TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01931 XX ID T01931 XX DT 05.11.1996 (created); ewi. DT 12.06.2015 (updated); hna. CO Copyright (C), QIAGEN. XX FA RelB XX SY I-Rel; IREL; RELB; v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian). XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004623 RELB; HGNC: RELB. XX HO Dorsal. XX CL C0020; Rel; XX SF N-terminally extended sequence when compared with the murine homolog [3]; SF no heterodimerization with c-Rel or RelA (p65) [1] [3]; XX FF constitutive activator in heterodimeric complexes with either NF-kappaB1 (p50) or NF-kappaB2 (p52) [1]; FF transcription repressing activity has also been reported [3]; FF activates the IkappaB-alpha gene, but is not a target for the IkappaB-alpha inhibitor and thus is not retained in the cytoplasm [1]; XX IN T01261 Brm; human, Homo sapiens. IN T08470 Daxx-isoform1; human, Homo sapiens. IN T22508 dpf2-isoform1; human, Homo sapiens. IN T22509 dpf2; human, Homo sapiens. IN T01925 NF-kappaB1; human, Homo sapiens. IN T01927 NF-kappaB2-p100; human, Homo sapiens. IN T00394 NF-kappaB2-p52; human, Homo sapiens. XX MX M03882 V$RELBP50_Q3. XX BS R61153. BS R30510. BS R40311. BS R61726. BS R25550. BS R25553. BS R30655. BS R30369. BS R30650. BS R29952. BS R24123. BS R25474. BS R25475. BS R68249. BS R68253. BS R22506. BS R66698. BS R66699. BS R66701. BS R64783. BS R32472. XX DR TRANSPATH: MO000019372. DR UniProtKB: Q01201; XX RN [1]; RE0004536. RX PUBMED: 7925301. RA Dobrzanski P., Ryseck R.-P., Bravo R. RT Differential interactions of RelB-NF-kappaB complexes with IkappaBalpha determine pools of constitutive and inducible NF-kappaB activity RL EMBO J. 13:4608-4616 (1994). RN [2]; RE0004560. RX PUBMED: 8441398. RA Dobrzanski P., Ryseck R. P., Bravo R. RT Both N- and C- terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif RL Mol. Cell. Biol. 13:1572-1582 (1993). RN [3]; RE0004564. RX PUBMED: 1577270. RA Ruben S. M., Klement J. F., Maher M., Coleman T. A., Chen C.-M., Rosen C. A. RT I-Rel: a novel rel-related protein that inhibits NF-kappaB transcriptional activity RL Genes Dev. 6:745-760 (1992). RN [4]; RE0051930. RX PUBMED: 17644309. RA Yamaguchi T., Miki Y., Yoshida K. RT Protein kinase C delta activates IkappaB-kinase alpha to induce the p53 tumor suppressor in response to oxidative stress. RL Cell. Signal. 19:2088-2097 (2007). RN [5]; RE0053206. RX PUBMED: 17183367. RA Maine G. N., Mao X., Komarck C. M., Burstein E. RT COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase. RL EMBO J. 26:436-447 (2007). RN [6]; RE0053845. RX PUBMED: 12709443. RA Derudder E., Dejardin E., Pritchard L. L., Green D. R., Korner M., Baud V. RT RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100. RL J. Biol. Chem. 278:23278-23284 (2003). RN [7]; RE0053976. RX PUBMED: 15708970. RA Hauer J., Puschner S., Ramakrishnan P., Simon U., Bongers M., Federle C., Engelmann H. RT TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs. RL Proc. Natl. Acad. Sci. USA 102:2874-2879 (2005). RN [8]; RE0054072. RX PUBMED: 11687592. RA Solan N. J., Miyoshi H., Carmona E. M., Bren G. D., Paya C. V. RT RelB cellular regulation and transcriptional activity are regulated by p100. RL J. Biol. Chem. 277:1405-1418 (2002). RN [9]; RE0054190. RX PUBMED: 12820969. RA Saccani S., Pantano S., Natoli G. RT Modulation of NF-kappaB activity by exchange of dimers. RL Mol. Cell 11:1563-1574 (2003). RN [10]; RE0058894. RX PUBMED: 11753650. RA Bren G. D., Solan N. J., Miyoshi H., Pennington K. N., Pobst L. J., Paya C. V. RT Transcription of the RelB gene is regulated by NF-kappaB. RL Oncogene 20:7722-7733 (2001). RN [11]; RE0070954. RX PUBMED: 20460684. RA Tando T., Ishizaka A., Watanabe H., Ito T., Iida S., Haraguchi T., Mizutani T., Izumi T., Isobe T., Akiyama T., Inoue J., Iba H. RT Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway. RL J. Biol. Chem. 285:21951-21960 (2010). XX //