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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T00122 XX ID T00122 XX DT 15.10.1992 (created); ewi. DT 05.02.2015 (updated); pro. CO Copyright (C), QIAGEN. XX FA c-Fos XX SY c-Fos; FBJ osteosarcoma oncogene; p55(c-fos). XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G000486 Fos. XX CL C0008; bZIP; 1.1.2.1.1. XX SF the apparent molecular weight may increase from 55 kDa to 62 kDa or more due to extensive phosphorylation [5] [26] [31] [32] [33]; SF heterodimerization through the leucine zipper motif; SF either leucine of the zipper may be exchanged, but substituting 2 or more abolishes its dimerization capability [11]; SF the leucine zipper causes dimerization specificity among bZIP class members, probably by establishing an optimal pattern of electrostatic and hydrophobic contacts [17] [13]; SF in the heterodimer, c-Fos also contacts the DNA via its basic region [8] [34]; SF c-Fos/c-Jun heterodimers bend the DNA in the opposite direction than c-Jun homodimers do [20]; SF the heterodimer with CRE-BP1/ATF-2 induces a strong bending towards the minor groove [20]; XX CP Mouse fibroblasts [67]; RAW264.7, RAW264.7 + IFNgamma, RAW264.7 + LPS [68]. XX FF activator (in heterodimer with c-Jun); FF mostly required during G0/G1 transition [58]; FF transforming activity depends on its C-terminal trans-activation domain [36]; FF (in contrast to other report) transforming activity assigned to the N-TA which is conserved among Fos proteins and has some homologous sequences in Jun proteins [61]; FF may be a prerequisite of myeloid differentiation [25]; FF precedes programmed cell death [40] [41]; FF null mutant mice can survive, but show some abnormalities in, e. g., bone development (osteopetrosis), lymphoid cells and gametogenesis [45]; FF numerous regulatory elements in the 5' upstream region confer responses to enhanced cAMP levels [47]; FF gene expression responsive to serum growth factors [48] [50] [51] [53]; FF inducible by GM-CSF [62]; FF c-Fos represses its own transcription by a mechanism that depends on its leucine zipper, but not on its DNA-binding capability [29] [46]; FF MyoD also inhibits c-fos expression by binding adjacent to a SRE and overlapping with an AP-1 site; FF a transcription elongation block in the 1st intron is modulated in a calcium-dependent manner [55]; FF the c-fos mRNA contains several degradation signals [56] [57]; FF nuclear translocation of c-Fos is inhibited by a labile protein which is inactivated in response to cAMP [42]; FF c-Fos activity is regulated by a redox mechanism involving Ref-1 [22]; FF Thr-232 is in a sequence environment that is homologous to Ser-73 of c-Jun and, consequently, is also phosphorylated by a MAP kinase in response to Ha-Ras leading to an increase in its trans-activation capability [37] [38]; FF phosphorylation at serine residues 362-364 is required for repression of c-fos expression, but does not affect trans-activation by c-Fos [39]; XX IN T00167 ATF-2-isoform1; human, Homo sapiens. IN T02056 ATF-2-isoform1; mouse, Mus musculus. IN T10136 ATF-2; human, Homo sapiens. IN T01303 ATF-4; human, Homo sapiens. IN T00051 ATF; human, Homo sapiens. IN T00131 c-Jun; mouse, Mus musculus. IN T00132 c-Jun; rat, Rattus norvegicus. IN T00133 c-Jun; human, Homo sapiens. IN T00134 c-Jun; chick, Gallus gallus. IN T00135 c-Jun; hamster, Cricetulus sp. IN T00017 C/EBPbeta-FL; mouse, Mus musculus. IN T01318 CBP; mouse, Mus musculus. IN T00967 E1A 12S protein; adenovirus. IN T00209 E1A 13S protein; adenovirus type 2. IN T00436 JunB; mouse, Mus musculus. IN T00437 JunD; mouse, Mus musculus. IN T01438 NRL; mouse, Mus musculus. IN T32110 SIRT1; mouse, Mus musculus. IN T01430 v-Maf; AS42, avian musculoaponeurotic fibrosarcoma virus. IN T00902 XBP-1; human, Homo sapiens. XX MX M00172 V$AP1FJ_Q2. MX M00517 V$AP1_01. MX M00924 V$AP1_Q2_01. MX M00926 V$AP1_Q4_01. MX M00925 V$AP1_Q6_01. MX M07600 V$CFOS_Q4. MX M03815 V$CFOS_Q6. XX BS R03540. BS R23034. BS R24899. BS R23218. BS R25247. BS R25249. BS R09882. BS R24701. BS R01037. BS R22860. BS R01559. BS R73852. BS R71632. BS R37825. BS R30131. BS R66081. BS R14477. BS R24867. BS R28410. BS R41852. BS R41854. BS R41855. BS R41858. BS R04079. BS R01062. BS R57736. BS R30107. BS R40185. BS R60089. BS R08510. BS R24785. BS R24797. BS R19643. BS R19645. BS R26628. BS R21509. BS R56972. BS R23479. BS R14663. BS R56648. BS R16979. BS R33767. BS R29889. XX DR TRANSPATH: MO000024721. DR UniProtKB: P01101; XX RN [1]; RE0000046. RX PUBMED: 3555845. RA Distel R. J., Ro H.-S., Rosen B. S., Groves D. L., Spiegelman B. M. RT Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos RL Cell 49:835-844 (1987). RN [2]; RE0000047. RX PUBMED: 3125983. RA Rauscher III F. J., Sambucetti L. C., Curran T., Distel R. J., Spiegelman B. M. RT Common DNA Binding Site for FOS Protein Complexes and Transcription Factor AP-1 RL Cell 52:471-480 (1988). RN [3]; RE0000096. RX PUBMED: 3006925. RA Ohlsson H., Edlund T. RT Sequence-Specific Interactions of Nuclear Factors with the Insulin Gene Enhancer RL Cell 45:35-44 (1986). RN [4]; RE0000106. RX PUBMED: 3135941. RA Sassone-Corsi P., Lamph W. W., Kamps M., Verma I. M. RT fos-associated cellular p39 is related to nuclear transcription factor AP-1 RL Cell 54:553-560 (1988). RN [5]; RE0000136. RX PUBMED: 6319013. RA Curran T., Miller A. D., Zokas L., Verma I. M. RT Viral and cellular fos proteins: a comparative analysis RL Cell 36:259-268 (1984). RN [6]; RE0000158. RX PUBMED: 1900458. RA Auwerx J., Sassone-Corsi P. RT IP-1: A dominant inhibitor of Fos/Jun whose activity is modulated by phosphorylation RL Cell 64:983-993 (1991). RN [7]; RE0000166. RX PUBMED: 2124518. RA Gaub M. P., Bellard M., Scheuer I., Chambon P., Sassone-Corsi P. RT Activation of the ovalbumin gene by the estrogen receptor involves the Fos-Jun complex RL Cell 63:1267-1276 (1990). RN [8]; RE0000243. RX PUBMED: 2492453. RA Schuermann M., Neuberg M., Hunter J. B., Jenuwein T., Ryseck R.-P., Bravo R., Mueller R. RT The leucine repeat motif in Fos protein mediates complex formation with Jun/AP-1 and is required for transformation RL Cell 56:507-516 (1989). RN [9]; RE0000442. RX PUBMED: 2511004. RA Nakabeppu Y., Nathans D. RT The basic region of Fos mediates specific DNA binding RL EMBO J. 8:3833-3841 (1989). RN [10]; RE0000521. RX PUBMED: 1714380. RA de Groot R. P., Karperien M., Pals C., Kruijer W. RT Characterization of the mouse junD promoter - high basal level activity due to an octamer motif RL EMBO J. 10:2523-2532 (1991). RN [11]; RE0000636. RX PUBMED: 2501150. RA Ransone L. J., Visvader J., Sassone-Corsi P., Verma I. M. RT Fos-Jun interaction: mutational analysis of the leucine zipper domain of both proteins RL Genes Dev. 3:770-781 (1989). RN [12]; RE0001460. RX PUBMED: 2501665. RA Wasylyk C., Wasylyk B., Heidecker G., Huleihel M., Rapp U. R. RT Expression of raf oncogenes activates the PEA1 transcription factor motif RL Mol. Cell. Biol. 9:2247-2250 (1989). RN [13]; RE0001773. RX PUBMED: 2506451. RA Neuberg M., Adamkiewicz J., Hunter J. B., Mueller R. RT A Fos protein containing the leucine zipper forms a homodimer which binds to the AP1 binding site RL Nature 341:243-245 (1989). RN [14]; RE0001940. RX PUBMED: 2518690. RA Angel P., Smeal T., Meek J., Karin M. RT jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner RL New Biol. 1:35-43 (1989). RN [15]; RE0001941. RX PUBMED: 1963081. RA Yang-Yen H.-F., Chiu R., Karin M. RT Elevation of AP-1 activity during F9 cell differentiation is due to increased c-Jun transcription RL New Biol. 2:351-361 (1990). RN [16]; RE0002171. RX PUBMED: 1651478. RA Haertig E., Loncarevic I. F., Buescher M., Herrlich P., Rahmsdorf H. J. RT A new cAMP response element in the transcribed region of the human c-fos gene RL Nucleic Acids Res. 19:4153-4159 (1991). RN [17]; RE0002182. RX PUBMED: 1901988. RA Schuermann M., Hunter J. B., Henning G., Mueller R. RT Non-leucine residues in the leucine repeats of Fos and Jun contribute to the stability and determine the specificity of dimerization RL Nucleic Acids Res. 19:739-746 (1991). RN [18]; RE0002408. RX PUBMED: 2453058. RA Piette J., Hirai S.-I., Yaniv M. RT Constitutive synthesis of activator protein 1 transcription factor after viral transformation of mouse fibroblasts RL Proc. Natl. Acad. Sci. USA 85:3401-3405 (1988). RN [19]; RE0002917. RX PUBMED: 8264639. RA Kataoka K., Noda M., Nishizawa M. RT Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun RL Mol. Cell. Biol. 14:700-712 (1994). RN [20]; RE0004643. RX PUBMED: 8355695. RA Kerppola T. K., Curran T. RT Selective DNA bending by a variety of bZIP proteins RL Mol. Cell. Biol. 13:5479-5489 (1993). RN [21]; RE0004659. RX PUBMED: 1904542. RA Abate C., Luk D., Curran T. RT Transcriptional regulation by Fos and Jun in vitro: Interaction among multiple activator and regulator domains RL Mol. Cell. Biol. 11:3624-3632 (1991). RN [22]; RE0004682. RX PUBMED: 1537340. RA Xanthoudakis S., Curran T. RT Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity RL EMBO J. 11:653-665 (1992). RN [23]; RE0004713. RX PUBMED: 8341696. RA Abate C., Baker S. J., Lees-Miller S. P., Anderson C. W., Marshak D. R., Curran T. RT Dimerization and DNA binding alter phosphorylation of Fos and Jun RL Proc. Natl. Acad. Sci. USA 90:6766-6770 (1993). RN [24]; RE0004730. RX PUBMED: 8264594. RA Hsu W., Kerppola T. K., Chen P.-L., Curran T., Chen-Kiang S. RT Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region RL Mol. Cell. Biol. 14:268-276 (1994). RN [25]; RE0004739. RX PUBMED: 8423806. RA Lord K. A., Abdollahi A., Hoffman-Liebermann B., Liebermann D. A. RT Proto-oncogenes of the fos/jun family of transcription factors are positive regulators of myeloid differentiation RL Mol. Cell. Biol. 13:841-851 (1993). RN [26]; RE0004798. RX PUBMED: 6283132. RA Curran T., Teich N. M. RT Candidate product of the FBJ murine osteosarcoma virus oncogene: characterization of a 55,000-Dalton phosphoprotein RL J. Virol. 42:114-122 (1982). RN [27]; RE0004799. RX PUBMED: 6292525. RA Curran T., Peters G., van Beveren C., Teich N. M., Verma I. M. RT FBJ murine osteosarcoma virus: identification and molecular cloning of biologically active proviral DNA RL J. Virol. 44:674-682 (1982). RN [28]; RE0004800. RX PUBMED: 6203214. RA Curran T., Verma I. M. RT FBR murine osteosarcoma virus RL Virology 135:218-228 (1984). RN [29]; RE0004803. RX PUBMED: 2513130. RA Lucibello F. C., Lowag C., Neuberg M., Mueller R. RT Trans-repression of the mouse c-fos promoter: A novel mechanism of fos-mediated trans-regulation RL Cell 59:999-1007 (1989). RN [30]; RE0004807. RX PUBMED: 3491427. RA Sambucetti L. C., Curran T. RT The Fos protein complex is associated with DNA in isolated nuclei and binds to DNA cellulose RL Science 234:1417-1419 (1986). RN [31]; RE0004808. RX PUBMED: 6514007. RA Kruijer W., Cooper J. A., Hunter T., Verma I. M. RT Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein RL Nature 312:711-716 (1984). RN [32]; RE0004809. RX PUBMED: 6334806. RA Mueller R., Bravo R., Burckhardt J., Curran T. RT Induction of c-fos gene and protein by growth factors precedes activation of c-myc RL Nature 312:716-720 (1984). RN [33]; RE0004810. RX PUBMED: 4035354. RA Curran T., Morgan J. I. RT Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines RL Science 229:1265-1268 (1985). RN [34]; RE0004811. RX PUBMED: 2494459. RA Neuberg M., Schuermann M., Hunter J. B., Mueller R. RT Two functionally different regions in Fos are required for the equence-specific DNA-interaction of the Fos/Jun protein complex RL Nature 338:589-590 (1989). RN [35]; RE0004812. RX PUBMED: 2108402. RA Hirai S.-I., Bourachot D., Yaniv M. RT Both Jun and Fos contribute to transcription activation by the heterodimer RL Oncogene 5:39-46 (1990). RN [36]; RE0004817. RX PUBMED: 7504176. RA Wisdom R., Verma I. M. RT Transformation by Fos proteins requires a C-terminal transactivation domain RL Mol. Cell. Biol. 13:7429-7438 (1993). RN [37]; RE0004821. RX PUBMED: 7816602. RA Bannister A. J., Brown H. J., Sutherland J. A., Kouzarides T. RT Phosphorylation of the c-Fos and c-Jun HOB1 motif stimulates its activation capacity RL Nucleic Acids Res. 22:5173-5176 (1994). RN [38]; RE0004822. RX PUBMED: 8072547. RA Deng T., Karin M. RT c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK RL Nature 371:171-175 (1994). RN [39]; RE0004825. RX PUBMED: 2122257. RA Ofir R., Dwarki V. J., Rashid D., Verma I. M. RT Phosphorylation of the C terminus of Fos protein is required for transcriptional transrepression of the c-fos promoter RL Nature 348:80-82 (1990). RN [40]; RE0004827. RX PUBMED: 1526968. RA Colotta F., Polentarutti N., Sironi M., Mantovani A. RT Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines RL J. Biol. Chem. 267:18278-18283 (1992). RN [41]; RE0004828. RX PUBMED: 8483500. RA Smeyne R. J., Vendrell M., Hayward M., Baker S. J., Miao G. G., Schilling K., Robertson L. M., Curran T., Morgan J. I. RT Continuous c-fos expression precedes programmed cell death in vivo RL Nature 363:166-169 (1993). RN [42]; RE0004830. RX PUBMED: 2119889. RA Roux P., Blanchard J.-M., Fernandez A., Lamb N., Jeanteur P., Piechaczyk M. RT Nuclear localization of c-Fos, but not v-Fos proteins, is controlled by extracellular signals RL Cell 63:341-351 (1990). RN [43]; RE0004831. RX PUBMED: 2840203. RA Schoenthal A., Herrlich P., Rahmsdorf H. J., Ponta H. RT Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters RL Cell 54:325-334 (1988). RN [44]; RE0004832. RX PUBMED: 3135940. RA Chiu R., Boyle W. J., Meek J., Smeal T., Hunter T., Karin M. RT The c-fos protein interacts with c-jun/AP-1 to stimulate transcription of AP-1 responsive genes RL Cell 54:541-552 (1988). RN [45]; RE0004835. RX PUBMED: 1423615. RA Johnson R. S., Spiegelman B. M., Papaioannou V. RT Pleiotropic effects of a null mutation in the c-fos proto-oncogene RL Cell 71:577-586 (1992). RN [46]; RE0004838. RX PUBMED: 2511006. RA Koenig H., Ponta H., Rahmsdorf U., Buescher M., Schoenthal A., Rahmsdorf H. J., Herrlich P. RT Autoregulation of fos: the dyad symmetry element as the major target of repression RL EMBO J. 8:2559-2566 (1989). RN [47]; RE0004839. RX PUBMED: 2555687. RA Berkowitz L. A., Riabowol K. T., Gilman M. Z. RT Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter RL Mol. Cell. Biol. 9:4272-4281 (1989). RN [48]; RE0004841. RX PUBMED: 2474755. RA Fujii M., Shalloway D., Verma I. M. RT Gene regulation by tyrosine kinases: src protein activates various promoters, including c-fos RL Mol. Cell. Biol. 9:2493-2499 (1989). RN [49]; RE0004847. RX PUBMED: 1647033. RA Foulkes N. S., Laoide B. M., Schlotter F., Sassone-Corsi P. RT Transcriptional antagonist cAMP-responsive element modulator (CREM) down-regulates c-fos cAMP-induced expression RL Proc. Natl. Acad. Sci. USA 88:5448-5452 (1991). RN [50]; RE0004851. RX PUBMED: 1922053. RA Gutman A., Wasylyk C., Wasylyk B. RT Cell-specific regulation of oncogene-responsive sequences of the c-fos promoter RL Mol. Cell. Biol. 11:5381-5387 (1991). RN [51]; RE0004852. RX PUBMED: 1906603. RA Lucibello F. C., Ehlert F., Mueller R. RT Multiple interdependent regulatory sites in the mouse c-fos promoter determine basal level transcription: cell type-specific effects RL Nucleic Acids Res. 19:3583-3591 (1991). RN [52]; RE0004854. RX PUBMED: 8464709. RA Rao G. N., LassJgue B., Griendling K. K., Alexander R. W., Berk B. C. RT Hydrogen peroxide-induced c-fos expression is mediated by arachidonic acid release: role of protein kinase C RL Nucleic Acids Res. 21:1259-1263 (1993). RN [53]; RE0004858. RX PUBMED: 8065316. RA Shibuya H., Kohu K., Yamada K., Barsoumian E. L., Perlmutter R. M., Taniguchi T. RT Functional dissection of p56lck, a protein tyrosine kinase which mediates interleukin-2-induced activation of the c-fos gene RL Mol. Cell. Biol. 14:5812-5819 (1994). RN [54]; RE0004859. RX PUBMED: 1901950. RA Mechti N., Piechaczyk M., Blanchard J.-M., Jeanteur P., Lebleu B. RT Sequence requirements for premature transcription arrest within the first intron of the mouse c-fos gene RL Mol. Cell. Biol. 11:2832-2841 (1991). RN [55]; RE0004860. RX PUBMED: 1901949. RA Collart M. A., Tourkine N., Belin D., Vassalli P., Jeanteur P., Blanchard J.-M. RT c-fos gene transcription in murine macrophages is modulated by a calcium-dependent block to elongation in intron 1 RL Mol. Cell. Biol. 11:2826-231 (1991). RN [56]; RE0004861. RX PUBMED: 1454537. RA Roy N., Laflamme G., Raymond V. RT 5' untranslated sequences modulate rapid mRNA degradation mediated by 3' AU-rich element in v-/c-fos recombinants RL Nucleic Acids Res. 20:5753-5762 (1992). RN [57]; RE0004862. RX PUBMED: 8336733. RA Wellington C. L., Greenberg M. E., Belasco J. G. RT The destabilizing elements in the coding region of c-fos mRNA are recognized as RNA RL Mol. Cell. Biol. 13:5034-5042 (1993). RN [58]; RE0004865. RX PUBMED: 1406676. RA Kovary K., Bravo R. RT Existence of different Fos/Jun complexes during the G0-to-G1 transition and during exponential growth in mouse fibroblasts: differential role of Fos proteins RL Mol. Cell. Biol. 12:5015-5023 (1992). RN [59]; RE0004871. RX PUBMED: 7680434. RA Sadowski H. B., Gilman M. Z. RT Cell-free activation of a DNA-binding protein by epidermal growth factor RL Nature 362:79-83 (1993). RN [60]; RE0004872. RX PUBMED: 7630732. RA Kim J., Struhl K. RT Determinants of half-site spacing preferences that distinguish AP-1 and ATF/CREB bZIP domains RL Nucleic Acids Res. 23:2531-2537 (1995). RN [61]; RE0004887. RX PUBMED: 8137828. RA Jooss K. U., Funk M., Mueller R. RT An autonomous N-terminal transactivation domain in Fos protein plays a crucial role in transformation RL EMBO J. 13:1467-1475 (1994). RN [62]; RE0025195. RX PUBMED: 8874187. RA Rajotte D., Sadowski H. B., Haman A., Gopalbhai K., Meloche S., Liu L., Krystal G., Hoang T. RT Contribution of both STAT and SRF/TCF to c-fos promoter activation by granulocyte-macrophage colony-stimulating factor. RL Blood 88:2906-2916 (1996). RN [63]; RE0036098. RX PUBMED: 11756554. RA Young M. R., Nair R., Bucheimer N., Tulsian P., Brown N., Chapp C., Hsu T. C., Colburn N. H. RT Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently. RL Mol. Cell. Biol. 22:587-598 (2002). RN [64]; RE0047119. RX PUBMED: 15596805. RA Wang X., Sonenshein G. E. RT Induction of the RelB NF-kappaB subunit by the cytomegalovirus IE1 protein is mediated via Jun kinase and c-Jun/Fra-2 AP-1 complexes RL J. Virol. 79:95-105 (2005). RN [65]; RE0047173. RX PUBMED: 15466214. RA Unni E., Sun S., Nan B., McPhaul M. J., Cheskis B., Mancini M. A., Marcelli M. RT Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence RL Cancer Res. 64:7156-68 (2004). RN [66]; RE0050710. RX PUBMED: 16123044. RA Monje P., Hernandez-Losa J., Lyons R. J., Castellone M. D., Gutkind J. S. RT Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1. RL J. Biol. Chem. 280:35081-35084 (2005). RN [67]; RE0051710. RX PUBMED: 15988009. RA Yang H., Magilnick N., Lee C., Kalmaz D., Ou X., Chan J. Y., Lu S. C. RT Nrf1 and Nrf2 regulate rat glutamate-cysteine ligase catalytic subunit transcription indirectly via NF-kappaB and AP-1. RL Mol. Cell. Biol. 25:5933-5946 (2005). RN [68]; RE0053512. RX PUBMED: 10975835. RA Kim Y. M., Im J. Y., Han S. H., Kang H. S., Choi I. RT IFN-gamma up-regulates IL-18 gene expression via IFN consensus sequence-binding protein and activator protein-1 elements in macrophages. RL J. Immunol. 165:3198-3205 (2000). RN [69]; RE0054332. RX PUBMED: 16723511. RA Godeny M. D., Sayeski P. P. RT ERK1/2 regulates ANG II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1. RL Am. J. Physiol. Cell Physiol. 291:C1308-17 (2006). RN [70]; RE0065826. RX PUBMED: 18653705. RA Wang Y., Fortin J., Lamba P., Bonomi M., Persani L., Roberson M. S., Bernard D. J. RT Activator protein-1 and smad proteins synergistically regulate human follicle-stimulating hormone beta-promoter activity. RL Endocrinology 149:5577-5591 (2008). RN [71]; RE0066089. RX PUBMED: 20042607. RA Zhang R., Chen H. Z., Liu J. J., Jia Y. Y., Zhang Z. Q., Yang R. F., Zhang Y., Xu J., Wei Y. S., Liu D. P., Liang C. C. RT SIRT1 Suppresses Activator Protein-1 Transcriptional Activity and Cyclooxygenase-2 Expression in Macrophages. RL J. Biol. Chem. 285:7097-7110 (2010). RN [72]; RE0066671. RX PUBMED: 19026785. RA Yang G., Li Y., Nishimura E. K., Xin H., Zhou A., Guo Y., Dong L., Denning M. F., Nickoloff B. J., Cui R. RT Inhibition of PAX3 by TGF-beta modulates melanocyte viability. RL Mol. Cell 32:554-563 (2008). RN [73]; RE0069910. RX PUBMED: 15322176. RA Lee J. M., Chung C. Y., Chiang W. W., Liou Y. H., Chen C. F., Liao N. S. RT IL-15Ralpha is a negative regulator of TCR-activated proliferation in CD4+ T cells. RL J. Immunol. 173:3155-3164 (2004). RN [74]; RE0070282. RX PUBMED: 10479680. RA Kurschner C., Yuzaki M. RT Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein. RL J. Neurosci. 19:7770-7780 (1999). RN [75]; RE0070405. RX PUBMED: 20849916. RA Fenster C. P., Chisnell H. K., Fry C. R., Fenster S. D. RT The role of CD4-dependent signaling in interleukin-16 induced c-Fos expression and facilitation of neurite outgrowth in cerebellar granule neurons. RL Neurosci. Lett. 485:212-216 (2010). RN [76]; RE0070715. RX PUBMED: 21068407. RA Kim K., Kim J. H., Youn B. U., Jin H. M., Kim N. RT Pim-1 regulates RANKL-induced osteoclastogenesis via NF-kappaB activation and NFATc1 induction. RL J. Immunol. 185:7460-7466 (2010). XX //