 352:733-736 (1991).
RN [5]; RE0001874.
RX PUBMED: 1956402.
RA Fan C.-M., Maniatis T.
RT Generation of p50 subunit of NF-kappaB by processing of p105 through an ATP-dependent pathway
RL Nature 354:395-398 (1991).
RN [6]; RE0002489.
RX PUBMED: 1992489.
RA Meyer R., Hatada E. N., Hohmann H.-P., Haiker M., Bartsch C., Roethlisberger U., Lahm H.-W., Schlaeger E. J., van Loon A. P. G. M., Scheidereit C.
RT Cloning of the DNA-binding subunit of human nuclear factor kappaB: the level of its mRNA is strongly regulated by phorbol ester or tumor necrosis factor alpha
RL Proc. Natl. Acad. Sci. USA 88:966-970 (1991).
RN [7]; RE0002873.
RX PUBMED: 1756723.
RA Blank V., Kourilsky P., Israel A.
RT Cytoplasmic retention, DNA binding and processing of the NF--kappaB p50 precursor are controlled by a small region in its C-terminus
RL EMBO J. 10:4159-4167 (1991).
RN [8]; RE0004490.
RX PUBMED: 8255759.
RA Mellits K. H., Hay R. T., Goodbourn S.
RT Proteolytic degradation of MAD3 (IkappaBkappa) and enhanced processing of the NF-kappaB precursor p105 are obligatory steps in the activation of NF-kappaB
RL Nucleic Acids Res. 21:5059-5066 (1993).
RN [9]; RE0004495.
RX PUBMED: 1547506.
RA Henkel T., Zabel U., van Zee K., Mueller J. M., Fanning E., Baeuerle P. A.
RT Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappaB subunit
RL Cell 68:1121-1133 (1992).
RN [10]; RE0004497.
RX PUBMED: 1508666.
RA Matthews J. R., Wakasugi N., Virelizier J. L., Yodoi J., Hay R. T.
RT Thioredoxin regulates the DNA binding activity of NF-kappaB by reduction of a disulphide bond involving cysteine 62
RL Nucleic Acids Res. 20:3821-3830 (1992).
RN [11]; RE0004507.
RX PUBMED: 7925300.
RA Naumann M., Scheidereit C.
RT Activation of NF-6B in vivo is regulated by multiple phosphorylations
RL EMBO J. 13:4597-4607 (1994).
RN [12]; RE0004508.
RX PUBMED: 1532257.
RA Hatada E. N., Nieters A., Wulczyn F. G., Naumann M., Meyer R., Nucifora G., McKeithan T. W., Scheidereit C.
RT The ankyrin repeat domains of the NF-kappaB precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF- kappaB DNA binding
RL Proc. Natl. Acad. Sci. USA 89:2489-2493 (1992).
RN [13]; RE0004509.
RX PUBMED: 8428580.
RA Naumann M., Wulczyn F. G., Scheidereit C.
RT The NF-kappaB precursor p105 and the proto-oncogene product Bcl-3 are IkappaB molecules and control nuclear translocation of NF-kappaB
RL EMBO J. 12:213-222 (1993).
RN [14]; RE0004515.
RX PUBMED: 1501885.
RA Hirai H., Fujisawa J., Suzuki T., Ueda K., Muramatsu M., Tsuboi A., Arai N., Yoshida M.
RT Transcriptional activator Tax of HTLV-1 binds to the NF-kappaB precursor p105
RL Oncogene 7:1737-1742 (1992).
RN [15]; RE0004516.
RX PUBMED: 1502202.
RA Paya C. V., Ten R. M., Bessia C., Alcami J., Hay R. T., Virelizier J.-L.
RT NF-kappaB-dependent induction of the NF-kappaB p50 subunit gene promoter underlies self-perpetuation of human immunodeficiency virus transcription in monocytic cells
RL Proc. Natl. Acad. Sci. USA 89:7826-7830 (1992).
RN [16]; RE0004519.
RX PUBMED: 1740105.
RA Ten R. M., Paya C. V., Israel N., Le Bail O., Mattei M.-G., Virelizier J.-L., Kurilsky P., IsraNl A.
RT The characterization of the promoter of the gene encoding the p50 subunit of NF-kappaB indicates that it participates in its own regulation
RL EMBO J. 11:195-203 (1992).
RN [17]; RE0004528.
RX PUBMED: 8087845.
RA Palombella V. J., Rando O. J., Goldberg A. L., Maniatis T.
RT The ubiquitin-proteasome pathway is required for processing the NF-kappaB1 precursor protein and the activation of NF-kappaB
RL Cell 78:773-785 (1994).
RN [18]; RE0018975.
RX PUBMED: 10835356.
RA Orian A., Gonen H., Bercovich B., Fajerman I., Eytan E., Israel A., Mercurio F., Iwai K., Schwartz A. L., Ciechanover A.
RT SCFbeta-TrCP ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase
RL EMBO J. 19:2580-2591 (2000).
RN [19]; RE0030766.
RX PUBMED: 12482991.
RA Lang V., Janzen J., Fischer G. Z., Soneji Y., Beinke S., Salmeron A., Allen H., Hay R. T., Ben-Neriah Y., Ley S. C.
RT betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.
RL Mol. Cell. Biol. 23:402-13 (2003).
RN [20]; RE0047741.
RX PUBMED: 9624136.
RA Boland M. P., O'Neill L. A.
RT Ceramide activates NFkappaB by inducing the processing of p105.
RL J. Biol. Chem. 273:15494-15500 (1998).
RN [21]; RE0049828.
RX PUBMED: 16204234.
RA Hassa P. O., Haenni S. S., Buerki C., Meier N. I., Lane W. S., Owen H., Gersbach M., Imhof R., Hottiger M. O.
RT Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.
RL J. Biol. Chem. 280:40450-40464 (2005).
RN [22]; RE0053206.
RX PUBMED: 17183367.
RA Maine G. N., Mao X., Komarck C. M., Burstein E.
RT COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase.
RL EMBO J. 26:436-447 (2007).
RN [23]; RE0053645.
RX PUBMED: 18045535.
RA Wan F., Anderson D. E., Barnitz R. A., Snow A., Bidere N., Zheng L., Hegde V., Lam L. T., Staudt L. M., Levens D., Deutsch W. A., Lenardo M. J.
RT Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation.
RL Cell 131:927-939 (2007).
RN [24]; RE0053748.
RX PUBMED: 12871932.
RA Demarchi F., Bertoli C., Sandy P., Schneider C.
RT Glycogen synthase kinase-3 beta regulates NF-kappa B1/p105 stability.
RL J. Biol. Chem. 278:39583-39590 (2003).
RN [25]; RE0055188.
RX PUBMED: 17921324.
RA Cortez D. M., Feldman M. D., Mummidi S., Valente A. J., Steffensen B., Vincenti M., Barnes J. L., Chandrasekar B.
RT IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta, NF-kappaB, and AP-1 activation.
RL Am. J. Physiol. Heart Circ. Physiol. 293:H3356-65 (2007).
RN [26]; RE0060983.
RX PUBMED: 16920985.
RA Lin C. H., Cheng H. W., Hsu M. J., Chen M. C., Lin C. C., Chen B. C.
RT c-Src mediates thrombin-induced NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells.
RL J. Immunol. 177:3427-3438 (2006).
RN [27]; RE0065066.
RX PUBMED: 18362142.
RA Kao C. Y., Kim C., Huang F., Wu R.
RT Requirements for two proximal NF-kappaB binding sites and IkappaB-zeta in IL-17A-induced human beta-defensin 2 expression by conducting airway epithelium.
RL J. Biol. Chem. 283:15309-15318 (2008).
RN [28]; RE0065087.
RX PUBMED: 17652082.
RA Patel D. N., King C. A., Bailey S. R., Holt J. W., Venkatachalam K., Agrawal A., Valente A. J., Chandrasekar B.
RT Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation.
RL J. Biol. Chem. 282:27229-27238 (2007).
RN [29]; RE0065762.
RX PUBMED: 16005433.
RA Lee J., Im Y. H., Jung H. H., Kim J. H., Park J. O., Kim K., Kim W. S., Ahn J. S., Jung C. W., Park Y. S., Kang W. K., Park K.
RT Curcumin inhibits interferon-alpha induced NF-kappaB and COX-2 in human A549 non-small cell lung cancer cells.
RL Biochem. Biophys. Res. Commun. 334:313-318 (2005).
RN [30]; RE0066377.
RX PUBMED: 12107827.
RA Nickoloff B. J., Qin J. Z., Chaturvedi V., Denning M. F., Bonish B., Miele L.
RT Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma.
RL Cell Death Differ. 9:842-855 (2002).
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