AC T05778
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ID T05778
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DT 04.12.2003 (created); oke.
DT 04.03.2010 (updated); mku.
CO Copyright (C), QIAGEN.
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FA ASC-2
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SY Activating signal cointegrator 2; Amplified in breast cancer protein 3; Cancer-amplified transcriptional coactivator ASC-2; NRC; Nuclear receptor coactivator 6; Peroxisome proliferator-activated receptor-interacting protein; PPAR-interacting protein; PRIP; RAP250; Thyroid hormone receptor-binding protein; TRBP.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009073 NCOA6; HGNC: NCOA6.
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SF contains two nuclear receptor interaction domains of LXXLL-type;
SF N-terminal LXXLL-motif binds several different nuclear receptors;
SF the second LXXLL-motif binds specifically to LXR-alpha and LXR-beta [1] [2];
SF activation domain AD consists of three subdomains: AD1, AD2, AD3;
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FF co-activator;
FF co-activator for PPAR, LXR [1];
FF recruits CBP to mediate transactivation by nuclear receptors [2];
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IN T00105 C/EBPalpha; human, Homo sapiens.
IN T08515 ER-beta; human, Homo sapiens.
IN T03828 HNF-4alpha; human, Homo sapiens.
IN T10036 HSF1; human, Homo sapiens.
IN T04453 LXR-beta; human, Homo sapiens.
IN T05351 PPARgamma; human, Homo sapiens.
IN T02748 RORbeta; human, Homo sapiens.
IN T02749 RORgamma; human, Homo sapiens.
IN T00765 SRF-L; mouse, Mus musculus.
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DR TRANSPATH: MO000038202.
DR UniProtKB: Q14686;
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RN [1]; RE0023608.
RX PUBMED: 12724417.
RA Kim S. W., Park K., Kwak E., Choi E., Lee S., Ham J., Kang H., Kim J. M., Hwang S. Y., Kong Y. Y., Lee K., Lee J. W.
RT Activating signal cointegrator 2 required for liver lipid metabolism mediated by liver X receptors in mice.
RL Mol. Cell. Biol. 23:3583-3592 (2003).
RN [2]; RE0023609.
RX PUBMED: 11158331.
RA Lee S. K., Jung S. Y., Kim Y. S., Na S. Y., Lee Y. C., Lee J. W.
RT Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2.
RL Mol. Endocrinol. 15:241-254 (2001).
RN [3]; RE0047831.
RX PUBMED: 11302752.
RA Hong S., Lee M. Y., Cheong J.
RT Functional interaction of transcriptional coactivator ASC-2 and C/EBPalpha in granulocyte differentiation of HL-60 promyelocytic cell.
RL Biochem. Biophys. Res. Commun. 282:1257-1262 (2001).
RN [4]; RE0047851.
RX PUBMED: 10847592.
RA Lee S. K., Na S. Y., Jung S. Y., Choi J. E., Jhun B. H., Cheong J., Meltzer P. S., Lee Y. C., Lee J. W.
RT Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2.
RL Mol. Endocrinol. 14:915-925 (2000).
RN [5]; RE0048044.
RX PUBMED: 14960326.
RA Hong S., Kim S. H., Heo M. A., Choi Y. H., Park M. J., Yoo M. A., Kim H. D., Kang H. S., Cheong J.
RT Coactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shock.
RL FEBS Lett. 559:165-170 (2004).
RN [6]; RE0054989.
RX PUBMED: 15604093.
RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M.
RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
RL Mol. Cell. Proteomics 4:205-213 (2005).
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