AC T01931
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ID T01931
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DT 05.11.1996 (created); ewi.
DT 12.06.2015 (updated); hna.
CO Copyright (C), QIAGEN.
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FA RelB
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SY I-Rel; IREL; RELB; v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (avian).
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004623 RELB; HGNC: RELB.
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HO Dorsal.
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CL C0020; Rel; 6.1.1.2.2.
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SF N-terminally extended sequence when compared with the murine homolog [3];
SF no heterodimerization with c-Rel or RelA (p65) [1] [3];
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FF constitutive activator in heterodimeric complexes with either NF-kappaB1 (p50) or NF-kappaB2 (p52) [1];
FF transcription repressing activity has also been reported [3];
FF activates the IkappaB-alpha gene, but is not a target for the IkappaB-alpha inhibitor and thus is not retained in the cytoplasm [1];
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IN T01261 Brm; human, Homo sapiens.
IN T08470 Daxx-isoform1; human, Homo sapiens.
IN T22508 dpf2-isoform1; human, Homo sapiens.
IN T22509 dpf2; human, Homo sapiens.
IN T01925 NF-kappaB1; human, Homo sapiens.
IN T01927 NF-kappaB2-p100; human, Homo sapiens.
IN T00394 NF-kappaB2-p52; human, Homo sapiens.
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MX M03882 V$RELBP50_Q3.
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BS R61153.
BS R30510.
BS R40311.
BS R61726.
BS R25550.
BS R25553.
BS R30655.
BS R30369.
BS R30650.
BS R29952.
BS R24123.
BS R25474.
BS R25475.
BS R68249.
BS R68253.
BS R22506.
BS R66698.
BS R66699.
BS R66701.
BS R64783.
BS R32472.
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DR TRANSPATH: MO000019372.
DR UniProtKB: Q01201;
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RN [1]; RE0004536.
RX PUBMED: 7925301.
RA Dobrzanski P., Ryseck R.-P., Bravo R.
RT Differential interactions of RelB-NF-kappaB complexes with IkappaBalpha determine pools of constitutive and inducible NF-kappaB activity
RL EMBO J. 13:4608-4616 (1994).
RN [2]; RE0004560.
RX PUBMED: 8441398.
RA Dobrzanski P., Ryseck R. P., Bravo R.
RT Both N- and C- terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motif
RL Mol. Cell. Biol. 13:1572-1582 (1993).
RN [3]; RE0004564.
RX PUBMED: 1577270.
RA Ruben S. M., Klement J. F., Maher M., Coleman T. A., Chen C.-M., Rosen C. A.
RT I-Rel: a novel rel-related protein that inhibits NF-kappaB transcriptional activity
RL Genes Dev. 6:745-760 (1992).
RN [4]; RE0051930.
RX PUBMED: 17644309.
RA Yamaguchi T., Miki Y., Yoshida K.
RT Protein kinase C delta activates IkappaB-kinase alpha to induce the p53 tumor suppressor in response to oxidative stress.
RL Cell. Signal. 19:2088-2097 (2007).
RN [5]; RE0053206.
RX PUBMED: 17183367.
RA Maine G. N., Mao X., Komarck C. M., Burstein E.
RT COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase.
RL EMBO J. 26:436-447 (2007).
RN [6]; RE0053845.
RX PUBMED: 12709443.
RA Derudder E., Dejardin E., Pritchard L. L., Green D. R., Korner M., Baud V.
RT RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100.
RL J. Biol. Chem. 278:23278-23284 (2003).
RN [7]; RE0053976.
RX PUBMED: 15708970.
RA Hauer J., Puschner S., Ramakrishnan P., Simon U., Bongers M., Federle C., Engelmann H.
RT TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs.
RL Proc. Natl. Acad. Sci. USA 102:2874-2879 (2005).
RN [8]; RE0054072.
RX PUBMED: 11687592.
RA Solan N. J., Miyoshi H., Carmona E. M., Bren G. D., Paya C. V.
RT RelB cellular regulation and transcriptional activity are regulated by p100.
RL J. Biol. Chem. 277:1405-1418 (2002).
RN [9]; RE0054190.
RX PUBMED: 12820969.
RA Saccani S., Pantano S., Natoli G.
RT Modulation of NF-kappaB activity by exchange of dimers.
RL Mol. Cell 11:1563-1574 (2003).
RN [10]; RE0058894.
RX PUBMED: 11753650.
RA Bren G. D., Solan N. J., Miyoshi H., Pennington K. N., Pobst L. J., Paya C. V.
RT Transcription of the RelB gene is regulated by NF-kappaB.
RL Oncogene 20:7722-7733 (2001).
RN [11]; RE0070954.
RX PUBMED: 20460684.
RA Tando T., Ishizaka A., Watanabe H., Ito T., Iida S., Haraguchi T., Mizutani T., Izumi T., Isobe T., Akiyama T., Inoue J., Iba H.
RT Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway.
RL J. Biol. Chem. 285:21951-21960 (2010).
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