AC T00258
XX
ID T00258
XX
DT 15.10.1992 (created); ewi.
DT 24.07.2014 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA ER-alpha
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SY ER; ERalpha; estrogen receptor; NR3A1.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009131 Esr1.
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CL C0002; CC (rec); 2.1.1.2.1.
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SF 1H NMR: 2 zinc ions coordinated by 4 Cys within each zinc finger;
SF 2 perpendicular alpha-helices;
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FF mediates gene regulation in response to estrogen hormone;
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IN T00132 c-Jun; rat, Rattus norvegicus.
IN T05362 CBP; rat, Rattus norvegicus.
IN T00258 ER-alpha; rat, Rattus norvegicus.
IN T10924 islet1; rat, Rattus norvegicus.
IN T05367 PGC-1; rat, Rattus norvegicus.
IN T00707 Pit-1; rat, Rattus norvegicus.
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MX M01801 V$ERALPHA_01.
MX M07283 V$ERALPHA_Q4.
MX M03547 V$ERALPHA_Q6_01.
MX M03820 V$ERALPHA_Q6_02.
MX M00191 V$ER_Q6.
MX M00959 V$ER_Q6_02.
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BS R02150.
BS R03564.
BS R03565.
BS R03570.
BS R03571.
BS R03572.
BS R03573.
BS R03574.
BS R32331.
BS R32332.
BS R27173.
BS R63011.
BS R16548.
BS R14197.
BS R03480.
BS R01267.
BS R02926.
BS R62685.
BS R01586.
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DR TRANSPATH: MO000024809.
DR TRANSCOMPEL: C00363.
DR UniProtKB: P06211;
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RN [1]; RE0001035.
RX PUBMED: 1894604.
RA Shupnik M. A., Rosenzweig B. A.
RT Identification of an estrogen-responsive element in the rat LHbeta gene
RL J. Biol. Chem. 266:17084-17091 (1991).
RN [2]; RE0001894.
RX PUBMED: 2247153.
RA Schwabe J. W. R., Neuhaus D., Rhodes D.
RT Solution structure of the DNA-binding domain of the oestrogen receptor
RL Nature 348:458-461 (1990).
RN [3]; RE0002036.
RX PUBMED: 3031601.
RA Koike S., Sakai M., Muramatsu M.
RT Molecular cloning and characterization of rat estrogen receptor cDNA
RL Nucleic Acids Res. 15:2499-2513 (1987).
RN [4]; RE0002075.
RX PUBMED: 1975094.
RA de Verneuil H., Metzger D.
RT The lack of transcriptional activation of the v-erbA oncogene is in part due to a mutation in the DNA binding domain of the protein
RL Nucleic Acids Res. 18:4489-4497 (1990).
RN [5]; RE0003778.
RX PUBMED: 1963474.
RA Seyfred M. A., Gorski J.
RT An interaction between the 5' flanking distal and proximal regulatory domains of the rat prolactin gene is required for transcriptinal activation by estrogens
RL Mol. Endocrinol. 4:1226-1234 (1990).
RN [6]; RE0003780.
RX PUBMED: 3882696.
RA Lubahn D. B., McCarty jr K. S., McCarty sr K. S.
RT Electrophoretic characterization of purified bovine, porcine, murine, rat, and human uterine estrogen receptors
RL J. Biol. Chem. 260:2515-2526 (1985).
RN [7]; RE0012307.
RX PUBMED: 8650195.
RA Kuiper G. G. J. M., Enmark E., Pelto-Huikko M., Nilsson S., Gustafsson J.-A.
RT Cloning of a novel estrogen receptor expressed in rat prostate and ovary
RL Proc. Natl. Acad. Sci. USA 93:5925-5930 (1996).
RN [8]; RE0047429.
RX PUBMED: 15569929.
RA Lu Q., Pallas D. C., Surks H. K., Baur W. E., Mendelsohn M. E., Karas R. H.
RT Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha.
RL Proc. Natl. Acad. Sci. USA 101:17126-17131 (2004).
RN [9]; RE0047471.
RX PUBMED: 15033165.
RA Cardona-Gomez P., Perez M., Avila J., Garcia-Segura L. M., Wandosell F.
RT Estradiol inhibits GSK3 and regulates interaction of estrogen receptors, GSK3, and beta-catenin in the hippocampus.
RL Mol. Cell. Neurosci. 25:363-373 (2004).
RN [10]; RE0047590.
RX PUBMED: 10809776.
RA Ying C., Lin D. H.
RT Estrogen-modulated estrogen receptor x Pit-1 protein complex formation and prolactin gene activation require novel protein synthesis.
RL J. Biol. Chem. 275:15407-15412 (2000).
RN [11]; RE0064958.
RX PUBMED: 18511507.
RA Chen Y. J., Lee M. T., Yao H. C., Hsiao P. W., Ke F. C., Hwang J. J.
RT Crucial role of estrogen receptor-alpha interaction with transcription coregulators in follicle-stimulating hormone and transforming growth factor beta1 up-regulation of steroidogenesis in rat ovarian granulosa cells.
RL Endocrinology 149:4658-4668 (2008).
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