AC T04792
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ID T04792
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DT 19.09.2001 (created); rio.
DT 26.03.2009 (updated); ach.
CO Copyright (C), QIAGEN.
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FA bach2
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SY BTB and CNC homolog 2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002723 Bach2.
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CL C0008; bZIP; 1.1.1.2.6.
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SF 38% amino acid identity to Bach1 T04793 [1];
SF contains a BTB (broad complex-tramtrack-bric-a-brac) domain which is a protein interaction motif [1];
SF binds both as dimer with MafK T01435 and as monomer to DNA [1];
SF bach2 consensus binding site is nearly identical to that of NF-E2 T00557 [1];
SF interacts with the co-repressor SMRT (NCOR2) T04690 [2];
SF physically interacts with MAZR T04796 through the BTB [3];
SF unusual CLS (cytoplasmic localization signal) mediates nuclear transport under oxidative stress conditions [4];
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CP (cell lines:) M1, NIH3T3, C1300, B220+, B31-1, 63-12, 18-81, NFS5.2, 38B9 [1] [2] [3].
CN (cell lines:) Mac-1+ [2].
EX apical ectodermal ridge of forelimb bud,,,Theiler Stage 17; very high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX apical ectodermal ridge of hindlimb bud,,,Theiler Stage 17; very high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX bone marrow,,,adult; very high; Northern blot; total RNA; [2].
EX bone marrow,B-lymphocyte,,adult; very high; RT-PCR; total RNA; [2].
EX bone marrow,basophil granulocyte,,adult; none; RT-PCR; total RNA; [2].
EX bone marrow,eosinophil granulocyte,,adult; none; RT-PCR; total RNA; [2].
EX bone marrow,macrophage,,adult; none; RT-PCR; total RNA; [2].
EX bone marrow,neutrophil granulocyte,,adult; none; RT-PCR; total RNA; [2].
EX bone marrow,red blood cell,,adult; none; RT-PCR; total RNA; [2].
EX brain,,,Theiler Stage 27; medium; Northern blot; mRNA (poly-A); [1].
EX brain,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX brain,,,adult; detectable; Northern blot; total RNA; [2].
EX forelimb bud,,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX heart,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX hindlimb bud,,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [3].
EX kidney (right and left),,,adult; none; Northern blot; mRNA (poly-A); [1].
EX liver,,,Theiler Stage 22; detectable; Northern blot; total RNA; [2].
EX liver,,,Theiler Stage 25; very low; Northern blot; mRNA (poly-A); [1].
EX liver,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX mouse, Mus musculus,,,Theiler Stage 16; detectable; Northern blot; mRNA (poly-A); [1].
EX mouse, Mus musculus,,,Theiler Stage 21; detectable; Northern blot; mRNA (poly-A); [1].
EX mouse, Mus musculus,,,Theiler Stage 25; detectable; Northern blot; mRNA (poly-A); [1].
EX muscles,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX small intestine,,,adult; none; Northern blot; mRNA (poly-A); [1].
EX spleen,,,adult; detectable; Northern blot; mRNA (poly-A); [1].
EX spleen,,,adult; detectable; Northern blot; total RNA; [2].
EX spleen,T-lymphocyte,,adult; none; RT-PCR; total RNA; [2].
EX thymus,,,adult; detectable; Northern blot; total RNA; [2].
EX thymus,T-lymphocyte,,adult; none; RT-PCR; total RNA; [2].
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FF transcriptional repressor as a heterodimer with small Maf proteins [1];
FF may play an important role in coordinating transcriptional activation and/or repression by MafK T01435 [1];
FF acts synergistically with MafK as repressor of the IgH 3' enhancer [2];
FF B-cell specific repressor, probably plays a role during B-cell maturation [2];
FF synergistic transactivation of the fgf4 gene expression by bach2 and MAZR T04796 [3];
FF cooperative role of bach2 and MAZR in limb bud development [3];
FF couples oxidative stress and transcriptional repression [4];
FF critical for class switch recombination and somatic hypermutation [5];
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IN T01435 MafK; mouse, Mus musculus.
IN T04796 MAZR; mouse, Mus musculus.
IN T04690 SMRT; mouse, Mus musculus.
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MX M00490 V$BACH2_01.
MX M07296 V$MAF_Q4.
MX M00983 V$MAF_Q6_01.
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BS R11185.
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DR TRANSPATH: MO000028602.
DR UniProtKB: P97303;
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RN [1]; RE0016914.
RX PUBMED: 8887638.
RA Oyake T., Itoh K., Motohashi H., Hayashi N., Hoshino H., Nishizawa M., Yamamoto M., Igarashi K.
RT Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site
RL Mol. Cell. Biol. 16:6083-6095 (1996).
RN [2]; RE0016920.
RX PUBMED: 9755173.
RA Muto A., Hoshino H., Madisen L., Yanai N., Obinata M., Karasuyama H., Hayashi N., Nakauchi H., Yamamoto M., Groudine M., Igarashi K.
RT Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer
RL EMBO J. 17:5734-5743 (1998).
RN [3]; RE0016921.
RX PUBMED: 10669750.
RA Kobayashi A., Yamagiwa H., Hoshino H., Muto A., Sato K., Morita M., Hayashi N., Yamamoto M., Igarashi K.
RT A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain
RL Mol. Cell. Biol. 20:1733-1746 (2000).
RN [4]; RE0016922.
RX PUBMED: 10809773.
RA Hoshino H., Kobayashi A., Yoshida M., Kudo N., Oyake T., Motohashi H., Hayashi N., Yamamoto M., Igarashi K.
RT Oxidative stress abolishes leptomycin B-sensitive nuclear export of transcription repressor Bach2 that counteracts activation of Maf recognition element
RL J. Biol. Chem. 275:15370-15376 (2000).
RN [5]; RE0024577.
RX PUBMED: 15152264.
RA Muto A., Tashiro S., Nakajima O., Hoshino H., Takahashi S., Sakoda E., Ikebe D., Yamamoto M., Igarashi K.
RT The transcriptional programme of antibody class switching involves the repressor Bach2.
RL Nature 429:566-571 (2004).
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