AC T02056
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ID T02056
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DT 28.01.1997 (created); hiwi.
DT 06.09.2013 (updated); spk.
CO Copyright (C), QIAGEN.
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FA ATF-2-isoform1
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SY ATF-2 (human); CRE-BP1; CREBP1; HB16; TREB-7; XBP-4; XBP4.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009504 Atf2.
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CL C0008; bZIP.
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SZ 487 AA; 52.3 kDa (cDNA) (calc.).
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SQ MSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKN
SQ CEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPSVVETTHQDSPL
SQ PHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSDSSVIIQQAVPSPTSSTVI
SQ TQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNVHVPAAVPLVRPVTMVPSV
SQ PGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGSGLVRTQSEESRPQSLQQP
SQ ATSTTETPASPAHTTPQTQNTSGRRRRAANEDPDEKRRKFLERNRAAASRCRQKRKVWVQ
SQ SLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPVTAMQKKSGYHTADKDDSS
SQ EDLSVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQMADQSTEPALSQIVMAPPS
SQ QAQPSGS
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SC Swiss-Prot#P16951-1
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FT 117 456 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 300 364 
PF00170; bZIP transcription factor.
FT 300 364 
SM00338; brlzneu.
FT 302 365 
PS50217; BZIP.
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SF alternative splice products: CRE-BP2 T01017, CRE-BP3 T02036;
SF Thr-69 and Thr-71 are essential for E1A-induced and ATF-2-isoform1-mediated transcriptional activation [1];
SF lacking the N-terminal zinc finger motif [2];
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CP ubiquitous [2].
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FF may be transcriptionally inert, presumably due to the lack of the N-terminal zinc finger motif found in human ATF-2-isoform1 T00167 [2];
FF required for normal skeletal and CNS development, lack of ATF-2-isoform1 leads to defects in enchondral ossification and causes ataxy, hyperactivity, and decreased hearing [4];
FF phosphorylation by a JNK/SAPK kinase of the MAPK family at Thr-69 and -71 mediates activation in response to UV or other cellular stresses [1] [3];
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IN T01017 ATF-2-isoform2; mouse, Mus musculus.
IN T00122 c-Fos; mouse, Mus musculus.
IN T10332 ipf1; Mammalia.
IN T09908 MafA; mouse, Mus musculus.
IN T14436 NeuroD-1; Mammalia.
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MX M07312 V$ATF2_Q6.
MX M00981 V$CREBATF_Q6.
MX M00041 V$CREBP1CJUN_01.
MX M00040 V$CREBP1_01.
MX M00179 V$CREBP1_Q2.
MX M00801 V$CREB_Q3.
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DR TRANSPATH: MO000026127.
DR EMBL: S76657;
DR UniProtKB: P16951-1;
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RN [1]; RE0005261.
RX PUBMED: 7737129.
RA Livingstone C., Patel G., Jones N.
RT ATF-2 contains a phosphorylation-dependent transcriptional activation domain
RL EMBO J. 14:1785-1797 (1995).
RN [2]; RE0005262.
RX PUBMED: 1531087.
RA Georgopoulos K., Morgan B. A., Moore D. D.
RT Functionally distinct isoforms of the CRE-BP DNA-binding protein mediate activity of a T-cell-specific enhancer
RL Mol. Cell. Biol. 12:747-757 (1992).
RN [3]; RE0005263.
RX PUBMED: 7737130.
RA van Dam H., Wilhelm D., Herr I., Steffen A., Herrlich P., Angel P.
RT ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents
RL EMBO J. 14:1798-1811 (1995).
RN [4]; RE0005264.
RX PUBMED: 8538792.
RA Reimold A. M., Grusby M. J., Kosaras B., Fries J. W. U., Mori R., Maniwa S., Clauss I. M., Collins T., Sidman R. L., Glimcher M. J., Glimcher L. H.
RT Chondrysplasia and neurological abnormalities in ATF-2 deficient mice
RL Nature 379:262-265 (1996).
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