AC T01430
XX
ID T01430
XX
DT 10.04.1995 (created); ewi.
DT 23.11.2004 (updated); vma.
CO Copyright (C), QIAGEN.
XX
FA v-Maf
XX
OS AS42, avian musculoaponeurotic fibrosarcoma virus
OC viridae; ss-RNA enveloped viruses; positive strand RNA viruses; retroviridae; oncovirinae; type C oncovirus group; avian type C oncoviruses
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CL C0008; bZIP.
XX
SZ 369 AA; 38.9 kDa (gene) (calc.).
XX
SQ MASELAMSGSDLPTSPLAMEYVNDFDLMKFEVKKEPVETDRIISQCGRLIAGGSLSSTPM
SQ STPCSSVPPSPSFSAPSPGSGTDQKTHLEDYYWMTGYPQQLNPEALGFSPEDAVEALINS
SQ SHHPLPGAFDGYARGQQLAAAAGGSVPAEEMGSAAAVVSAVIAAAAAQGGAPHYHHHHHH
SQ PHHGGGGGGGGHPHGAAPGSAPPSSASSSAAGSGGGGGGGGGGAGGLHHPHHGGGGGGGG
SQ LHFDDRFSDEQLVTMSMRELNRQLRGVSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRH
SQ VLESEKNQLLQQVEHLKQEISRLVRERDAYKEKYEKLVSNGFRENGSSSDNPSSPEFFMY
SQ PRESSTTVM
XX
SC Swiss-Prot#P23091
XX
FT 1 348 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 245 339 
PF03131; bZIP Maf transcription factor.
FT 270 336 
SM00338; brlzneu.
FT 274 337 
PS50217; BZIP.
XX
SF size of the gag-maf fusion protein: 864 AA, 95 kDa (gene), 100 kDa (SDS), with some variation among different clones [4];
SF binds to TRE-type and CRE-type elements (MAREs, Maf recognition elements) with equal affinity [1];
SF DNA-binding specificity is similar to but differs from that of AP-1 in recognizing also the motif tTactAa [1] [7];
SF also slightly varying specificities of v-Maf dimers with different AP-1 family members [3];
SF N-terminal trans-activation domain is missing in several related proteins (MafK, MafF, MafG) [2] [7];
SF transforming activity strongly depends on the C-terminal approx. 100 AA, which is potentiated by the N-terminal two-third [6];
XX
FF transcriptional activator [7];
FF transforming activity [6];
XX
IN T00122 c-Fos; mouse, Mus musculus.
IN T01082 NRL; human, Homo sapiens.
IN T01438 NRL; mouse, Mus musculus.
IN T00888 v-Fos; FBR MuLV, FBR murine osteosarcoma virus.
IN T00893 v-Jun; ASV 17, avian sarcoma virus 17.
IN T01430 v-Maf; AS42, avian musculoaponeurotic fibrosarcoma virus.
XX
MX M00983 V$MAF_Q6_01.
MX M00035 V$VMAF_01.
XX
BS R04114.
BS R04116.
BS R04904.
XX
DR TRANSPATH: MO000013710.
DR EMBL: M26769;
DR UniProtKB: P23091;
XX
RN [1]; RE0002917.
RX PUBMED: 8264639.
RA Kataoka K., Noda M., Nishizawa M.
RT Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun
RL Mol. Cell. Biol. 14:700-712 (1994).
RN [2]; RE0003520.
RX PUBMED: 8361754.
RA Fujiwara K. T., Kataoka K., Nishizawa M.
RT Two new members of the maf oncogene family, mafK and mafF, encode nuclear b-Zip proteins lacking putative trans-activator domain
RL Oncogene 8:2371-2380 (1993).
RN [3]; RE0004866.
RX PUBMED: 8108109.
RA Kerppola T. K., Curran T.
RT Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun
RL Oncogene 9:675-684 (1994).
RN [4]; RE0004902.
RX PUBMED: 1585647.
RA Kawai S., Goto N., Kataoka K., Saegusa T., Shinno-Kohno H., Nishizawa M.
RT Isolation of the avian transforming retrovirus, AS42, carrying the v-maf oncogene and initial characterization of its gene product
RL Virology 188:778-784 (1992).
RN [5]; RE0004903.
RX PUBMED: 2554284.
RA Nishizawa M., Kataoka K., Goto N., Fujiwara K. T., Kawai S.
RT v-maf, a viral oncogene that encodes a leucine zipper motif
RL Proc. Natl. Acad. Sci. USA 86:7711-7715 (1989).
RN [6]; RE0004904.
RX PUBMED: 8383235.
RA Kataoka K., Nishizawa M., Kawai S.
RT Structure-function analysis of the maf oncogene product, a member of the b-Zip protein family
RL J. Virol. 67:2133-2141 (1993).
RN [7]; RE0004906.
RX PUBMED: 7935473.
RA Kataoka K., Fujiwara K. T., Noda M., Nishizawa M.
RT MafB, a new Maf family transcription activator that can associate with Maf and Fos but not with Jun
RL Mol. Cell. Biol. 14:7581-7591 (1994).
XX
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