AC T04453
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ID T04453
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DT 01.05.2001 (created); mas.
DT 21.07.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA LXR-beta
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SY LXR B; LXRB; NER; NR1H2; nuclear orphan receptor LXR-beta; orphan nuclear receptor OR-1; oxysterol receptor LXR-beta; ubiquitously expressed nuclear receptor; UR.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002742 NR1H2; HGNC: NR1H2.
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CL C0002; CC (rec); 2.1.2.7.2.
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FF functional activation by oxysterols 24(S),25-epoxycholesterol, 24(S)-hydroxycholesterol and 22(R)-hydroxycholesterol [1] [2];
FF ligand selectivity distinct from isoform T02752 (weaker binding to 5,6-24(S),25-di-epoxycholesterol) [1];
FF heterodimerization with RXR-alpha T01345: this dimer seems to induce transcription of CEPT gene G001194 in response to sterols (9-cis retinoid acid, 22(R)-hydroxycholesterol) via binding to promotor region R09975 [3];
FF seems to play a critical role in regulation of cholesterol homeostasis probably as a member of new hormonal signaling pathway that activates transcription in response to oxysterols [2];
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IN T05778 ASC-2; human, Homo sapiens.
IN T33762 DRIP205; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T02938 FOXO3a; human, Homo sapiens.
IN T04687 NCOR1; human, Homo sapiens.
IN T01345 RXR-alpha; human, Homo sapiens.
IN T01334 RXR-beta; human, Homo sapiens.
IN T04807 RXR-gamma; human, Homo sapiens.
IN T04689 SMRT; human, Homo sapiens.
IN T04632 SRC-1; human, Homo sapiens.
IN T04640 SRC3; human, Homo sapiens.
IN T22485 ZXDL; human, Homo sapiens.
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MX M00965 V$DR4_Q2.
MX M00647 V$LXR_Q3.
MX M03795 V$LXR_Q6.
MX M07280 V$NR1NR2_Q3.
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BS R37612.
BS R09975.
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DR TRANSPATH: MO000028303.
DR UniProtKB: P55055;
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RN [1]; RE0013644.
RX PUBMED: 9874807.
RA Janowski B. A., Grogan M. J., Jones S. A., Wisely G. B., Kliewer S. A., Corey E. J., Mangelsdorf D. J.
RT Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta
RL Proc. Natl. Acad. Sci. USA 96:266-271 (1999).
RN [2]; RE0016108.
RX PUBMED: 9013544.
RA Lehmann J. M., Kliewer S. A., Moore L. B., Smith-Oliver T. A., Oliver B. B., Su J. L., Sundseth S. S., Winegar D. A., Blanchard D. E., Spencer T. A., Willson T. M.
RT Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
RL J. Biol. Chem. 272:3137-3140 (1997).
RN [3]; RE0016120.
RX PUBMED: 10683381.
RA Luo Y., Tall A. R.
RT Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element
RL J. Clin. Invest. 105:513-520 (2000).
RN [4]; RE0022921.
RX PUBMED: 12393874.
RA Mo J., Fang S. J., Chen W., Blobe G. C.
RT Regulation of ALK-1 signaling by the nuclear receptor LXRbeta.
RL J. Biol. Chem. 277:50788-50794 (2002).
RN [5]; RE0054989.
RX PUBMED: 15604093.
RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M.
RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
RL Mol. Cell. Proteomics 4:205-213 (2005).
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