AC T00967
XX
ID T00967
XX
DT 29.06.1993 (created); ewi.
DT 09.05.2008 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA E1A 12S protein
XX
SY E1A 12S protein.
XX
OS adenovirus
OC viridae; ds-DNA nonenveloped viruses; adenoviridae
XX
SZ 243 AA; 26.4 kDa (gene) (calc.).
XX
SQ MRHIICHGGVITEEMAASLLDQLIEEVLADNLPPPSHFEPPTLHELYDLDVTAPEDPNEE
SQ AVSQIFPDSVMLAVQEGIDLLTFPPAPGSPEPPHLSRQPEQPEQRALGPVSMPNLVPEVI
SQ DLTCHEAGFPPSDDEDEEGPVSEPEPEPEPEPEPARPTRRPKLVPAILRRPTSPVSRECN
SQ SSTDSCDSGPSNTPPEIHPVVPLCPIKPVAVRVGGRRQAVECIEDLLNESGQPLDLSCKR
SQ PRP
XX
FT 1 243 
PF02703; Early E1A protein.
XX
FF inhibits induction of interferon-stimulated response element binding factors E and M;
FF dissociates E2F-cyclin-A-complexes, for which CR1 and CR2 are essential;
FF interaction with CRE-BP1 or c-Fos may be indirect [3];
FF CR2 is essential for induction of proliferation of primary BRK cells but can be substituted by a homolog sequence from SV40 T-Ag (101-118) [6];
XX
IN T00035 AP-2alphaA; human, Homo sapiens.
IN T00167 ATF-2-isoform1; human, Homo sapiens.
IN T00122 c-Fos; mouse, Mus musculus.
IN T00123 c-Fos; human, Homo sapiens.
IN T00124 c-Fos; rat, Rattus norvegicus.
IN T00125 c-Fos; chick, Gallus gallus.
IN T00131 c-Jun; mouse, Mus musculus.
IN T00132 c-Jun; rat, Rattus norvegicus.
IN T00133 c-Jun; human, Homo sapiens.
IN T00134 c-Jun; chick, Gallus gallus.
IN T00135 c-Jun; hamster, Cricetulus sp.
IN T01427 p300; human, Homo sapiens.
IN T00722 pRb; human, Homo sapiens.
XX
DR TRANSPATH: MO000025306.
DR EMBL: X14757;
DR UniProtKB: P03254-2;
XX
RN [1]; RE0000795.
RX PUBMED: 1829698.
RA Raychaudhuri P., Bagchi S., Devoto S. H., Kraus V. B., Moran E., Nevins J. R.
RT Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes
RL Genes Dev. 5:1200-1211 (1991).
RN [2]; RE0002173.
RX PUBMED: 1832217.
RA Ackrill A. M., Foster G. R., Laxton C. D., Flavell D. M., Stark G. R., Kerr I. M.
RT Inhibition of the cellular response to interferons by products of the adenovirus type 5 E1A oncogene
RL Nucleic Acids Res. 19:4387-4393 (1991).
RN [3]; RE0002247.
RX PUBMED: 1832215.
RA Maguire K., Shi X.-P., Horikoshi N., Rappaport J., Rosenberg M., Weinmann R.
RT Interactions between adenovirus E1A and members of the AP-1 family of cellular transcription factors
RL Oncogene 6:1417-1422 (1991).
RN [4]; RE0002909.
RX PUBMED: 1534143.
RA Rikitake Y., Moran E.
RT DNA-binding properties of the E1A-associated 300-Kilodalton protein
RL Mol. Cell. Biol. 12:2826-2836 (1992).
RN [5]; RE0013301.
RX PUBMED: 2138977.
RA Hu Q. J., Dyson N., Harlow E.
RT The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.
RL EMBO J. 9:1147-1155 (1990).
RN [6]; RE0013313.
RX PUBMED: 2968523.
RA Moran E.
RT A region of SV40 large T antigen can substitute for a transforming domain of the adenovirus E1A products.
RL Nature 334:168-170 (1988).
RN [7]; RE0013314.
RX PUBMED: 3000772.
RA Stabel S., Argos P., Philipson L.
RT The release of growth arrest by microinjection of adenovirus E1A DNA.
RL EMBO J. 4:2329-2336 (1985).
XX
//