AC T00888
XX
ID T00888
XX
DT 12.03.1993 (created); ewi.
DT 28.08.2007 (updated); apk.
CO Copyright (C), QIAGEN.
XX
FA v-Fos
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SY gag-fos; v-Fos.
XX
OS FBR MuLV, FBR murine osteosarcoma virus
OC viridae; ss-RNA enveloped viruses; positive strand RNA viruses; retroviridae; oncovirinae; type C oncovirus group; mammalian type C oncoviruses
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CL C0008; bZIP.
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SZ 244 AA; 26.6 kDa (gene) (calc.).
XX
SQ DSLSYYHSPADSFSSMGSPVNTQDFCADLSVSSANFIPTETAISTSPDLQWLVQPTLVSS
SQ VAPSQTRAPHPYGLPTQSAGAYARAGMVKTVSGGRAQSIGRRGKVEQLSPEEEVKRRIRR
SQ ERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPAC
SQ KIPDDLGFPEEMSVASLDLTGGLLPLLNDPEPKPSLEPVKSSFDDFLFPASSGHSGFISM
SQ AGWQ
XX
FT 36 60 
N-terminal transcription activation domain (N-TA, by homology) [6].
FT 111 175 
PF00170; bZIP transcription factor.
FT 111 175 
SM00338; brlzneu.
FT 113 176 
PS50217; BZIP.
XX
SF expressed as a gag-fos fusion protein of 75 kDa [3];
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FF activator [7];
FF nuclear translocation appears not to be controlled by external signals (in contrast to c-Fos) [5];
FF trans-activation by and DNA-binding of the gag-fos fusion protein is decreased compared with c-Fos due to N-terminal myristylation [1];
FF transformation by FBR, however, depends on the gag-fos myristylation [7];
FF activation of the alpha(III) collagen promoter operates through interaction of a negative regulatory region with C/EBPalpha [7];
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IN T00131 c-Jun; mouse, Mus musculus.
IN T00132 c-Jun; rat, Rattus norvegicus.
IN T00133 c-Jun; human, Homo sapiens.
IN T00134 c-Jun; chick, Gallus gallus.
IN T00135 c-Jun; hamster, Cricetulus sp.
IN T01436 MafF; chick, Gallus gallus.
IN T01437 MafG; chick, Gallus gallus.
IN T01434 MafK; chick, Gallus gallus.
IN T01435 MafK; mouse, Mus musculus.
IN T01430 v-Maf; AS42, avian musculoaponeurotic fibrosarcoma virus.
XX
BS R02963.
BS R04116.
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DR TRANSPATH: MO000025247.
DR EMBL: K02712;
DR UniProtKB: P29176;
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RN [1]; RE0001581.
RX PUBMED: 1846672.
RA Kamata N., Jotte R. M., Holt J. T.
RT Myristylation alters DNA-binding activity and transactivation of FBR (gag-fos) protein
RL Mol. Cell. Biol. 11:765-772 (1991).
RN [2]; RE0002917.
RX PUBMED: 8264639.
RA Kataoka K., Noda M., Nishizawa M.
RT Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun
RL Mol. Cell. Biol. 14:700-712 (1994).
RN [3]; RE0004800.
RX PUBMED: 6203214.
RA Curran T., Verma I. M.
RT FBR murine osteosarcoma virus
RL Virology 135:218-228 (1984).
RN [4]; RE0004801.
RX PUBMED: 6383726.
RA Mueller R., Verma I. M.
RT Expression of cellular oncogenes
RL Curr. Top. Microbiol. Immunol. 112:73-115 (1984).
RN [5]; RE0004830.
RX PUBMED: 2119889.
RA Roux P., Blanchard J.-M., Fernandez A., Lamb N., Jeanteur P., Piechaczyk M.
RT Nuclear localization of c-Fos, but not v-Fos proteins, is controlled by extracellular signals
RL Cell 63:341-351 (1990).
RN [6]; RE0004887.
RX PUBMED: 8137828.
RA Jooss K. U., Funk M., Mueller R.
RT An autonomous N-terminal transactivation domain in Fos protein plays a crucial role in transformation
RL EMBO J. 13:1467-1475 (1994).
RN [7]; RE0007060.
RX PUBMED: 8206947.
RA Jotte R. M., Kamata N., Holt J. T.
RT Myristylation-dependent transactivation by FBR v-fos is regulated by C/EBP
RL J. Biol. Chem. 269:16383-16396 (1994).
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