TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00581 XX ID T00581 XX DT 26.01.1993 (created); hse. DT 19.05.2016 (updated); mom. CO Copyright (C), QIAGEN. XX FA C/EBPbeta XX SY AGP/EBP; ANF-2; C/EBP beta; C/EBP-beta; C/EBPbeta; CCAAT Enhancer Binding Protein beta; CEBPB; CRP2; H-APF-2; IL-6DBP; LAP; LAP1; NF-IL6; NF-M; nuclear factor NF-IL6; TCF5; transcription factor 5. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G002899 CEBPB; HGNC: CEBPB. XX CL C0008; bZIP; XX SF there are three forms encoded by the human CEBPbeta gene that result from the usage of different in frame AUGs of the same mRNA species [11]; SF very relaxed DNA-binding specificity, may even bind to AP-1 sites and may heterodimerize with either c-Fos or c-Jun [7]; SF the leucine zipper motif may also interact with the Rel-domain of NF-kappaB1 (p50) thus causing synergistic effects of both factors [8] [12]; SF interaction with hypophosphorylated Rb protein enhances DNA-binding and trans-activation [10]; XX CP widespread; most abundant in spleen; liver, kidney after stimulation [1]; MCF-7 + E2 [25]. XX FF transcriptional activator in vitro and in vivo [1]; FF involved in acute phase reactions, inflammation and hematopoiesis; FF induced by IL-1, IL-6, LPS [11] [1]; FF master regulator of the acute-phase response [1]; FF regulates constitutive as well as IL-1-induced transcription of IL-6 [1]; FF at the IL-6 promoter, it acts antagonistically to the p53 tumor suppressor [4]; FF protein is abundant in liver due to posttranscriptional regulation [1]; FF phosphorylation by p21(ras)-dependent MAP kinases enhances transcriptional activation [5]; FF trans-activation is repressed by association with c-Fos or c-Jun [7]; FF transcriptional synergy with NF-kappaB in response to TNFalpha [13]; FF interacts with NF-ATc2 in hepatocytes [14]; XX IN T01303 ATF-4; human, Homo sapiens. IN T05499 BAF47; human, Homo sapiens. IN T00123 c-Fos; human, Homo sapiens. IN T00133 c-Jun; human, Homo sapiens. IN T09921 c-Myb; mouse, Mus musculus. IN T00108 C/EBPalpha-isoform1; rat, Rattus norvegicus. IN T00105 C/EBPalpha; human, Homo sapiens. IN T00109 C/EBPdelta; rat, Rattus norvegicus. IN T00583 C/EBPdelta; human, Homo sapiens. IN T01114 C/EBPdelta; mouse, Mus musculus. IN T05963 CA150; human, Homo sapiens. IN T00127 CHOP-10; mouse, Mus musculus. IN T19664 CREB1{pS133}; human, Homo sapiens. IN T00261 ER-alpha; human, Homo sapiens. IN T09260 MEF-2D; human, Homo sapiens. IN T00593 NF-kappaB1-p50; human, Homo sapiens. IN T01948 NFATc2; human, Homo sapiens. IN T21984 p300; human, Homo sapiens. IN T10456 p50; human, Homo sapiens. IN T00671 p53; human, Homo sapiens. IN T00722 pRb; human, Homo sapiens. IN T00594 RelA-p65-isoform1; human, Homo sapiens. IN T22463 SNF2H; human, Homo sapiens. XX MX M00109 V$CEBPB_01. MX M00117 V$CEBPB_02. MX M04690 V$CEBPB_04. MX M07080 V$CEBPB_06. MX M07413 V$CEBPB_07. MX M08910 V$CEBPB_08. MX M07315 V$CEBPB_Q3. MX M01896 V$CEBPB_Q6. MX M00912 V$CEBP_Q2_01. MX M00770 V$CEBP_Q3. XX BS R08094. BS R24880. BS R06683. BS R36359. BS R00207. BS R26350. BS R04099. BS R04575. BS R04912. BS R02585. BS R60960. BS R66453. BS R00698. BS R08140. BS R60851. BS R60853. BS R64858. BS R60654. BS R25363. BS R25369. BS R15122. BS R33020. BS R26345. BS R26349. BS R40911. BS R39662. BS R25229. BS R32465. BS R32466. BS R08103. BS R40724. BS R26806. BS R26807. BS R26808. BS R26809. BS R26811. BS R26814. BS R26815. BS R29444. BS R35966. BS R13463. BS R27098. BS R42404. BS R42423. BS R42424. BS R42425. BS R58493. BS R58513. BS R26696. BS R68425. BS R68426. BS R35880. BS R34699. BS R00239. BS R25581. BS R30671. BS R39252. BS R60613. BS R60616. BS R04504. BS R23930. BS R23954. BS R24132. BS R26225. BS R26229. BS R23529. BS R23530. BS R16633. BS R65669. BS R65670. BS R33325. BS R31151. BS R31147. BS R42181. BS R66785. BS R29968. BS R68421. BS R68422. BS R68166. BS R24131. BS R36414. BS R26655. BS R57171. BS R26888. BS R24472. BS R34906. BS R68419. BS R26690. BS R35494. BS R35495. BS R32367. BS R69242. BS R33638. BS R33639. BS R62853. BS R36332. BS R00627. BS R31172. BS R36307. BS R72064. BS R34962. BS R63686. BS R23648. BS R33561. BS R08087. BS R74057. BS R14528. BS R14529. BS R14533. BS R14457. BS R14458. BS R08084. BS R13567. BS R26352. BS R29513. BS R27930. BS R03136. BS R08093. BS R24918. BS R30530. BS R02908. BS R26934. BS R27621. BS R68427. BS R68429. BS R68430. BS R68431. BS R31358. BS R31359. BS R37840. BS R26592. BS R40154. BS R68423. BS R04491. BS R29074. BS R29075. BS R29250. BS R14439. BS R63403. BS R63509. BS R63445. BS R63470. BS R36292. BS R42004. BS R27628. BS R34771. BS R74061. BS R40492. BS R68159. BS R29614. BS R66644. BS R68424. BS R63136. BS R35967. BS R40954. BS R40955. BS R40956. BS R40957. BS R40958. BS R40959. BS R40960. BS R40961. BS R61342. BS R36260. BS R36262. BS R36263. BS R31285. BS R24978. BS R62442. BS R31180. BS R69697. BS R69698. BS R69699. BS R08091. BS R08092. BS R37846. BS R40066. BS R71703. BS R21802. BS R27938. BS R04480. BS R23085. BS R13167. BS R13168. BS R13169. BS R30770. BS R21118. BS R73263. BS R21443. BS R04502. BS R27058. BS R27059. BS R42260. BS R25985. BS R60335. BS R26382. BS R30533. BS R04503. BS R26798. BS R04479. BS R08086. BS R33202. BS R33281. BS R00089. BS R26556. BS R29550. BS R16511. BS R19571. BS R00600. BS R35588. BS R29228. BS R26163. BS R26164. BS R02216. BS R00111. BS R08096. BS R19750. BS R13282. BS R23206. BS R36276. BS R08138. BS R01268. BS R03730. BS R03732. BS R03733. XX DR TRANSPATH: MO000019381. DR TRANSCOMPEL: C00095. DR TRANSCOMPEL: C00098. DR TRANSCOMPEL: C00101. DR TRANSCOMPEL: C00110. DR TRANSCOMPEL: C00115. DR TRANSCOMPEL: C00152. DR TRANSCOMPEL: C00155. DR TRANSCOMPEL: C00178. DR TRANSCOMPEL: C00317. DR TRANSCOMPEL: C00321. DR TRANSCOMPEL: C00322. DR TRANSCOMPEL: C00323. DR TRANSCOMPEL: C00324. DR TRANSCOMPEL: C00388. DR TRANSCOMPEL: C00406. DR TRANSCOMPEL: C00532. DR TRANSCOMPEL: C00577. DR UniProtKB: P17676; XX RN [1]; RE0000469. RX PUBMED: 2112087. RA Akira S., Isshiki H., Sugita T., Tanabe O., Kinoshita S., Nishio Y., Nakajima T., Hirano T., Kishimoto T. RT A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family RL EMBO J. 9:1897-1906 (1990). RN [2]; RE0001110. RX PUBMED: 8144615. RA Brasier A. R., Kumar A. RT Identification of a novel determinant for basic domain-leucine zipper DNA binding activity in the acute-phase inducible nuclear factor-interleukin-6 transcription factor RL J. Biol. Chem. 269:10341-10351 (1994). RN [3]; RE0001943. RX PUBMED: 1710143. RA Isshiki H., Akira S., Sugita T., Nishio Y., Hashimoto S., Pawlowski T., Suematsu S., Kishimoto T. RT Reciprocal expression of NF-IL6 and C/EBP in hepatocytes: possible involvement of NF-IL6 in acute phase protein gene expression RL New Biol. 3:63-70 (1991). RN [4]; RE0003029. RX PUBMED: 8325885. RA Margulies L., Sehgal P. B. RT Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBPbeta (NF-IL-6) activity by p53 species RL J. Biol. Chem. 268:15096-15100 (1993). RN [5]; RE0003030. RX PUBMED: 8384717. RA Nakajima T., Kinoshita S., Sasagawa T., Sasaki K., Naruto M., Kishimoto T., Akira S. RT Phosphorylation at threonine-235 by ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6 RL Proc. Natl. Acad. Sci. USA 90:2207-2211 (1993). RN [6]; RE0003187. RX PUBMED: 2111442. RA Isshiki H., Akira S., Tanabe O., Nakajima T., Shimamoto T., Hirano T., Kishimoto T. RT Constitutive and Interleukin-1 (IL-1)-Inducible Factors Interact with the IL-1-Responsive Element in the IL-6 Gene RL Mol. Cell. Biol. 10:2757-2764 (1990). RN [7]; RE0004730. RX PUBMED: 8264594. RA Hsu W., Kerppola T. K., Chen P.-L., Curran T., Chen-Kiang S. RT Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region RL Mol. Cell. Biol. 14:268-276 (1994). RN [8]; RE0006254. RX PUBMED: 8234276. RA Matsusaka T., Fujikawa K., Nishio Y., Mukaida N., Matsushima K., Kishimoto T., Akira S. RT Transcription factors NF-IL6 and NF-kappaB synergistically activate transcription of the inflammatory cytokines interleukin 6 and interleukin 8 RL Proc. Natl. Acad. Sci. USA 90:10193-10197 (1993). RN [9]; RE0006266. RX PUBMED: 7935377. RA Klampfer L., Lee T. H., Hsu W., Vilcek J., Chen-Kiang S. RT NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1 RL Mol. Cell. Biol. 14:6561-6569 (1994). RN [10]; RE0006633. RX PUBMED: 8552662. RA Chen P.-L., Riley D. J., Chen-Kiang S., Lee W.-H. RT Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6 RL Proc. Natl. Acad. Sci. USA 93:465-469 (1996). RN [11]; RE0007308. RX PUBMED: 8455626. RA Hsu W., Chen-Kiang S. RT Convergent regulation of NF-Il6 and Oct-1 synthesis by interleukin-6 and retinoic acid signaling in embryonal carcinoma cells RL Mol. Cell. Biol. 13:2515-2523 (1993). RN [12]; RE0016587. RX PUBMED: 1518839. RA LeClair K. P., Blanar M. A., Sharp P. A. RT The p50 subunit of NF-kB associates with the NF-IL6 transcription factor. RL Proc. Natl. Acad. Sci. USA 89:8145-8149 (1992). RN [13]; RE0023683. RX PUBMED: 14514692. RA Papin S., Cazeneuve C., Duquesnoy P., Jeru I., Sahali D., Amselem S. RT The tumor necrosis factor alpha-dependent activation of the human mediterranean fever (MEFV) promoter is mediated by a synergistic interaction between C/EBP beta and NF kappaB p65. RL J. Biol. Chem. 278:48839-48847 (2003). RN [14]; RE0023877. RX PUBMED: 12606546. RA Yang T. T., Chow C. W. RT Transcription cooperation by NFAT.C/EBP composite enhancer complex. RL J. Biol. Chem. 278:15874-15885 (2003). RN [15]; RE0027771. RX PUBMED: 10590092. RA Schwartz C., Catez P., Rohr O., Lecestre D., Aunis D., Schaeffer E. RT Functional interactions between C/EBP, Sp1, and COUP-TF regulate human immunodeficiency virus type 1 gene transcription in human brain cells. RL J. Virol. 74:65-73 (2000). RN [16]; RE0030566. RX PUBMED: 12947119. RA Zhang F., Lin M., Abidi P., Thiel G., Liu J. RT Specific interaction of Egr1 and c/EBPbeta leads to the transcriptional activation of the human low density lipoprotein receptor gene. RL J. Biol. Chem. 278:44246-54 (2003). RN [17]; RE0037509. RX PUBMED: 14759369. RA Mo X., Kowenz-Leutz E., Xu H., Leutz A. RT Ras induces mediator complex exchange on C/EBP beta RL Mol. Cell 13:241-50 (2004). RN [18]; RE0046890. RX PUBMED: 9442384. RA Kirschning C. J., Unbehaun A., Fiedler G., Hallatschek W., Lamping N., Pfeil D., Schumann R. R. RT The transcriptional activation pattern of lipopolysaccharide binding protein (LBP) involving transcription factors AP-1 and C/EBP beta RL Immunobiology 198:124-35 (1997). RN [19]; RE0047237. RX PUBMED: 7594592. RA Nagulapalli S., Pongubala J. M., Atchison M. L. RT Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3) RL J. Immunol. 155:4330-8 (1995). RN [20]; RE0047943. RX PUBMED: 9343424. RA Mink S., Haenig B., Klempnauer K. H. RT Interaction and functional collaboration of p300 and C/EBPbeta. RL Mol. Cell. Biol. 17:6609-6617 (1997). RN [21]; RE0047992. RX PUBMED: 11792321. RA Tahirov T. H., Sato K., Ichikawa-Iwata E., Sasaki M., Inoue-Bungo T., Shiina M., Kimura K., Takata S., Fujikawa A., Morii H., Kumasaka T., Yamamoto M., Ishii S., Ogata K. RT Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter. RL Cell 108:57-70 (2002). RN [22]; RE0048515. RX PUBMED: 16644732. RA McFie P. J., Wang G. L., Timchenko N. A., Wilson H. L., Hu X., Roesler W. J. RT Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein alpha. RL J. Biol. Chem. 281:18069-18080 (2006). RN [23]; RE0049113. RX PUBMED: 16397300. RA Wang J. M., Ko C. Y., Chen L. C., Wang W. L., Chang W. C. RT Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene. RL Nucleic Acids Res. 34:217-231 (2006). RN [24]; RE0053048. RX PUBMED: 17724128. RA Yamamoto M., Uematsu S., Okamoto T., Matsuura Y., Sato S., Kumar H., Satoh T., Saitoh T., Takeda K., Ishii K. J., Takeuchi O., Kawai T., Akira S. RT Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency. RL J. Exp. Med. 204:2233-2239 (2007). RN [25]; RE0053774. RX PUBMED: 16651265. RA Dong J., Tsai-Morris C. H., Dufau M. L. RT A novel estradiol/estrogen receptor alpha-dependent transcriptional mechanism controls expression of the human prolactin receptor. RL J. Biol. Chem. 281:18825-18836 (2006). RN [26]; RE0055188. RX PUBMED: 17921324. RA Cortez D. M., Feldman M. D., Mummidi S., Valente A. J., Steffensen B., Vincenti M., Barnes J. L., Chandrasekar B. RT IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta, NF-kappaB, and AP-1 activation. RL Am. J. Physiol. Heart Circ. Physiol. 293:H3356-65 (2007). RN [27]; RE0055446. RX PUBMED: 17540774. RA Pham T. H., Langmann S., Schwarzfischer L., El Chartouni C., Lichtinger M., Klug M., Krause S. W., Rehli M. RT CCAAT enhancer-binding protein beta regulates constitutive gene expression during late stages of monocyte to macrophage differentiation. RL J. Biol. Chem. 282:21924-21933 (2007). RN [28]; RE0063561. RX PUBMED: 18339625. RA Li H., Gade P., Nallar S. C., Raha A., Roy S. K., Karra S., Reddy J. K., Reddy S. P., Kalvakolanu D. V. RT The Med1 subunit of transcriptional mediator plays a central role in regulating CCAAT/enhancer-binding protein-beta-driven transcription in response to interferon-gamma. RL J. Biol. Chem. 283:13077-13086 (2008). RN [29]; RE0065087. RX PUBMED: 17652082. RA Patel D. N., King C. A., Bailey S. R., Holt J. W., Venkatachalam K., Agrawal A., Valente A. J., Chandrasekar B. RT Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation. RL J. Biol. Chem. 282:27229-27238 (2007). RN [30]; RE0068524. RX PUBMED: 20829351. RA Zannetti C., Bonnay F., Takeshita F., Parroche P., Menetrier-Caux C., Tommasino M., Hasan U. A. RT C/EBP{delta} and STAT-1 Are Required for TLR8 Transcriptional Activity. RL J. Biol. Chem. 285:34773-34780 (2010). RN [31]; RE0068544. RX PUBMED: 18820298. RA Wang W. L., Lee Y. C., Yang W. M., Chang W. C., Wang J. M. RT Sumoylation of LAP1 is involved in the HDAC4-mediated repression of COX-2 transcription. RL Nucleic Acids Res. 36:6066-6079 (2008). RN [32]; RE0070633. RX PUBMED: 19592659. RA Sikder H., Zhao Y., Balato A., Chapoval A., Fishelevich R., Gade P., Singh I. S., Kalvakolanu D. V., Johnson P. F., Gaspari A. A. RT A central role for transcription factor C/EBP-beta in regulating CD1d gene expression in human keratinocytes. RL J. Immunol. 183:1657-1666 (2009). XX //