AC T00590
AS T10434.
XX
ID T00590
XX
DT 15.10.1992 (created); ewi.
DT 04.06.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
XX
FA NF-kappaB
XX
SY NFkappaB; Nuclear Factor kappa B.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
HO TC-IIA.
XX
CL C0020; Rel.
XX
SF described as DNA-binding activity, constituted either by a p50 homodimer T00593, a p50/p65 heterodimer T00593 T00594 (or related components), or a heterotetramer;
SF Zn2+-dependent DNA-binding [16];
XX
CP ubiquitous; MCF-7 [51].
XX
FF inducible activator;
FF induced by TNF [50] [17];
FF induced by PKA- or PKC-mediated signals, dsRNA [11] [7] [39] [44] [29] [20];
FF heterodimers p50:p65 are inducible by neuropeptide Substance P and this induction depends on intracellular Ca2+ mobilization [49];
FF key regulator of genes involved in responses to infection, inflammation, stress [48] [49] [50] [46];
FF reduced activity under oxidizing conditions by reactive oxygen intermediates (ROI) [12];
FF a CD28 receptor - tyrosine kinase - PLA2 - 5-lipoxygenase - ROI pathway activates NF-kappaB activity in certain T cells [47];
FF TNF-signalling may involve a phosphatidylcholine-specific PLC and subsequent sphingomyelin breakdown [42];
FF binding sites for NF-kappaB are often overlap with NF-ATp/c binding sites [48] [49];
FF acts synergistically with STAT1 for the regulation of many inflammatory genes [50];
XX
IN T00168 c-Rel; human, Homo sapiens.
IN T00950 IkappaB-alpha; human, Homo sapiens.
IN T00414 IkappaB-beta; human, Homo sapiens.
IN T00416 IkappaB-beta; chick, Gallus gallus.
IN T00971 IkappaB-beta; mouse, Mus musculus.
IN T00759 Sp1; human, Homo sapiens.
IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T).
XX
MX M00054 V$NFKAPPAB_01.
MX M08891 V$NFKB1_Q4.
MX M00208 V$NFKB_C.
MX M00194 V$NFKB_Q6.
MX M00774 V$NFKB_Q6_01.
XX
BS R20825.
BS R20924.
BS R37499.
BS R37751.
BS R02915.
BS R02916.
BS R20630.
BS R26200.
BS R26495.
BS R27932.
BS R56830.
BS R56831.
BS R56846.
BS R56841.
BS R56833.
BS R56844.
BS R00806.
BS R00808.
BS R00699.
BS R00700.
BS R00701.
BS R00702.
BS R00703.
BS R41748.
BS R14659.
BS R63971.
BS R59873.
BS R59877.
BS R63146.
BS R20691.
BS R29919.
BS R33981.
BS R56879.
BS R29246.
BS R74078.
BS R74079.
BS R56894.
BS R30351.
BS R14640.
BS R21071.
BS R21072.
BS R74058.
BS R12279.
BS R14430.
BS R14431.
BS R25318.
BS R27015.
BS R57446.
BS R27591.
BS R16928.
BS R32146.
BS R03340.
BS R03341.
BS R25466.
BS R58572.
BS R56884.
BS R20988.
BS R04475.
BS R12092.
BS R34139.
BS R25605.
BS R18510.
BS R22937.
BS R22941.
BS R03342.
BS R41945.
BS R56892.
BS R30959.
BS R29797.
BS R39859.
BS R08088.
BS R28359.
BS R28480.
BS R28550.
BS R73757.
BS R00920.
BS R00923.
BS R35460.
BS R13472.
BS R13473.
BS R13474.
BS R24519.
BS R56860.
BS R34335.
BS R24754.
BS R30068.
BS R00940.
BS R00942.
BS R00943.
BS R29952.
BS R00933.
BS R00935.
BS R03673.
BS R30260.
BS R34058.
BS R34061.
BS R34062.
BS R01634.
BS R12708.
BS R25017.
BS R30979.
BS R02909.
BS R26564.
BS R30143.
BS R42134.
BS R27192.
BS R73961.
BS R33449.
BS R39330.
BS R02923.
BS R38723.
BS R29088.
BS R58773.
BS R70832.
BS R70833.
BS R58395.
BS R58397.
BS R62888.
BS R25352.
BS R25353.
BS R63048.
BS R19783.
BS R33535.
BS R37207.
BS R74062.
BS R27228.
BS R27229.
BS R17045.
BS R42383.
BS R56896.
BS R27455.
BS R34235.
BS R26362.
BS R26363.
BS R23920.
BS R11382.
BS R31369.
BS R61346.
BS R31409.
BS R27891.
BS R34801.
BS R34802.
BS R17119.
BS R17121.
BS R27221.
BS R01349.
BS R34542.
BS R03275.
BS R73897.
BS R73912.
BS R56876.
BS R56885.
BS R27433.
BS R24686.
BS R32229.
BS R22550.
BS R56877.
BS R56878.
BS R61967.
BS R33969.
BS R56886.
BS R30054.
BS R73153.
BS R37899.
BS R74076.
BS R74077.
BS R34141.
BS R34142.
BS R03186.
BS R14565.
BS R56865.
BS R56872.
BS R56881.
BS R40795.
BS R32204.
BS R26754.
BS R28975.
BS R13277.
BS R33967.
BS R00605.
BS R00606.
BS R14716.
BS R14717.
BS R00877.
BS R29147.
BS R74074.
BS R02951.
BS R24514.
BS R37722.
BS R01056.
BS R01058.
BS R01060.
BS R01065.
BS R04397.
BS R68091.
BS R68096.
BS R68097.
BS R21135.
BS R08104.
BS R02217.
BS R04556.
BS R12714.
BS R16598.
BS R13306.
BS R14446.
BS R37512.
BS R37513.
BS R12707.
BS R38577.
BS R03733.
BS R04905.
BS R08108.
BS R01406.
XX
DR TRANSPATH: MO000019669.
DR TRANSCOMPEL: C00057.
DR TRANSCOMPEL: C00061.
DR TRANSCOMPEL: C00101.
DR TRANSCOMPEL: C00140.
DR TRANSCOMPEL: C00152.
DR TRANSCOMPEL: C00153.
DR TRANSCOMPEL: C00155.
DR TRANSCOMPEL: C00156.
DR TRANSCOMPEL: C00165.
DR TRANSCOMPEL: C00234.
DR TRANSCOMPEL: C00235.
DR TRANSCOMPEL: C00257.
DR TRANSCOMPEL: C00302.
DR TRANSCOMPEL: C00305.
DR TRANSCOMPEL: C00306.
DR TRANSCOMPEL: C00307.
DR TRANSCOMPEL: C00308.
DR TRANSCOMPEL: C00318.
DR TRANSCOMPEL: C00319.
DR TRANSCOMPEL: C00322.
DR TRANSCOMPEL: C00323.
DR TRANSCOMPEL: C00324.
DR TRANSCOMPEL: C00326.
DR TRANSCOMPEL: C00327.
DR TRANSCOMPEL: C00337.
DR TRANSCOMPEL: C00340.
DR TRANSCOMPEL: C00341.
DR TRANSCOMPEL: C00342.
DR TRANSCOMPEL: C00346.
DR TRANSCOMPEL: C00357.
DR TRANSCOMPEL: C00414.
XX
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RT Substance P activates coincident NF-AT- and NF-kappa B-dependent adhesion molecule gene expression in microvascular endothelial cells through intracellular calcium mobilization.
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RT Peroxisome proliferator-activated receptor-gamma activates p53 gene promoter binding to the nuclear factor-kappaB sequence in human MCF7 breast cancer cells.
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RT Rapid expression and activation of MMP-2 and MMP-9 upon exposure of human breast cancer cells (MCF-7) to fibronectin in serum free medium.
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RT Pneumocystis cell wall beta-glucan stimulates calcium-dependent signaling of IL-8 secretion by human airway epithelial cells.
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RT Differential cytokine regulation by NF-kappaB and AP-1 in Jurkat T-cells.
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RT The scaffold protein TANK/I-TRAF inhibits NF-kappaB activation by recruiting polo-like kinase 1.
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RT Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins.
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RT Second messenger role for Mg2+ revealed by human T-cell immunodeficiency.
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RT SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis.
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RT Toll-like receptor 4 is involved in bacterial endotoxin-induced endothelial cell injury and SOC-mediated calcium regulation.
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RT SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex.
RL Nature 471:633-636 (2011).
XX
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