AC T01948
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ID T01948
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DT 18.11.1996 (created); ewi.
DT 15.01.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA NFATc2
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SY NF-AT1; NF-ATc2; NF-ATp; NFAT1; NFATC2; NFATp; Nuclear Factor of Activated T-cells p.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004687 NFATC2; HGNC: NFATC2.
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CL C0052; REL/NFAT; 6.1.3.0.2.
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SF binds DNA as a monomer;
SF N-terminal transactivation domain is involved in interactions with co-activator CBP [9];
SF C-terminal activation domain of NFATc2 is necessary and sufficient for interactions with human TAFII130 [8];
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CP Colocalized in Arcuate nucleus of the hypothalamus [10].
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FF activator;
FF induced upon T-cell activation via intracellular Ca2+ mobilization and calcineurin activation;
FF induced by neuropeptide Substance P in vascular endothelial cells in a Ca2+ dependent manner [4];
FF dephosphorylation by calcineurin is required for nuclear translocation;
FF a number of cytokine genes are activated by NF-AT in synergy with AP-1;
FF serves to provide a particular orientation of Jun-Fos heterodimers on DNA in Jun-Fos-NFAT-DNA complexes [6] [7];
FF binding sites are often overlap with NF-kappaB binding sites [4];
FF in hepatocytes, interacts with C/EBP-alpha and C/EBP-beta [5];
FF can recruit histone acetyltransferase activity (HAT) to the promoters of regulated genes [9];
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IN T00105 C/EBPalpha; human, Homo sapiens.
IN T00581 C/EBPbeta; human, Homo sapiens.
IN T02214 CBP-isoform1; human, Homo sapiens.
IN T02328 TAFII135; human, Homo sapiens.
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MX M03555 V$NFAT1_Q4.
MX M07365 V$NFAT1_Q5.
MX M01281 V$NFAT1_Q6.
MX M02265 V$NFATC2_01.
MX M07608 V$NFAT_Q3.
MX M00935 V$NFAT_Q4_01.
MX M00302 V$NFAT_Q6.
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BS R24112.
BS R29672.
BS R29954.
BS R00702.
BS R64126.
BS R29890.
BS R68448.
BS R31300.
BS R31303.
BS R31304.
BS R08181.
BS R08182.
BS R30033.
BS R57514.
BS R68030.
BS R05082.
BS R05091.
BS R05094.
BS R74080.
BS R30062.
BS R13414.
BS R28018.
BS R24088.
BS R65897.
BS R65898.
BS R65899.
BS R13475.
BS R08183.
BS R29619.
BS R29670.
BS R00930.
BS R00931.
BS R24997.
BS R27348.
BS R29768.
BS R68306.
BS R05071.
BS R08170.
BS R14628.
BS R29951.
BS R29645.
BS R24127.
BS R67126.
BS R24474.
BS R39585.
BS R29835.
BS R56100.
BS R14626.
BS R14627.
BS R29765.
BS R29724.
BS R29735.
BS R08185.
BS R69250.
BS R69251.
BS R04064.
BS R24087.
BS R30940.
BS R05080.
BS R27351.
BS R73942.
BS R29658.
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DR TRANSPATH: MO000026044.
DR TRANSCOMPEL: C00108.
DR TRANSCOMPEL: C00109.
DR TRANSCOMPEL: C00157.
DR TRANSCOMPEL: C00160.
DR TRANSCOMPEL: C00162.
DR TRANSCOMPEL: C00166.
DR TRANSCOMPEL: C00350.
DR TRANSCOMPEL: C00352.
DR TRANSCOMPEL: C00353.
DR TRANSCOMPEL: C00354.
DR TRANSCOMPEL: C00413.
DR TRANSCOMPEL: C00495.
DR TRANSCOMPEL: C00647.
DR TRANSCOMPEL: C00648.
DR UniProtKB: Q13469;
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RN [1]; RE0004486.
RX PUBMED: 8202141.
RA Northrop J. P., Ho S. N., Chen L., Thomas D. J., Timmerman L. A., Nolan G. P., Admon A., Crabtree G. R.
RT NF-AT components define a family of transcription factors targeted in T-cell activation
RL Nature 369:497-502 (1994).
RN [2]; RE0004632.
RX PUBMED: 7739550.
RA Masuda E. S., Naito Y., Tokumitsu H., Campbell D., Saito F., Hannum C., Arai K.-I., Arai N.
RT NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the Thymus
RL Mol. Cell. Biol. 15:2697-2706 (1995).
RN [3]; RE0017781.
RX PUBMED: 11287617.
RA Kaminuma O., Deckert M., Elly C., Liu Y. C., Altman A.
RT Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter.
RL Mol. Cell. Biol. 21:3126-3136 (2001).
RN [4]; RE0022953.
RX PUBMED: 10553096.
RA Quinlan K. L., Naik S. M., Cannon G., Armstrong C. A., Bunnett N. W., Ansel J. C., Caughman S. W.
RT Substance P activates coincident NF-AT- and NF-kappa B-dependent adhesion molecule gene expression in microvascular endothelial cells through intracellular calcium mobilization.
RL J. Immunol. 163:5656-5665 (1999).
RN [5]; RE0023877.
RX PUBMED: 12606546.
RA Yang T. T., Chow C. W.
RT Transcription cooperation by NFAT.C/EBP composite enhancer complex.
RL J. Biol. Chem. 278:15874-15885 (2003).
RN [6]; RE0023932.
RX PUBMED: 11320240.
RA Ramirez-Carrozzi V. R., Kerppola T. K.
RT Dynamics of Fos-Jun-NFAT1 complexes.
RL Proc. Natl. Acad. Sci. USA 98:4893-4898 (2001).
RN [7]; RE0023933.
RX PUBMED: 11259418.
RA Ramirez-Carrozzi V. R., Kerppola T. K.
RT Control of the orientation of Fos-Jun binding and the transcriptional cooperativity of Fos-Jun-NFAT1 complexes.
RL J. Biol. Chem. 276:21797-21808 (2001).
RN [8]; RE0024034.
RX PUBMED: 11313476.
RA Kim L. J., Seto A. G., Nguyen T. N., Goodrich J. A.
RT Human Taf(II)130 is a coactivator for NFATp.
RL Mol. Cell. Biol. 21:3503-3513 (2001).
RN [9]; RE0024038.
RX PUBMED: 9625762.
RA Garcia-Rodriguez C., Rao A.
RT Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP).
RL J. Exp. Med. 187:2031-2036 (1998).
RN [10]; RE0049874.
RX PUBMED: 15319455.
RA Asai M., Iwasaki Y., Yoshida M., Mutsuga-Nakayama N., Arima H., Ito M., Takano K., Oiso Y.
RT Nuclear factor of activated T cells (NFAT) is involved in the depolarization-induced activation of growth hormone-releasing hormone gene transcription in vitro.
RL Mol. Endocrinol. 18:3011-3019 (2004).
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