AC T00105
XX
ID T00105
XX
DT 15.10.1992 (created); ewi.
DT 22.05.2015 (updated); msr.
CO Copyright (C), QIAGEN.
XX
FA C/EBPalpha
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SY BPc; C/EBP; C/EBP alpha; C/EBPalpha; CBP; CCAAT Enhancer Binding Protein alpha; CCAAT/enhancer binding protein alpha; CEBPA; EBP20.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G001170 CEBPA; HGNC: CEBPA.
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CL C0008; bZIP; 1.1.8.1.1.
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CP hepatocytes. adipocytes, macrophages; Keratinocyte nuclear extract [9].
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FF activator;
FF inhibits cell proliferation by enhancing the level of p21 (WAF-1) [4];
FF this is due to enhanced gene expression and posttranslational stabilization of p21 [4];
FF one of the key regulators of adipocyte differentiation;
FF acts cooperatively and physically interacts with NF-ATc4 [5];
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IN T00040 AR; human, Homo sapiens.
IN T05778 ASC-2; human, Homo sapiens.
IN T01303 ATF-4; human, Homo sapiens.
IN T09531 ATF-4; human, Homo sapiens.
IN T04877 ATF-5; human, Homo sapiens.
IN T18798 ATFa-isoform3; human, Homo sapiens.
IN T18808 B-ATF; human, Homo sapiens.
IN T18804 batf3; human, Homo sapiens.
IN T01261 Brm; human, Homo sapiens.
IN T08461 c-Jun; human, Homo sapiens.
IN T00105 C/EBPalpha; human, Homo sapiens.
IN T00017 C/EBPbeta-FL; mouse, Mus musculus.
IN T00459 C/EBPbeta-FL; rat, Rattus norvegicus.
IN T06595 C/EBPbeta-FL; human, Homo sapiens.
IN T00581 C/EBPbeta; human, Homo sapiens.
IN T00109 C/EBPdelta; rat, Rattus norvegicus.
IN T00583 C/EBPdelta; human, Homo sapiens.
IN T01114 C/EBPdelta; mouse, Mus musculus.
IN T09139 C/EBPdelta; human, Homo sapiens.
IN T04883 C/EBPepsilon; human, Homo sapiens.
IN T00216 C/EBPgamma; mouse, Mus musculus.
IN T09524 C/EBPgamma; human, Homo sapiens.
IN T01488 Cdk2; human, Homo sapiens.
IN T09526 CHOP-10-isoform1; human, Homo sapiens.
IN T00127 CHOP-10; mouse, Mus musculus.
IN T01387 CHOP-10; human, Homo sapiens.
IN T09550 CREBPA-Alpha; human, Homo sapiens.
IN T00593 NF-kappaB1-p50; human, Homo sapiens.
IN T01804 NF-YA; human, Homo sapiens.
IN T08564 NF-YB; Mammalia.
IN T01948 NFATc2; human, Homo sapiens.
IN T02462 NFATc4; human, Homo sapiens.
XX
MX M00116 V$CEBPA_01.
MX M07205 V$CEBPA_03.
MX M07412 V$CEBPA_04.
MX M07037 V$CEBPA_Q4.
MX M01866 V$CEBPA_Q6.
MX M00159 V$CEBP_01.
MX M00201 V$CEBP_C.
MX M00190 V$CEBP_Q2.
MX M00912 V$CEBP_Q2_01.
MX M00770 V$CEBP_Q3.
MX M00249 V$CHOP_01.
XX
BS R26350.
BS R04246.
BS R04247.
BS R04592.
BS R04911.
BS R71538.
BS R04603.
BS R60851.
BS R60853.
BS R64858.
BS R29895.
BS R20226.
BS R20228.
BS R00138.
BS R03657.
BS R26345.
BS R26349.
BS R56779.
BS R73673.
BS R40724.
BS R29444.
BS R27098.
BS R40250.
BS R27443.
BS R32639.
BS R30671.
BS R38277.
BS R72226.
BS R72228.
BS R35639.
BS R35640.
BS R23954.
BS R23529.
BS R23530.
BS R21124.
BS R32730.
BS R31151.
BS R31147.
BS R33581.
BS R38275.
BS R36411.
BS R08081.
BS R57171.
BS R60551.
BS R00422.
BS R34906.
BS R62159.
BS R29896.
BS R26690.
BS R20520.
BS R62853.
BS R32327.
BS R00627.
BS R35570.
BS R36307.
BS R34962.
BS R63686.
BS R42314.
BS R08087.
BS R38423.
BS R38292.
BS R14528.
BS R14529.
BS R14533.
BS R67223.
BS R21789.
BS R38180.
BS R21707.
BS R20524.
BS R59332.
BS R59333.
BS R59334.
BS R39786.
BS R39787.
BS R31180.
BS R08091.
BS R08092.
BS R59157.
BS R21802.
BS R15892.
BS R23085.
BS R30770.
BS R27058.
BS R42260.
BS R42264.
BS R01456.
BS R25207.
BS R62138.
BS R67817.
BS R33202.
BS R00089.
BS R26163.
BS R26164.
BS R19750.
BS R01185.
BS R03730.
BS R03732.
BS R03733.
XX
DR TRANSPATH: MO000019418.
DR TRANSCOMPEL: C00089.
DR TRANSCOMPEL: C00145.
DR TRANSCOMPEL: C00155.
DR TRANSCOMPEL: C00186.
DR TRANSCOMPEL: C00413.
DR TRANSCOMPEL: C00551.
DR UniProtKB: P49715;
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RN [1]; RE0001961.
RX PUBMED: 2495523.
RA Lucero M. A., Sanchez D., Ochoa A. R., Brunel F., Cohen G. N., Baralle F. E., Zakin M. M.
RT Interaction of DNA-binding proteins with the tissue-specific human apolipoprotein-AII enhancer
RL Nucleic Acids Res. 17:2283-2300 (1989).
RN [2]; RE0002710.
RX PUBMED: 8211160.
RA Wagner S., Green M. R.
RT HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization
RL Science 262:395-399 (1993).
RN [3]; RE0005499.
RX PUBMED: 7575576.
RA Antonson P., Xanthopoulos K. G.
RT Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBPalpha)
RL Biochem. Biophys. Res. Commun. 215:106-113 (1995).
RN [4]; RE0006259.
RX PUBMED: 8846917.
RA Timchenko N. A., Wilde M., Nakanishi M., Smith J. R., Darlington G. J.
RT CCAAT/enhancer-binding protein alpha (C/EBPalpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein
RL Genes Dev. 10:804-815 (1996).
RN [5]; RE0023877.
RX PUBMED: 12606546.
RA Yang T. T., Chow C. W.
RT Transcription cooperation by NFAT.C/EBP composite enhancer complex.
RL J. Biol. Chem. 278:15874-15885 (2003).
RN [6]; RE0033804.
RX PUBMED: 15294971.
RA Takeshita F., Suzuki K., Sasaki S., Ishii N., Klinman D. M., Ishii K. J.
RT Transcriptional regulation of the human TLR9 gene.
RL J. Immunol. 173:2552-61 (2004).
RN [7]; RE0035887.
RX PUBMED: 14701740.
RA Ross S. E., Radomska H. S., Wu B., Zhang P., Winnay J. N., Bajnok L., Wright W. S., Schaufele F., Tenen D. G., MacDougald O. A.
RT Phosphorylation of C/EBPalpha inhibits granulopoiesis.
RL Mol. Cell. Biol. 24:675-686 (2004).
RN [8]; RE0042688.
RX PUBMED: 11684017.
RA Wang H., Iakova P., Wilde M., Welm A., Goode T., Roesler W. J., Timchenko N. A.
RT C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4
RL Mol. Cell 8:817-28 (2001).
RN [9]; RE0045707.
RX PUBMED: 10037704.
RA Agarwal C., Efimova T., Welter J. F., Crish J. F., Eckert R. L.
RT CCAAT/enhancer-binding proteins. A role in regulation of human involucrin promoter response to phorbol ester
RL J. Biol. Chem. 274:6190-4 (1999).
RN [10]; RE0047115.
RX PUBMED: 10706719.
RA Tsutsumi-Ishii Y., Hasebe T., Nagaoka I.
RT Role of CCAAT/enhancer-binding protein site in transcription of human neutrophil peptide-1 and -3 defensin genes
RL J. Immunol. 164:3264-73 (2000).
RN [11]; RE0047831.
RX PUBMED: 11302752.
RA Hong S., Lee M. Y., Cheong J.
RT Functional interaction of transcriptional coactivator ASC-2 and C/EBPalpha in granulocyte differentiation of HL-60 promyelocytic cell.
RL Biochem. Biophys. Res. Commun. 282:1257-1262 (2001).
RN [12]; RE0048287.
RX PUBMED: 12805554.
RA Newman J. R., Keating A. E.
RT Comprehensive identification of human bZIP interactions with coiled-coil arrays.
RL Science 300:2097-2101 (2003).
RN [13]; RE0048356.
RX PUBMED: 16455820.
RA Chattopadhyay S., Gong E. Y., Hwang M., Park E., Lee H. J., Hong C. Y., Choi H. S., Cheong J. H., Kwon H. B., Lee K.
RT The CCAAT enhancer-binding protein-alpha negatively regulates the transactivation of androgen receptor in prostate cancer cells.
RL Mol. Endocrinol. 20:984-995 (2006).
RN [14]; RE0048459.
RX PUBMED: 12091339.
RA Reddy V. A., Iwama A., Iotzova G., Schulz M., Elsasser A., Vangala R. K., Tenen D. G., Hiddemann W., Behre G.
RT Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions.
RL Blood 100:483-490 (2002).
RN [15]; RE0048551.
RX PUBMED: 16254192.
RA Paz-Priel I., Cai D. H., Wang D., Kowalski J., Blackford A., Liu H., Heckman C. A., Gombart A. F., Koeffler H. P., Boxer L. M., Friedman A. D.
RT CCAAT/enhancer binding protein alpha (C/EBPalpha) and C/EBPalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappaB p50.
RL Mol. Cancer Res. 3:585-596 (2005).
RN [16]; RE0055471.
RX PUBMED: 19054766.
RA Dhawan P., Weider R., Christakos S.
RT CCAAT Enhancer-binding Protein {alpha} Is a Molecular Target of 1,25-Dihydroxyvitamin D3 in MCF-7 Breast Cancer Cells.
RL J. Biol. Chem. 284:3086-3095 (2009).
RN [17]; RE0065087.
RX PUBMED: 17652082.
RA Patel D. N., King C. A., Bailey S. R., Holt J. W., Venkatachalam K., Agrawal A., Valente A. J., Chandrasekar B.
RT Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation.
RL J. Biol. Chem. 282:27229-27238 (2007).
RN [18]; RE0072582.
RX PUBMED: 21856370.
RA Wu Y. L., Peng X. E., Wang D., Chen W. N., Lin X.
RT Human liver fatty acid binding protein (hFABP1) gene is regulated by liver-enriched transcription factors HNF3beta and C/EBPalpha.
RL Biochimie 94:384-392 (2012).
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