AC T09908
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ID T09908
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DT 06.11.2006 (created); sts.
DT 10.12.2014 (updated); pro.
CO Copyright (C), QIAGEN.
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FA MafA
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SY INS; insulin; Pancreatic beta-cell specific transcriptional activator.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G021406 Mafa.
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CL C0008; bZIP.
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SZ 359 AA; 37.6 kDa (gene) (calc.).
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SQ MAAELAMGAELPSSPLAIEYVNDFDLMKFEVKKEPPEAERFCHRLPPGSLSSTPLSTPCS
SQ SVPSSPSFCAPSPGTGGGAGGGGSAAQAGGAPGPPSGGPGTVGGASGKAVLEDLYWMSGY
SQ QHHLNPEALNLTPEDAVEALIGSGHHGAHHGAHHPAAAAAYEAFRGQSFAGGGGADDMGA
SQ GHHHGAHHTAHHHHSAHHHHHHHHHHGGSGHHGGGAGHGGGGAGHHVRLEERFSDDQLVS
SQ MSVRELNRQLRGFSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHILESEKCQLQSQVE
SQ QLKLEVGRLAKERDLYKEKYEKLAGRGGPGGAGGAGFPREPSPAQAGPGAAKGAPDFFL
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SC translated from EMBL:AB086961
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FT 109 143 
PF08383; Maf_N.
FT 231 325 
PF03131; bZIP_Maf.
FT 232 324 
Carboxy-terminal basic domain and leucine zipper [1].
FT 256 322 
SM00338; brlzneu.
FT 260 323 
PS50217; BZIP.
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CP Eye and Pancreatic beta cell [1]; Expression of MafA in the somite cells, the anterior neural tube cells and the liver cells; Also detected in brain, lung, spleen, pancreas, kidney and INS-1 cells [2].
CN Brain,Trachea,Lung,Heart,Stomach,Duodenum,Small intestine, colon, liver, spleen, kidney, bladder, testis and Skeletal muscle. [1].
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IN T02056 ATF-2-isoform1; mouse, Mus musculus.
IN T30181 CREBPA; Mammalia.
IN T10332 ipf1; Mammalia.
IN T14436 NeuroD-1; Mammalia.
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MX M01139 V$LMAF_Q2.
MX M01709 V$MAFA_Q4.
MX M07325 V$MAFA_Q4_01.
MX M03796 V$MAFA_Q5.
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BS R19765.
BS R20766.
BS R20765.
BS R20779.
BS R30307.
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DR TRANSPATH: MO000090663.
DR EMBL: AB086961;
DR UniProtKB: Q8CF90; Q8CF90.
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RN [1]; RE0048632.
RX PUBMED: 12368292.
RA Kataoka K., Han S. I., Shioda S., Hirai M., Nishizawa M., Handa H.
RT MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene.
RL J. Biol. Chem. 277:49903-49910 (2002).
RN [2]; RE0049594.
RX PUBMED: 14680841.
RA Kajihara M., Sone H., Amemiya M., Katoh Y., Isogai M., Shimano H., Yamada N., Takahashi S.
RT Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter.
RL Biochem. Biophys. Res. Commun. 312:831-842 (2003).
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//