AC T18466
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ID T18466
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DT 10.03.2005 (created); nvo.
DT 03.09.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA IRF-7
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SY interferon regulatory factor 7; IRF-7A; IRF7; IRF7A.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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IN T09531 ATF-4; human, Homo sapiens.
IN T23082 ATF-4; Mammalia.
IN T23091 p300; Mammalia.
IN T25745 RNF96-isoform1; human, Homo sapiens.
IN T30703 SIRT1; Mammalia.
IN T09538 Smad3; Mammalia.
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MX M00453 V$IRF7_01.
MX M01884 V$IRF7_Q3.
MX M03793 V$IRF7_Q3_01.
MX M08887 V$IRF_Q4.
MX M00772 V$IRF_Q6.
MX M00972 V$IRF_Q6_01.
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BS R26722.
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DR TRANSPATH: MO000046786.
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RN [1]; RE0016765.
RX PUBMED: 10938111.
RA Lin R., Genin P., Mamane Y., Hiscott J.
RT Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7
RL Mol. Cell. Biol. 20:6342-6353 (2000).
RN [2]; RE0024011.
RX PUBMED: 10357819.
RA Yie J., Merika M., Munshi N., Chen G., Thanos D.
RT The role of HMG I(Y) in the assembly and function of the IFN-beta enhanceosome.
RL EMBO J. 18:3074-3089 (1999).
RN [3]; RE0041914.
RX PUBMED: 15251447.
RA Zhang J., Xu L. G., Han K. J., Wei X., Shu H. B.
RT PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis
RL FEBS Lett. 570:97-101 (2004).
RN [4]; RE0042128.
RX PUBMED: 12374802.
RA Caillaud A., Prakash A., Smith E., Masumi A., Hovanessian A. G., Levy D. E., Marie I.
RT Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding
RL J. Biol. Chem. 277:49417-21 (2002).
RN [5]; RE0042129.
RX PUBMED: 12604599.
RA Yang H., Lin C. H., Ma G., Baffi M. O., Wathelet M. G.
RT Interferon regulatory factor-7 synergizes with other transcription factors through multiple interactions with p300/CBP coactivators
RL J. Biol. Chem. 278:15495-504 (2003).
RN [6]; RE0042995.
RX PUBMED: 14729983.
RA Qing J., Liu C., Choy L., Wu R. Y., Pagano J. S., Derynck R.
RT Transforming growth factor beta/Smad3 signaling regulates IRF-7 function and transcriptional activation of the beta interferon promoter
RL Mol. Cell. Biol. 24:1411-25 (2004).
RN [7]; RE0051469.
RX PUBMED: 15767370.
RA Uematsu S., Sato S., Yamamoto M., Hirotani T., Kato H., Takeshita F., Matsuda M., Coban C., Ishii K. J., Kawai T., Takeuchi O., Akira S.
RT Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction.
RL J. Exp. Med. 201:915-923 (2005).
RN [8]; RE0053730.
RX PUBMED: 16153868.
RA Xu L. G., Wang Y. Y., Han K. J., Li L. Y., Zhai Z., Shu H. B.
RT VISA is an adapter protein required for virus-triggered IFN-beta signaling.
RL Mol. Cell 19:727-740 (2005).
RN [9]; RE0054266.
RX PUBMED: 15367631.
RA tenOever B. R., Sharma S., Zou W., Sun Q., Grandvaux N., Julkunen I., Hemmi H., Yamamoto M., Akira S., Yeh W. C., Lin R., Hiscott J.
RT Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity.
RL J. Virol. 78:10636-10649 (2004).
RN [10]; RE0054730.
RX PUBMED: 16306937.
RA Hacker H., Redecke V., Blagoev B., Kratchmarova I., Hsu L. C., Wang G. G., Kamps M. P., Raz E., Wagner H., Hacker G., Mann M., Karin M.
RT Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6.
RL Nature 439:204-207 (2006).
RN [11]; RE0054797.
RX PUBMED: 16484229.
RA Zhao J., Kong H. J., Li H., Huang B., Yang M., Zhu C., Bogunovic M., Zheng F., Mayer L., Ozato K., Unkeless J., Xiong H.
RT IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathways.
RL J. Biol. Chem. 281:10073-10080 (2006).
RN [12]; RE0054898.
RX PUBMED: 17823124.
RA Gatot J. S., Gioia R., Chau T. L., Patrascu F., Warnier M., Close P., Chapelle J. P., Muraille E., Brown K., Siebenlist U., Piette J., Dejardin E., Chariot A.
RT Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF.
RL J. Biol. Chem. 282:31131-31146 (2007).
RN [13]; RE0055029.
RX PUBMED: 18641315.
RA Higgs R., Ni Gabhann J., Ben Larbi N., Breen E. P., Fitzgerald K. A., Jefferies C. A.
RT The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3.
RL J. Immunol. 181:1780-1786 (2008).
RN [14]; RE0064916.
RX PUBMED: 15695821.
RA Schoenemeyer A., Barnes B. J., Mancl M. E., Latz E., Goutagny N., Pitha P. M., Fitzgerald K. A., Golenbock D. T.
RT The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling.
RL J. Biol. Chem. 280:17005-17012 (2005).
RN [15]; RE0065785.
RX PUBMED: 19479062.
RA Konno H., Yamamoto T., Yamazaki K., Gohda J., Akiyama T., Semba K., Goto H., Kato A., Yujiri T., Imai T., Kawaguchi Y., Su B., Takeuchi O., Akira S., Tsunetsugu-Yokota Y., Inoue J.
RT TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA.
RL PLoS ONE 4:e5674 (2009).
RN [16]; RE0069228.
RX PUBMED: 20668674.
RA Higgs R., Lazzari E., Wynne C., Ni Gabhann J., Espinosa A., Wahren-Herlenius M., Jefferies C. A.
RT Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors.
RL PLoS ONE 5:e11776 (2010).
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