AC T08776
XX
ID T08776
XX
DT 29.03.2006 (created); kau.
DT 21.04.2015 (updated); mka.
CO Copyright (C), QIAGEN.
XX
FA c-Fos
XX
SY c-Fos; FBJ osteosarcoma oncogene; p55(c-fos).
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G000218 FOS; HGNC: FOS.
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CL C0008; bZIP.
XX
SZ 380 AA; 40.7 kDa (cDNA) (calc.), 55-65 kDa (SDS)
XX
SQ MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANF
SQ IPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRA
SQ QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ
SQ TEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFT
SQ LPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYA
SQ ADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRK
SQ GSSSNEPSSDSLSSPTLLAL
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SC translated from EMBL:BC004490
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FT 135 199 
PF00170; bZIP transcription factor.
FT 135 199 
SM00338; brlzneu.
FT 137 200 
PS50217; BZIP.
FT 210 270 
C-terminal trans-activation domain (C-TA) [5].
XX
IN T00167 ATF-2-isoform1; human, Homo sapiens.
IN T09531 ATF-4; human, Homo sapiens.
IN T18798 ATFa-isoform3; human, Homo sapiens.
IN T08461 c-Jun; human, Homo sapiens.
IN T08587 c-Jun; mouse, Mus musculus.
IN T09526 CHOP-10-isoform1; human, Homo sapiens.
IN T09550 CREBPA-Alpha; human, Homo sapiens.
IN T08990 Fra-2-isoform1; human, Homo sapiens.
IN T08491 JunB; human, Homo sapiens.
IN T08995 JunD; human, Homo sapiens.
IN T09646 MafB; human, Homo sapiens.
IN T30231 SIRT1-isoform1; human, Homo sapiens.
XX
MX M00172 V$AP1FJ_Q2.
MX M00517 V$AP1_01.
MX M02280 V$AP1_02.
MX M00924 V$AP1_Q2_01.
MX M00926 V$AP1_Q4_01.
MX M00925 V$AP1_Q6_01.
MX M03815 V$CFOS_Q6.
XX
BS R03910.
BS R16318.
BS R67301.
BS R67302.
BS R05036.
BS R05079.
BS R04032.
XX
DR TRANSPATH: MO000079681.
DR EMBL: K00650; HSFOS.
DR EMBL: M15429; HSCFOS01.
DR EMBL: V01512; HSCFOS.
DR EMBL: X53723; HSCFOSRE.
DR UniProtKB: P01100; FOS_HUMAN.
DR PDB: 1fos.
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RN [1]; RE0005544.
RX PUBMED: 1631061.
RA Chevray P. M., Nathans D.
RT Protein interaction cloning in yeast: identification of mammalian proteins that react with the leucine zipper of Jun
RL Proc. Natl. Acad. Sci. USA 89:5789-5793 (1992).
RN [2]; RE0048287.
RX PUBMED: 12805554.
RA Newman J. R., Keating A. E.
RT Comprehensive identification of human bZIP interactions with coiled-coil arrays.
RL Science 300:2097-2101 (2003).
RN [3]; RE0066089.
RX PUBMED: 20042607.
RA Zhang R., Chen H. Z., Liu J. J., Jia Y. Y., Zhang Z. Q., Yang R. F., Zhang Y., Xu J., Wei Y. S., Liu D. P., Liang C. C.
RT SIRT1 Suppresses Activator Protein-1 Transcriptional Activity and Cyclooxygenase-2 Expression in Macrophages.
RL J. Biol. Chem. 285:7097-7110 (2010).
RN [4]; RE0070412.
RX PUBMED: 20498278.
RA Adler J., Reuven N., Kahana C., Shaul Y.
RT c-Fos proteasomal degradation is activated by a default mechanism, and its regulation by NAD(P)H:quinone oxidoreductase 1 determines c-Fos serum response kinetics.
RL Mol. Cell. Biol. 30:3767-3778 (2010).
RN [5]; RE0004812.
RX PUBMED: 2108402.
RA Hirai S.-I., Bourachot D., Yaniv M.
RT Both Jun and Fos contribute to transcription activation by the heterodimer
RL Oncogene 5:39-46 (1990).
XX
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