AC T01387
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ID T01387
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DT 08.12.1994 (created); ewi.
DT 27.03.2015 (updated); asv.
CO Copyright (C), QIAGEN.
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FA CHOP-10
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SY C/EBP homologous protein 10; CEBPZ; CHOP; CHOP-10; CHOP10; DDIT3; DNA-damage-inducible transcript 3; GADD 153; GADD153; growth arrest and DNA-damage-inducible gene 153; MGC4154.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009609 DDIT3; HGNC: DDIT3.
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CL C0008; bZIP; 1.1.8.1.6.
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SF the oncogenic variant TLS-CHOP has a large N-terminal extension;
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CP adipocytes [2].
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FF inducible by calcium ions [1];
FF causes cell growth arrest at/around the G1/S checkpoint [2];
FF an oncogenic variant, TLS-CHOP, is associated with adipose tissue myxoid liposarcoma;
FF it is not capable to induce growth arrest [2];
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IN T18809 B-ATF; human, Homo sapiens.
IN T00105 C/EBPalpha; human, Homo sapiens.
IN T04883 C/EBPepsilon; human, Homo sapiens.
IN T04884 C/EBPgamma; human, Homo sapiens.
IN T04875 DBP; human, Homo sapiens.
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MX M00249 V$CHOP_01.
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BS R04603.
BS R42132.
BS R70462.
BS R63595.
BS R63632.
BS R65107.
BS R25985.
BS R64741.
BS R03475.
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DR TRANSPATH: MO000020832.
DR UniProtKB: P35638; GA15_HUMAN.
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RN [1]; RE0001111.
RX PUBMED: 1400365.
RA Bartlett J. D., Luethy J. D., Carlson S. G., Sollott S. J., Holbrook N. J.
RT Calcium ionophore A23187 induces expression of the growth arrest and DNA damage inducible CCAAT/enhancer-binding protein (C/EBP)-related gene gadd153
RL J. Biol. Chem. 267:20465-20470 (1992).
RN [2]; RE0007049.
RX PUBMED: 8125258.
RA Barone M. V., Crozat A., Tabaee A., Philipson L., Ron D.
RT CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest
RL Genes Dev. 15:453-464 (1995).
RN [3]; RE0049681.
RX PUBMED: 15897896.
RA Benali-Furet N. L., Chami M., Houel L., De Giorgi F., Vernejoul F., Lagorce D., Buscail L., Bartenschlager R., Ichas F., Rizzuto R., Paterlini-Brechot P.
RT Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion.
RL Oncogene 24:4921-4933 (2005).
RN [4]; RE0066024.
RX PUBMED: 15308577.
RA Gery S., Park D. J., Vuong P. T., Chih D. Y., Lemp N., Koeffler H. P.
RT Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes.
RL Blood 104:3911-3917 (2004).
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