AC T01095
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ID T01095
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DT 24.02.1994 (created); ewi.
DT 05.08.2014 (updated); msr.
CO Copyright (C), QIAGEN.
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FA ATF-3
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SY activating transcription factor 3; Liver regeneration factor 1; LRF-1.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002873 Atf3.
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CL C0008; bZIP; 1.1.2.2.1.
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SF forms homodimers, but preferentially binds to DNA as heterodimers with c-Jun or JunB [2];
SF no heterodimers with c-Fos [2];
SF highest affinity to CRE, but also binding TRE or ATF-sites with 6-8-fold or 2-3-fold lower affinity (homo- and heterodimers, resp.) [2];
SF highly similar to ATF-3;
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CP mainly in regenerating liver; lower in intestine, stomach, muscle, lung; weak in kidney [1].
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FF Activated by serum in mid to late G1 stage of cell cycle in 3Y1 cells [4];
FF activator of c-Jun-responsive promoter (in combination with c-Jun);
FF LRF-1 heterodimers with c-Jun trans-activate through AP-1 and ATF sites [2];
FF LRF-1/JunB heterodimers repress stimulation mediated by c-Fos or c-Jun [2];
FF expression peaks 2-3h after hepatectomy [1];
FF LRF-1 complexes with c-Jun and with JunB rise during G0/G1 transition, the relative concentration of the latter still increasing during G1 [2];
FF induced in sensory and motoneurons in the spinal cord after nerve injury [3];
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IN T01095 ATF-3; rat, Rattus norvegicus.
IN T00131 c-Jun; mouse, Mus musculus.
IN T00132 c-Jun; rat, Rattus norvegicus.
IN T00133 c-Jun; human, Homo sapiens.
IN T00134 c-Jun; chick, Gallus gallus.
IN T00135 c-Jun; hamster, Cricetulus sp.
IN T00436 JunB; mouse, Mus musculus.
IN T06445 JunB; rat, Rattus norvegicus.
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MX M00513 V$ATF3_Q6.
MX M01863 V$ATF3_Q6_01.
MX M07313 V$ATF3_Q6_02.
MX M00981 V$CREBATF_Q6.
MX M00801 V$CREB_Q3.
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BS R00362.
BS R03668.
BS R31484.
BS R00592.
BS R31456.
BS R63137.
BS R31431.
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DR TRANSPATH: MO000025393.
DR UniProtKB: P29596;
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RN [1]; RE0002543.
RX PUBMED: 1902565.
RA Hsu J. C., Laz T., Mohn K. L., Taub R.
RT Identification of LRF-1, a leucine-zipper protein that is rapidly and highly induced in regenerating liver
RL Proc. Natl. Acad. Sci. USA 88:3511-3515 (1991).
RN [2]; RE0004648.
RX PUBMED: 1406655.
RA Hsu J. C., Bravo R., Taub R.
RT Interactions among LRF-1, JunB, c-Jun, and c-Fos define a regulatory program in the G1 phase of liver regeneration
RL Mol. Cell. Biol. 12:4654-4665 (1991).
RN [3]; RE0017062.
RX PUBMED: 10673325.
RA Tsujino H., Kondo E., Fukuoka T., Dai Y., Tokunaga A., Miki K., Yonenobu K., Ochi T., Noguchi K.
RT Activating transcription factor 3 (ATF3) induction by axotomy in sensory and motoneurons: A novel neuronal marker of nerve injury
RL Mol. Cell. Neurosci. 15:170-182 (2000).
RN [4]; RE0053807.
RX PUBMED: 9511728.
RA Shimizu M., Nomura Y., Suzuki H., Ichikawa E., Takeuchi A., Suzuki M., Nakamura T., Nakajima T., Oda K.
RT Activation of the rat cyclin A promoter by ATF2 and Jun family members and its suppression by ATF4.
RL Exp. Cell Res. 239:93-103 (1998).
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