AC T00902
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ID T00902
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DT 12.03.1993 (created); ewi.
DT 21.06.2016 (updated); hna.
CO Copyright (C), QIAGEN.
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FA XBP-1
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SY hXBP-1; TREB-5; TREB5; X box binding protein 1; X-box binding protein 1; XBP-1; XBP1; XBP2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006882 XBP1; HGNC: XBP1.
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CL C0008; bZIP; 1.1.5.0.1.
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SF conflicting data: A33,R34 is G33,Q34,A35 in [4];
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CP ubiquitous [4].
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FF ligand independent synergistic enhancement of ERa activity by co-expression of SRC-1 and XBP-1S or XBP-1U [5];
FF binds to the X-box elements of class II MHC genes [3] [2] [1];
FF different from RF-X;
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IN T00122 c-Fos; mouse, Mus musculus.
IN T00123 c-Fos; human, Homo sapiens.
IN T00124 c-Fos; rat, Rattus norvegicus.
IN T00125 c-Fos; chick, Gallus gallus.
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MX M00538 V$HTF_01.
MX M00251 V$XBP1_01.
MX M01770 V$XBP1_02.
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BS R56979.
BS R72606.
BS R66046.
BS R61800.
BS R03105.
BS R01087.
BS R03104.
BS R67979.
BS R39637.
BS R04604.
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DR TRANSPATH: MO000015029.
DR UniProtKB: P17861;
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RN [1]; RE0001619.
RX PUBMED: 1901941.
RA Vilen B. J., Cogswell J. P., Ting J. P.-Y.
RT Stereospecific alignment of the X and Y elements is required for major histocompatibility complex class II DRA promoter function
RL Mol. Cell. Biol. 11:2406-2415 (1991).
RN [2]; RE0002482.
RX PUBMED: 1903538.
RA Ono S. J., Liou H.-C., Davidon R., Strominger J. L., Glimcher L. H.
RT Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility gene and forms a heterodimer with c-fos
RL Proc. Natl. Acad. Sci. USA 88:4309-4312 (1991).
RN [3]; RE0002716.
RX PUBMED: 2321018.
RA Liou H.-C., Boothby M. R., Finn P. W., Davidson R., Nabavi N., Zeleznik-Le N. J., Ting J. P.-Y., Glimcher L. H.
RT A new member of the leucine zipper class of proteins that binds to the HLA DRalpha promoter
RL Science 247:1581-1584 (1990).
RN [4]; RE0003157.
RX PUBMED: 2196176.
RA Yoshimura T., Fujisawa J.-I., Yoshida M.
RT Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain
RL EMBO J. 9:2537-2542 (1990).
RN [5]; RE0047405.
RX PUBMED: 12954762.
RA Ding L., Yan J., Zhu J., Zhong H., Lu Q., Wang Z., Huang C., Ye Q.
RT Ligand-independent activation of estrogen receptor alpha by XBP-1.
RL Nucleic Acids Res. 31:5266-5274 (2003).
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