TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T08495 XX ID T08495 XX DT 30.01.2006 (created); res. DT 15.06.2015 (updated); asv. CO Copyright (C), QIAGEN. XX FA c-Ets-1 XX SY c-Ets-1; c-Ets-1 54; c-Ets-1A; Ets1; p54; p54c-Ets-1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G000217 ETS1; HGNC: Ets1. XX CL C0016; ETS; XX CP Dimethylsulfoxide treated erythroblasts [10]. XX FF Overexpression inhibits erythroid differentiation in K562 cells [10]; FF P42 isoform inhibits tumorigenicity of colon cancer DLD-1 cells (mouse) by inducing apoptosis [7]; FF Me2SO-inducible [9]; FF Binding activity of c-Ets-1 upon Transferrin Receptor gene is downmodulated during erythroid maturation in response to the dimethyl sulfoxide treatment. [10]; FF Both p42 and p51 can induce apoptosis in mouse MOP8 cells [7]; XX IN T10523 c-Ets-2; human, Homo sapiens. IN T08587 c-Jun; mouse, Mus musculus. IN T02944 Daxx; human, Homo sapiens. IN T08590 JunB; mouse, Mus musculus. IN T08536 JunD; mouse, Mus musculus. IN T00671 p53; human, Homo sapiens. IN T22434 Prox-1-isoform1; human, Homo sapiens. IN T04632 SRC-1; human, Homo sapiens. IN T04640 SRC3; human, Homo sapiens. XX MX M00032 V$CETS1P54_01. MX M00074 V$CETS1P54_02. MX M01078 V$CETS1P54_03. MX M02063 V$CETS1_02. MX M01870 V$CETS1_Q6. MX M03977 V$ETS1_02. MX M04692 V$ETS1_04. MX M04703 V$ETS1_05. MX M04822 V$ETS1_06. MX M04886 V$ETS1_07. MX M00339 V$ETS1_B. MX M08881 V$ETSLIKE_Q4. MX M00340 V$ETS_B. MX M00771 V$ETS_Q4. MX M00971 V$ETS_Q6. XX BS R19160. BS R31226. BS R04050. BS R26156. BS R26589. BS R28635. BS R29802. BS R26234. BS R25503. BS R25504. BS R26717. BS R56828. BS R26588. BS R19694. BS R21313. BS R65046. BS R65047. BS R63873. BS R23182. BS R23196. BS R36999. BS R00604. BS R25459. BS R25460. BS R25463. BS R25511. BS R42430. BS R37791. BS R26368. BS R26369. BS R28630. BS R28632. BS R66853. BS R73629. BS R66865. BS R66867. BS R28164. BS R25983. BS R35819. BS R41362. BS R37000. BS R35879. BS R39411. BS R65060. BS R29739. BS R73050. BS R38325. BS R19534. BS R29733. BS R36904. BS R26594. BS R26595. BS R59386. BS R59388. BS R62387. BS R62388. BS R65352. BS R59839. BS R59007. BS R12728. BS R25331. BS R55806. BS R31008. BS R59006. BS R60667. BS R31223. BS R22307. BS R23482. BS R36244. BS R71869. BS R72410. BS R38514. BS R62401. BS R25528. BS R25529. BS R26667. BS R37184. BS R35635. BS R14803. BS R14156. BS R40232. BS R67202. BS R29978. BS R32684. BS R27187. BS R25496. BS R64205. BS R35424. BS R31068. BS R24059. BS R26598. BS R26599. BS R29725. BS R36638. BS R68282. BS R20708. BS R20709. BS R42074. BS R25987. BS R26155. BS R34298. BS R20307. BS R20309. XX DR TRANSPATH: MO000059013. DR TRANSCOMPEL: C00477. DR TRANSCOMPEL: C00640. DR UniProtKB: P14921; ETS1_HUMAN. XX RN [1]; RE0016689. RX PUBMED: 7648395. RA Bassuk A. G., Leiden J. M. RT A direct physical association between ETS and AP-1 transcription factors in normal human T cells. RL Immunity 3:223-237 (1995). RN [2]; RE0016714. RX PUBMED: 9334186. RA Basuyaux J. P., Ferreira E., Stehelin D., Buttice G. RT The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner. RL J. Biol. Chem. 272:26188-26195 (1997). RN [3]; RE0048002. RX PUBMED: 15788656. RA Myers E., Hill A. D., Kelly G., McDermott E. W., O'Higgins N. J., Buggy Y., Young L. S. RT Associations and interactions between Ets-1 and Ets-2 and coregulatory proteins, SRC-1, AIB1, and NCoR in breast cancer. RL Clin. Cancer Res. 11:2111-2122 (2005). RN [4]; RE0048225. RX PUBMED: 15123671. RA Liu H., Holm M., Xie X. Q., Wolf-Watz M., Grundstrom T. RT AML1/Runx1 recruits calcineurin to regulate granulocyte macrophage colony-stimulating factor by Ets1 activation. RL J. Biol. Chem. 279:29398-29408 (2004). RN [5]; RE0048258. RX PUBMED: 12743594. RA Pei H., Yordy J. S., Leng Q., Zhao Q., Watson D. K., Li R. RT EAPII interacts with ETS1 and modulates its transcriptional function. RL Oncogene 22:2699-2709 (2003). RN [6]; RE0048396. RX PUBMED: 16818466. RA Presnell S. R., Zhang L., Ramilo C. A., Chan H. W., Lutz C. T. RT Functional redundancy of transcription factor-binding sites in the killer cell Ig-like receptor (KIR) gene promoter. RL Int. Immunol. 18:1221-1232 (2006). RN [7]; RE0048558. RX PUBMED: 16103071. RA Pei H., Li C., Adereth Y., Hsu T., Watson D. K., Li R. RT Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis. RL Cancer Res. 65:7205-7213 (2005). RN [8]; RE0048582. RX PUBMED: 11919190. RA Czuwara-Ladykowska J., Sementchenko V. I., Watson D. K., Trojanowska M. RT Ets1 is an effector of the transforming growth factor beta (TGF-beta ) signaling pathway and an antagonist of the profibrotic effects of TGF-beta. RL J. Biol. Chem. 277:20399-20408 (2002). RN [9]; RE0048958. RX PUBMED: 9874259. RA Minami T., Tachibana K., Imanishi T., Doi T. RT Both Ets-1 and GATA-1 are essential for positive regulation of platelet factor 4 gene expression. RL Eur. J. Biochem. 258:879-889 (1998). RN [10]; RE0052679. RX PUBMED: 12439744. RA Marziali G., Perrotti E., Ilari R., Lulli V., Coccia E. M., Moret R., Kuhn L. C., Testa U., Battistini A. RT Role of Ets-1 in transcriptional regulation of transferrin receptor and erythroid differentiation. RL Oncogene 21:7933-7944 (2002). RN [11]; RE0054892. RX PUBMED: 16373364. RA Wang J., Shannon M. F., Young I. G. RT A role for Ets1, synergizing with AP-1 and GATA-3 in the regulation of IL-5 transcription in mouse Th2 lymphocytes. RL Int. Immunol. 18:313-323 (2006). XX //