AC T00581
XX
ID T00581
XX
DT 26.01.1993 (created); hse.
DT 19.05.2016 (updated); mom.
CO Copyright (C), QIAGEN.
XX
FA C/EBPbeta
XX
SY AGP/EBP; ANF-2; C/EBP beta; C/EBP-beta; C/EBPbeta; CCAAT Enhancer Binding Protein beta; CEBPB; CRP2; H-APF-2; IL-6DBP; LAP; LAP1; NF-IL6; NF-M; nuclear factor NF-IL6; TCF5; transcription factor 5.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G002899 CEBPB; HGNC: CEBPB.
XX
CL C0008; bZIP; 1.1.8.1.2.
XX
SF there are three forms encoded by the human CEBPbeta gene that result from the usage of different in frame AUGs of the same mRNA species [11];
SF very relaxed DNA-binding specificity, may even bind to AP-1 sites and may heterodimerize with either c-Fos or c-Jun [7];
SF the leucine zipper motif may also interact with the Rel-domain of NF-kappaB1 (p50) thus causing synergistic effects of both factors [8] [12];
SF interaction with hypophosphorylated Rb protein enhances DNA-binding and trans-activation [10];
XX
CP widespread; most abundant in spleen; liver, kidney after stimulation [1]; MCF-7 + E2 [25].
XX
FF transcriptional activator in vitro and in vivo [1];
FF involved in acute phase reactions, inflammation and hematopoiesis;
FF induced by IL-1, IL-6, LPS [11] [1];
FF master regulator of the acute-phase response [1];
FF regulates constitutive as well as IL-1-induced transcription of IL-6 [1];
FF at the IL-6 promoter, it acts antagonistically to the p53 tumor suppressor [4];
FF protein is abundant in liver due to posttranscriptional regulation [1];
FF phosphorylation by p21(ras)-dependent MAP kinases enhances transcriptional activation [5];
FF trans-activation is repressed by association with c-Fos or c-Jun [7];
FF transcriptional synergy with NF-kappaB in response to TNFalpha [13];
FF interacts with NF-ATc2 in hepatocytes [14];
XX
IN T01303 ATF-4; human, Homo sapiens.
IN T05499 BAF47; human, Homo sapiens.
IN T00123 c-Fos; human, Homo sapiens.
IN T00133 c-Jun; human, Homo sapiens.
IN T09921 c-Myb; mouse, Mus musculus.
IN T00108 C/EBPalpha-isoform1; rat, Rattus norvegicus.
IN T00105 C/EBPalpha; human, Homo sapiens.
IN T00109 C/EBPdelta; rat, Rattus norvegicus.
IN T00583 C/EBPdelta; human, Homo sapiens.
IN T01114 C/EBPdelta; mouse, Mus musculus.
IN T05963 CA150; human, Homo sapiens.
IN T00127 CHOP-10; mouse, Mus musculus.
IN T19664 CREB1{pS133}; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T09260 MEF-2D; human, Homo sapiens.
IN T00593 NF-kappaB1-p50; human, Homo sapiens.
IN T01948 NFATc2; human, Homo sapiens.
IN T21984 p300; human, Homo sapiens.
IN T10456 p50; human, Homo sapiens.
IN T00671 p53; human, Homo sapiens.
IN T00722 pRb; human, Homo sapiens.
IN T00594 RelA-p65-isoform1; human, Homo sapiens.
IN T22463 SNF2H; human, Homo sapiens.
XX
MX M00109 V$CEBPB_01.
MX M00117 V$CEBPB_02.
MX M04690 V$CEBPB_04.
MX M07080 V$CEBPB_06.
MX M07413 V$CEBPB_07.
MX M08910 V$CEBPB_08.
MX M07315 V$CEBPB_Q3.
MX M01896 V$CEBPB_Q6.
MX M00912 V$CEBP_Q2_01.
MX M00770 V$CEBP_Q3.
XX
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BS R02216.
BS R00111.
BS R08096.
BS R19750.
BS R13282.
BS R23206.
BS R36276.
BS R08138.
BS R01268.
BS R03730.
BS R03732.
BS R03733.
XX
DR TRANSPATH: MO000019381.
DR TRANSCOMPEL: C00095.
DR TRANSCOMPEL: C00098.
DR TRANSCOMPEL: C00101.
DR TRANSCOMPEL: C00110.
DR TRANSCOMPEL: C00115.
DR TRANSCOMPEL: C00152.
DR TRANSCOMPEL: C00155.
DR TRANSCOMPEL: C00178.
DR TRANSCOMPEL: C00317.
DR TRANSCOMPEL: C00321.
DR TRANSCOMPEL: C00322.
DR TRANSCOMPEL: C00323.
DR TRANSCOMPEL: C00324.
DR TRANSCOMPEL: C00388.
DR TRANSCOMPEL: C00406.
DR TRANSCOMPEL: C00532.
DR TRANSCOMPEL: C00577.
DR UniProtKB: P17676;
XX
RN [1]; RE0000469.
RX PUBMED: 2112087.
RA Akira S., Isshiki H., Sugita T., Tanabe O., Kinoshita S., Nishio Y., Nakajima T., Hirano T., Kishimoto T.
RT A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family
RL EMBO J. 9:1897-1906 (1990).
RN [2]; RE0001110.
RX PUBMED: 8144615.
RA Brasier A. R., Kumar A.
RT Identification of a novel determinant for basic domain-leucine zipper DNA binding activity in the acute-phase inducible nuclear factor-interleukin-6 transcription factor
RL J. Biol. Chem. 269:10341-10351 (1994).
RN [3]; RE0001943.
RX PUBMED: 1710143.
RA Isshiki H., Akira S., Sugita T., Nishio Y., Hashimoto S., Pawlowski T., Suematsu S., Kishimoto T.
RT Reciprocal expression of NF-IL6 and C/EBP in hepatocytes: possible involvement of NF-IL6 in acute phase protein gene expression
RL New Biol. 3:63-70 (1991).
RN [4]; RE0003029.
RX PUBMED: 8325885.
RA Margulies L., Sehgal P. B.
RT Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBPbeta (NF-IL-6) activity by p53 species
RL J. Biol. Chem. 268:15096-15100 (1993).
RN [5]; RE0003030.
RX PUBMED: 8384717.
RA Nakajima T., Kinoshita S., Sasagawa T., Sasaki K., Naruto M., Kishimoto T., Akira S.
RT Phosphorylation at threonine-235 by ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6
RL Proc. Natl. Acad. Sci. USA 90:2207-2211 (1993).
RN [6]; RE0003187.
RX PUBMED: 2111442.
RA Isshiki H., Akira S., Tanabe O., Nakajima T., Shimamoto T., Hirano T., Kishimoto T.
RT Constitutive and Interleukin-1 (IL-1)-Inducible Factors Interact with the IL-1-Responsive Element in the IL-6 Gene
RL Mol. Cell. Biol. 10:2757-2764 (1990).
RN [7]; RE0004730.
RX PUBMED: 8264594.
RA Hsu W., Kerppola T. K., Chen P.-L., Curran T., Chen-Kiang S.
RT Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region
RL Mol. Cell. Biol. 14:268-276 (1994).
RN [8]; RE0006254.
RX PUBMED: 8234276.
RA Matsusaka T., Fujikawa K., Nishio Y., Mukaida N., Matsushima K., Kishimoto T., Akira S.
RT Transcription factors NF-IL6 and NF-kappaB synergistically activate transcription of the inflammatory cytokines interleukin 6 and interleukin 8
RL Proc. Natl. Acad. Sci. USA 90:10193-10197 (1993).
RN [9]; RE0006266.
RX PUBMED: 7935377.
RA Klampfer L., Lee T. H., Hsu W., Vilcek J., Chen-Kiang S.
RT NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1
RL Mol. Cell. Biol. 14:6561-6569 (1994).
RN [10]; RE0006633.
RX PUBMED: 8552662.
RA Chen P.-L., Riley D. J., Chen-Kiang S., Lee W.-H.
RT Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6
RL Proc. Natl. Acad. Sci. USA 93:465-469 (1996).
RN [11]; RE0007308.
RX PUBMED: 8455626.
RA Hsu W., Chen-Kiang S.
RT Convergent regulation of NF-Il6 and Oct-1 synthesis by interleukin-6 and retinoic acid signaling in embryonal carcinoma cells
RL Mol. Cell. Biol. 13:2515-2523 (1993).
RN [12]; RE0016587.
RX PUBMED: 1518839.
RA LeClair K. P., Blanar M. A., Sharp P. A.
RT The p50 subunit of NF-kB associates with the NF-IL6 transcription factor.
RL Proc. Natl. Acad. Sci. USA 89:8145-8149 (1992).
RN [13]; RE0023683.
RX PUBMED: 14514692.
RA Papin S., Cazeneuve C., Duquesnoy P., Jeru I., Sahali D., Amselem S.
RT The tumor necrosis factor alpha-dependent activation of the human mediterranean fever (MEFV) promoter is mediated by a synergistic interaction between C/EBP beta and NF kappaB p65.
RL J. Biol. Chem. 278:48839-48847 (2003).
RN [14]; RE0023877.
RX PUBMED: 12606546.
RA Yang T. T., Chow C. W.
RT Transcription cooperation by NFAT.C/EBP composite enhancer complex.
RL J. Biol. Chem. 278:15874-15885 (2003).
RN [15]; RE0027771.
RX PUBMED: 10590092.
RA Schwartz C., Catez P., Rohr O., Lecestre D., Aunis D., Schaeffer E.
RT Functional interactions between C/EBP, Sp1, and COUP-TF regulate human immunodeficiency virus type 1 gene transcription in human brain cells.
RL J. Virol. 74:65-73 (2000).
RN [16]; RE0030566.
RX PUBMED: 12947119.
RA Zhang F., Lin M., Abidi P., Thiel G., Liu J.
RT Specific interaction of Egr1 and c/EBPbeta leads to the transcriptional activation of the human low density lipoprotein receptor gene.
RL J. Biol. Chem. 278:44246-54 (2003).
RN [17]; RE0037509.
RX PUBMED: 14759369.
RA Mo X., Kowenz-Leutz E., Xu H., Leutz A.
RT Ras induces mediator complex exchange on C/EBP beta
RL Mol. Cell 13:241-50 (2004).
RN [18]; RE0046890.
RX PUBMED: 9442384.
RA Kirschning C. J., Unbehaun A., Fiedler G., Hallatschek W., Lamping N., Pfeil D., Schumann R. R.
RT The transcriptional activation pattern of lipopolysaccharide binding protein (LBP) involving transcription factors AP-1 and C/EBP beta
RL Immunobiology 198:124-35 (1997).
RN [19]; RE0047237.
RX PUBMED: 7594592.
RA Nagulapalli S., Pongubala J. M., Atchison M. L.
RT Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3)
RL J. Immunol. 155:4330-8 (1995).
RN [20]; RE0047943.
RX PUBMED: 9343424.
RA Mink S., Haenig B., Klempnauer K. H.
RT Interaction and functional collaboration of p300 and C/EBPbeta.
RL Mol. Cell. Biol. 17:6609-6617 (1997).
RN [21]; RE0047992.
RX PUBMED: 11792321.
RA Tahirov T. H., Sato K., Ichikawa-Iwata E., Sasaki M., Inoue-Bungo T., Shiina M., Kimura K., Takata S., Fujikawa A., Morii H., Kumasaka T., Yamamoto M., Ishii S., Ogata K.
RT Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter.
RL Cell 108:57-70 (2002).
RN [22]; RE0048515.
RX PUBMED: 16644732.
RA McFie P. J., Wang G. L., Timchenko N. A., Wilson H. L., Hu X., Roesler W. J.
RT Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein alpha.
RL J. Biol. Chem. 281:18069-18080 (2006).
RN [23]; RE0049113.
RX PUBMED: 16397300.
RA Wang J. M., Ko C. Y., Chen L. C., Wang W. L., Chang W. C.
RT Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene.
RL Nucleic Acids Res. 34:217-231 (2006).
RN [24]; RE0053048.
RX PUBMED: 17724128.
RA Yamamoto M., Uematsu S., Okamoto T., Matsuura Y., Sato S., Kumar H., Satoh T., Saitoh T., Takeda K., Ishii K. J., Takeuchi O., Kawai T., Akira S.
RT Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency.
RL J. Exp. Med. 204:2233-2239 (2007).
RN [25]; RE0053774.
RX PUBMED: 16651265.
RA Dong J., Tsai-Morris C. H., Dufau M. L.
RT A novel estradiol/estrogen receptor alpha-dependent transcriptional mechanism controls expression of the human prolactin receptor.
RL J. Biol. Chem. 281:18825-18836 (2006).
RN [26]; RE0055188.
RX PUBMED: 17921324.
RA Cortez D. M., Feldman M. D., Mummidi S., Valente A. J., Steffensen B., Vincenti M., Barnes J. L., Chandrasekar B.
RT IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta, NF-kappaB, and AP-1 activation.
RL Am. J. Physiol. Heart Circ. Physiol. 293:H3356-65 (2007).
RN [27]; RE0055446.
RX PUBMED: 17540774.
RA Pham T. H., Langmann S., Schwarzfischer L., El Chartouni C., Lichtinger M., Klug M., Krause S. W., Rehli M.
RT CCAAT enhancer-binding protein beta regulates constitutive gene expression during late stages of monocyte to macrophage differentiation.
RL J. Biol. Chem. 282:21924-21933 (2007).
RN [28]; RE0063561.
RX PUBMED: 18339625.
RA Li H., Gade P., Nallar S. C., Raha A., Roy S. K., Karra S., Reddy J. K., Reddy S. P., Kalvakolanu D. V.
RT The Med1 subunit of transcriptional mediator plays a central role in regulating CCAAT/enhancer-binding protein-beta-driven transcription in response to interferon-gamma.
RL J. Biol. Chem. 283:13077-13086 (2008).
RN [29]; RE0065087.
RX PUBMED: 17652082.
RA Patel D. N., King C. A., Bailey S. R., Holt J. W., Venkatachalam K., Agrawal A., Valente A. J., Chandrasekar B.
RT Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation.
RL J. Biol. Chem. 282:27229-27238 (2007).
RN [30]; RE0068524.
RX PUBMED: 20829351.
RA Zannetti C., Bonnay F., Takeshita F., Parroche P., Menetrier-Caux C., Tommasino M., Hasan U. A.
RT C/EBP{delta} and STAT-1 Are Required for TLR8 Transcriptional Activity.
RL J. Biol. Chem. 285:34773-34780 (2010).
RN [31]; RE0068544.
RX PUBMED: 18820298.
RA Wang W. L., Lee Y. C., Yang W. M., Chang W. C., Wang J. M.
RT Sumoylation of LAP1 is involved in the HDAC4-mediated repression of COX-2 transcription.
RL Nucleic Acids Res. 36:6066-6079 (2008).
RN [32]; RE0070633.
RX PUBMED: 19592659.
RA Sikder H., Zhao Y., Balato A., Chapoval A., Fishelevich R., Gade P., Singh I. S., Kalvakolanu D. V., Johnson P. F., Gaspari A. A.
RT A central role for transcription factor C/EBP-beta in regulating CD1d gene expression in human keratinocytes.
RL J. Immunol. 183:1657-1666 (2009).
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