TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00394 XX ID T00394 XX DT 15.10.1992 (created); ewi. DT 30.01.2013 (updated); spk. CO Copyright (C), QIAGEN. XX FA NF-kappaB2-p52 XX SY Lyt-10; NF-kappaB2; NF-kappaB2 (p52); NFKB2-p50B; p52. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX CL C0020; Rel. XX SF N-terminal half of a 100-kDa precursor T01927 from which it is released by proteolytic clipping [11]; XX CP ubiquitous. XX FF constitutive activator when heterodimerized with RelB [9]; FF transcriptionally inert DNA-binding homodimer forms trans-activating ternary complexes with Bcl-3 [4] [6]; FF the NFKB2 gene contains two promoters [8]; FF at least four kappaB sites mediate positive autoregulation in response to phorbol esters or TNF-alpha [8]; XX IN T01928 Bcl-3; human, Homo sapiens. IN T08910 Bcl-3; human, Homo sapiens. IN T17532 Bcl-3; Mammalia. IN T00168 c-Rel; human, Homo sapiens. IN T27186 GILZ-isoform1; human, Homo sapiens. IN T22436 IkappaB-epsilon-xxb2; human, Homo sapiens. IN T00593 NF-kappaB1-p50; human, Homo sapiens. IN T00594 RelA-p65-isoform1; human, Homo sapiens. IN T01931 RelB; human, Homo sapiens. IN T01932 RelB; mouse, Mus musculus. XX MX M00208 V$NFKB_C. MX M00774 V$NFKB_Q6_01. XX BS R00922. BS R17059. BS R17060. BS R17061. BS R17063. BS R01059. XX DR TRANSPATH: MO000019367. XX RN [1]; RE0001376. RX PUBMED: 2677676. RA Mauxion F., Sen R. RT Alteration of a Single Nucleotide Allows Efficient Binding of H2TF1/KBF1 to the Immunoglobulin k Enhancer B Motif RL Mol. Cell. Biol. 9:3548-3552 (1989). RN [2]; RE0001873. RX PUBMED: 1876189. RA Schmid R. M., Perkins N. D., Duckett C. S., Andrews P. C., Nabel G. J. RT Cloning of an NF-kappaB subunit which stimulates HIV transcription in synergy with p65 RL Nature 352:733-736 (1991). RN [3]; RE0002005. RX PUBMED: 2566973. RA Fujita T., Miyamoto M., Kimura Y., Hammer J., Taniguchi T. RT Involvement of a cis-element that binds an H2TF-1/NFkappaB like factor(s) in the virus-induced interferon-beta gene expression RL Nucleic Acids Res. 17:3335-3346 (1989). RN [4]; RE0004493. RX PUBMED: 7559449. RA Pan J., McEver R. P. RT Regulation of the human P-selection promoter by Bcl-3 and specific homodimeric members of the NF-kappaB/Rel family RL J. Biol. Chem. 270:23077-23083 (1995). RN [5]; RE0004507. RX PUBMED: 7925300. RA Naumann M., Scheidereit C. RT Activation of NF-6B in vivo is regulated by multiple phosphorylations RL EMBO J. 13:4597-4607 (1994). RN [6]; RE0004533. RX PUBMED: 8453667. RA Bours V., Franzoso G., Azarenko V., Park S., Kanno T., Brown K., Siebenlist U. RT The oncoprotein Bcl-3 directly transactivates through kappaB motifs via association with DNA-binding p50B homodimers RL Cell 72:729-739 (1993). RN [7]; RE0004534. RX PUBMED: 8360178. RA Potter D. A., Larson C. J., Eckes P., Schmid R. M., Nabel G. J., Verdine G. L., Sharp P. A. RT Purification of the major histocompatibility complex class I transcription factor H2TF1. The full-length product of the nfkb2 gene RL J. Biol. Chem. 268:18882-18890 (1993). RN [8]; RE0004535. RX PUBMED: 7969113. RA Liptay S., Schmid R. M., Nabel E. G., Nabel G. J. RT Transcriptional regulation of NF-kappaB2: evidence for kappaB-mediated positive and negative autoregulation RL Mol. Cell. Biol. 14:7695-7703 (1994). RN [9]; RE0004536. RX PUBMED: 7925301. RA Dobrzanski P., Ryseck R.-P., Bravo R. RT Differential interactions of RelB-NF-kappaB complexes with IkappaBalpha determine pools of constitutive and inducible NF-kappaB activity RL EMBO J. 13:4608-4616 (1994). RN [10]; RE0004537. RX PUBMED: 1531086. RA Bours V., Burd P. R., Brown K., Villalobos J., Park S., Ryseck R. P., Bravo R., Kelly K., Siebenlist U. RT A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B site RL Mol. Cell. Biol. 12:685-695 (1992). RN [11]; RE0004538. RX PUBMED: 8458581. RA Mercurio F., Didonato J. A., Rosette C., Karin M. RT p105 and p98 precursor proteins play an active role in NF-kappaB-mediated signal transduction RL Genes Dev. 7:705-718 (1993). RN [12]; RE0004539. RX PUBMED: 8413211. RA Scheinman R. I., Beg A. A., Baldwin jr A. S. RT NF-kappaB p100 (Lyt-10) is a component of H2TF1 and can function as an IkappaB-like molecule RL Mol. Cell. Biol. 13:6089-6101 (1993). RN [13]; RE0004540. RX PUBMED: 1760839. RA Neri A., Chang C.-C., Lombardi L., Salina M., Corradini P., Maiolo A. T., Chaganti R. S. K., Dalla-Favera R. RT B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappaB p50 RL Cell 67:1075-1087 (1991). RN [14]; RE0004636. RX PUBMED: 8439294. RA Zhang W. W., Zhang L.-X., Busch R. K., Farres J., Busch H. RT Purification and characterization of a DNA-binding heterodimer of 52 and 100 kDa from HeLa cells RL J. Biochem. 290:267-272 (1993). RN [15]; RE0029416. RX PUBMED: 11994270. RA Fong A., Sun S. C. RT Genetic Evidence for the Essential Role of beta -Transducin Repeat-containing Protein in the Inducible Processing of NF-kappa B2/p100. RL J. Biol. Chem. 277:22111-4 (2002). RN [16]; RE0030779. RX PUBMED: 12556537. RA Muller J. R., Siebenlist U. RT Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathways. RL J. Biol. Chem. 278:12006-12 (2003). RN [17]; RE0037635. RX PUBMED: 14617774. RA Song S. W., Fuller G. N., Khan A., Kong S., Shen W., Taylor E., Ramdas L., Lang F. F., Zhang W. RT IIp45, an insulin-like growth factor binding protein 2 (IGFBP-2) binding protein, antagonizes IGFBP-2 stimulation of glioma cell invasion RL Proc. Natl. Acad. Sci. USA 100:13970-5 (2003). RN [18]; RE0044053. RX PUBMED: 15084608. RA Liao G., Zhang M., Harhaj E. W., Sun S. C. RT Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation RL J. Biol. Chem. 279:26243-50 (2004). RN [19]; RE0046561. RX PUBMED: 11468175. RA Ayroldi E., Migliorati G., Bruscoli S., Marchetti C., Zollo O., Cannarile L., D'Adamio F., Riccardi C. RT Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB RL Blood 98:743-53 (2001). RN [20]; RE0051641. RX PUBMED: 15208311. RA Hu W. H., Mo X. M., Walters W. M., Brambilla R., Bethea J. R. RT TNAP, a novel repressor of NF-kappaB-inducing kinase, suppresses NF-kappaB activation. RL J. Biol. Chem. 279:35975-35983 (2004). RN [21]; RE0051644. RX PUBMED: 11239468. RA Xiao G., Harhaj E. W., Sun S. C. RT NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. RL Mol. Cell 7:401-409 (2001). RN [22]; RE0052978. RX PUBMED: 18022362. RA Varfolomeev E., Blankenship J. W., Wayson S. M., Fedorova A. V., Kayagaki N., Garg P., Zobel K., Dynek J. N., Elliott L. O., Wallweber H. J., Flygare J. A., Fairbrother W. J., Deshayes K., Dixit V. M., Vucic D. RT IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. RL Cell 131:669-681 (2007). RN [23]; RE0053642. RX PUBMED: 15140882. RA Xiao G., Fong A., Sun S. C. RT Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation. RL J. Biol. Chem. 279:30099-30105 (2004). RN [24]; RE0053939. RX PUBMED: 12524526. RA Mordmuller B., Krappmann D., Esen M., Wegener E., Scheidereit C. RT Lymphotoxin and lipopolysaccharide induce NF-kappaB-p52 generation by a co-translational mechanism. RL EMBO Rep. 4:82-87 (2003). RN [25]; RE0053976. RX PUBMED: 15708970. RA Hauer J., Puschner S., Ramakrishnan P., Simon U., Bongers M., Federle C., Engelmann H. RT TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs. RL Proc. Natl. Acad. Sci. USA 102:2874-2879 (2005). RN [26]; RE0054105. RX PUBMED: 14676825. RA Amir R. E., Haecker H., Karin M., Ciechanover A. RT Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase. RL Oncogene 23:2540-2547 (2004). RN [27]; RE0054132. RX PUBMED: 11726516. RA Xiao G., Cvijic M. E., Fong A., Harhaj E. W., Uhlik M. T., Waterfield M., Sun S. C. RT Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha. RL EMBO J. 20:6805-6815 (2001). RN [28]; RE0063550. RX PUBMED: 18292573. RA Madge L. A., Kluger M. S., Orange J. S., May M. J. RT Lymphotoxin-alpha 1 beta 2 and LIGHT induce classical and noncanonical NF-kappa B-dependent proinflammatory gene expression in vascular endothelial cells. RL J. Immunol. 180:3467-3477 (2008). XX //