TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01002 XX ID T01002 XX DT 25.01.1994 (created); ewi. DT 20.02.2015 (updated); jmh. CO Copyright (C), QIAGEN. XX FA TCF-1 XX SY T-cell factor 1; TCF-1; TCF7; transcription factor 7 (T-cell specific, HMG-box). XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004674 TCF7; HGNC: TCF7. XX CL C0015; HMG; XX SF bind to minor groove of a Watson-Crick double helix by recognizing the WWCAAAG [4]; SF multitude of TCF-1 proteins from 25 to 55 kDa due to structure of TCF-1 gene: 2 alternative upstream promoters, presence of 13 exons (Ia', Ib', I, II, IIa, III, IV, IVa, V, VI, VII, VIII, IX, X) and existence of a second reading frame in the last exon encoding an extended C terminus [4]; SF a total of 96 different mRNAs is possible; SF high similarity to lymphoid factor LEF-1, mouse TCF and chicken TCF; SF alternative exon IIa coding for ERKCSPREGUDWPRILQUK, insertion of this exon between exon II and III will result in the production of a 16-kDa protein lacking DNA-binding properties [5]; XX CP T cells [5]; nucleus of intestine epithelial cells, basal epithelial cells of mammary gland tissue [6] [5] [6]. XX FF several of the TCF-1 isoforms mimic LEF-1 in transactivating transcription through T-cell receptor alpha-chain enhancer [5]; XX IN T10136 ATF-2; human, Homo sapiens. IN T14513 beta-catenin; Mammalia. IN T01308 CREBPA; human, Homo sapiens. IN T05686 Grg4; mouse, Mus musculus. XX MX M00978 V$LEF1TCF1_Q4. MX M00805 V$LEF1_Q2. MX M08977 V$TCF1_08. MX M03857 V$TCF1_Q5. MX M07433 V$TCF1_Q5_01. MX M08902 V$TCF7RELATED_Q4. XX BS R15188. BS R08563. BS R64130. BS R03576. BS R08268. BS R28283. BS R33556. BS R33870. BS R72859. BS R66396. BS R66398. BS R66399. BS R02248. XX DR TRANSPATH: MO000025333. DR EMBL: X63901; DR EMBL: Z47365; DR UniProtKB: P36402; TCF1_HUMAN. XX RN [1]; RE0000465. RX PUBMED: 1989880. RA van de Wetering M., Oosterwegel M., Dooijes D., Clevers H. RT Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box RL EMBO J. 10:123-132 (1991). RN [2]; RE0001044. RX PUBMED: 1569101. RA van de Wetering M., Oosterwegel M., Holstege F., Dooyes D., Suijkerbuijk R., van Kessel A. G., Clevers H. RT The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization. RL J. Biol. Chem. 267:8530-8536 (1992). RN [3]; RE0003115. RX PUBMED: 1639073. RA van de Wetering M., Clevers H. RT Sequence-specific interaction of the HMG box proteins TCF-1 and SRY occurs within the minor groove of a Watson-Crick double helix RL EMBO J. 11:3039-3044 (1992). RN [4]; RE0005014. RX PUBMED: 7640309. RA Mayer K., Wolff E., Clevers H., Ballhausen W. G. RT The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA RL Biochim. Biophys. Acta 1263:169-172 (1995). RN [5]; RE0012301. RX PUBMED: 8622675. RA van de Wetering M., Castrop J., Korinek V., Clevers H. RT Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties RL Mol. Cell. Biol. 16:745-752 (1996). RN [6]; RE0014033. RX PUBMED: 10489374. RA Roose J., Huls G., van Beest M., Moerer P., van der Horn K., Goldschmeding R., Logtenberg T., Clevers H. RT Synergy Between Tumor Suppressor APC and the beta-Catenin-Tcf4 Target Tcf1 RL Science 285:1923-1926 (1999). XX //