AC T04938
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ID T04938
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DT 27.11.2001 (created); mas.
DT 02.04.2015 (updated); asv.
CO Copyright (C), QIAGEN.
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FA Nrf2
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SY NF-E2 related factor 2; NFE2-related factor 2; NFE2L2; NRF-2; NRF2; nuclear factor, erythroid derived 2, like 2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002918 Nfe2l2.
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HO CNC (D. melanogaster).
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CL C0008; bZIP; 1.1.1.2.3.
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SF belongs to the CNC (Cap'n'collar) domain containing subfamily of bZIP transcription factors and has high sequence similarity to subfamily members p45-NFE2, NRF1, and NRF2 [1];
SF forms heterodimer with MafK T05576;
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CP (embryonic:) (in situ:) expressed at E7, E11, E15, E17 [1]; E15.5 (in situ): highest level in digestive tract and also high levels in liver, lung, kidney [1]; expressed in central nervous system (lateral ventricle, choroid plexus), stomach, brown fat tissue [1] (adult:) heart, spleen, lung, liver, skeletal muscle, kidney, testis [1] [1]; hepatic cells treated with D3T [5].
EX alveolar epithelium of left lung,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX alveolar epithelium of right lung,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX brain,,,adult; low; Northern blot; RNA (undefined); [1].
EX bronchi,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX brown fat,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX choroid plexus of fourth ventricle,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX epithelium of olfactory region of nasal cavity,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX heart,,,adult; medium; Northern blot; RNA (undefined); [1].
EX intestine,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX kidney (right and left),,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX kidney (right and left),,,adult; high; Northern blot; RNA (undefined); [1].
EX large intestine,,,Theiler Stage 23; very high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX lateral ventricles (right and left),,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX liver,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX liver,,,adult; high; Northern blot; RNA (undefined); [1].
EX lung,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX lung,,,adult; high; Northern blot; RNA (undefined); [1].
EX mouse, Mus musculus,,,Theiler Stage 10; medium; Northern blot; RNA (undefined); [1].
EX mouse, Mus musculus,,,Theiler Stage 18; low; Northern blot; RNA (undefined); [1].
EX mouse, Mus musculus,,,Theiler Stage 23; medium; Northern blot; RNA (undefined); [1].
EX mouse, Mus musculus,,,Theiler Stage 25; high; Northern blot; RNA (undefined); [1].
EX muscles,,,adult; high; Northern blot; RNA (undefined); [1].
EX oesophagus,,,Theiler Stage 23; very high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX renal tubules,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX small intestine,,,Theiler Stage 23; very high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX spleen,,,adult; medium; Northern blot; RNA (undefined); [1].
EX stomach,,,Theiler Stage 23; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX submandibular gland,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX testis (right and left),,,Theiler Stage 23; very low; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX testis (right and left),,,adult; low; Northern blot; RNA (undefined); [1].
EX thyroid gland,,,Theiler Stage 23; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
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FF Over expression leads to induction of tBHQ mediated c-Jun G000487, c-Fos G000486, p65 G009183 and p50 genes G006465 [8];
FF important for transcriptional induction of antioxidant enzymes and phase II drug metabolizing enzymes through ARE (antioxidant response element/electrophile response element) [3];
FF no detectable effect of targeted disruption of gene function (homozygous knock-out mouse) under standard laboratory conditions: mutant mice were normal in appearance, in anatomy, and in behavior, developed normally, were not anemic, reached adulthood, and could reproduce [1];
FF but in aged female mice knock-out of the gene has physiological effect: they displayed a shortened lifespan and developed severe glomerulonephritis [4];
FF Nrf2 levels increased in response to treatment with various phase 2 enzyme inducers like the anticarcinogen D3T [6];
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IN T08977 ATF-3; mouse, Mus musculus.
IN T14095 ATF-3; Mammalia.
IN T01435 MafK; mouse, Mus musculus.
IN T01331 RXR-alpha; mouse, Mus musculus.
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MX M07296 V$MAF_Q4.
MX M00983 V$MAF_Q6_01.
MX M07220 V$NFE2L2_03.
MX M07610 V$NRF2_Q3.
MX M00821 V$NRF2_Q4.
MX M07265 V$NRF2_Q4_01.
MX M03835 V$NRF2_Q6.
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BS R05653.
BS R25859.
BS R34209.
BS R22554.
BS R33391.
BS R21769.
BS R21770.
BS R66542.
BS R62645.
BS R38696.
BS R66998.
BS R66991.
BS R66994.
BS R32801.
BS R25842.
BS R56230.
BS R71370.
BS R23007.
BS R66056.
BS R66058.
BS R22540.
BS R13440.
BS R29926.
BS R31453.
BS R37665.
BS R66045.
BS R66042.
BS R66044.
BS R27140.
BS R27141.
BS R13588.
BS R22894.
BS R63910.
BS R27130.
BS R27131.
BS R61973.
BS R70184.
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DR TRANSPATH: MO000028713.
DR UniProtKB: Q60795;
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RN [1]; RE0017295.
RX PUBMED: 8943040.
RA Chan K., Lu R., Chang J. C., Kan Y. W.
RT NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development
RL Proc. Natl. Acad. Sci. USA 93:13943-13948 (1996).
RN [2]; RE0017296.
RX PUBMED: 7726861.
RA Chui D. H., Tang W., Orkin S. H.
RT cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related transcription factor
RL Biochem. Biophys. Res. Commun. 209:40-46 (1995).
RN [3]; RE0017305.
RX PUBMED: 11708801.
RA Zhu M., Fahl W. E.
RT Functional characterization of transcription regulators that interact with the electrophile response element
RL Biochem. Biophys. Res. Commun. 289:212-219 (2001).
RN [4]; RE0017306.
RX PUBMED: 11576348.
RA Yoh K., Itoh K., Enomoto A., Hirayama A., Yamaguchi N., Kobayashi M., Morito N., Koyama A., Yamamoto M., Takahashi S.
RT Nrf2-deficient female mice develop lupus-like autoimmune nephritis
RL Kidney Int. 60:1343-1353 (2001).
RN [5]; RE0023128.
RX PUBMED: 11471548.
RA Kwak M. K., Itoh K., Yamamoto M., Sutter T. R., Kensler T. W.
RT Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione.
RL Mol. Med. 7:135-145 (2001).
RN [6]; RE0023138.
RX PUBMED: 11940647.
RA Kwak M. K., Itoh K., Yamamoto M., Kensler T. W.
RT Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter.
RL Mol. Cell. Biol. 22:2883-2892 (2002).
RN [7]; RE0035897.
RX PUBMED: 15292179.
RA Papaiahgari S., Kleeberger S. R., Cho H. Y., Kalvakolanu D. V., Reddy S. P.
RT NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells.
RL J. Biol. Chem. 279:42302-42312 (2004).
RN [8]; RE0051710.
RX PUBMED: 15988009.
RA Yang H., Magilnick N., Lee C., Kalmaz D., Ou X., Chan J. Y., Lu S. C.
RT Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1.
RL Mol. Cell. Biol. 25:5933-5946 (2005).
RN [9]; RE0052100.
RX PUBMED: 18199529.
RA Brown S. L., Sekhar K. R., Rachakonda G., Sasi S., Freeman M. L.
RT Activating transcription factor 3 is a novel repressor of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2)-regulated stress pathway.
RL Cancer Res. 68:364-368 (2008).
RN [10]; RE0052122.
RX PUBMED: 16551619.
RA Salazar M., Rojo A. I., Velasco D., de Sagarra R. M., Cuadrado A.
RT Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2.
RL J. Biol. Chem. 281:14841-14851 (2006).
RN [11]; RE0052235.
RX PUBMED: 16785233.
RA He X., Chen M. G., Lin G. X., Ma Q.
RT Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer.
RL J. Biol. Chem. 281:23620-23631 (2006).
RN [12]; RE0068188.
RX PUBMED: 20173742.
RA Komatsu M., Kurokawa H., Waguri S., Taguchi K., Kobayashi A., Ichimura Y., Sou Y. S., Ueno I., Sakamoto A., Tong K. I., Kim M., Nishito Y., Iemura S., Natsume T., Ueno T., Kominami E., Motohashi H., Tanaka K., Yamamoto M.
RT The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
RL Nat. Cell Biol. 12:213-223 (2010).
RN [13]; RE0070335.
RX PUBMED: 21245377.
RA Rada P., Rojo A. I., Chowdhry S., McMahon M., Hayes J. D., Cuadrado A.
RT SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.
RL Mol. Cell. Biol. 31:1121-1133 (2011).
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