AC T09531
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ID T09531
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DT 30.10.2006 (created); kau.
DT 06.02.2015 (updated); sup.
CO Copyright (C), QIAGEN.
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FA ATF-4
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SY activating transcription factor 4; ATF-4; ATF4; C/ATF; CREB-2; hCREB2; TAXREB67; TAXREB67 homolog; TR67; YAVREB67.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002874 ATF4; HGNC: ATF4.
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CL C0008; bZIP.
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SZ 351 AA; 38.6 kDa (cDNA) (calc.).
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SQ MTEMSFLSSEVLVGDLMSPFDPSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSE
SQ WLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTC
SQ DLFAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHSFSL
SQ ELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPSTRG
SQ SPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKR
SQ AEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP
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SC Swiss-Prot#P18848
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FT 249 351 
repressor activity [3].
FT 276 340 
PF00170; bZIP transcription factor.
FT 276 340 
SM00338; brlzneu.
FT 278 341 
PS50217; BZIP.
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IN T01313 ATF-3-isoform1; human, Homo sapiens.
IN T18798 ATFa-isoform3; human, Homo sapiens.
IN T18808 B-ATF; human, Homo sapiens.
IN T18804 batf3; human, Homo sapiens.
IN T08776 c-Fos; human, Homo sapiens.
IN T19051 c-MAF-isoform2; human, Homo sapiens.
IN T00105 C/EBPalpha; human, Homo sapiens.
IN T06595 C/EBPbeta-FL; human, Homo sapiens.
IN T09139 C/EBPdelta; human, Homo sapiens.
IN T04883 C/EBPepsilon; human, Homo sapiens.
IN T09524 C/EBPgamma; human, Homo sapiens.
IN T09526 CHOP-10-isoform1; human, Homo sapiens.
IN T09550 CREBPA-Alpha; human, Homo sapiens.
IN T05984 FosB; human, Homo sapiens.
IN T09569 Hlf-isoform1; human, Homo sapiens.
IN T18466 IRF-7; Mammalia.
IN T01599 Nfe2l1-xbb1; human, Homo sapiens.
IN T27866 Zhangfei; human, Homo sapiens.
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MX M00514 V$ATF4_Q2.
MX M07246 V$ATF4_Q5.
MX M01864 V$ATF4_Q6.
MX M00981 V$CREBATF_Q6.
MX M00801 V$CREB_Q3.
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BS R03924.
BS R11554.
BS R03906.
BS R00207.
BS R56308.
BS R56309.
BS R66102.
BS R62945.
BS R62947.
BS R03916.
BS R26801.
BS R01358.
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DR TRANSPATH: MO000089817.
DR EMBL: AL022312; HS1104E15.
DR EMBL: D90209; HSYAVREB.
DR EMBL: M86842; HSCREB2A.
DR UniProtKB: P18848; ATF4_HUMAN.
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RN [1]; RE0000666.
RX PUBMED: 2516827.
RA Hai T., Liu F., Coukos W. J., Green M. R.
RT Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers
RL Genes Dev. 3:2083-2090 (1989).
RN [2]; RE0000787.
RX PUBMED: 8504929.
RA Vinson C. R., Hai T., Boyd S. M.
RT Dimerization specificity of the leucine zipper-containing bZIP motif on DNA binding: prediction and rational design
RL Genes Dev. 7:1047-1058 (1993).
RN [3]; RE0002560.
RX PUBMED: 1534408.
RA Karpinski B. A., Morle G. D., Huggenvik J., Uhler M. D., Leiden J. M.
RT Molecular cloning of human CREB-2: An ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element
RL Proc. Natl. Acad. Sci. USA 89:4820-4824 (1992).
RN [4]; RE0002561.
RX PUBMED: 1827203.
RA Hai T., Curran T.
RT Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity
RL Proc. Natl. Acad. Sci. USA 88:3720-3724 (1991).
RN [5]; RE0003154.
RX PUBMED: 1847461.
RA Tsujimoto A., Nyunoya H., Morita T., Sato T., Shimotohno K.
RT Isolation of cDNAs for DNA-Binding Proteins Which Specifically Bind to a tax-Responsive Enhancer Element in the Long Terminal Repeat of Human T-Cell Leukemia Virus Type I
RL J. Virol. 65:1420-1426 (1991).
RN [6]; RE0004521.
RX PUBMED: 7692236.
RA Kaszubska W., Hooft van Huijsduijnen R., Ghersa P., DeRaemy-Schenk A.-M., Chen B. P. C., Hai T., DeLamarter J. F., Whelan J.
RT Cyclic AMP-independent ATF family members interact with NF-kappaB and function in the activation of the E-selectin promoter in response to cytokines
RL Mol. Cell. Biol. 13:7180-7190 (1993).
RN [7]; RE0017064.
RX PUBMED: 11038375.
RA Lim C., Sohn H., Gwack Y., Choe J.
RT Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus (human herpesvirus-8) binds ATF4/CREB2 and inhibits its transcriptional activation activity
RL J. Gen. Virol. 81:2645-2652 (2000).
RN [8]; RE0048287.
RX PUBMED: 12805554.
RA Newman J. R., Keating A. E.
RT Comprehensive identification of human bZIP interactions with coiled-coil arrays.
RL Science 300:2097-2101 (2003).
RN [9]; RE0070798.
RX PUBMED: 21148039.
RA Liang Q., Deng H., Sun C. W., Townes T. M., Zhu F.
RT Negative regulation of IRF7 activation by activating transcription factor 4 suggests a cross-regulation between the IFN responses and the cellular integrated stress responses.
RL J. Immunol. 186:1001-1010 (2011).
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