AC T04640
XX
ID T04640
XX
DT 24.07.2001 (created); mas.
DT 15.05.2014 (updated); ili.
CO Copyright (C), QIAGEN.
XX
FA SRC3
XX
SY ACTR; ACTR/RAC3/AIB1/TRAM-1; AIB1; CAGH16; CTG26; NCOA3; nuclear receptor coactivator 3; p/CIP; pCIP; RAC3; SRC3; steroid receptor coactivator-3; TNRC14; TNRC16; TRAM-1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G002759 NCOA3; HGNC: NCOA3.
XX
CL C0010; bHLH; 1.2.5.3.3.
XX
SF coactivator for the nuclear receptor superfamily (stimulates transactivation) [2];
SF shows histone acetyltransferase (HAT) activity [3];
SF ligand-dependent interaction with nuclear receptors (AF-2 dependent) [3];
SF association with several nuclear receptors on their DNA-bindings sites (e.g. following dimers: RXR-alpha T01345/RXR-alpha T01345, TR-beta T00851/RXR-alpha T01345, RAR-alpha T00719/RXR-alpha T01345) [3];
XX
EX adrenal gland (right and left),,,adult; very low; Northern blot; mRNA (poly-A); [2].
EX bone marrow,,,adult; low; Northern blot; mRNA (poly-A); [2].
EX brain,,,adult; medium; Northern blot; RNA (undefined); [3].
EX brain,,,adult; very low; Northern blot; mRNA (poly-A); [2].
EX heart,,,adult; high; Northern blot; RNA (undefined); [3].
EX heart,,,adult; high; Northern blot; mRNA (poly-A); [2].
EX kidney (right and left),,,adult; very low; Northern blot; RNA (undefined); [3].
EX kidney (right and left),,,adult; very low; Northern blot; mRNA (poly-A); [2].
EX liver,,,adult; low; Northern blot; RNA (undefined); [3].
EX liver,,,adult; very low; Northern blot; mRNA (poly-A); [2].
EX lung (right and left),,,adult; low; Northern blot; RNA (undefined); [3].
EX lung (right and left),,,adult; very low; Northern blot; mRNA (poly-A); [2].
EX mammary gland,,,adult; high; Northern blot; mRNA (poly-A); [2].
EX muscles,,,adult; high; Northern blot; RNA (undefined); [3].
EX muscles,,,adult; high; Northern blot; mRNA (poly-A); [2].
EX pancreas,,,adult; high; Northern blot; RNA (undefined); [3].
EX pituitary gland of diencephalon,,,adult; high; Northern blot; mRNA (poly-A); [2].
EX placenta,,,adult; high; Northern blot; RNA (undefined); [3].
EX stomach,,,adult; very low; Northern blot; mRNA (poly-A); [2].
EX testis (right and left),,,adult; high; Northern blot; mRNA (poly-A); [2].
EX uterus,,,adult; high; Northern blot; mRNA (poly-A); [2].
XX
IN T08487 AR-isoform1; human, Homo sapiens.
IN T00040 AR; human, Homo sapiens.
IN T08495 c-Ets-1; human, Homo sapiens.
IN T10523 c-Ets-2; human, Homo sapiens.
IN T15118 CBP; Mammalia.
IN T08300 ER-alpha-L; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T08515 ER-beta; human, Homo sapiens.
IN T09602 ER; Mammalia.
IN T02765 ERR1; human, Homo sapiens.
IN T04644 ERR3-isoform1; mouse, Mus musculus.
IN T05076 GR; human, Homo sapiens.
IN T02752 LXR-alpha; human, Homo sapiens.
IN T04453 LXR-beta; human, Homo sapiens.
IN T09029 LXR-beta; human, Homo sapiens.
IN T01946 NFATc3; human, Homo sapiens.
IN T00719 NR1B1-isoform1; human, Homo sapiens.
IN T05299 NR1B1; human, Homo sapiens.
IN T08321 p53-isoform1; human, Homo sapiens.
IN T00720 RAR-gamma; human, Homo sapiens.
IN T01345 RXR-alpha; human, Homo sapiens.
IN T00841 T3R-alpha; rat, Rattus norvegicus.
IN T00851 T3R-beta1; human, Homo sapiens.
IN T08264 T3R-beta; human, Homo sapiens.
IN T00885 VDR; human, Homo sapiens.
XX
DR TRANSPATH: MO000028473.
DR UniProtKB: Q9Y6Q9;
XX
RN [1]; RE0006133.
RX PUBMED: 9192892.
RA Torchia J., Rose D. W., Inostroza J., Westin S., Glass C. K., Rosenfeld M. G.
RT The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
RL Nature 387:677-684 (1997).
RN [2]; RE0016496.
RX PUBMED: 9765300.
RA Suen C. S., Berrodin T. J., Mastroeni R., Cheskis B. J., Lyttle C. R., Frail D. E.
RT A transcriptional coactivator, steroid receptor coactivator-3, selectively augments steroid receptor transcriptional activity
RL J. Biol. Chem. 273:27645-27653 (1998).
RN [3]; RE0016535.
RX PUBMED: 9267036.
RA Chen H., Lin R. J., Schiltz R. L., Chakravarti D., Nash A., Nagy L., Privalsky M. L., Nakatani Y., Evans R. M.
RT Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300
RL Cell 90:569-580 (1997).
RN [4]; RE0018271.
RX PUBMED: 10617585.
RA Naltner A., Ghaffari M., Whitsett J. A., Yan C.
RT Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent.
RL J. Biol. Chem. 275:56-62 (2000).
RN [5]; RE0033835.
RX PUBMED: 11747336.
RA Gnanapragasam V. J., Leung H. Y., Pulimood A. S., Neal D. E., Robson C. N.
RT Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer.
RL Br. J. Cancer 85:1928-36 (2001).
RN [6]; RE0041230.
RX PUBMED: 10747867.
RA Kobayashi Y., Kitamoto T., Masuhiro Y., Watanabe M., Kase T., Metzger D., Yanagisawa J., Kato S.
RT p300 mediates functional synergism between AF-1 and AF-2 of estrogen receptor alpha and beta by interacting directly with the N-terminal A/B domains
RL J. Biol. Chem. 275:15645-51 (2000).
RN [7]; RE0046883.
RX PUBMED: 15169784.
RA Mishra S. K., Talukder A. H., Gururaj A. E., Yang Z., Singh R. R., Mahoney M. G., Franci C., Vadlamudi R. K., Kumar R.
RT Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathway
RL J. Biol. Chem. 279:32709-15 (2004).
RN [8]; RE0047715.
RX PUBMED: 11266503.
RA Zilliacus J., Holter E., Wakui H., Tazawa H., Treuter E., Gustafsson J. A.
RT Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140.
RL Mol. Endocrinol. 15:501-511 (2001).
RN [9]; RE0048002.
RX PUBMED: 15788656.
RA Myers E., Hill A. D., Kelly G., McDermott E. W., O'Higgins N. J., Buggy Y., Young L. S.
RT Associations and interactions between Ets-1 and Ets-2 and coregulatory proteins, SRC-1, AIB1, and NCoR in breast cancer.
RL Clin. Cancer Res. 11:2111-2122 (2005).
RN [10]; RE0048011.
RX PUBMED: 10551785.
RA Lee S. K., Kim H. J., Kim J. W., Lee J. W.
RT Steroid receptor coactivator-1 and its family members differentially regulate transactivation by the tumor suppressor protein p53.
RL Mol. Endocrinol. 13:1924-1933 (1999).
RN [11]; RE0048217.
RX PUBMED: 11971985.
RA Wu R. C., Qin J., Hashimoto Y., Wong J., Xu J., Tsai S. Y., Tsai M. J., O'Malley B. W.
RT Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase.
RL Mol. Cell. Biol. 22:3549-3561 (2002).
RN [12]; RE0048366.
RX PUBMED: 16373397.
RA Li J., Fu J., Toumazou C., Yoon H. G., Wong J.
RT A role of the amino-terminal (N) and carboxyl-terminal (C) interaction in binding of androgen receptor to chromatin.
RL Mol. Endocrinol. 20:776-785 (2006).
RN [13]; RE0051310.
RX PUBMED: 16354658.
RA Albers M., Blume B., Schlueter T., Wright M. B., Kober I., Kremoser C., Deuschle U., Koegl M.
RT A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors.
RL J. Biol. Chem. 281:4920-4930 (2006).
RN [14]; RE0051786.
RX PUBMED: 10224118.
RA Jimenez-Lara A. M., Aranda A.
RT Lysine 246 of the vitamin D receptor is crucial for ligand-dependent interaction with coactivators and transcriptional activity.
RL J. Biol. Chem. 274:13503-13510 (1999).
RN [15]; RE0053575.
RX PUBMED: 10866661.
RA Font de Mora J., Brown M.
RT AIB1 is a conduit for kinase-mediated growth factor signaling to the estrogen receptor.
RL Mol. Cell. Biol. 20:5041-5047 (2000).
RN [16]; RE0054247.
RX PUBMED: 15604293.
RA Cui Y., Zhang M., Pestell R., Curran E. M., Welshons W. V., Fuqua S. A.
RT Phosphorylation of estrogen receptor alpha blocks its acetylation and regulates estrogen sensitivity.
RL Cancer Res. 64:9199-9208 (2004).
RN [17]; RE0054653.
RX PUBMED: 10490106.
RA Chen H., Lin R. J., Xie W., Wilpitz D., Evans R. M.
RT Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase.
RL Cell 98:675-686 (1999).
RN [18]; RE0054989.
RX PUBMED: 15604093.
RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M.
RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
RL Mol. Cell. Proteomics 4:205-213 (2005).
RN [19]; RE0055017.
RX PUBMED: 16227615.
RA Yi P., Wu R. C., Sandquist J., Wong J., Tsai S. Y., Tsai M. J., Means A. R., O'Malley B. W.
RT Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1).
RL Mol. Cell. Biol. 25:9687-9699 (2005).
RN [20]; RE0062855.
RX PUBMED: 19117054.
RA Karmakar S., Foster E. A., Smith C. L.
RT Estradiol downregulation of the tumor suppressor gene BTG2 requires estrogen receptor-alpha and the REA corepressor.
RL Int. J. Cancer 124:1841-1851 (2009).
RN [21]; RE0062988.
RX PUBMED: 17998543.
RA Zou J. X., Revenko A. S., Li L. B., Gemo A. T., Chen H. W.
RT ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification.
RL Proc. Natl. Acad. Sci. USA 104:18067-18072 (2007).
RN [22]; RE0065788.
RX PUBMED: 19198599.
RA Kajiro M., Hirota R., Nakajima Y., Kawanowa K., So-ma K., Ito I., Yamaguchi Y., Ohie S. H., Kobayashi Y., Seino Y., Kawano M., Kawabe Y., Takei H., Hayashi S., Kurosumi M., Murayama A., Kimura K., Yanagisawa J.
RT The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways.
RL Nat. Cell Biol. 11:312-319 (2009).
XX
//