AC T10136
AS T01802.
XX
ID T10136
XX
DT 06.06.2006 (created); anu.
DT 29.01.2015 (updated); ros.
CO Copyright (C), QIAGEN.
XX
FA ATF-2
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SY activating transcription factor 2; ATF2; CRE-BP1; HB16; TREB7.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G000232 ATF2; HGNC: ATF2.
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CL C0008; bZIP; 1.1.1.3.1.
XX
CP MCF10A+TGF-beta [10].
XX
IN T00122 c-Fos; mouse, Mus musculus.
IN T00133 c-Jun; human, Homo sapiens.
IN T18378 CBP; human, Homo sapiens.
IN T08562 CREB1; human, Homo sapiens.
IN T16141 LEF-1; human, Homo sapiens.
IN T09259 NF-IX; human, Homo sapiens.
IN T00545 POU2F1; human, Homo sapiens.
IN T01002 TCF-1; human, Homo sapiens.
IN T00915 YY1; human, Homo sapiens.
XX
MX M01862 V$ATF2_Q5.
MX M07312 V$ATF2_Q6.
MX M00981 V$CREBATF_Q6.
MX M00041 V$CREBP1CJUN_01.
MX M00040 V$CREBP1_01.
MX M00179 V$CREBP1_Q2.
MX M00801 V$CREB_Q3.
XX
BS R25002.
BS R16162.
BS R70684.
BS R70686.
BS R70688.
BS R25007.
BS R20975.
BS R58475.
BS R58515.
BS R23060.
BS R20509.
BS R60519.
BS R25037.
BS R35096.
BS R25396.
BS R29897.
BS R36617.
BS R32731.
BS R32733.
BS R25287.
BS R61468.
BS R30029.
BS R34434.
BS R21737.
BS R72604.
BS R31609.
BS R56088.
BS R63602.
BS R63630.
BS R64460.
BS R25050.
BS R62462.
BS R33869.
BS R34121.
BS R23170.
BS R62693.
BS R24998.
BS R61454.
BS R29829.
BS R14470.
BS R33878.
BS R38969.
BS R60701.
BS R13230.
BS R01217.
BS R25032.
XX
DR TRANSPATH: MO000082535.
DR UniProtKB: P15336;
XX
RN [1]; RE0047834.
RX PUBMED: 7769693.
RA Zhou Q., Gedrich R. W., Engel D. A.
RT Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB.
RL J. Virol. 69:4323-4330 (1995).
RN [2]; RE0047872.
RX PUBMED: 9685505.
RA Yamaguchi Y., Wada T., Suzuki F., Takagi T., Hasegawa J., Handa H.
RT Casein kinase II interacts with the bZIP domains of several transcription factors.
RL Nucleic Acids Res. 26:3854-3861 (1998).
RN [3]; RE0049579.
RX PUBMED: 16533805.
RA Ho D. T., Bardwell A. J., Grewal S., Iverson C., Bardwell L.
RT Interacting JNK-docking sites in MKK7 promote binding and activation of JNK mitogen-activated protein kinases.
RL J. Biol. Chem. 281:13169-13179 (2006).
RN [4]; RE0049641.
RX PUBMED: 15695103.
RA Long A. A., Chapman N. R., Innes B., Europe-Finner G. N., Robson S. C.
RT Expression and interaction of the transcriptional coregulators, CBP/p300, in the human myometrium during pregnancy and labor.
RL J. Soc. Gynecol. Invest. 12:92-97 (2005).
RN [5]; RE0050737.
RX PUBMED: 17700520.
RA Maekawa T., Sano Y., Shinagawa T., Rahman Z., Sakuma T., Nomura S., Licht J. D., Ishii S.
RT ATF-2 controls transcription of Maspin and GADD45alpha genes independently from p53 to suppress mammary tumors.
RL Oncogene 27:1045-1054 (2007).
RN [6]; RE0051948.
RX PUBMED: 16357519.
RA Chakrabarty S., Kondratick L.
RT Insulin-like growth factor binding protein-2 stimulates proliferation and activates multiple cascades of the mitogen-activated protein kinase pathways in NIH-OVCAR3 human epithelial ovarian cancer cells.
RL Cancer Biol. Ther. 5:189-197 (2006).
RN [7]; RE0053061.
RX PUBMED: 17296604.
RA Johnson J., Albarani V., Nguyen M., Goldman M., Willems F., Aksoy E.
RT Protein kinase Calpha is involved in interferon regulatory factor 3 activation and type I interferon-beta synthesis.
RL J. Biol. Chem. 282:15022-15032 (2007).
RN [8]; RE0053588.
RX PUBMED: 17974568.
RA Maiti A., Hait N. C., Beckman M. J.
RT Extracellular calcium-sensing receptor activation induces vitamin D receptor levels in proximal kidney HK-2G cells by a mechanism that requires phosphorylation of p38alpha MAPK.
RL J. Biol. Chem. 283:175-183 (2008).
RN [9]; RE0053619.
RX PUBMED: 12453892.
RA Lee M. Y., Jung C. H., Lee K., Choi Y. H., Hong S., Cheong J.
RT Activating transcription factor-2 mediates transcriptional regulation of gluconeogenic gene PEPCK by retinoic acid.
RL Diabetes 51:3400-3407 (2002).
RN [10]; RE0053633.
RX PUBMED: 17258390.
RA Kim E. S., Sohn Y. W., Moon A.
RT TGF-beta-induced transcriptional activation of MMP-2 is mediated by activating transcription factor (ATF)2 in human breast epithelial cells.
RL Cancer Lett. 252:147-156 (2007).
RN [11]; RE0053667.
RX PUBMED: 15601748.
RA Wahab N. A., Weston B. S., Mason R. M.
RT Connective tissue growth factor CCN2 interacts with and activates the tyrosine kinase receptor TrkA.
RL J. Am. Soc. Nephrol. 16:340-351 (2005).
RN [12]; RE0054902.
RX PUBMED: 18222647.
RA Muniyappa H., Das K. C.
RT Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: a MLK-3-MKK7-dependent mechanism.
RL Cell. Signal. 20:675-683 (2008).
RN [13]; RE0055188.
RX PUBMED: 17921324.
RA Cortez D. M., Feldman M. D., Mummidi S., Valente A. J., Steffensen B., Vincenti M., Barnes J. L., Chandrasekar B.
RT IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta, NF-kappaB, and AP-1 activation.
RL Am. J. Physiol. Heart Circ. Physiol. 293:H3356-65 (2007).
RN [14]; RE0055337.
RX PUBMED: 17311279.
RA Liang K. C., Lee C. W., Lin W. N., Lin C. C., Wu C. B., Luo S. F., Yang C. M.
RT Interleukin-1beta induces MMP-9 expression via p42/p44 MAPK, p38 MAPK, JNK, and nuclear factor-kappaB signaling pathways in human tracheal smooth muscle cells.
RL J. Cell. Physiol. 211:759-770 (2007).
RN [15]; RE0067078.
RX PUBMED: 20519498.
RA Markovics J. A., Araya J., Cambier S., Jablons D., Hill A., Wolters P. J., Nishimura S. L.
RT Transcription of the transforming growth factor {beta} (TGF-{beta}) activating integrin {beta}8 subunit is regulated by SP3, AP-1 and the P38 pathway.
RL J. Biol. Chem. 285:24695-24706 (2010).
RN [16]; RE0067905.
RX PUBMED: 15916964.
RA Bhoumik A., Takahashi S., Breitweiser W., Shiloh Y., Jones N., Ronai Z.
RT ATM-dependent phosphorylation of ATF2 is required for the DNA damage response.
RL Mol. Cell 18:577-587 (2005).
RN [17]; RE0068114.
RX PUBMED: 12110590.
RA Ouwens D. M., de Ruiter N. D., Van der Zon G. C., Carter A. P., Schouten J., van der Burgt C., Kooistra K., Bos J. L., Maassen J. A., van Dam H.
RT Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38.
RL EMBO J. 21:3782-3793 (2002).
RN [18]; RE0070313.
RX PUBMED: 21466707.
RA Zhao L. J., Hua X., He S. F., Ren H., Qi Z. T.
RT Interferon alpha regulates MAPK and STAT1 pathways in human hepatoma cells.
RL Virol. J. 8:157 (2011).
RN [19]; RE0071671.
RX PUBMED: 19109253.
RA Carta L., Smaldone S., Zilberberg L., Loch D., Dietz H. C., Rifkin D. B., Ramirez F.
RT p38 MAPK is an early determinant of promiscuous Smad2/3 signaling in the aortas of fibrillin-1 (Fbn1)-null mice.
RL J. Biol. Chem. 284:5630-5636 (2009).
RN [20]; RE0073075.
RX PUBMED: 22128168.
RA Yamagata K., Li X., Ikegaki S., Oneyama C., Okada M., Nishita M., Minami Y.
RT Dissection of Wnt5a-Ror2 signaling leading to matrix metalloproteinase (MMP-13) expression.
RL J. Biol. Chem. 287:1588-1599 (2012).
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