TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00583 XX ID T00583 XX DT 23.03.1993 (created); ewi. DT 25.06.2015 (updated); pro. CO Copyright (C), QIAGEN. XX FA C/EBPdelta XX SY C/EBPdelta; CRP3; NF-IL6beta. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G005929 CEBPD; HGNC: CEBPD. XX CL C0008; bZIP; XX SF same DNA-binding specificity as C/EBPbeta / NF-IL6; XX CP ubiquitous [1]. XX FF Induction by IL-6 is attenuated by Mevastatin [4]; FF induction of C/EBPdelta (in contrast to C/EBPbeta) by IL-6 is at the transcriptional level [3]; FF stronger transcriptional activator than C/BEPbeta; FF both can act synergistically [1]; FF undetectable levels in normal cells, but induced by LPS or inflammatory cytokines [1]; XX IN T00105 C/EBPalpha; human, Homo sapiens. IN T00017 C/EBPbeta-FL; mouse, Mus musculus. IN T00459 C/EBPbeta-FL; rat, Rattus norvegicus. IN T00581 C/EBPbeta; human, Homo sapiens. IN T00583 C/EBPdelta; human, Homo sapiens. IN T00216 C/EBPgamma; mouse, Mus musculus. IN T22386 FANCD2; human, Homo sapiens. IN T10037 PU.1; Mammalia. XX MX M07316 V$CEBPD_Q3. MX M00621 V$CEBPD_Q6. MX M03571 V$CEBPD_Q6_01. MX M00912 V$CEBP_Q2_01. MX M00770 V$CEBP_Q3. XX BS R36359. BS R60851. BS R60853. BS R29895. BS R20226. BS R20228. BS R40911. BS R63875. BS R63876. BS R63878. BS R08103. BS R29444. BS R04501. BS R30671. BS R39252. BS R23930. BS R23954. BS R24132. BS R23529. BS R23530. BS R16633. BS R34906. BS R29896. BS R26686. BS R66374. BS R27930. BS R03136. BS R24918. BS R03527. BS R63881. BS R30018. BS R63888. BS R63892. BS R31180. BS R68572. BS R71191. BS R27938. BS R23085. BS R33202. BS R02216. BS R23206. BS R36276. BS R13309. XX DR TRANSPATH: MO000002641. DR UniProtKB: P49716; XX RN [1]; RE0002487. RX PUBMED: 1741402. RA Kinoshita S., Akira S., Kishimoto T. RT A member of the C/EBP family, NF-IL6beta, forms a heterodimer and transcriptionally synergizes with NF-IL6 RL Proc. Natl. Acad. Sci. USA 89:1473-1476 (1992). RN [2]; RE0003041. RX PUBMED: 8314590. RA Cleutjens C. B., van Eekelen C. C., van Dekken H., Smit E. M., Hagemeijer A., Wagner M. J., Wells D. E., Trapman J. RT The human C/EBP delta ( CRP3/CELF ) gene: structure and chromosomal localization RL Genomics 16:520-523 (1993). RN [3]; RE0007063. RX PUBMED: 7680115. RA Ramji D. P., Vitelli A., Tronche F., Cortese R., Ciliberto G. RT The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms RL Nucleic Acids Res. 21:289-294 (1993). RN [4]; RE0047238. RX PUBMED: 15718495. RA Dong J., Fujii S., Li H., Nakabayashi H., Sakai M., Nishi S., Goto D., Furumoto T., Imagawa S., Zaman T. A., Kitabatake A. RT Interleukin-6 and mevastatin regulate plasminogen activator inhibitor-1 through CCAAT/enhancer-binding protein-delta RL Arterioscler. Thromb. Vasc. Biol. 25:1078-84 (2005). RN [5]; RE0049113. RX PUBMED: 16397300. RA Wang J. M., Ko C. Y., Chen L. C., Wang W. L., Chang W. C. RT Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene. RL Nucleic Acids Res. 34:217-231 (2006). RN [6]; RE0054609. RX PUBMED: 16322893. RA Tang D., Sivko G. S., DeWille J. W. RT Promoter methylation reduces C/EBPdelta (CEBPD) gene expression in the SUM-52PE human breast cancer cell line and in primary breast tumors. RL Breast Cancer Res. Treat. 95:161-170 (2006). RN [7]; RE0068524. RX PUBMED: 20829351. RA Zannetti C., Bonnay F., Takeshita F., Parroche P., Menetrier-Caux C., Tommasino M., Hasan U. A. RT C/EBP{delta} and STAT-1 Are Required for TLR8 Transcriptional Activity. RL J. Biol. Chem. 285:34773-34780 (2010). XX //