AC T00122
XX
ID T00122
XX
DT 15.10.1992 (created); ewi.
DT 05.02.2015 (updated); pro.
CO Copyright (C), QIAGEN.
XX
FA c-Fos
XX
SY c-Fos; FBJ osteosarcoma oncogene; p55(c-fos).
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G000486 Fos.
XX
CL C0008; bZIP; 1.1.2.1.1.
XX
SF the apparent molecular weight may increase from 55 kDa to 62 kDa or more due to extensive phosphorylation [5] [26] [31] [32] [33];
SF heterodimerization through the leucine zipper motif;
SF either leucine of the zipper may be exchanged, but substituting 2 or more abolishes its dimerization capability [11];
SF the leucine zipper causes dimerization specificity among bZIP class members, probably by establishing an optimal pattern of electrostatic and hydrophobic contacts [17] [13];
SF in the heterodimer, c-Fos also contacts the DNA via its basic region [8] [34];
SF c-Fos/c-Jun heterodimers bend the DNA in the opposite direction than c-Jun homodimers do [20];
SF the heterodimer with CRE-BP1/ATF-2 induces a strong bending towards the minor groove [20];
XX
CP Mouse fibroblasts [67]; RAW264.7, RAW264.7 + IFNgamma, RAW264.7 + LPS [68].
XX
FF activator (in heterodimer with c-Jun);
FF mostly required during G0/G1 transition [58];
FF transforming activity depends on its C-terminal trans-activation domain [36];
FF (in contrast to other report) transforming activity assigned to the N-TA which is conserved among Fos proteins and has some homologous sequences in Jun proteins [61];
FF may be a prerequisite of myeloid differentiation [25];
FF precedes programmed cell death [40] [41];
FF null mutant mice can survive, but show some abnormalities in, e. g., bone development (osteopetrosis), lymphoid cells and gametogenesis [45];
FF numerous regulatory elements in the 5' upstream region confer responses to enhanced cAMP levels [47];
FF gene expression responsive to serum growth factors [48] [50] [51] [53];
FF inducible by GM-CSF [62];
FF c-Fos represses its own transcription by a mechanism that depends on its leucine zipper, but not on its DNA-binding capability [29] [46];
FF MyoD also inhibits c-fos expression by binding adjacent to a SRE and overlapping with an AP-1 site;
FF a transcription elongation block in the 1st intron is modulated in a calcium-dependent manner [55];
FF the c-fos mRNA contains several degradation signals [56] [57];
FF nuclear translocation of c-Fos is inhibited by a labile protein which is inactivated in response to cAMP [42];
FF c-Fos activity is regulated by a redox mechanism involving Ref-1 [22];
FF Thr-232 is in a sequence environment that is homologous to Ser-73 of c-Jun and, consequently, is also phosphorylated by a MAP kinase in response to Ha-Ras leading to an increase in its trans-activation capability [37] [38];
FF phosphorylation at serine residues 362-364 is required for repression of c-fos expression, but does not affect trans-activation by c-Fos [39];
XX
IN T00167 ATF-2-isoform1; human, Homo sapiens.
IN T02056 ATF-2-isoform1; mouse, Mus musculus.
IN T10136 ATF-2; human, Homo sapiens.
IN T01303 ATF-4; human, Homo sapiens.
IN T00051 ATF; human, Homo sapiens.
IN T00131 c-Jun; mouse, Mus musculus.
IN T00132 c-Jun; rat, Rattus norvegicus.
IN T00133 c-Jun; human, Homo sapiens.
IN T00134 c-Jun; chick, Gallus gallus.
IN T00135 c-Jun; hamster, Cricetulus sp.
IN T00017 C/EBPbeta-FL; mouse, Mus musculus.
IN T01318 CBP; mouse, Mus musculus.
IN T00967 E1A 12S protein; adenovirus.
IN T00209 E1A 13S protein; adenovirus type 2.
IN T00436 JunB; mouse, Mus musculus.
IN T00437 JunD; mouse, Mus musculus.
IN T01438 NRL; mouse, Mus musculus.
IN T32110 SIRT1; mouse, Mus musculus.
IN T01430 v-Maf; AS42, avian musculoaponeurotic fibrosarcoma virus.
IN T00902 XBP-1; human, Homo sapiens.
XX
MX M00172 V$AP1FJ_Q2.
MX M00517 V$AP1_01.
MX M00924 V$AP1_Q2_01.
MX M00926 V$AP1_Q4_01.
MX M00925 V$AP1_Q6_01.
MX M07600 V$CFOS_Q4.
MX M03815 V$CFOS_Q6.
XX
BS R03540.
BS R23034.
BS R24899.
BS R23218.
BS R25247.
BS R25249.
BS R09882.
BS R24701.
BS R01037.
BS R22860.
BS R01559.
BS R73852.
BS R71632.
BS R37825.
BS R30131.
BS R66081.
BS R14477.
BS R24867.
BS R28410.
BS R41852.
BS R41854.
BS R41855.
BS R41858.
BS R04079.
BS R01062.
BS R57736.
BS R30107.
BS R40185.
BS R60089.
BS R08510.
BS R24785.
BS R24797.
BS R19643.
BS R19645.
BS R26628.
BS R21509.
BS R56972.
BS R23479.
BS R14663.
BS R56648.
BS R16979.
BS R33767.
BS R29889.
XX
DR TRANSPATH: MO000024721.
DR UniProtKB: P01101;
XX
RN [1]; RE0000046.
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RT Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos
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RT Common DNA Binding Site for FOS Protein Complexes and Transcription Factor AP-1
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RT Sequence-Specific Interactions of Nuclear Factors with the Insulin Gene Enhancer
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RT Non-leucine residues in the leucine repeats of Fos and Jun contribute to the stability and determine the specificity of dimerization
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