TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00105 XX ID T00105 XX DT 15.10.1992 (created); ewi. DT 22.05.2015 (updated); msr. CO Copyright (C), QIAGEN. XX FA C/EBPalpha XX SY BPc; C/EBP; C/EBP alpha; C/EBPalpha; CBP; CCAAT Enhancer Binding Protein alpha; CCAAT/enhancer binding protein alpha; CEBPA; EBP20. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G001170 CEBPA; HGNC: CEBPA. XX CL C0008; bZIP; XX CP hepatocytes. adipocytes, macrophages; Keratinocyte nuclear extract [9]. XX FF activator; FF inhibits cell proliferation by enhancing the level of p21 (WAF-1) [4]; FF this is due to enhanced gene expression and posttranslational stabilization of p21 [4]; FF one of the key regulators of adipocyte differentiation; FF acts cooperatively and physically interacts with NF-ATc4 [5]; XX IN T00040 AR; human, Homo sapiens. IN T05778 ASC-2; human, Homo sapiens. IN T01303 ATF-4; human, Homo sapiens. IN T09531 ATF-4; human, Homo sapiens. IN T04877 ATF-5; human, Homo sapiens. IN T18798 ATFa-isoform3; human, Homo sapiens. IN T18808 B-ATF; human, Homo sapiens. IN T18804 batf3; human, Homo sapiens. IN T01261 Brm; human, Homo sapiens. IN T08461 c-Jun; human, Homo sapiens. IN T00105 C/EBPalpha; human, Homo sapiens. IN T00017 C/EBPbeta-FL; mouse, Mus musculus. IN T00459 C/EBPbeta-FL; rat, Rattus norvegicus. IN T06595 C/EBPbeta-FL; human, Homo sapiens. IN T00581 C/EBPbeta; human, Homo sapiens. IN T00109 C/EBPdelta; rat, Rattus norvegicus. IN T00583 C/EBPdelta; human, Homo sapiens. IN T01114 C/EBPdelta; mouse, Mus musculus. IN T09139 C/EBPdelta; human, Homo sapiens. IN T04883 C/EBPepsilon; human, Homo sapiens. IN T00216 C/EBPgamma; mouse, Mus musculus. IN T09524 C/EBPgamma; human, Homo sapiens. IN T01488 Cdk2; human, Homo sapiens. IN T09526 CHOP-10-isoform1; human, Homo sapiens. IN T00127 CHOP-10; mouse, Mus musculus. IN T01387 CHOP-10; human, Homo sapiens. IN T09550 CREBPA-Alpha; human, Homo sapiens. IN T00593 NF-kappaB1-p50; human, Homo sapiens. IN T01804 NF-YA; human, Homo sapiens. IN T08564 NF-YB; Mammalia. IN T01948 NFATc2; human, Homo sapiens. IN T02462 NFATc4; human, Homo sapiens. XX MX M00116 V$CEBPA_01. MX M07205 V$CEBPA_03. MX M07412 V$CEBPA_04. MX M07037 V$CEBPA_Q4. MX M01866 V$CEBPA_Q6. MX M00159 V$CEBP_01. MX M00201 V$CEBP_C. MX M00190 V$CEBP_Q2. MX M00912 V$CEBP_Q2_01. MX M00770 V$CEBP_Q3. MX M00249 V$CHOP_01. XX BS R26350. BS R04246. BS R04247. BS R04592. BS R04911. BS R71538. BS R04603. BS R60851. BS R60853. BS R64858. BS R29895. BS R20226. BS R20228. BS R00138. BS R03657. BS R26345. BS R26349. BS R56779. BS R73673. BS R40724. BS R29444. BS R27098. BS R40250. BS R27443. BS R32639. BS R30671. BS R38277. BS R72226. BS R72228. BS R35639. BS R35640. BS R23954. BS R23529. BS R23530. BS R21124. BS R32730. BS R31151. BS R31147. BS R33581. BS R38275. BS R36411. BS R08081. BS R57171. BS R60551. BS R00422. BS R34906. BS R62159. BS R29896. BS R26690. BS R20520. BS R62853. BS R32327. BS R00627. BS R35570. BS R36307. BS R34962. BS R63686. BS R42314. BS R08087. BS R38423. BS R38292. BS R14528. BS R14529. BS R14533. BS R67223. BS R21789. BS R38180. BS R21707. BS R20524. BS R59332. BS R59333. BS R59334. BS R39786. BS R39787. BS R31180. BS R08091. BS R08092. BS R59157. BS R21802. BS R15892. BS R23085. BS R30770. BS R27058. BS R42260. BS R42264. BS R01456. BS R25207. BS R62138. BS R67817. BS R33202. BS R00089. BS R26163. BS R26164. BS R19750. BS R01185. BS R03730. BS R03732. BS R03733. XX DR TRANSPATH: MO000019418. DR TRANSCOMPEL: C00089. DR TRANSCOMPEL: C00145. DR TRANSCOMPEL: C00155. DR TRANSCOMPEL: C00186. DR TRANSCOMPEL: C00413. DR TRANSCOMPEL: C00551. DR UniProtKB: P49715; XX RN [1]; RE0001961. RX PUBMED: 2495523. RA Lucero M. A., Sanchez D., Ochoa A. R., Brunel F., Cohen G. N., Baralle F. E., Zakin M. M. RT Interaction of DNA-binding proteins with the tissue-specific human apolipoprotein-AII enhancer RL Nucleic Acids Res. 17:2283-2300 (1989). RN [2]; RE0002710. RX PUBMED: 8211160. RA Wagner S., Green M. R. RT HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization RL Science 262:395-399 (1993). RN [3]; RE0005499. RX PUBMED: 7575576. RA Antonson P., Xanthopoulos K. G. RT Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBPalpha) RL Biochem. Biophys. Res. Commun. 215:106-113 (1995). RN [4]; RE0006259. RX PUBMED: 8846917. RA Timchenko N. A., Wilde M., Nakanishi M., Smith J. R., Darlington G. J. RT CCAAT/enhancer-binding protein alpha (C/EBPalpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein RL Genes Dev. 10:804-815 (1996). RN [5]; RE0023877. RX PUBMED: 12606546. RA Yang T. T., Chow C. W. RT Transcription cooperation by NFAT.C/EBP composite enhancer complex. RL J. Biol. Chem. 278:15874-15885 (2003). RN [6]; RE0033804. RX PUBMED: 15294971. RA Takeshita F., Suzuki K., Sasaki S., Ishii N., Klinman D. M., Ishii K. J. RT Transcriptional regulation of the human TLR9 gene. RL J. Immunol. 173:2552-61 (2004). RN [7]; RE0035887. RX PUBMED: 14701740. RA Ross S. E., Radomska H. S., Wu B., Zhang P., Winnay J. N., Bajnok L., Wright W. S., Schaufele F., Tenen D. G., MacDougald O. A. RT Phosphorylation of C/EBPalpha inhibits granulopoiesis. RL Mol. Cell. Biol. 24:675-686 (2004). RN [8]; RE0042688. RX PUBMED: 11684017. RA Wang H., Iakova P., Wilde M., Welm A., Goode T., Roesler W. J., Timchenko N. A. RT C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4 RL Mol. Cell 8:817-28 (2001). RN [9]; RE0045707. RX PUBMED: 10037704. RA Agarwal C., Efimova T., Welter J. F., Crish J. F., Eckert R. L. RT CCAAT/enhancer-binding proteins. A role in regulation of human involucrin promoter response to phorbol ester RL J. Biol. Chem. 274:6190-4 (1999). RN [10]; RE0047115. RX PUBMED: 10706719. RA Tsutsumi-Ishii Y., Hasebe T., Nagaoka I. RT Role of CCAAT/enhancer-binding protein site in transcription of human neutrophil peptide-1 and -3 defensin genes RL J. Immunol. 164:3264-73 (2000). RN [11]; RE0047831. RX PUBMED: 11302752. RA Hong S., Lee M. Y., Cheong J. RT Functional interaction of transcriptional coactivator ASC-2 and C/EBPalpha in granulocyte differentiation of HL-60 promyelocytic cell. RL Biochem. Biophys. Res. Commun. 282:1257-1262 (2001). RN [12]; RE0048287. RX PUBMED: 12805554. RA Newman J. R., Keating A. E. RT Comprehensive identification of human bZIP interactions with coiled-coil arrays. RL Science 300:2097-2101 (2003). RN [13]; RE0048356. RX PUBMED: 16455820. RA Chattopadhyay S., Gong E. Y., Hwang M., Park E., Lee H. J., Hong C. Y., Choi H. S., Cheong J. H., Kwon H. B., Lee K. RT The CCAAT enhancer-binding protein-alpha negatively regulates the transactivation of androgen receptor in prostate cancer cells. RL Mol. Endocrinol. 20:984-995 (2006). RN [14]; RE0048459. RX PUBMED: 12091339. RA Reddy V. A., Iwama A., Iotzova G., Schulz M., Elsasser A., Vangala R. K., Tenen D. G., Hiddemann W., Behre G. RT Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions. RL Blood 100:483-490 (2002). RN [15]; RE0048551. RX PUBMED: 16254192. RA Paz-Priel I., Cai D. H., Wang D., Kowalski J., Blackford A., Liu H., Heckman C. A., Gombart A. F., Koeffler H. P., Boxer L. M., Friedman A. D. RT CCAAT/enhancer binding protein alpha (C/EBPalpha) and C/EBPalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappaB p50. RL Mol. Cancer Res. 3:585-596 (2005). RN [16]; RE0055471. RX PUBMED: 19054766. RA Dhawan P., Weider R., Christakos S. RT CCAAT Enhancer-binding Protein {alpha} Is a Molecular Target of 1,25-Dihydroxyvitamin D3 in MCF-7 Breast Cancer Cells. RL J. Biol. Chem. 284:3086-3095 (2009). RN [17]; RE0065087. RX PUBMED: 17652082. RA Patel D. N., King C. A., Bailey S. R., Holt J. W., Venkatachalam K., Agrawal A., Valente A. J., Chandrasekar B. RT Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation. RL J. Biol. Chem. 282:27229-27238 (2007). RN [18]; RE0072582. RX PUBMED: 21856370. RA Wu Y. L., Peng X. E., Wang D., Chen W. N., Lin X. RT Human liver fatty acid binding protein (hFABP1) gene is regulated by liver-enriched transcription factors HNF3beta and C/EBPalpha. RL Biochimie 94:384-392 (2012). XX //