AC T01441
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ID T01441
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DT 10.04.1995 (created); ewi.
DT 21.12.2007 (updated); pch.
CO Copyright (C), QIAGEN.
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FA NF-E2 p45
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SY 45kDa; NF-E2; NFE2; nuclear factor erythroid 2 p45; nuclear factor, erythroid derived 2; p45; p45nf-e2; p45NFE2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014479 Nfe2.
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HO Cnc (D. melanogaster).
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CL C0008; bZIP; 1.1.1.2.1.
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SF bZIP domain is similar to that of AP-1 components;
SF outside bZIP: similar to Cnc (D. melanogaster);
SF no homodimeric DNA-binding, obligate heterodimer with a ubiquitous Maf component (NF-E2 p18), which in most cases corresponds to MafK [1] [2];
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CP spleen, bone marrow [1]; pluripotent hematopoietic stem cells [6] [6] [1].
CN brain, heart, kidney, large intestine, liver, skeletal muscle, testis [1].
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FF binding to the shorter half of an asymmetrical AP-1-like motif [2];
FF erythroid-specific component of NF-E2 [1];
FF the ubiquitous MafK component of NF-E2 appears to be present in limiting amounts [1];
FF p45 effects on erythrocyte-specific regulations seem to be redundant since they can be compensated in p45-null mice [4];
FF however, in megakaryocytes it is absolutely required for cell maturation and platelet formation [5];
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IN T01436 MafF; chick, Gallus gallus.
IN T01437 MafG; chick, Gallus gallus.
IN T01434 MafK; chick, Gallus gallus.
IN T01435 MafK; mouse, Mus musculus.
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MX M07296 V$MAF_Q4.
MX M00983 V$MAF_Q6_01.
MX M00037 V$NFE2_01.
MX M02104 V$NFE2_Q6.
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BS R22710.
BS R20890.
BS R04549.
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DR TRANSPATH: MO000025666.
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RN [1]; RE0002919.
RX PUBMED: 8469283.
RA Andrews N. C., Erdjument-Bromage H., Davidson M. B., Tempst P., Orkin S. H.
RT Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein
RL Nature 362:722-728 (1993).
RN [2]; RE0003521.
RX PUBMED: 8265578.
RA Andrews N. C., Kotkow K. J., Ney P. A., Erdjument-Bromage H., Tempst P., Orkin S. H.
RT The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-Maf oncogene
RL Proc. Natl. Acad. Sci. USA 90:11488-11492 (1993).
RN [3]; RE0004917.
RX PUBMED: 8504248.
RA Crossley M., Orkin S.
RT Regulation of the beta-globin locus
RL Curr. Opin. Gen. Dev. 3:232-237 (1993).
RN [4]; RE0006604.
RX PUBMED: 7567998.
RA Shivdasani R. A., Orkin S. H.
RT Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2
RL Proc. Natl. Acad. Sci. USA 92:8690-8694 (1995).
RN [5]; RE0006608.
RX PUBMED: 7774011.
RA Shivdasani R. A., Rosenblatt M. F., Zucker-Franklin D., Jackson C. W., Hunt P., Saris C. J. M., Orkin S. H.
RT Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development
RL Cell 81:695-704 (1995).
RN [6]; RE0013450.
RX PUBMED: 7538677.
RA Orlic D., Anderson S., Biesecker L. G., Sorrentino B. P., Bodine D. M.
RT Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7.
RL Proc. Natl. Acad. Sci. USA 92:4601-4605 (1995).
RN [7]; RE0049261.
RX PUBMED: 16287851.
RA Shyu Y. C., Lee T. L., Ting C. Y., Wen S. C., Hsieh L. J., Li Y. C., Hwang J. L., Lin C. C., Shen C. K.
RT Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the mammalian beta-like globin gene locus.
RL Mol. Cell. Biol. 25:10365-10378 (2005).
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