TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01430 XX ID T01430 XX DT 10.04.1995 (created); ewi. DT 23.11.2004 (updated); vma. CO Copyright (C), QIAGEN. XX FA v-Maf XX OS AS42, avian musculoaponeurotic fibrosarcoma virus OC viridae; ss-RNA enveloped viruses; positive strand RNA viruses; retroviridae; oncovirinae; type C oncovirus group; avian type C oncoviruses XX CL C0008; bZIP. XX SZ 369 AA; 38.9 kDa (gene) (calc.). XX SQ MASELAMSGSDLPTSPLAMEYVNDFDLMKFEVKKEPVETDRIISQCGRLIAGGSLSSTPM SQ STPCSSVPPSPSFSAPSPGSGTDQKTHLEDYYWMTGYPQQLNPEALGFSPEDAVEALINS SQ SHHPLPGAFDGYARGQQLAAAAGGSVPAEEMGSAAAVVSAVIAAAAAQGGAPHYHHHHHH SQ PHHGGGGGGGGHPHGAAPGSAPPSSASSSAAGSGGGGGGGGGGAGGLHHPHHGGGGGGGG SQ LHFDDRFSDEQLVTMSMRELNRQLRGVSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRH SQ VLESEKNQLLQQVEHLKQEISRLVRERDAYKEKYEKLVSNGFRENGSSSDNPSSPEFFMY SQ PRESSTTVM XX SC Swiss-Prot#P23091 XX FT 1 348 PF00478; IMP dehydrogenase / GMP reductase domain. FT 245 339 PF03131; bZIP Maf transcription factor. FT 270 336 SM00338; brlzneu. FT 274 337 PS50217; BZIP. XX SF size of the gag-maf fusion protein: 864 AA, 95 kDa (gene), 100 kDa (SDS), with some variation among different clones [4]; SF binds to TRE-type and CRE-type elements (MAREs, Maf recognition elements) with equal affinity [1]; SF DNA-binding specificity is similar to but differs from that of AP-1 in recognizing also the motif tTactAa [1] [7]; SF also slightly varying specificities of v-Maf dimers with different AP-1 family members [3]; SF N-terminal trans-activation domain is missing in several related proteins (MafK, MafF, MafG) [2] [7]; SF transforming activity strongly depends on the C-terminal approx. 100 AA, which is potentiated by the N-terminal two-third [6]; XX FF transcriptional activator [7]; FF transforming activity [6]; XX IN T00122 c-Fos; mouse, Mus musculus. IN T01082 NRL; human, Homo sapiens. IN T01438 NRL; mouse, Mus musculus. IN T00888 v-Fos; FBR MuLV, FBR murine osteosarcoma virus. IN T00893 v-Jun; ASV 17, avian sarcoma virus 17. IN T01430 v-Maf; AS42, avian musculoaponeurotic fibrosarcoma virus. XX MX M00983 V$MAF_Q6_01. MX M00035 V$VMAF_01. XX BS R04114. BS R04116. BS R04904. XX DR TRANSPATH: MO000013710. DR EMBL: M26769; DR UniProtKB: P23091; XX RN [1]; RE0002917. RX PUBMED: 8264639. RA Kataoka K., Noda M., Nishizawa M. RT Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun RL Mol. Cell. Biol. 14:700-712 (1994). RN [2]; RE0003520. RX PUBMED: 8361754. RA Fujiwara K. T., Kataoka K., Nishizawa M. RT Two new members of the maf oncogene family, mafK and mafF, encode nuclear b-Zip proteins lacking putative trans-activator domain RL Oncogene 8:2371-2380 (1993). RN [3]; RE0004866. RX PUBMED: 8108109. RA Kerppola T. K., Curran T. RT Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun RL Oncogene 9:675-684 (1994). RN [4]; RE0004902. RX PUBMED: 1585647. RA Kawai S., Goto N., Kataoka K., Saegusa T., Shinno-Kohno H., Nishizawa M. RT Isolation of the avian transforming retrovirus, AS42, carrying the v-maf oncogene and initial characterization of its gene product RL Virology 188:778-784 (1992). RN [5]; RE0004903. RX PUBMED: 2554284. RA Nishizawa M., Kataoka K., Goto N., Fujiwara K. T., Kawai S. RT v-maf, a viral oncogene that encodes a leucine zipper motif RL Proc. Natl. Acad. Sci. USA 86:7711-7715 (1989). RN [6]; RE0004904. RX PUBMED: 8383235. RA Kataoka K., Nishizawa M., Kawai S. RT Structure-function analysis of the maf oncogene product, a member of the b-Zip protein family RL J. Virol. 67:2133-2141 (1993). RN [7]; RE0004906. RX PUBMED: 7935473. RA Kataoka K., Fujiwara K. T., Noda M., Nishizawa M. RT MafB, a new Maf family transcription activator that can associate with Maf and Fos but not with Jun RL Mol. Cell. Biol. 14:7581-7591 (1994). XX //