AC T04674
XX
ID T04674
XX
DT 23.08.2001 (created); rio.
DT 03.09.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA IRF-7A
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SY interferon regulatory factor 7.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002599 IRF7; HGNC: IRF7.
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CL C0022; trp; 3.5.3.0.7.1.
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SZ 503 AA; 54.3 kDa (calc.).
XX
SQ MALAPERAAPRVLFGEWLLGEISSGCYEGLQWLDEARTCFRVPWKHFARKDLSEADARIF
SQ KAWAVARGRWPPSSRGGGPPPEAETAERAGWKTNFRCALRSTRRFVMLRDNSGDPADPHK
SQ VYALSRELCWREGPGTDQTEAEAPAAVPPPQGGPPGPFLAHTHAGLQAPGPLPAPAGDKG
SQ DLLLQAVQQSCLADHLLTASWGADPVPTKAPGEGQEGLPLTGACAGGPGLPAGELYGWAV
SQ ETTPSPGPQPAALTTGEAAAPESPHQAEPYLSPSPSACTAVQEPSPGALDVTIMYKGRTV
SQ LQKVVGHPSCTFLYGPPDPAVRATDPQQVAFPSPAELPDQKQLRYTEELLRHVAPGLHLE
SQ LRGPQLWARRMGKCKVYWEVGGPPGSASPSTPACLLPRNCDTPIFDFRVFFQELVEFRAR
SQ QRRGSPRYTIYLGFGQDLSAGRPKEKSLVLVKLEPWLCRVHLEGTQREGVSSLDSSSLSL
SQ CLSSANSLYDDIECFLMELEQPA
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SC translated from EMBL #U53830
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FT 7 127 
SM00348; IRF.
FT 11 127 
PF00605; Interferon regulatory factor transcription f.
FT 284 462 
IAD IRF assocition domain [2].
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SF IAD domain, conserved within IRF family, is responsible for protein-protein interactions [2];
SF is a phosphoprotein that becomes additionally phosphorylated in response to virus infection [3];
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IN T25745 RNF96-isoform1; human, Homo sapiens.
IN T17026 RNF96; human, Homo sapiens.
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MX M00453 V$IRF7_01.
MX M08887 V$IRF_Q4.
MX M00772 V$IRF_Q6.
MX M00972 V$IRF_Q6_01.
XX
BS R10367.
BS R10368.
BS R10369.
BS R10370.
BS R10371.
BS R10372.
BS R10373.
BS R10374.
BS R10375.
BS R10376.
BS R10377.
BS R10378.
BS R10379.
BS R10380.
BS R10381.
BS R10382.
BS R10383.
BS R10384.
BS R10385.
BS R10386.
BS R10387.
BS R10388.
BS R10389.
BS R10390.
BS R10391.
BS R10392.
BS R10393.
BS R10394.
BS R14432.
BS R74071.
BS R14454.
BS R14802.
BS R34309.
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DR TRANSPATH: MO000028497.
DR TRANSCOMPEL: C00334.
DR EMBL: U53830;
DR UniProtKB: Q92985-1;
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RN [1]; RE0016765.
RX PUBMED: 10938111.
RA Lin R., Genin P., Mamane Y., Hiscott J.
RT Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7
RL Mol. Cell. Biol. 20:6342-6353 (2000).
RN [2]; RE0017830.
RX PUBMED: 10586038.
RA Meraro D., Hashmueli S., Koren B., Azriel A., Oumard A., Kirchhoff S., Hauser H., Nagulapalli S., Atchison M. L., Levi B.- Z.
RT Protein-protein and DNA-protein interactions affect the activity of lymphoid-specific IFN regulatory factors.
RL J. Immunol. 163:6468-6478 (1999).
RN [3]; RE0024013.
RX PUBMED: 9660935.
RA Wathelet M. G., Lin C. H., Parekh B. S., Ronco L. V., Howley P. M., Maniatis T.
RT Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo.
RL Mol. Cell 1:507-518 (1998).
RN [4]; RE0070798.
RX PUBMED: 21148039.
RA Liang Q., Deng H., Sun C. W., Townes T. M., Zhu F.
RT Negative regulation of IRF7 activation by activating transcription factor 4 suggests a cross-regulation between the IFN responses and the cellular integrated stress responses.
RL J. Immunol. 186:1001-1010 (2011).
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