AC T01435
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ID T01435
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DT 10.04.1995 (created); ewi.
DT 11.03.2011 (updated); lat.
CO Copyright (C), QIAGEN.
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FA MafK
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SY NF-E2 p18; NF-E2 p18 subunit; NFE2U.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006380 Mafk.
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CL C0008; bZIP; 1.1.3.2.3.
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SF Dimerization is required for binding of basic region-leucine zipper proteins to DNA [12];
SF lacking the putative N-terminal activation domain of v-Maf;
SF binds to TRE-type elements [3];
SF ubiquitous component of NF-E2;
SF within the NF-E2 heterodimer, MafK contacts the larger half of the asymmetric binding site [3];
SF does not bind alone to some NF-E2 sites, but enhances greatly the affinity of NF-E2 p45 [3];
SF no heterodimerization with v-Jun [2];
SF dimeric binding with Bach1 T04793 and Bach2 T04792 to DNA [7];
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EX brain,,,adult; medium; Northern blot; total RNA; [4].
EX heart,,,adult; high; Northern blot; total RNA; [4].
EX kidney (right and left),,,adult; high; Northern blot; total RNA; [4].
EX liver,,,Theiler Stage 20; detectable; Northern blot; total RNA; [4].
EX liver,,,Theiler Stage 22; detectable; Northern blot; total RNA; [4].
EX liver,,,Theiler Stage 24; detectable; Northern blot; total RNA; [4].
EX liver,,,Theiler Stage 27; detectable; Northern blot; total RNA; [4].
EX liver,,,adult; low; Northern blot; total RNA; [4].
EX lung,,,adult; high; Northern blot; total RNA; [4].
EX muscles,,,adult; low; Northern blot; total RNA; [4].
EX spleen,,,adult; low; Northern blot; total RNA; [4].
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FF activator (as NF-E2, the heterodimer with NF-E2 p45);
FF homodimer: transcriptional repressor [4];
FF expression peaks in fetal liver 14d of gestation [4];
FF limiting component of NF-E2 [5];
FF redundant activity, can be compensated by other Maf family members [6];
FF acts synergistically with Bach2 T04792 as repressor of the IgH 3' enhancer [8];
FF MafK-null mutant mice are phenotypically normal [10];
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IN T04793 Bach1; mouse, Mus musculus.
IN T04792 bach2; mouse, Mus musculus.
IN T01436 MafF; chick, Gallus gallus.
IN T01437 MafG; chick, Gallus gallus.
IN T01435 MafK; mouse, Mus musculus.
IN T01441 NF-E2 p45; mouse, Mus musculus.
IN T01440 NF-E2p45; human, Homo sapiens.
IN T01598 Nrf2; chick, Gallus gallus.
IN T04938 Nrf2; mouse, Mus musculus.
IN T00888 v-Fos; FBR MuLV, FBR murine osteosarcoma virus.
IN T01453 v-Fos; NK24, avian retrovirus.
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MX M02776 V$MAFK_03.
MX M02880 V$MAFK_04.
MX M02022 V$MAFK_Q3.
MX M07296 V$MAF_Q4.
MX M00983 V$MAF_Q6_01.
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BS R22556.
BS R11187.
BS R11185.
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DR TRANSPATH: MO000008880.
DR UniProtKB: Q61827;
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RN [1]; RE0002919.
RX PUBMED: 8469283.
RA Andrews N. C., Erdjument-Bromage H., Davidson M. B., Tempst P., Orkin S. H.
RT Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein
RL Nature 362:722-728 (1993).
RN [2]; RE0003519.
RX PUBMED: 7891713.
RA Kataoka K., Igarashi K., Itoh K., Fujiwara K. T., Noda M., Yamamoto M., Nishizawa M.
RT Small Maf protein heterodimerize with Fos and may act as competetive repressor of the NF-E2 transcription factor
RL Mol. Cell. Biol. 15:2180-2190 (1995).
RN [3]; RE0003521.
RX PUBMED: 8265578.
RA Andrews N. C., Kotkow K. J., Ney P. A., Erdjument-Bromage H., Tempst P., Orkin S. H.
RT The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-Maf oncogene
RL Proc. Natl. Acad. Sci. USA 90:11488-11492 (1993).
RN [4]; RE0006603.
RX PUBMED: 7706310.
RA Igarashi K., Itoh K., Motohashi H., Hayashi N., Matuzaki Y., Nakauchi H., Nishizawa M., Yamamoto M.
RT Activity and expression of murine small Maf family protein MafK
RL J. Biol. Chem. 270:7615-7624 (1995).
RN [5]; RE0006605.
RX PUBMED: 7638211.
RA Igarashi K., Itoh K., Hayashi N., Nishizawa M., Yamamoto M.
RT Conditional expression of the ubiquitous transcription factor MafK induces erythroleukemia cell differentation
RL Proc. Natl. Acad. Sci. USA 92:7445-7449 (1995).
RN [6]; RE0006607.
RX PUBMED: 8622968.
RA Kotkow K. J., Orkin S. H.
RT Complexity of the erythroid transcription factor NF-E2 as revealed by gene targeting of the mouse p18 NF-E2 locus
RL Proc. Natl. Acad. Sci. USA 93:3514-3518 (1996).
RN [7]; RE0016914.
RX PUBMED: 8887638.
RA Oyake T., Itoh K., Motohashi H., Hayashi N., Hoshino H., Nishizawa M., Yamamoto M., Igarashi K.
RT Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site
RL Mol. Cell. Biol. 16:6083-6095 (1996).
RN [8]; RE0016920.
RX PUBMED: 9755173.
RA Muto A., Hoshino H., Madisen L., Yanai N., Obinata M., Karasuyama H., Hayashi N., Nakauchi H., Yamamoto M., Groudine M., Igarashi K.
RT Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer
RL EMBO J. 17:5734-5743 (1998).
RN [9]; RE0016931.
RX PUBMED: 11387216.
RA Ogawa K., Sun J., Taketani S., Nakajima O., Nishitani C., Sassa S., Hayashi N., Yamamoto M., Shibahara S., Fujita H., Igarashi K.
RT Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1
RL EMBO J. 20:2835-2843 (2001).
RN [10]; RE0023511.
RX PUBMED: 9679061.
RA Shavit J. A., Motohashi H., Onodera K., Akasaka J., Yamamoto M., Engel J. D.
RT Impaired megakaryopoiesis and behavioral defects in mafG-null mutant mice.
RL Genes Dev. 12:2164-2174 (1998).
RN [11]; RE0031242.
RX PUBMED: 11544260.
RA Ingley E., Chappell D., Poon S. Y., Sarna M. K., Beaumont J. G., Williams J. H., Stillitano J. P., Tsai S., Leedman P. J., Tilbrook P. A., Klinken S. P.
RT Thyroid hormone receptor-interacting protein 1 modulates cytokine and nuclear hormone signaling in erythroid cells.
RL J. Biol. Chem. 276:43428-34 (2001).
RN [12]; RE0050439.
RX PUBMED: 17046816.
RA Ochiai K., Katoh Y., Ikura T., Hoshikawa Y., Noda T., Karasuyama H., Tashiro S., Muto A., Igarashi K.
RT Plasmacytic transcription factor Blimp-1 is repressed by Bach2 in B cells.
RL J. Biol. Chem. 281:38226-38234 (2006).
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