TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01313 XX ID T01313 XX DT 22.10.1994 (created); ewi. DT 17.06.2013 (updated); mkl. CO Copyright (C), QIAGEN. XX FA ATF-3-isoform1 XX SY activating transcription factor 3; ATF-3. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G002871 ATF3; HGNC: ATF3. XX CL C0008; bZIP; XX SZ 181 AA; 20.6 kDa (cDNA) (calc.). XX SQ MMLQHPGQVSASEVSASAIVPCLSPPGSLVFEDFANLTPFVKEELRFAIQNKHLCHRMSS SQ ALESVTVSDRPLGVSITKAEVAPEEDERKKRRRERNKIAAAKCRNKKKEKTECLQKESEK SQ LESVNAELKAQIEELKNEKQHLIYMLNLHRPTCIVRAQNGRTPEDERNLFIQQIKEGTLQ SQ S XX SC Swiss-Prot#P18847-1 XX FT 84 138 PF07716; Basic region leucine zipper. FT 84 148 SM00338; brlzneu. FT 86 149 PS50217; BZIP. XX SF splice variant: ATF-3-isoform1 deltaZip [2]; SF no interaction with Tax of HTLV-I; SF associates only with NF-kappaB1/p50, but not with RelA/ p65 subunit of NF-kappaB [5]; SF can tolerate variations in the center of the binding sites if the flanking sequences are favorable [8]; XX FF repressor, presumably by stabilizing binding of inhibitory factors [2]; FF a similar interaction and concomitant sequestration may lead to the activation of promoters which do not reveal ATF sites [2]; FF mediates gene activation synergistically with c-Jun in response to FGF / Ras and cAMP, but only the former enhances ATF-3-isoform1 protein levels [7]; FF induces Tax-dependent transactivation by a mechanism that is enhanced further by PKA [6]; FF anisomycin and cotransfection of ATF2 T01802 and c-Jun T00133 activates ATF-3-isoform1 expression [9]; FF repressor of TNF-alpha induced E-selectin gene expression [10]; FF autorepressor of its own gene [8] [11]; FF stress-induced expression by homocysteine [11]; FF may have a functional role in homocysteinemia-associated andothelial dysfunction [11]; FF plays a critical role in accelerating caspase protease activation and apoptosis [12]; XX IN T00167 ATF-2-isoform1; human, Homo sapiens. IN T01382 ATF-2; rat, Rattus norvegicus. IN T09531 ATF-4; human, Homo sapiens. IN T00051 ATF; human, Homo sapiens. IN T18798 ATFa-isoform3; human, Homo sapiens. IN T18804 batf3; human, Homo sapiens. IN T00131 c-Jun; mouse, Mus musculus. IN T00132 c-Jun; rat, Rattus norvegicus. IN T00133 c-Jun; human, Homo sapiens. IN T00134 c-Jun; chick, Gallus gallus. IN T00135 c-Jun; hamster, Cricetulus sp. IN T08461 c-Jun; human, Homo sapiens. IN T09524 C/EBPgamma; human, Homo sapiens. IN T09526 CHOP-10-isoform1; human, Homo sapiens. IN T09550 CREBPA-Alpha; human, Homo sapiens. IN T08491 JunB; human, Homo sapiens. IN T08995 JunD; human, Homo sapiens. IN T00593 NF-kappaB1-p50; human, Homo sapiens. XX MX M00513 V$ATF3_Q6. MX M01863 V$ATF3_Q6_01. MX M07313 V$ATF3_Q6_02. MX M00981 V$CREBATF_Q6. MX M00801 V$CREB_Q3. XX BS R03924. BS R16636. BS R16637. BS R11477. BS R11553. BS R16691. BS R01258. BS R34851. BS R11552. BS R00777. BS R00779. BS R34855. BS R01358. XX DR TRANSPATH: MO000025574. DR EMBL: L19871; DR UniProtKB: P18847-1; XX RN [1]; RE0000666. RX PUBMED: 2516827. RA Hai T., Liu F., Coukos W. J., Green M. R. RT Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers RL Genes Dev. 3:2083-2090 (1989). RN [2]; RE0001083. RX PUBMED: 7515060. RA Chen B. P. C., Liang G., Whelan J., Hai T. RT ATF3 and ATF3deltaZip. Transcriptional repression versus activation by alternatively spliced isoforms RL J. Biol. Chem. 269:15819-15826 (1994). RN [3]; RE0002270. RX PUBMED: 2835770. RA Lin Y.-S., Green M. R. RT Interaction of a common cellular transcription factor, ATF, with regulatory elements in both E1a- and cyclic AMP-inducible promoters RL Proc. Natl. Acad. Sci. USA 85:3396-3400 (1988). RN [4]; RE0002561. RX PUBMED: 1827203. RA Hai T., Curran T. RT Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity RL Proc. Natl. Acad. Sci. USA 88:3720-3724 (1991). RN [5]; RE0004521. RX PUBMED: 7692236. RA Kaszubska W., Hooft van Huijsduijnen R., Ghersa P., DeRaemy-Schenk A.-M., Chen B. P. C., Hai T., DeLamarter J. F., Whelan J. RT Cyclic AMP-independent ATF family members interact with NF-kappaB and function in the activation of the E-selectin promoter in response to cytokines RL Mol. Cell. Biol. 13:7180-7190 (1993). RN [6]; RE0006674. RX PUBMED: 8007991. RA Low K. G., Chu H.-M., Tan Y., Schwartz P. M., Daniels G. M., Melner M. H., Comb M. J. RT Novel interactions between human T-cell leukemia virus type I Tax and activating transcription factor 3 at a cyclic AMP-responsive element RL Mol. Cell. Biol. 14:4958-4974 (1994). RN [7]; RE0006675. RX PUBMED: 7935470. RA Tan Y., Low K. G., Boccia C., Grossman J., Comb M. J. RT Fibroblast growth factor and cyclic AMP (cAMP) synergistically activate gene expression at a cAMP response element RL Mol. Cell. Biol. 14:7546-7556 (1994). RN [8]; RE0017052. RX PUBMED: 10748147. RA Wolfgang C. D., Liang G., Okamoto Y., Allen A. E., Hai T. RT Transcriptional autorepression of the stress-inducible gene ATF3 RL J. Biol. Chem. 275:16865-16870 (2000). RN [9]; RE0017054. RX PUBMED: 8576171. RA Liang G., Wolfgang C. D., Chen B. P., Chen T. H., Hai T. RT ATF3 gene. Genomic organization, promoter, and regulation. RL J. Biol. Chem. 271:1695-1701 (1996). RN [10]; RE0017057. RX PUBMED: 10964678. RA Nawa T., Nawa M. T., Cai Y., Zhang C., Uchimura I., Narumi S., Numano F., Kitajima S. RT Repression of TNF-alpha-induced E-selectin expression by PPAR activators: involvement of transcriptional repressor LRF-1/ATF3 RL Biochem. Biophys. Res. Commun. 275:406-411 (2000). RN [11]; RE0017058. RX PUBMED: 10979959. RA Cai Y., Zhang C., Nawa T., Aso T., Tanaka M., Oshiro S., Ichijo H., Kitajima S. RT Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH(2)-terminal kinase and promoter response element RL Blood 96:2140-2148 (2000). RN [12]; RE0017063. RX PUBMED: 11473362. RA Mashima T., Udagawa S., Tsuruo T. RT Involvement of transcriptional repressor ATF3 in acceleration of caspase protease activation during DNA damaging agent-induced apoptosis RL J. Cell. Physiol. 188:352-358 (2001). RN [13]; RE0048287. RX PUBMED: 12805554. RA Newman J. R., Keating A. E. RT Comprehensive identification of human bZIP interactions with coiled-coil arrays. RL Science 300:2097-2101 (2003). XX //