AC T00132
XX
ID T00132
XX
DT 15.10.1992 (created); ewi.
DT 29.01.2016 (updated); mom.
CO Copyright (C), QIAGEN.
XX
FA c-Jun
XX
SY AP-1; c-Jun; Jun; JunA; p39; p39 c-jun; proto-oncogene c-Jun; RJG-9; transcription factor c-Jun.
XX
OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G008873 Jun.
XX
CL C0008; bZIP; 1.1.1.1.1.
XX
SF dimerization through the leucine zipper motif that governs the dimerization specificity among bZIP class members [22] [20] [10];
SF two zippers motifs associate in parallel orientation [21];
SF zipper dimerization juxtaposes the basic regions to form a contiguous DNA-binding interface [20];
SF upon DNA-binding, the basic regions adopt alpha-helical conformation to form a long helix along with that of the zipper regions [12];
SF opposite DNA bending by homodimers and by c-Jun/c-Fos heterodimers [34] [3];
SF the leucine zipper of c-Jun interacts with the HLH domain of MyoD [29];
SF trans-activation and transforming activity correlate within the N-terminal 168 AA [39];
SF homology boxes with c-Fos (HOB1 and HOB2) independently trans-activate in a cooperative manner [42];
XX
CP widespread, highest levels in lung [32]; PTZ treated hippocampus and amygdaloid nucleus [50]; estrogen treated or untreated rat hypothalamic and pituitary nuclear extracts of ovariectomized (OVX) females [52]; adrenal gland (medulla specific) [53].
XX
FF PD98059 and SB203580 reduces the HNE induced expression in L2 cells [51];
FF Activated by serum in mid to late G1 stage of cell cycle in 3Y1 cells [56];
FF activator;
FF in some case may activate gene transcription without direct binding to DNA, for example through protein-protein interactions with Sp1 [45];
FF inhibits myogenesis by direct interactions with MyoD [28] [29];
FF exhibits transforming activity which is enhanced by c-Fos, but inhibited by JunB [40];
FF significant enhancement of dimerization by Tax;
FF c-jun gene is induced by retinoic acid and adenoviral E1A [27];
FF oxidation of Cys-272 disables DNA-binding which is thought to be part of a regulatory redox mechanism [33];
FF target of a signalling cascade starting with Ha-Ras and resulting in c-Jun phosphorylation on Ser-63 and Ser-73 by JNK protein kinases [26] [36] [38] [41];
FF phosphorylation by p34(cdc2) at the N-terminal (63/73) and the C-terminal sites (near the DNA-binding domain) [26];
FF phosphorylation the C-terminal sites is reversed by protein phosphatase 2a (PP2A), but not by PP1 [37];
FF association of c-Jun with IP-1, a labile 30-40 kDa protein, inhibits DNA-binding [2];
FF adenoviral E1A interacts with c-Jun in particular when present in a heterodimer with CRE-BP1/ATF-2 which subsequently induces the c-jun gene through its distal AP-1 site [35];
FF involved in the cAMP dependent regulation of catecholamine neurotransmitter biosynthesis [43];
FF DNA-binding of c-Jun to the MT-IIA promoter is stimulated by reducing compounds found in rat liver as well as Trx and Trx reductase, which stabilizes the reduced activated state of c-Jun [33];
XX
IN T08443 AML3; mouse, Mus musculus.
IN T00167 ATF-2-isoform1; human, Homo sapiens.
IN T01017 ATF-2-isoform2; mouse, Mus musculus.
IN T01313 ATF-3-isoform1; human, Homo sapiens.
IN T01095 ATF-3; rat, Rattus norvegicus.
IN T01303 ATF-4; human, Homo sapiens.
IN T00051 ATF; human, Homo sapiens.
IN T10523 c-Ets-2; human, Homo sapiens.
IN T00122 c-Fos; mouse, Mus musculus.
IN T00123 c-Fos; human, Homo sapiens.
IN T00124 c-Fos; rat, Rattus norvegicus.
IN T00125 c-Fos; chick, Gallus gallus.
IN T00132 c-Jun; rat, Rattus norvegicus.
IN T01308 CREBPA; human, Homo sapiens.
IN T02198 deltaFosB; mouse, Mus musculus.
IN T00967 E1A 12S protein; adenovirus.
IN T00209 E1A 13S protein; adenovirus type 2.
IN T00258 ER-alpha; rat, Rattus norvegicus.
IN T00291 FosB; mouse, Mus musculus.
IN T00292 Fra-1; mouse, Mus musculus.
IN T01208 Fra-1; rat, Rattus norvegicus.
IN T00333 GR; rat, Rattus norvegicus.
IN T04878 Ref-1; human, Homo sapiens.
IN T00888 v-Fos; FBR MuLV, FBR murine osteosarcoma virus.
XX
MX M00172 V$AP1FJ_Q2.
MX M00517 V$AP1_01.
MX M00924 V$AP1_Q2_01.
MX M00926 V$AP1_Q4_01.
MX M00925 V$AP1_Q6_01.
MX M03541 V$CJUN_Q6.
MX M00041 V$CREBP1CJUN_01.
XX
BS R00362.
BS R03668.
BS R22690.
BS R22753.
BS R25274.
BS R16636.
BS R00592.
BS R00930.
BS R03059.
BS R01036.
BS R24985.
BS R13430.
BS R21760.
BS R21763.
BS R14470.
BS R03102.
BS R21495.
BS R35000.
BS R29771.
BS R30581.
BS R55861.
BS R55862.
BS R37508.
BS R37509.
BS R37510.
BS R37511.
BS R67607.
BS R09471.
BS R35602.
BS R38883.
BS R22727.
BS R57949.
BS R57952.
BS R57953.
BS R57954.
BS R57958.
BS R57964.
BS R38851.
BS R19673.
BS R30004.
BS R34572.
BS R25273.
BS R26776.
BS R26384.
BS R26186.
BS R26777.
BS R26497.
BS R41012.
BS R33738.
BS R32247.
BS R31550.
BS R01491.
BS R35124.
BS R63406.
BS R63408.
XX
DR TRANSPATH: MO000001269.
DR TRANSCOMPEL: C00115.
DR TRANSCOMPEL: C00411.
DR TRANSCOMPEL: C00636.
DR UniProtKB: P17325;
XX
RN [1]; RE0000157.
RX PUBMED: 1846781.
RA Boyle W. J., Smeal T., Defize L. H. K., Angel P., Woodgett G. R., Karin M., Hunter T.
RT Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity
RL Cell 64:573-584 (1991).
RN [2]; RE0000158.
RX PUBMED: 1900458.
RA Auwerx J., Sassone-Corsi P.
RT IP-1: A dominant inhibitor of Fos/Jun whose activity is modulated by phosphorylation
RL Cell 64:983-993 (1991).
RN [3]; RE0000239.
RX PUBMED: 1906785.
RA Kerppola T. K., Curran T.
RT Fos-Jun heterodimers and Jun homodimers bend DNA in opposite orientations: implications for transcription factor cooperativity
RL Cell 66:317-326 (1991).
RN [4]; RE0000248.
RX PUBMED: 2169352.
RA Yang-Yen H.-F., Chambard J.-C., Sun Y.-L., Smeal T., Schmidt T. J., Drouin J., Karin M.
RT Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction
RL Cell 62:1205-1215 (1990).
RN [5]; RE0000641.
RX PUBMED: 2467839.
RA Rauscher III F. J., Voulalas P. J., Franza jr B. R., Curran T.
RT Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro
RL Genes Dev. 2:1687-1699 (1988).
RN [6]; RE0000662.
RX PUBMED: 2498163.
RA Bartel D. P., Sheng M., Lau L. F., Greenberg M. E.
RT Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction
RL Genes Dev. 3:304-313 (1989).
RN [7]; RE0001155.
RX PUBMED: 2536818.
RA Yamaguchi Y., Satake M., Ito Y.
RT Two overlapping sequence motifs within the polyomavirus enhancer are independently the targets of stimulation by both the tumor promoter 12-O-tetradecanoylphorbol-13-acetate and the Ha-ras oncogene
RL J. Virol. 63:1040-1048 (1989).
RN [8]; RE0001453.
RX PUBMED: 2115122.
RA Gius D., Cao X., Rauscher III F. J., Cohen D. R., Curran T., Sukhatme V. P.
RT Transcriptional Activation and Repression by Fos Are Independent Functions: The C Terminus Represses Immediate-Early Gene Expression via CArG Elements
RL Mol. Cell. Biol. 10:4243-4255 (1990).
RN [9]; RE0001460.
RX PUBMED: 2501665.
RA Wasylyk C., Wasylyk B., Heidecker G., Huleihel M., Rapp U. R.
RT Expression of raf oncogenes activates the PEA1 transcription factor motif
RL Mol. Cell. Biol. 9:2247-2250 (1989).
RN [10]; RE0001770.
RX PUBMED: 2974122.
RA Kouzarides T., Ziff E.
RT The role of the leucine zipper in the fos-jun interaction
RL Nature 336:646-651 (1988).
RN [11]; RE0001771.
RX PUBMED: 2505081.
RA Kouzarides T., Ziff E.
RT Leucine zippers of fos, jun and GCN4 dictate dimerization specificity and thereby control DNA binding
RL Nature 340:568-571 (1989).
RN [12]; RE0001901.
RX PUBMED: 2120592.
RA Patel L., Abate C., Curan T.
RT Altered protein conformation on DNA binding by Fos and Jun
RL Nature 347:572-574 (1990).
RN [13]; RE0001940.
RX PUBMED: 2518690.
RA Angel P., Smeal T., Meek J., Karin M.
RT jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner
RL New Biol. 1:35-43 (1989).
RN [14]; RE0001941.
RX PUBMED: 1963081.
RA Yang-Yen H.-F., Chiu R., Karin M.
RT Elevation of AP-1 activity during F9 cell differentiation is due to increased c-Jun transcription
RL New Biol. 2:351-361 (1990).
RN [15]; RE0002170.
RX PUBMED: 1906606.
RA Buttice G., Quinones S., Kurkinen M.
RT The AP-1 site is required for basal expression but is not necessary for TPA-response of the human stromelysin gene
RL Nucleic Acids Res. 19:3723-3731 (1991).
RN [16]; RE0002407.
RX PUBMED: 3174663.
RA Saffen D. W., Cole A. J., Worley P. F., Christy B. A., Ryder K., Baraban J. M.
RT Convulsant-induced increase in transcription factor messenger RNAs in rat brain
RL Proc. Natl. Acad. Sci. USA 85:7795-7799 (1988).
RN [17]; RE0002408.
RX PUBMED: 2453058.
RA Piette J., Hirai S.-I., Yaniv M.
RT Constitutive synthesis of activator protein 1 transcription factor after viral transformation of mouse fibroblasts
RL Proc. Natl. Acad. Sci. USA 85:3401-3405 (1988).
RN [18]; RE0002543.
RX PUBMED: 1902565.
RA Hsu J. C., Laz T., Mohn K. L., Taub R.
RT Identification of LRF-1, a leucine-zipper protein that is rapidly and highly induced in regenerating liver
RL Proc. Natl. Acad. Sci. USA 88:3511-3515 (1991).
RN [19]; RE0002561.
RX PUBMED: 1827203.
RA Hai T., Curran T.
RT Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity
RL Proc. Natl. Acad. Sci. USA 88:3720-3724 (1991).
RN [20]; RE0002619.
RX PUBMED: 2494701.
RA Turner R., Tjian R.
RT Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers
RL Science 243:1689-1694 (1989).
RN [21]; RE0002620.
RX PUBMED: 2494702.
RA Gentz R., Rauscher III F. J., Abate C., Curan T.
RT Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains
RL Science 243:1695-1699 (1989).
RN [22]; RE0002698.
RX PUBMED: 2503872.
RA O'Shea E. K., Rutkowski R., Stafford III W. F., Kim P. S.
RT Preferential heterodimer formation by isolated leucine zippers from Fos and Jun
RL Science 245:646-648 (1989).
RN [23]; RE0002710.
RX PUBMED: 8211160.
RA Wagner S., Green M. R.
RT HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization
RL Science 262:395-399 (1993).
RN [24]; RE0002772.
RX PUBMED: 2114014.
RA Naranjo J. R., Mellstroem B., Auwerx J., Mollinedo F., Sassone-Corsi P.
RT Unusual c-fos induction upon chromaffin PC12 differentiation by sodium butyrate: loss of fos autoregulatory function
RL Nucleic Acids Res. 18:3605-3610 (1990).
RN [25]; RE0002953.
RX PUBMED: 1328860.
RA Baker S. J., Kerppola T. K., Luk D., Vandenberg M. T., Marshak D. R., Curran T., Abate C.
RT Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts
RL Mol. Cell. Biol. 12:4694- 4705 (1992).
RN [26]; RE0002997.
RX PUBMED: 1630458.
RA Smeal T., Binetruy B., Mercola D., Grover-Bardwick A., Heidecker G., Rapp U. R., Karin M.
RT Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73
RL Mol. Cell. Biol. 12:3507-3513 (1992).
RN [27]; RE0003149.
RX PUBMED: 1310930.
RA Kitabayashi I., Kawakami Z., Chiu R., Ozawa K., Matsuoka T., Toyoshima S., Umesono K., Evans R. M., Gachelin G., Yokoyama K.
RT Transcriptional regulation of the c-jun gene by retinoic acid and E1A during differentiation of F9 cells
RL EMBO J. 11:167-175 (1992).
RN [28]; RE0003225.
RX PUBMED: 1313772.
RA Li L., Chambard J. C., Karin M., Olson E. N.
RT Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression
RL Genes Dev. 6:676-689 (1992).
RN [29]; RE0003418.
RX PUBMED: 1310896.
RA Bengal E., Ransone L., Scharfmann R., Dwarki V. J., Tapscott S. J., Weintraub H., Verma I. M.
RT Functional antagonism between c-Jun and MyoD proteins: a direct physical association
RL Cell 68:507-519 (1992).
RN [30]; RE0004648.
RX PUBMED: 1406655.
RA Hsu J. C., Bravo R., Taub R.
RT Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration
RL Mol. Cell. Biol. 12:4654-4665 (1991).
RN [31]; RE0004651.
RX PUBMED: 2113275.
RA Kitabayashi I., Saka F., Gachelin G., Yokoyama K.
RT Nucleotide sequence of rat c-jun protooncogene
RL Nucleic Acids Res. 18:3400-3400 (1990).
RN [32]; RE0004652.
RX PUBMED: 2507134.
RA Sakai M., Okuda A., Hatayama I., Sato K., Nishi S., Muramatsu M.
RT Structure and expression of the rat c-jun messenger RNA: tissue distribution and increase during chemical hepatocarcinogenesis
RL Cancer Res. 49:5633-5637 (1989).
RN [33]; RE0004656.
RX PUBMED: 2118682.
RA Abate C., Patel L., Rauscher III F. J., Curran T.
RT Redox regulation of Fos and Jun DNA-binding activity in vitro
RL Science 249:1157-1161 (1990).
RN [34]; RE0004658.
RX PUBMED: 1957173.
RA Kerppola T. K., Curran T.
RT DNA bending by Fos and Jun: the flexible hinge model
RL Science 254:1210-1214 (1991).
RN [35]; RE0004665.
RX PUBMED: 8382609.
RA van Dam H., Duyndam M., Rottier R., Bosch A., de Vries-Smits L., Herrlich P., Zantema A., Angel P., van der Eb A. J.
RT Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amin acid adenovirus E1A protein
RL EMBO J. 12:479-487 (1993).
RN [36]; RE0004674.
RX PUBMED: 7935387.
RA Minden A., Lin A., Smeal T., Derijard B., Cobb M., Davis R., Karin M.
RT c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases
RL Mol. Cell. Biol. 14:6683-6688 (1994).
RN [37]; RE0004676.
RX PUBMED: 8384305.
RA Alberts A. S., Deng T., Lin A., Meinkoth J. L., Schoenthal A., Mumby M. C., Karin M., Feramisco J. R.
RT Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements
RL Mol. Cell. Biol. 13:2104-2112 (1993).
RN [38]; RE0004681.
RX PUBMED: 1749429.
RA Smeal T., Binetruy B., Mercola D. A., Birrer M., Karin M.
RT Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73
RL Nature 354:494-496 (1991).
RN [39]; RE0004683.
RX PUBMED: 1944289.
RA Alani R., Brown P., BinJtruy B., Dosaka H., Rosenberg R. K., Angel P., Karin M., Birrer M. J.
RT The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells
RL Mol. Cell. Biol. 11:6286-6295 (1991).
RN [40]; RE0004707.
RX PUBMED: 2513129.
RA Schuette J., Viallet J., Nau M., Segal S., Fedorko J., Minna J.
RT jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun
RL Cell 59:987-997 (1989).
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RX PUBMED: 8177321.
RA Kyriakis J. M., Banerjee P., Nikolakaki E., Dai T., Rudie E. A., Ahmad M. F., Avruch J., Woodgett J. R.
RT The stress-activated protein kinase subfamily of c-Jun kinases
RL Nature 369:156-160 (1994).
RN [42]; RE0004818.
RX PUBMED: 1516835.
RA Sutherland J. A., Cook A., Bannister A. J., Kouzarides T.
RT Conserved motifs in Fos and Jun define a new class of activation domain
RL Genes Dev. 6:1810-1819 (1992).
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RX PUBMED: 9341190.
RA Swanson D. J., Zellmer E., Lewis E. J.
RT The homeodomain protein Arix interacts synergistically with cyclic AMP to regulate expression of neurotransmitter biosynthetic genes
RL J. Biol. Chem. 272:27382-27392 (1997).
RN [44]; RE0023220.
RX PUBMED: 11274169.
RA Hess J., Porte D., Munz C., Angel P.
RT AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element.
RL J. Biol. Chem. 276:20029-20038 (2001).
RN [45]; RE0024063.
RX PUBMED: 10506225.
RA Kardassis D., Papakosta P., Pardali K., Moustakas A.
RT c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1.
RL J. Biol. Chem. 274:29572-29581 (1999).
RN [46]; RE0028250.
RX PUBMED: 11312266.
RA Roux P. P., Bhakar A. L., Kennedy T. E., Barker P. A.
RT The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway.
RL J. Biol. Chem. 276:23097-104 (2001).
RN [47]; RE0031973.
RX PUBMED: 12376548.
RA Salehi A. H., Xanthoudakis S., Barker P. A.
RT NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.
RL J. Biol. Chem. 277:48043-50 (2002).
RN [48]; RE0047202.
RX PUBMED: 14662744.
RA Marsh H. N., Dubreuil C. I., Quevedo C., Lee A., Majdan M., Walsh G. S., Hausdorff S., Said F. A., Zoueva O., Kozlowski M., Siminovitch K., Neel B. G., Miller F. D., Kaplan D. R.
RT SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase
RL J. Cell Biol. 163:999-1010 (2003).
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RX PUBMED: 16877354.
RA Tan J., Shepherd R. K.
RT Aminoglycoside-induced degeneration of adult spiral ganglion neurons involves differential modulation of tyrosine kinase B and p75 neurotrophin receptor signaling.
RL Am. J. Pathol. 169:528-543 (2006).
RN [50]; RE0051328.
RX PUBMED: 8774943.
RA Asanuma M., Nishibayashi S., Kondo Y., Iwata E., Tsuda M., Ogawa N.
RT Effects of single cyclosporin A pretreatment on pentylenetetrazol-induced convulsion and on TRE-binding activity in the rat brain.
RL Mol. Brain Res. 33:29-36 (1995).
RN [51]; RE0051366.
RX PUBMED: 16195535.
RA Zhang H., Liu H., Iles K. E., Liu R. M., Postlethwait E. M., Laperche Y., Forman H. J.
RT 4-Hydroxynonenal induces rat gamma-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling.
RL Am. J. Respir. Cell Mol. Biol. 34:174-181 (2006).
RN [52]; RE0051430.
RX PUBMED: 9645966.
RA Zhu Y. S., Pfaff D. W.
RT Differential regulation of AP-1 DNA binding activity in rat hypothalamus and pituitary by estrogen.
RL Mol. Brain Res. 55:115-125 (1998).
RN [53]; RE0051794.
RX PUBMED: 10825388.
RA Won J. S., Lee J. K., Song D. K., Huh S. O., Jung J. S., Kim Y. H., Choi M. R., Suh H. W.
RT Cycloheximide increases proenkephalin and tyrosine hydroxylase gene expression in rat adrenal medulla.
RL Mol. Pharmacol. 57:1173-1181 (2000).
RN [54]; RE0052052.
RX PUBMED: 8584023.
RA Berlanga J. J., Fresno Vara J. A., Martin-Perez J., Garcia-Ruiz J. P.
RT Prolactin receptor is associated with c-src kinase in rat liver.
RL Mol. Endocrinol. 9:1461-1467 (1995).
RN [55]; RE0053743.
RX PUBMED: 18083124.
RA Li A. Y., Han M., Zheng B., Wen J. K.
RT Roscovitine inhibits ERK1/2 activation induced by angiotensin II in vascular smooth muscle cells.
RL FEBS Lett. 582:243-248 (2008).
RN [56]; RE0053807.
RX PUBMED: 9511728.
RA Shimizu M., Nomura Y., Suzuki H., Ichikawa E., Takeuchi A., Suzuki M., Nakamura T., Nakajima T., Oda K.
RT Activation of the rat cyclin A promoter by ATF2 and Jun family members and its suppression by ATF4.
RL Exp. Cell Res. 239:93-103 (1998).
RN [57]; RE0055100.
RX PUBMED: 18307989.
RA Yong-LiuLi C., Zong Y. Y., Yu C. Z., Wang W., Yan J. Z., Zhang G. Y.
RT Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion.
RL FEBS Lett. 582:1298-1306 (2008).
RN [58]; RE0063357.
RX PUBMED: 18676085.
RA Yu H. M., Xu J., Li C., Zhou C., Zhang F., Han D., Zhang G. Y.
RT Coupling between neuronal nitric oxide synthase and glutamate receptor 6-mediated c-Jun N-terminal kinase signaling pathway via S-nitrosylation contributes to ischemia neuronal death.
RL Neuroscience 155:1120-1132 (2008).
RN [59]; RE0063905.
RX PUBMED: 12786973.
RA Shinoda S., Skradski S. L., Araki T., Schindler C. K., Meller R., Lan J. Q., Taki W., Simon R. P., Henshall D. C.
RT Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal-regulating kinase 1 during seizure-induced neuronal death.
RL Eur. J. Neurosci. 17:2065-2076 (2003).
RN [60]; RE0064151.
RX PUBMED: 17244530.
RA Xia Y., Wang J., Liu T. J., Yung W. K., Hunter T., Lu Z.
RT c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis.
RL Mol. Cell 25:219-232 (2007).
RN [61]; RE0064958.
RX PUBMED: 18511507.
RA Chen Y. J., Lee M. T., Yao H. C., Hsiao P. W., Ke F. C., Hwang J. J.
RT Crucial role of estrogen receptor-alpha interaction with transcription coregulators in follicle-stimulating hormone and transforming growth factor beta1 up-regulation of steroidogenesis in rat ovarian granulosa cells.
RL Endocrinology 149:4658-4668 (2008).
RN [62]; RE0067125.
RX PUBMED: 10937548.
RA Takeda M., Kato H., Takamiya A., Yoshida A., Kiyama H.
RT Injury-specific expression of activating transcription factor-3 in retinal ganglion cells and its colocalized expression with phosphorylated c-Jun.
RL Invest. Ophthalmol. Vis. Sci. 41:2412-2421 (2000).
RN [63]; RE0070404.
RX PUBMED: 20516211.
RA Da Costa C. R., Villadiego J., Sancho R., Fontana X., Packham G., Nateri A. S., Behrens A.
RT Bag1-L is a phosphorylation-dependent coactivator of c-Jun during neuronal apoptosis.
RL Mol. Cell. Biol. 30:3842-3852 (2010).
RN [64]; RE0071579.
RX PUBMED: 20231272.
RA Loesch M., Zhi H. Y., Hou S. W., Qi X. M., Li R. S., Basir Z., Iftner T., Cuenda A., Chen G.
RT p38gamma MAPK cooperates with c-Jun in trans-activating matrix metalloproteinase 9.
RL J. Biol. Chem. 285:15149-15158 (2010).
XX
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