AC T25745
XX
ID T25745
XX
DT 04.09.2006 (created); rad.
DT 03.09.2014 (updated); spk.
CO Copyright (C), QIAGEN.
XX
FA RNF96-isoform1
XX
SY KAP-1; KAP1; KRAB-associated protein 1; KRAB-interacting protein 1; KRIP-1; Nuclear corepressor KAP-1; RING finger protein 96; RNF96; TF1B; TIF1-beta; TIF1B; TRIM28; tripartite motif-containing 28; Tripartite motif-containing protein 28.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G019861 TRIM28; HGNC: TRIM28.
XX
SZ 835 AA; 88.5 kDa (calc.).
XX
SQ MAASAAAASAAAASAASGSPGPGEGSAGGEKRSTAPSAAASASASAAASSPAGGGAEALE
SQ LLEHCGVCRERLRPEREPRLLPCLHSACSACLGPAAPAAANSSGDGGAAGDGTVVDCPVC
SQ KQQCFSKDIVENYFMRDSGSKAATDAQDANQCCTSCEDNAPATSYCVECSEPLCETCVEA
SQ HQRVKYTKDHTVRSTGPAKSRDGERTVYCNVHKHEPLVLFCESCDTLTCRDCQLNAHKDH
SQ QYQFLEDAVRNQRKLLASLVKRLGDKHATLQKSTKEVRSSIRQVSDVQKRVQVDVKMAIL
SQ QIMKELNKRGRVLVNDAQKVTEGQQERLERQHWTMTKIQKHQEHILRFASWALESDNNTA
SQ LLLSKKLIYFQLHRALKMIVDPVEPHGEMKFQWDLNAWTKSAEAFGKIVAERPGTNSTGP
SQ APMAPPRAPGPLSKQGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVKRSRSGEGEVSG
SQ LMRKVPRVSLERLDLDLTADSQPPVFKVFPGSTTEDYNLIVIERGAAAAATGQPGTAPAG
SQ TPGAPPLAGMAIVKEEETEAAIGAPPTATEGPETKPVLMALAEGPGAEGPRLASPSGSTS
SQ SGLEVVAPEGTSAPGGGPGTLDDSATICRVCQKPGDLVMCNQCEFCFHLDCHLPALQDVP
SQ GEEWSCSLCHVLPDLKEEDGSLSLDGADSTGVVAKLSPANQRKCERVLLALFCHEPCRPL
SQ HQLATDSTFSLDQPGGTLDLTLIRARLQEKLSPPYSSPQEFAQDVGRMFKQFNKLTEDKA
SQ DVQSIIGLQRFFETRMNEAFGDTKFSAVLVEPPPMSLPGAGLSSQELSGGPGDGP
XX
SC Swiss-Prot#Q13263-1
XX
FT 65 120 
PF00097; zf-C3HC4.
FT 65 120 
SM00184; ring_2.
FT 65 121 
PS50089; ZF_RING_2.
FT 148 195 
PF00643; zf-B_box.
FT 148 195 
PS50119; ZF_BBOX.
FT 148 195 
SM00336; bboxneu5.
FT 204 245 
PF00643; zf-B_box.
FT 204 245 
PS50119; ZF_BBOX.
FT 204 245 
SM00336; bboxneu5.
FT 252 378 
SM00502; RAD_5.
FT 625 672 PS50016; ZF_PHD_2.
FT 627 670 SM00249; PHD_3.
FT 627 672 PF00628; PHD.
FT 628 669 SM00184; ring_2.
FT 697 801 SM00297; bromo_6.
XX
IN T18466 IRF-7; Mammalia.
IN T04674 IRF-7A; human, Homo sapiens.
XX
DR TRANSPATH: MO000086239.
DR UniProtKB: Q13263-1; TIF1B_HUMAN.
XX
RN [1]; RE0038632.
RX PUBMED: 11585818.
RA Satou A., Taira T., Iguchi-Ariga S. M., Ariga H.
RT A novel transrepression pathway of c-Myc. Recruitment of a transcriptional corepressor complex to c-Myc by MM-1, a c-Myc-binding protein
RL J. Biol. Chem. 276:46562-7 (2001).
RN [2]; RE0048806.
RX PUBMED: 17079232.
RA Lee Y. K., Thomas S. N., Yang A. J., Ann D. K.
RT Doxorubicin downregulates KAP1 SUMOylation that relieves its transcription repression on p21WAF1/CIP1 in breast cancer MCF-7 cells.
RL J. Biol. Chem. 282:1595-1606 (2006).
RN [3]; RE0049039.
RX PUBMED: 16107876.
RA Wang C., Ivanov A., Chen L., Fredericks W. J., Seto E., Rauscher FJ 3. r. d., Chen J.
RT MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.
RL EMBO J. 24:3279-3290 (2005).
XX
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