AC T04690
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ID T04690
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DT 03.09.2001 (created); mas.
DT 08.01.2014 (updated); ili.
CO Copyright (C), QIAGEN.
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FA SMRT
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SY N-COR2; nuclear receptor co-repressor 2; silencing mediator of retinoic acid and thyroid hormone; SMRT; SMRTE; T3 receptor-associating factor; TRAC.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002794 Ncor2.
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CL C0022; trp; 3.5.1.2.2.
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SF contains separate domains for interaction with nuclear receptors and repression function [2];
SF interacts with Bach2 T04792 [3];
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EX cortical plate,,,Theiler Stage 22; very low; RNA-in situ hybridization (not further specified); RNA (undefined); [9].
EX external granular layer of isocortex,,,Theiler Stage 22; low; RNA-in situ hybridization (not further specified); RNA (undefined); [9].
EX external pyramidal layer of isocortex,,,Theiler Stage 22; low; RNA-in situ hybridization (not further specified); RNA (undefined); [9].
EX liver,,,Theiler Stage 22; low; RNA-in situ hybridization (not further specified); RNA (undefined); [9].
EX marginal layer of future cebral cortex,,,Theiler Stage 22; very low; RNA-in situ hybridization (not further specified); RNA (undefined); [9].
EX thalamus,,,Theiler Stage 22; very low; RNA-in situ hybridization (not further specified); RNA (undefined); [9].
EX thymic stroma,,,Theiler Stage 22; high; Western blot; protein; [9].
EX thymic stroma,,,Theiler Stage 23; high; Western blot; protein; [9].
EX thymus,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [9].
EX thymus,,,Theiler Stage 22; high; Western blot; protein; [9].
EX thymus,,,Theiler Stage 23; high; Western blot; protein; [9].
EX thymus,thymocyte,,Theiler Stage 22; low; Western blot; protein; [9].
EX thymus,thymocyte,,Theiler Stage 23; low; Western blot; protein; [9].
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FF involved in mediation of transcriptional repression by (unliganded) nuclear receptors (direct binding to nuclear receptors) [1];
FF recruitment of histone deacetylase complexes important for transcriptional repression [1];
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IN T04792 bach2; mouse, Mus musculus.
IN T22468 BCL11A-isoform1; human, Homo sapiens.
IN T05347 PPARgamma; mouse, Mus musculus.
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DR TRANSPATH: MO000028511.
DR UniProtKB: Q9WU42;
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RN [1]; RE0005939.
RX PUBMED: 9150137.
RA Nagy L., Kao H.-Y., Chakravarti D., Lin R. J., Hassig C. A., Ayer D. E., Schreiber S. L., Evans R. M.
RT Nuclear receptor repression mediated by a complex containing SMRT, mSin3a, and histone deacetylase
RL Cell 89:373-380 (1997).
RN [2]; RE0016802.
RX PUBMED: 10617570.
RA Nagy L., Kao H. Y., Love J. D., Li C., Banayo E., Gooch J. T., Krishna V., Chatterjee K., Evans R. M., Schwabe J. W.
RT Mechanism of corepressor binding and release from nuclear hormone receptors
RL Genes Dev. 13:3209-3216 (1999).
RN [3]; RE0016920.
RX PUBMED: 9755173.
RA Muto A., Hoshino H., Madisen L., Yanai N., Obinata M., Karasuyama H., Hayashi N., Nakauchi H., Yamamoto M., Groudine M., Igarashi K.
RT Identification of Bach2 as a B-cell-specific partner for small maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer
RL EMBO J. 17:5734-5743 (1998).
RN [4]; RE0038030.
RX PUBMED: 11509652.
RA Guenther M. G., Barak O., Lazar M. A.
RT The SMRT and N-CoR corepressors are activating cofactors for histone deacetylase 3
RL Mol. Cell. Biol. 21:6091-101 (2001).
RN [5]; RE0048488.
RX PUBMED: 15691842.
RA Yu C., Markan K., Temple K. A., Deplewski D., Brady M. J., Cohen R. N.
RT The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis.
RL J. Biol. Chem. 280:13600-13605 (2005).
RN [6]; RE0054318.
RX PUBMED: 17928865.
RA Jepsen K., Solum D., Zhou T., McEvilly R. J., Kim H. J., Glass C. K., Hermanson O., Rosenfeld M. G.
RT SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron.
RL Nature 450:415-419 (2007).
RN [7]; RE0064487.
RX PUBMED: 17371839.
RA Lim S., Luo M., Koh M., Yang M., bin Abdul Kadir M. N., Tan J. H., Ye Z., Wang W., Melamed P.
RT Distinct mechanisms involving diverse histone deacetylases repress expression of the two gonadotropin beta-subunit genes in immature gonadotropes, and their actions are overcome by gonadotropin-releasing hormone.
RL Mol. Cell. Biol. 27:4105-4120 (2007).
RN [8]; RE0071716.
RX PUBMED: 22028470.
RA Carlson S. M., Chouinard C. R., Labadorf A., Lam C. J., Schmelzle K., Fraenkel E., White F. M.
RT Large-scale discovery of ERK2 substrates identifies ERK-mediated transcriptional regulation by ETV3.
RL Sci. Signal. 4:rs11 (2011).
RN [9]; RE0016806.
RX PUBMED: 11030619.
RA Jepsen K., Hermanson O., Onami T. M., Gleiberman A. S., Lunyak V., McEvilly R. J., Kurokawa R., Kumar V., Liu F., Seto E., Hedrick S. M., Mandel G., Glass C. K., Rose D. W., Rosenfeld M. G.
RT Combinatorial roles of the nuclear receptor corepressor in transcription and development
RL Cell 102:753-763 (2000).
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