TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00841 AS T00839. XX ID T00841 XX DT 15.10.1992 (created); ewi. DT 08.12.2015 (updated); sup. CO Copyright (C), QIAGEN. XX FA T3R-alpha XX SY c-ErbAalpha; T3R-alpha; thyroid hormone receptor-alpha; TR. XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G005220 Thra. XX CL C0002; CC (rec); XX SF two splice variants are known, see T3R-alpha1 T01342, T3R-alpha2 T01343; XX FF T3-binding with KD = 0.4 nM (alpha1); FF may enhance transcriptional activation by c-Jun; FF phosphorylation; XX IN T34290 Alien; human, Homo sapiens. IN T00117 CF1; fruit fly, Drosophila melanogaster. IN T00719 NR1B1-isoform1; human, Homo sapiens. IN T00720 RAR-gamma; human, Homo sapiens. IN T00716 RAR; monkey, Cercopithecus aethiops. IN T00717 RAR; mouse, Mus musculus. IN T01331 RXR-alpha; mouse, Mus musculus. IN T01345 RXR-alpha; human, Homo sapiens. IN T04640 SRC3; human, Homo sapiens. XX MX M01724 V$T3RALPHA_Q6. MX M00963 V$T3R_Q6. XX BS R04447. BS R27672. BS R01465. BS R03953. BS R04783. BS R04784. BS R04785. BS R04786. BS R04787. BS R01673. BS R31685. BS R38689. BS R03192. BS R03956. BS R03958. BS R29449. BS R03942. BS R03102. BS R29251. BS R02595. BS R03886. BS R22508. BS R35101. BS R30519. BS R00614. BS R00615. BS R00617. BS R00619. BS R00621. BS R03959. BS R01617. BS R04018. BS R56397. BS R29451. BS R02694. BS R02695. BS R02696. BS R03523. BS R35103. XX DR TRANSPATH: MO000025211. DR TRANSCOMPEL: C00504. DR EMBL: M18028; DR EMBL: X07409; DR UniProtKB: P63059; XX RN [1]; RE0000843. RX PUBMED: 3032962. RA Ye Z.-S., Samuels H. H. RT Cell- and Sequence-specific Binding of Nuclear Proteins to 5'-Flanking DNA of the Rat Growth Hormone Gene RL J. Biol. Chem. 262:6313-6317 (1987). RN [2]; RE0000878. RX PUBMED: 2457590. RA Murray M. B., Zilz N. D., McCreary N. L., MacDonald M. J., Towle H. C. RT Isolation and characterization of rat cDNA clones for two distinct thyroid hormone receptors RL J. Biol. Chem. 263:12770-12777 (1988). RN [3]; RE0000994. RX PUBMED: 2033067. RA Tansey W. P., Catanzaro D. F. RT Sp1 and thyroid hormone receptor differentially activate expression of human growth hormone and chorionic somatomammotropin genes RL J. Biol. Chem. 266:9805-9813 (1991). RN [4]; RE0001498. RX PUBMED: 1922030. RA Lazar M. A., Berrodin T. J., Harding H. P. RT Differential DNA binding by monomeric, homodimeric, and potentially heteromeric forms of the thyroid hormone receptor RL Mol. Cell. Biol. 11:5005-5015 (1991). RN [5]; RE0001838. RX PUBMED: 2841611. RA Izumo S., Mahdavi V. RT Thyroid hormone receptor alpha isoforms generated by alternative splicing differentially activate myosin HC gene transcription RL Nature 334:539-542 (1988). RN [6]; RE0001851. RX PUBMED: 2733791. RA Damm K., Thompson C. C., Evans R. M. RT Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist RL Nature 339:593-597 (1989). RN [7]; RE0002075. RX PUBMED: 1975094. RA de Verneuil H., Metzger D. RT The lack of transcriptional activation of the v-erbA oncogene is in part due to a mutation in the DNA binding domain of the protein RL Nucleic Acids Res. 18:4489-4497 (1990). RN [8]; RE0002245. RX PUBMED: 1349165. RA Sharif M., Privalsky M. L. RT V-erbA and c-erbA proteins enhance transcriptional activation by c-jun RL Oncogene 7:953-960 (1992). RN [9]; RE0002738. RX PUBMED: 2159385. RA Baniahmad A., Steiner C., Koehne A. C., Renkawitz R. RT Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding site RL Cell 61:505-514 (1990). RN [10]; RE0002748. RX PUBMED: 2332433. RA Petty K. J., Desvergne B., Mitsuhashi T., Nikodem V. M. RT Identification of a thyroid hormone response element in the malic enzyme gene RL J. Biol. Chem. 265:7395-7400 (1990). RN [11]; RE0047704. RX PUBMED: 10207062. RA Dressel U., Thormeyer D., Altincicek B., Paululat A., Eggert M., Schneider S., Tenbaum S. P., Renkawitz R., Baniahmad A. RT Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily. RL Mol. Cell. Biol. 19:3383-3394 (1999). RN [12]; RE0064418. RX PUBMED: 8163464. RA Bogazzi F., Hudson L. D., Nikodem V. M. RT A novel heterodimerization partner for thyroid hormone receptor. Peroxisome proliferator-activated receptor. RL J. Biol. Chem. 269:11683-11686 (1994). XX //