AC T08495
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ID T08495
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DT 30.01.2006 (created); res.
DT 15.06.2015 (updated); asv.
CO Copyright (C), QIAGEN.
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FA c-Ets-1
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SY c-Ets-1; c-Ets-1 54; c-Ets-1A; Ets1; p54; p54c-Ets-1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G000217 ETS1; HGNC: Ets1.
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CL C0016; ETS; 3.5.2.1.1.
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CP Dimethylsulfoxide treated erythroblasts [10].
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FF Overexpression inhibits erythroid differentiation in K562 cells [10];
FF P42 isoform inhibits tumorigenicity of colon cancer DLD-1 cells (mouse) by inducing apoptosis [7];
FF Me2SO-inducible [9];
FF Binding activity of c-Ets-1 upon Transferrin Receptor gene is downmodulated during erythroid maturation in response to the dimethyl sulfoxide treatment. [10];
FF Both p42 and p51 can induce apoptosis in mouse MOP8 cells [7];
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IN T10523 c-Ets-2; human, Homo sapiens.
IN T08587 c-Jun; mouse, Mus musculus.
IN T02944 Daxx; human, Homo sapiens.
IN T08590 JunB; mouse, Mus musculus.
IN T08536 JunD; mouse, Mus musculus.
IN T00671 p53; human, Homo sapiens.
IN T22434 Prox-1-isoform1; human, Homo sapiens.
IN T04632 SRC-1; human, Homo sapiens.
IN T04640 SRC3; human, Homo sapiens.
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MX M00032 V$CETS1P54_01.
MX M00074 V$CETS1P54_02.
MX M01078 V$CETS1P54_03.
MX M02063 V$CETS1_02.
MX M01870 V$CETS1_Q6.
MX M03977 V$ETS1_02.
MX M04692 V$ETS1_04.
MX M04703 V$ETS1_05.
MX M04822 V$ETS1_06.
MX M04886 V$ETS1_07.
MX M00339 V$ETS1_B.
MX M08881 V$ETSLIKE_Q4.
MX M00340 V$ETS_B.
MX M00771 V$ETS_Q4.
MX M00971 V$ETS_Q6.
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BS R19160.
BS R31226.
BS R04050.
BS R26156.
BS R26589.
BS R28635.
BS R29802.
BS R26234.
BS R25503.
BS R25504.
BS R26717.
BS R56828.
BS R26588.
BS R19694.
BS R21313.
BS R65046.
BS R65047.
BS R63873.
BS R23182.
BS R23196.
BS R36999.
BS R00604.
BS R25459.
BS R25460.
BS R25463.
BS R25511.
BS R42430.
BS R37791.
BS R26368.
BS R26369.
BS R28630.
BS R28632.
BS R66853.
BS R73629.
BS R66865.
BS R66867.
BS R28164.
BS R25983.
BS R35819.
BS R41362.
BS R37000.
BS R35879.
BS R39411.
BS R65060.
BS R29739.
BS R73050.
BS R38325.
BS R19534.
BS R29733.
BS R36904.
BS R26594.
BS R26595.
BS R59386.
BS R59388.
BS R62387.
BS R62388.
BS R65352.
BS R59839.
BS R59007.
BS R12728.
BS R25331.
BS R55806.
BS R31008.
BS R59006.
BS R60667.
BS R31223.
BS R22307.
BS R23482.
BS R36244.
BS R71869.
BS R72410.
BS R38514.
BS R62401.
BS R25528.
BS R25529.
BS R26667.
BS R37184.
BS R35635.
BS R14803.
BS R14156.
BS R40232.
BS R67202.
BS R29978.
BS R32684.
BS R27187.
BS R25496.
BS R64205.
BS R35424.
BS R31068.
BS R24059.
BS R26598.
BS R26599.
BS R29725.
BS R36638.
BS R68282.
BS R20708.
BS R20709.
BS R42074.
BS R25987.
BS R26155.
BS R34298.
BS R20307.
BS R20309.
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DR TRANSPATH: MO000059013.
DR TRANSCOMPEL: C00477.
DR TRANSCOMPEL: C00640.
DR UniProtKB: P14921; ETS1_HUMAN.
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RN [1]; RE0016689.
RX PUBMED: 7648395.
RA Bassuk A. G., Leiden J. M.
RT A direct physical association between ETS and AP-1 transcription factors in normal human T cells.
RL Immunity 3:223-237 (1995).
RN [2]; RE0016714.
RX PUBMED: 9334186.
RA Basuyaux J. P., Ferreira E., Stehelin D., Buttice G.
RT The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner.
RL J. Biol. Chem. 272:26188-26195 (1997).
RN [3]; RE0048002.
RX PUBMED: 15788656.
RA Myers E., Hill A. D., Kelly G., McDermott E. W., O'Higgins N. J., Buggy Y., Young L. S.
RT Associations and interactions between Ets-1 and Ets-2 and coregulatory proteins, SRC-1, AIB1, and NCoR in breast cancer.
RL Clin. Cancer Res. 11:2111-2122 (2005).
RN [4]; RE0048225.
RX PUBMED: 15123671.
RA Liu H., Holm M., Xie X. Q., Wolf-Watz M., Grundstrom T.
RT AML1/Runx1 recruits calcineurin to regulate granulocyte macrophage colony-stimulating factor by Ets1 activation.
RL J. Biol. Chem. 279:29398-29408 (2004).
RN [5]; RE0048258.
RX PUBMED: 12743594.
RA Pei H., Yordy J. S., Leng Q., Zhao Q., Watson D. K., Li R.
RT EAPII interacts with ETS1 and modulates its transcriptional function.
RL Oncogene 22:2699-2709 (2003).
RN [6]; RE0048396.
RX PUBMED: 16818466.
RA Presnell S. R., Zhang L., Ramilo C. A., Chan H. W., Lutz C. T.
RT Functional redundancy of transcription factor-binding sites in the killer cell Ig-like receptor (KIR) gene promoter.
RL Int. Immunol. 18:1221-1232 (2006).
RN [7]; RE0048558.
RX PUBMED: 16103071.
RA Pei H., Li C., Adereth Y., Hsu T., Watson D. K., Li R.
RT Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis.
RL Cancer Res. 65:7205-7213 (2005).
RN [8]; RE0048582.
RX PUBMED: 11919190.
RA Czuwara-Ladykowska J., Sementchenko V. I., Watson D. K., Trojanowska M.
RT Ets1 is an effector of the transforming growth factor beta (TGF-beta ) signaling pathway and an antagonist of the profibrotic effects of TGF-beta.
RL J. Biol. Chem. 277:20399-20408 (2002).
RN [9]; RE0048958.
RX PUBMED: 9874259.
RA Minami T., Tachibana K., Imanishi T., Doi T.
RT Both Ets-1 and GATA-1 are essential for positive regulation of platelet factor 4 gene expression.
RL Eur. J. Biochem. 258:879-889 (1998).
RN [10]; RE0052679.
RX PUBMED: 12439744.
RA Marziali G., Perrotti E., Ilari R., Lulli V., Coccia E. M., Moret R., Kuhn L. C., Testa U., Battistini A.
RT Role of Ets-1 in transcriptional regulation of transferrin receptor and erythroid differentiation.
RL Oncogene 21:7933-7944 (2002).
RN [11]; RE0054892.
RX PUBMED: 16373364.
RA Wang J., Shannon M. F., Young I. G.
RT A role for Ets1, synergizing with AP-1 and GATA-3 in the regulation of IL-5 transcription in mouse Th2 lymphocytes.
RL Int. Immunol. 18:313-323 (2006).
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