AC T00106
XX
ID T00106
XX
DT 24.03.1993 (created); ewi.
DT 01.03.2007 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA C/EBP
XX
SY C/EBP; DmC/EBP; slbo; slow border cells; slow border protein.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
GE G018884 slbo.
XX
CL C0008; bZIP.
XX
SZ 444 AA; 49.0 kDa (cDNA) (calc.).
XX
SQ MLNMESPQMYADAVQTLAQLDLKKEPPLQQATIGQITLTAMSTAQQQQQQQQQQQQQQQQ
SQ QQQQPQQQTTDANNNTSQDAALLVKQHAMHQMQQVAALGSNNNLLQKQMLQQYSTQTDLD
SQ ELTTQEITLDLQHLIDDQFRDTETLGIFSDMVTSPGGLSATLRRANGLGGAKVLQQQTLR
SQ NQHGYGGRGGGGGAGGALAYMPQPVHATYNNSSDENSSVGSDSSTIKEEPIDPEYRRHLQ
SQ EAASQQAAFMGNGAGLYNGYGSGANGLTGGGNPLNGGNTTPSSNGSNGSTGSSNGSQFTN
SQ LTTANVLAHHNLPQPGGRSRSTHVLKQHSKLHAQQQHQQHQQQQQHRKHSNKHVDKGTDE
SQ YRRRRERNNIAVRKSREKAKVRSREVEERVKSLLKEKDALIRQLGEMTNELQLHKQIYMQ
SQ LMNHANPEVSRVCRSFLNTNEHSL
XX
SC Swiss-Prot#Q02637
XX
FT 5 312 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 356 420 
SM00338; brlzneu.
FT 357 410 
PF07716; Basic region leucine zipper.
FT 358 421 
PS50217; BZIP.
XX
SF nine amino acid residues of the basic region are important for factor function (Y361, R365, E366, N368, N369, R373, S375, R376, and K380), six of them essential for DNA-binding (R365, E366, N368, N369, S375, R376), whereas the zipper domain may be replaced by that of GCN4 without loss of function [3];
XX
CP late embryos: lining cell of gut and epidermis.
XX
FF may be required for expression of gene products that mediate border cell migration [1];
FF deletion mutations cause late embryonic lethality, before or upon hatching [2];
FF appears to autoregulate its own gene [2];
XX
IN T00106 C/EBP; fruit fly, Drosophila melanogaster.
IN T00459 C/EBPbeta-FL; rat, Rattus norvegicus.
IN T00216 C/EBPgamma; mouse, Mus musculus.
IN T00127 CHOP-10; mouse, Mus musculus.
XX
MX M01087 I$CEBP_Q6.
MX M02362 I$SLBO_01.
XX
BS R17379.
BS R17380.
BS R17381.
BS R17389.
BS R17391.
BS R17392.
BS R17393.
BS R17394.
BS R17792.
BS R17627.
BS R17628.
BS R17629.
XX
DR TRANSPATH: MO000002653.
DR EMBL: L00632;
DR UniProtKB: Q02637;
DR FLYBASE: FBgn0005638.
XX
RN [1]; RE0000211.
RX PUBMED: 1394432.
RA Montell D. J., Rorth P., Spradling A. C.
RT slow border cells, a locus required for developmentally regulated cell migration during oogenesis, encodes Drosophila C/EBP
RL Cell 71:51-62 (1992).
RN [2]; RE0003037.
RX PUBMED: 1459454.
RA Rorth P., Montell D. J.
RT Drosophila C/EBP: a tissue-specific DNA-binding protein required for embryonic development
RL Genes Dev. 6:2299-2311 (1992).
RN [3]; RE0006667.
RX PUBMED: 7997882.
RA Rorth F.
RT Specification of C/EBP function during Drosophila development by the bZIP basic region
RL Science 266:1878-1881 (1994).
XX
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