TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01948 XX ID T01948 XX DT 18.11.1996 (created); ewi. DT 15.01.2016 (updated); mkl. CO Copyright (C), QIAGEN. XX FA NFATc2 XX SY NF-AT1; NF-ATc2; NF-ATp; NFAT1; NFATC2; NFATp; Nuclear Factor of Activated T-cells p. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004687 NFATC2; HGNC: NFATC2. XX CL C0052; REL/NFAT; XX SF binds DNA as a monomer; SF N-terminal transactivation domain is involved in interactions with co-activator CBP [9]; SF C-terminal activation domain of NFATc2 is necessary and sufficient for interactions with human TAFII130 [8]; XX CP Colocalized in Arcuate nucleus of the hypothalamus [10]. XX FF activator; FF induced upon T-cell activation via intracellular Ca2+ mobilization and calcineurin activation; FF induced by neuropeptide Substance P in vascular endothelial cells in a Ca2+ dependent manner [4]; FF dephosphorylation by calcineurin is required for nuclear translocation; FF a number of cytokine genes are activated by NF-AT in synergy with AP-1; FF serves to provide a particular orientation of Jun-Fos heterodimers on DNA in Jun-Fos-NFAT-DNA complexes [6] [7]; FF binding sites are often overlap with NF-kappaB binding sites [4]; FF in hepatocytes, interacts with C/EBP-alpha and C/EBP-beta [5]; FF can recruit histone acetyltransferase activity (HAT) to the promoters of regulated genes [9]; XX IN T00105 C/EBPalpha; human, Homo sapiens. IN T00581 C/EBPbeta; human, Homo sapiens. IN T02214 CBP-isoform1; human, Homo sapiens. IN T02328 TAFII135; human, Homo sapiens. XX MX M03555 V$NFAT1_Q4. MX M07365 V$NFAT1_Q5. MX M01281 V$NFAT1_Q6. MX M02265 V$NFATC2_01. MX M07608 V$NFAT_Q3. MX M00935 V$NFAT_Q4_01. MX M00302 V$NFAT_Q6. XX BS R24112. BS R29672. BS R29954. BS R00702. BS R64126. BS R29890. BS R68448. BS R31300. BS R31303. BS R31304. BS R08181. BS R08182. BS R30033. BS R57514. BS R68030. BS R05082. BS R05091. BS R05094. BS R74080. BS R30062. BS R13414. BS R28018. BS R24088. BS R65897. BS R65898. BS R65899. BS R13475. BS R08183. BS R29619. BS R29670. BS R00930. BS R00931. BS R24997. BS R27348. BS R29768. BS R68306. BS R05071. BS R08170. BS R14628. BS R29951. BS R29645. BS R24127. BS R67126. BS R24474. BS R39585. BS R29835. BS R56100. BS R14626. BS R14627. BS R29765. BS R29724. BS R29735. BS R08185. BS R69250. BS R69251. BS R04064. BS R24087. BS R30940. BS R05080. BS R27351. BS R73942. BS R29658. XX DR TRANSPATH: MO000026044. DR TRANSCOMPEL: C00108. DR TRANSCOMPEL: C00109. DR TRANSCOMPEL: C00157. DR TRANSCOMPEL: C00160. DR TRANSCOMPEL: C00162. DR TRANSCOMPEL: C00166. DR TRANSCOMPEL: C00350. DR TRANSCOMPEL: C00352. DR TRANSCOMPEL: C00353. DR TRANSCOMPEL: C00354. DR TRANSCOMPEL: C00413. DR TRANSCOMPEL: C00495. DR TRANSCOMPEL: C00647. DR TRANSCOMPEL: C00648. DR UniProtKB: Q13469; XX RN [1]; RE0004486. RX PUBMED: 8202141. RA Northrop J. P., Ho S. N., Chen L., Thomas D. J., Timmerman L. A., Nolan G. P., Admon A., Crabtree G. R. RT NF-AT components define a family of transcription factors targeted in T-cell activation RL Nature 369:497-502 (1994). RN [2]; RE0004632. RX PUBMED: 7739550. RA Masuda E. S., Naito Y., Tokumitsu H., Campbell D., Saito F., Hannum C., Arai K.-I., Arai N. RT NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the Thymus RL Mol. Cell. Biol. 15:2697-2706 (1995). RN [3]; RE0017781. RX PUBMED: 11287617. RA Kaminuma O., Deckert M., Elly C., Liu Y. C., Altman A. RT Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter. RL Mol. Cell. Biol. 21:3126-3136 (2001). RN [4]; RE0022953. RX PUBMED: 10553096. RA Quinlan K. L., Naik S. M., Cannon G., Armstrong C. A., Bunnett N. W., Ansel J. C., Caughman S. W. RT Substance P activates coincident NF-AT- and NF-kappa B-dependent adhesion molecule gene expression in microvascular endothelial cells through intracellular calcium mobilization. RL J. Immunol. 163:5656-5665 (1999). RN [5]; RE0023877. RX PUBMED: 12606546. RA Yang T. T., Chow C. W. RT Transcription cooperation by NFAT.C/EBP composite enhancer complex. RL J. Biol. Chem. 278:15874-15885 (2003). RN [6]; RE0023932. RX PUBMED: 11320240. RA Ramirez-Carrozzi V. R., Kerppola T. K. RT Dynamics of Fos-Jun-NFAT1 complexes. RL Proc. Natl. Acad. Sci. USA 98:4893-4898 (2001). RN [7]; RE0023933. RX PUBMED: 11259418. RA Ramirez-Carrozzi V. R., Kerppola T. K. RT Control of the orientation of Fos-Jun binding and the transcriptional cooperativity of Fos-Jun-NFAT1 complexes. RL J. Biol. Chem. 276:21797-21808 (2001). RN [8]; RE0024034. RX PUBMED: 11313476. RA Kim L. J., Seto A. G., Nguyen T. N., Goodrich J. A. RT Human Taf(II)130 is a coactivator for NFATp. RL Mol. Cell. Biol. 21:3503-3513 (2001). RN [9]; RE0024038. RX PUBMED: 9625762. RA Garcia-Rodriguez C., Rao A. RT Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP). RL J. Exp. Med. 187:2031-2036 (1998). RN [10]; RE0049874. RX PUBMED: 15319455. RA Asai M., Iwasaki Y., Yoshida M., Mutsuga-Nakayama N., Arima H., Ito M., Takano K., Oiso Y. RT Nuclear factor of activated T cells (NFAT) is involved in the depolarization-induced activation of growth hormone-releasing hormone gene transcription in vitro. RL Mol. Endocrinol. 18:3011-3019 (2004). XX //