AC T00127
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ID T00127
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DT 23.03.1993 (created); ewi.
DT 18.12.2014 (updated); ros.
CO Copyright (C), QIAGEN.
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FA CHOP-10
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SY C/EBP homologous protein 10; C/EBP-homologous protein; C/EBP-homologous protein-10; CHOP; CHOP-10; DDIT3; DNA-damage inducible transcript 3; GADD 153 (hamster); GADD153.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005982 Ddit3.
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CL C0008; bZIP; 1.1.8.1.6.
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CP liver enriched.
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FF inhibits DNA-binding of C/EBPalpha or C/EBPbeta [1];
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IN T00106 C/EBP; fruit fly, Drosophila melanogaster.
IN T01386 C/EBP; Aplysia, Aplysia californica.
IN T01388 C/EBP; clawed frog, Xenopus laevis.
IN T00104 C/EBPalpha-isoform1; mouse, Mus musculus.
IN T00108 C/EBPalpha-isoform1; rat, Rattus norvegicus.
IN T00105 C/EBPalpha; human, Homo sapiens.
IN T00107 C/EBPalpha; chick, Gallus gallus.
IN T00017 C/EBPbeta-FL; mouse, Mus musculus.
IN T00459 C/EBPbeta-FL; rat, Rattus norvegicus.
IN T00581 C/EBPbeta; human, Homo sapiens.
IN T09410 C/EBPbeta; Mammalia.
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MX M00249 V$CHOP_01.
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BS R04603.
BS R63002.
BS R63004.
BS R64371.
BS R64364.
BS R64365.
BS R64367.
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DR TRANSPATH: MO000020830.
DR UniProtKB: P35639;
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RN [1]; RE0000743.
RX PUBMED: 1547942.
RA Ron D., Habener J. F.
RT CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription
RL Genes Dev. 6:439-453 (1992).
RN [2]; RE0006317.
RX PUBMED: 8650547.
RA Wang X. Z., Ron D.
RT Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase
RL Science 272:1347-1349 (1996).
RN [3]; RE0049681.
RX PUBMED: 15897896.
RA Benali-Furet N. L., Chami M., Houel L., De Giorgi F., Vernejoul F., Lagorce D., Buscail L., Bartenschlager R., Ichas F., Rizzuto R., Paterlini-Brechot P.
RT Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion.
RL Oncogene 24:4921-4933 (2005).
RN [4]; RE0053139.
RX PUBMED: 16571599.
RA Yamada T., Ishihara H., Tamura A., Takahashi R., Yamaguchi S., Takei D., Tokita A., Satake C., Tashiro F., Katagiri H., Aburatani H., Miyazaki J., Oka Y.
RT WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells.
RL Hum. Mol. Genet. 15:1600-1609 (2006).
RN [5]; RE0071034.
RX PUBMED: 20660158.
RA Muaddi H., Majumder M., Peidis P., Papadakis A. I., Holcik M., Scheuner D., Kaufman R. J., Hatzoglou M., Koromilas A. E.
RT Phosphorylation of eIF2alpha at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.
RL Mol. Biol. Cell 21:3220-3231 (2010).
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