AC T01002
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ID T01002
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DT 25.01.1994 (created); ewi.
DT 20.02.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA TCF-1
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SY T-cell factor 1; TCF-1; TCF7; transcription factor 7 (T-cell specific, HMG-box).
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004674 TCF7; HGNC: TCF7.
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CL C0015; HMG; 4.1.3.0.1.
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SF bind to minor groove of a Watson-Crick double helix by recognizing the WWCAAAG [4];
SF multitude of TCF-1 proteins from 25 to 55 kDa due to structure of TCF-1 gene: 2 alternative upstream promoters, presence of 13 exons (Ia', Ib', I, II, IIa, III, IV, IVa, V, VI, VII, VIII, IX, X) and existence of a second reading frame in the last exon encoding an extended C terminus [4];
SF a total of 96 different mRNAs is possible;
SF high similarity to lymphoid factor LEF-1, mouse TCF and chicken TCF;
SF alternative exon IIa coding for ERKCSPREGUDWPRILQUK, insertion of this exon between exon II and III will result in the production of a 16-kDa protein lacking DNA-binding properties [5];
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CP T cells [5]; nucleus of intestine epithelial cells, basal epithelial cells of mammary gland tissue [6] [5] [6].
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FF several of the TCF-1 isoforms mimic LEF-1 in transactivating transcription through T-cell receptor alpha-chain enhancer [5];
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IN T10136 ATF-2; human, Homo sapiens.
IN T14513 beta-catenin; Mammalia.
IN T01308 CREBPA; human, Homo sapiens.
IN T05686 Grg4; mouse, Mus musculus.
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MX M00978 V$LEF1TCF1_Q4.
MX M00805 V$LEF1_Q2.
MX M08977 V$TCF1_08.
MX M03857 V$TCF1_Q5.
MX M07433 V$TCF1_Q5_01.
MX M08902 V$TCF7RELATED_Q4.
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BS R15188.
BS R08563.
BS R64130.
BS R03576.
BS R08268.
BS R28283.
BS R33556.
BS R33870.
BS R72859.
BS R66396.
BS R66398.
BS R66399.
BS R02248.
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DR TRANSPATH: MO000025333.
DR EMBL: X63901;
DR EMBL: Z47365;
DR UniProtKB: P36402; TCF1_HUMAN.
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RN [1]; RE0000465.
RX PUBMED: 1989880.
RA van de Wetering M., Oosterwegel M., Dooijes D., Clevers H.
RT Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box
RL EMBO J. 10:123-132 (1991).
RN [2]; RE0001044.
RX PUBMED: 1569101.
RA van de Wetering M., Oosterwegel M., Holstege F., Dooyes D., Suijkerbuijk R., van Kessel A. G., Clevers H.
RT The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.
RL J. Biol. Chem. 267:8530-8536 (1992).
RN [3]; RE0003115.
RX PUBMED: 1639073.
RA van de Wetering M., Clevers H.
RT Sequence-specific interaction of the HMG box proteins TCF-1 and SRY occurs within the minor groove of a Watson-Crick double helix
RL EMBO J. 11:3039-3044 (1992).
RN [4]; RE0005014.
RX PUBMED: 7640309.
RA Mayer K., Wolff E., Clevers H., Ballhausen W. G.
RT The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA
RL Biochim. Biophys. Acta 1263:169-172 (1995).
RN [5]; RE0012301.
RX PUBMED: 8622675.
RA van de Wetering M., Castrop J., Korinek V., Clevers H.
RT Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties
RL Mol. Cell. Biol. 16:745-752 (1996).
RN [6]; RE0014033.
RX PUBMED: 10489374.
RA Roose J., Huls G., van Beest M., Moerer P., van der Horn K., Goldschmeding R., Logtenberg T., Clevers H.
RT Synergy Between Tumor Suppressor APC and the beta-Catenin-Tcf4 Target Tcf1
RL Science 285:1923-1926 (1999).
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