AC T00583
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ID T00583
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DT 23.03.1993 (created); ewi.
DT 25.06.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA C/EBPdelta
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SY C/EBPdelta; CRP3; NF-IL6beta.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G005929 CEBPD; HGNC: CEBPD.
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CL C0008; bZIP; 1.1.8.1.4.
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SF same DNA-binding specificity as C/EBPbeta / NF-IL6;
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CP ubiquitous [1].
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FF Induction by IL-6 is attenuated by Mevastatin [4];
FF induction of C/EBPdelta (in contrast to C/EBPbeta) by IL-6 is at the transcriptional level [3];
FF stronger transcriptional activator than C/BEPbeta;
FF both can act synergistically [1];
FF undetectable levels in normal cells, but induced by LPS or inflammatory cytokines [1];
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IN T00105 C/EBPalpha; human, Homo sapiens.
IN T00017 C/EBPbeta-FL; mouse, Mus musculus.
IN T00459 C/EBPbeta-FL; rat, Rattus norvegicus.
IN T00581 C/EBPbeta; human, Homo sapiens.
IN T00583 C/EBPdelta; human, Homo sapiens.
IN T00216 C/EBPgamma; mouse, Mus musculus.
IN T22386 FANCD2; human, Homo sapiens.
IN T10037 PU.1; Mammalia.
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MX M07316 V$CEBPD_Q3.
MX M00621 V$CEBPD_Q6.
MX M03571 V$CEBPD_Q6_01.
MX M00912 V$CEBP_Q2_01.
MX M00770 V$CEBP_Q3.
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BS R36359.
BS R60851.
BS R60853.
BS R29895.
BS R20226.
BS R20228.
BS R40911.
BS R63875.
BS R63876.
BS R63878.
BS R08103.
BS R29444.
BS R04501.
BS R30671.
BS R39252.
BS R23930.
BS R23954.
BS R24132.
BS R23529.
BS R23530.
BS R16633.
BS R34906.
BS R29896.
BS R26686.
BS R66374.
BS R27930.
BS R03136.
BS R24918.
BS R03527.
BS R63881.
BS R30018.
BS R63888.
BS R63892.
BS R31180.
BS R68572.
BS R71191.
BS R27938.
BS R23085.
BS R33202.
BS R02216.
BS R23206.
BS R36276.
BS R13309.
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DR TRANSPATH: MO000002641.
DR UniProtKB: P49716;
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RN [1]; RE0002487.
RX PUBMED: 1741402.
RA Kinoshita S., Akira S., Kishimoto T.
RT A member of the C/EBP family, NF-IL6beta, forms a heterodimer and transcriptionally synergizes with NF-IL6
RL Proc. Natl. Acad. Sci. USA 89:1473-1476 (1992).
RN [2]; RE0003041.
RX PUBMED: 8314590.
RA Cleutjens C. B., van Eekelen C. C., van Dekken H., Smit E. M., Hagemeijer A., Wagner M. J., Wells D. E., Trapman J.
RT The human C/EBP delta ( CRP3/CELF ) gene: structure and chromosomal localization
RL Genomics 16:520-523 (1993).
RN [3]; RE0007063.
RX PUBMED: 7680115.
RA Ramji D. P., Vitelli A., Tronche F., Cortese R., Ciliberto G.
RT The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms
RL Nucleic Acids Res. 21:289-294 (1993).
RN [4]; RE0047238.
RX PUBMED: 15718495.
RA Dong J., Fujii S., Li H., Nakabayashi H., Sakai M., Nishi S., Goto D., Furumoto T., Imagawa S., Zaman T. A., Kitabatake A.
RT Interleukin-6 and mevastatin regulate plasminogen activator inhibitor-1 through CCAAT/enhancer-binding protein-delta
RL Arterioscler. Thromb. Vasc. Biol. 25:1078-84 (2005).
RN [5]; RE0049113.
RX PUBMED: 16397300.
RA Wang J. M., Ko C. Y., Chen L. C., Wang W. L., Chang W. C.
RT Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene.
RL Nucleic Acids Res. 34:217-231 (2006).
RN [6]; RE0054609.
RX PUBMED: 16322893.
RA Tang D., Sivko G. S., DeWille J. W.
RT Promoter methylation reduces C/EBPdelta (CEBPD) gene expression in the SUM-52PE human breast cancer cell line and in primary breast tumors.
RL Breast Cancer Res. Treat. 95:161-170 (2006).
RN [7]; RE0068524.
RX PUBMED: 20829351.
RA Zannetti C., Bonnay F., Takeshita F., Parroche P., Menetrier-Caux C., Tommasino M., Hasan U. A.
RT C/EBP{delta} and STAT-1 Are Required for TLR8 Transcriptional Activity.
RL J. Biol. Chem. 285:34773-34780 (2010).
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