TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00590 AS T10434. XX ID T00590 XX DT 15.10.1992 (created); ewi. DT 04.06.2015 (updated); jmh. CO Copyright (C), QIAGEN. XX FA NF-kappaB XX SY NFkappaB; Nuclear Factor kappa B. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX HO TC-IIA. XX CL C0020; Rel. XX SF described as DNA-binding activity, constituted either by a p50 homodimer T00593, a p50/p65 heterodimer T00593 T00594 (or related components), or a heterotetramer; SF Zn2+-dependent DNA-binding [16]; XX CP ubiquitous; MCF-7 [51]. XX FF inducible activator; FF induced by TNF [50] [17]; FF induced by PKA- or PKC-mediated signals, dsRNA [11] [7] [39] [44] [29] [20]; FF heterodimers p50:p65 are inducible by neuropeptide Substance P and this induction depends on intracellular Ca2+ mobilization [49]; FF key regulator of genes involved in responses to infection, inflammation, stress [48] [49] [50] [46]; FF reduced activity under oxidizing conditions by reactive oxygen intermediates (ROI) [12]; FF a CD28 receptor - tyrosine kinase - PLA2 - 5-lipoxygenase - ROI pathway activates NF-kappaB activity in certain T cells [47]; FF TNF-signalling may involve a phosphatidylcholine-specific PLC and subsequent sphingomyelin breakdown [42]; FF binding sites for NF-kappaB are often overlap with NF-ATp/c binding sites [48] [49]; FF acts synergistically with STAT1 for the regulation of many inflammatory genes [50]; XX IN T00168 c-Rel; human, Homo sapiens. IN T00950 IkappaB-alpha; human, Homo sapiens. IN T00414 IkappaB-beta; human, Homo sapiens. IN T00416 IkappaB-beta; chick, Gallus gallus. IN T00971 IkappaB-beta; mouse, Mus musculus. IN T00759 Sp1; human, Homo sapiens. IN T00897 v-Rel; REV-T, reticuloendotheliosis virus (strain T). XX MX M00054 V$NFKAPPAB_01. MX M08891 V$NFKB1_Q4. MX M00208 V$NFKB_C. MX M00194 V$NFKB_Q6. MX M00774 V$NFKB_Q6_01. XX BS R20825. BS R20924. BS R37499. BS R37751. BS R02915. BS R02916. BS R20630. BS R26200. BS R26495. BS R27932. BS R56830. BS R56831. BS R56846. BS R56841. BS R56833. BS R56844. BS R00806. BS R00808. BS R00699. BS R00700. BS R00701. BS R00702. BS R00703. BS R41748. BS R14659. BS R63971. BS R59873. BS R59877. BS R63146. BS R20691. BS R29919. BS R33981. BS R56879. BS R29246. BS R74078. BS R74079. BS R56894. BS R30351. BS R14640. BS R21071. BS R21072. BS R74058. BS R12279. BS R14430. BS R14431. BS R25318. BS R27015. BS R57446. BS R27591. BS R16928. BS R32146. BS R03340. BS R03341. BS R25466. BS R58572. BS R56884. BS R20988. BS R04475. BS R12092. BS R34139. BS R25605. BS R18510. BS R22937. BS R22941. BS R03342. BS R41945. BS R56892. BS R30959. BS R29797. BS R39859. BS R08088. BS R28359. BS R28480. BS R28550. BS R73757. BS R00920. BS R00923. BS R35460. BS R13472. BS R13473. BS R13474. BS R24519. BS R56860. BS R34335. BS R24754. BS R30068. BS R00940. BS R00942. BS R00943. BS R29952. BS R00933. BS R00935. BS R03673. BS R30260. BS R34058. BS R34061. BS R34062. BS R01634. BS R12708. BS R25017. BS R30979. BS R02909. BS R26564. BS R30143. BS R42134. BS R27192. BS R73961. BS R33449. BS R39330. BS R02923. BS R38723. BS R29088. BS R58773. BS R70832. BS R70833. BS R58395. BS R58397. BS R62888. BS R25352. BS R25353. BS R63048. BS R19783. BS R33535. BS R37207. BS R74062. BS R27228. BS R27229. BS R17045. BS R42383. BS R56896. BS R27455. BS R34235. BS R26362. BS R26363. BS R23920. BS R11382. BS R31369. BS R61346. BS R31409. BS R27891. BS R34801. BS R34802. BS R17119. BS R17121. BS R27221. BS R01349. BS R34542. BS R03275. BS R73897. BS R73912. BS R56876. BS R56885. BS R27433. BS R24686. BS R32229. BS R22550. BS R56877. BS R56878. BS R61967. BS R33969. BS R56886. BS R30054. BS R73153. BS R37899. BS R74076. BS R74077. BS R34141. BS R34142. BS R03186. BS R14565. BS R56865. BS R56872. BS R56881. BS R40795. BS R32204. BS R26754. BS R28975. BS R13277. BS R33967. BS R00605. BS R00606. BS R14716. BS R14717. BS R00877. BS R29147. BS R74074. BS R02951. BS R24514. BS R37722. BS R01056. BS R01058. BS R01060. BS R01065. BS R04397. BS R68091. BS R68096. BS R68097. BS R21135. BS R08104. BS R02217. BS R04556. BS R12714. BS R16598. BS R13306. BS R14446. BS R37512. BS R37513. BS R12707. BS R38577. BS R03733. BS R04905. BS R08108. BS R01406. XX DR TRANSPATH: MO000019669. DR TRANSCOMPEL: C00057. DR TRANSCOMPEL: C00061. DR TRANSCOMPEL: C00101. DR TRANSCOMPEL: C00140. DR TRANSCOMPEL: C00152. DR TRANSCOMPEL: C00153. DR TRANSCOMPEL: C00155. DR TRANSCOMPEL: C00156. DR TRANSCOMPEL: C00165. DR TRANSCOMPEL: C00234. DR TRANSCOMPEL: C00235. DR TRANSCOMPEL: C00257. DR TRANSCOMPEL: C00302. DR TRANSCOMPEL: C00305. DR TRANSCOMPEL: C00306. DR TRANSCOMPEL: C00307. DR TRANSCOMPEL: C00308. DR TRANSCOMPEL: C00318. DR TRANSCOMPEL: C00319. DR TRANSCOMPEL: C00322. DR TRANSCOMPEL: C00323. DR TRANSCOMPEL: C00324. DR TRANSCOMPEL: C00326. DR TRANSCOMPEL: C00327. DR TRANSCOMPEL: C00337. DR TRANSCOMPEL: C00340. DR TRANSCOMPEL: C00341. DR TRANSCOMPEL: C00342. DR TRANSCOMPEL: C00346. DR TRANSCOMPEL: C00357. DR TRANSCOMPEL: C00414. XX RN [1]; RE0000088. RX PUBMED: 3091258. RA Sen R., Baltimore D. RT Multiple nuclear factors interact with the immunoglobulin enhancer sequences RL Cell 46:705-716 (1986). RN [2]; RE0000090. RX PUBMED: 3129195. RA Baeuerle P. A., Baltimore D. RT Activation of DNA-Binding Activity in an Apparently Cytoplasmic Precursor of the NF-kB Transcription Factor RL Cell 53:211-217 (1988). RN [3]; RE0000093. RX PUBMED: 2495183. RA Lenardo M. J., Fan C.-M., Maniatis T., Baltimore D. RT The Involvement of NF-kB in beta-Interferon Gene Regulation Reveals Its Role as Widely Inducible Mediator of Signal Transduction RL Cell 57:287-294 (1989). RN [4]; RE0000169. RX PUBMED: 2203533. RA Gilmore T. D. RT NF-kappaB, KBF1, dorsal, and related matters RL Cell 62:841-843 (1990). RN [5]; RE0000174. RX PUBMED: 1988149. RA Lewin B. RT Oncogenic conversion by regulatory changes in transcription factors RL Cell 64:303-312 (1991). RN [6]; RE0000216. RX PUBMED: 2225078. RA Ballard D. W., Walker W. H., Doerre S., Sista P., Molitor J. A., Dixon E. P., Peffer N. J., Hannink M., Greene W. C. RT The v-rel oncogene encodes a kappaB enhancer binding protein that inhibits NF-kappaB function RL Cell 63:803-814 (1990). RN [7]; RE0000285. RX PUBMED: 3076097. RA Baeuerle P. A., Lenardo M., Pierce J. W., Baltimore D. RT Phorbol-ester-induced activation of the NF-kappaB transcription factor involves dissociation of an apparently cytoplasmic NF-kappaB/inhibitor complex RL Cold Spring Harb. Symp. Quant. Biol. 53:789-798 (1988). RN [8]; RE0000356. RX PUBMED: 3443102. RA Dinter H., Chiu R., Imagawa M., Karin M., Jones K. A. RT in vitro activation of the HIV-1 enhancer in extracts from cells treated with a phorbol ester tumor promoter RL EMBO J. 6:4067-4071 (1987). RN [9]; RE0000458. RX PUBMED: 2050119. RA Urban M. B., Schreck R., Baeuerle P. A. RT NF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit RL EMBO J. 10:1817-1825 (1991). RN [10]; RE0000506. RX PUBMED: 1935902. RA Schmitz M. L., Baeuerle P. A. RT The p65 subunit is responsible for the strong transcription activating potential of NF-kappaB RL EMBO J. 10:3805-3817 (1991). RN [11]; RE0000507. RX PUBMED: 2663471. RA Visvanathan K. V., Goodbourn S. RT Double-stranded RNA activates binding of NF-kappaB to an inducible element in the human beta-interferon promoter RL EMBO J. 8:1129-1138 (1989). RN [12]; RE0000508. RX PUBMED: 2065663. RA Schreck R., Rieber P., Baeuerle P. A. RT Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappaB transcription factor and HIV-1 RL EMBO J. 10:2247-2258 (1991). RN [13]; RE0000609. RX PUBMED: 2691328. RA Baeuerle P., Baltimore D. RT A 65-kD subunit of active NF-kappaB is required for inhibition of NF-kappaB by IkappaB RL Genes Dev. 3:1689-1698 (1989). RN [14]; RE0000673. RX PUBMED: 2844627. RA Clark L., Pollock R. M., Hay R. T. RT Identification and purification of EBP1: a HeLa cell protein that binds to a region overlapping the core of the SV40 enhancer RL Genes Dev. 2:991-1002 (1988). RN [15]; RE0000726. RX PUBMED: 2125960. RA Urban M. B., Baeuerle P. A. RT The 65-kD subunit of NF-kappaB is a receptor for IkappaB and a modulator of DNA-binding specificity RL Genes Dev. 4:1975-1984 (1990). RN [16]; RE0000973. RX PUBMED: 1985897. RA Zabel U., Schreck R., Baeuerle P. A. RT DNA binding of purified transcription factor NF-kappaB RL J. Biol. Chem. 266:252-260 (1991). RN [17]; RE0000978. RX PUBMED: 2176217. RA Hohmann H.-P., Brockhaus M., Baeuerle P. A., Remy R., Kolbeck R., van Loon A. P. G. M. RT Expression of the types A and B tumor necrosis factor (TNF) receptors is independently regulated, and both receptors mediate activation of the transcription factor NF-kappaB RL J. Biol. Chem. 265:22409-22417 (1990). RN [18]; RE0001339. RX PUBMED: 2747640. RA Edbrooke M. R., Burt D. W., Cheshire J. K., Woo P. RT Identification of cis-Acting Sequences Responsible for Phorbol Ester Induction of Human Serum A Gene Expression via a Nuclear Factor kB-Like Transcription Factor RL Mol. Cell. Biol. 9:1908-1916 (1989). RN [19]; RE0001387. RX PUBMED: 2557547. RA Stein B., Rahmsdorf H. J., Steffen A., Litfin M., Herrlich P. RT UV-Induced DNA Damage Is an Intermediate Step in UV-Induced Expression of Human Immunodeficiency Virus Type 1 Collagenase, c-fos and Metallothionein RL Mol. Cell. Biol. 9:5169-5181 (1989). RN [20]; RE0001632. RX PUBMED: 2548081. RA Shirakawa F., Mizel S. B. RT In vitro activation and nuclear translocation of NF-kappaB catalyzed by cyclic AMP-dependent protein kinase and protein kinase C RL Mol. Cell. Biol. 9:2424-2430 (1991). RN [21]; RE0001791. RX PUBMED: 2825023. RA Franza jr B. R., Josephs S. F., Gilman M. Z., Ryan W., Clarkson B. RT Characterization of cellular proteins recognizing the HIV enhancer using a microscale DNA-affinity precipitation assay RL Nature 330:391-395 (1987). RN [22]; RE0001809. RX PUBMED: 2838755. RA Leung K., Nabel G. J. RT HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-kB-like factor RL Nature 333:776-778 (1988). RN [23]; RE0001871. RX PUBMED: 2023633. RA Bachelerie F., Alcami J., Arenzana-Seisdedos F., Virelizier J.-L. RT HIV enhancer activity perpetuated by NF-kappaB induction on infection of monocytes RL Nature 350:709-712 (1991). RN [24]; RE0001872. RX PUBMED: 2017258. RA Riviere Y., Blank V., Kourilsky P., Israel A. RT Processing of the precursor of NF-kappaB by the HIV-1 protease during acute infection RL Nature 350:625-626 (1991). RN [25]; RE0002301. RX PUBMED: 3200827. RA Gaynor R. B., Kuwabara M. D., Wu F. K., Garcia J. A., Harrich D., Briskin M., Wall R., Sigman D. S. RT Repeated B motifs in the human immunodeficiency virus type I long terminal repeat enhancer region do not exhibit cooperative factor binding RL Proc. Natl. Acad. Sci. USA 85:9406-9410 (1988). RN [26]; RE0002302. RX PUBMED: 3133660. RA Kawakami K., Scheidereit C., Roeder R. G. RT Identification and purification of a human immunoglobulin-enhancer-binding protein (NF-kappaB) that activates transcription from a human immunodeficiency virus type 1 promoter in vitro RL Proc. Natl. Acad. Sci. USA 85:4700-4704 (1988). RN [27]; RE0002303. RX PUBMED: 2494664. RA Osborn L., Kunkel S., Nabel G. J. RT Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kB RL Proc. Natl. Acad. Sci. USA 86:2336-2340 (1989). RN [28]; RE0002320. RX PUBMED: 3132714. RA Lowenthal J. W., Boehnlein E., Ballard D. W., Greene W. C. RT Regulation of interleukin 2 receptor alpha subunit (Tac of CD25 antigen) gene expression: Binding of inducible nuclear proteins to discrete promoter sequences correlates with transcriptional activation RL Proc. Natl. Acad. Sci. USA 85:4468-4472 (1988). RN [29]; RE0002391. RX PUBMED: 2762307. RA Duh E. J., Maury W. J., Folks T. M., Fauci A. S., Rabson A. B. RT Tumor necrosis factor alpha activates human immunodeficiency virus type 1 through induction of nuclear factor binding to the NF-kB sites in the long terminal repeat RL Proc. Natl. Acad. Sci. USA 86:5974-5978 (1989). RN [30]; RE0002417. RX PUBMED: 2263603. RA Molitor J. A., Walker W. H., Doerre S., Ballard D. W., Greene W. C. RT NF-kappaB: a family of inducible and differentially expressed enhancer-binding proteins in human T cells RL Proc. Natl. Acad. Sci. USA 87:10028-10032 (1990). RN [31]; RE0002484. RX PUBMED: 1903539. RA Toledano M. B., Leonard W. J. RT Modulation of transcription factor NF-kappaB binding activity by oxidation-reduction in vitro RL Proc. Natl. Acad. Sci. USA 88:4328-4332 (1991). RN [32]; RE0002605. RX PUBMED: 2497518. RA Hoyos B., Ballard D. W., Boehnlein E., Siekevitz M., Greene W. C. RT Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression RL Science 244:457-460 (1989). RN [33]; RE0002615. RX PUBMED: 2843985. RA Ballard D. W., Boehnlein E., Lowenthal J. W., Wano Y., Franza B. R., Greene W. C. RT HTLV-I Tax Induces Cellular Proteins That Activate the kB Element in the IL-2 Receptor alpha Gene RL Science 241:1652-1655 (1988). RN [34]; RE0002616. RX PUBMED: 2838905. RA Ruben S., Poteat H., Tan T.-H., Kawakami K., Roeder R., Haseltine W., Rosen C. A. RT Cellular Transcription Factors and Regulation of IL-2 Receptor Gene Expression by HTLV-I tax Gene Product RL Science 241:89-92 (1988). RN [35]; RE0002617. RX PUBMED: 2497520. RA Cross S. L., Halden N. F., Lenardo M. J., Leonard W. J. RT Functionally Distinct NF-kB Binding Sites in the Immunoglobulin k and IL-2 Receptor alpha Chain Genes RL Science 244:466-469 (1989). RN [36]; RE0002764. RX PUBMED: 2192263. RA Zhang Y., Lin J.-X., Vilcek J. RT Interleukin-6 induction by tumor necrosis factor and interleukin-1 in human fibroblasts involves activation of a nuclear factor binding to a kappaB-like sequence RL Mol. Cell. Biol. 10:3818-3823 (1990). RN [37]; RE0002769. RX PUBMED: 2183031. RA Libermann T. A., Baltimore D. RT Activation of interleukin-6 gene expression through the NF-kappaB transcription factor RL Mol. Cell. Biol. 10:2327-2334 (1990). RN [38]; RE0002922. RX PUBMED: 1406630. RA Kunsch C., Ruben S. M., Rosen C. A. RT Selection of optimal kappaB/Rel DNA-binding motifs: interaction of both subunits of NF-kappaB with DNA is required for transcriptional activation RL Mol. Cell. Biol. 12:4412-4421 (1992). RN [39]; RE0004441. RX PUBMED: 8449662. RA Grilli M., Chiu J. J.-S., Lenardo M. J. RT NF-kappaB and Rel: Participants in a multiform transcriptional regulatory system RL Int. Rev. Cytol. 143:1-62 (1993). RN [40]; RE0004493. RX PUBMED: 7559449. RA Pan J., McEver R. P. RT Regulation of the human P-selection promoter by Bcl-3 and specific homodimeric members of the NF-kappaB/Rel family RL J. Biol. Chem. 270:23077-23083 (1995). RN [41]; RE0004502. RX PUBMED: 7544915. RA Rothe M., Sarma V., Dixit V. M., Goeddel D. V. RT TRAF2-mediated activation of NF-kappaB by TNF receptor 2 and CD40 RL Science 269:1424-1427 (1995). RN [42]; RE0004506. RX PUBMED: 1330325. RA Schuetze S., Potthoff K., Machleidt T., Berkovic D., Wiegmann K., Kroenke M. RT TNF activates NF-kappaB by phosphatidylcholine-specific phospholipase C-induced 'acidic' sphingomyelin breakdown RL Cell 71:765-776 (1992). RN [43]; RE0004507. RX PUBMED: 7925300. RA Naumann M., Scheidereit C. RT Activation of NF-6B in vivo is regulated by multiple phosphorylations RL EMBO J. 13:4597-4607 (1994). RN [44]; RE0004511. RX PUBMED: 3096580. RA Sen R., Baltimore D. RT Inducibility of kappa immunoglobulin enhancer-binding protein NF-kappaB by a posttranslational mechanism RL Cell 47:921-928 (1986). RN [45]; RE0004532. RX PUBMED: 8127864. RA Schenk H., Klein M., Erdbruegger W., Droege W., Schulze-Osthoff K. RT Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappaB and AP-1 RL Proc. Natl. Acad. Sci. USA 91:1672-1676 (1994). RN [46]; RE0004637. RX PUBMED: 8011280. RA Baeuerle P. A., Henkel T. A. RT Function and activation of NF-kappa B in the immune system RL Annu. Rev. Immunol. 12:141-179 (1994). RN [47]; RE0004638. RX PUBMED: 7641692. RA Los M., Schenk H., Hexel K., Baeuerle P. A., Droege W., Schulz-Osthoff K. RT IL-2 gene expression and NF-kappaB activation through CD28 requires reactive oxygen production by 5-lipoxygenase RL EMBO J. 14:3731-3740 (1995). RN [48]; RE0013419. RX PUBMED: 9374532. RA Sica A., Dorman L., Viggiano V., Cippitelli M., Ghosh P., Rice N., Young H. A. RT Interaction of NF-kappaB and NFAT with the interferon-gamma promoter RL J. Biol. Chem. 272:30412-304120 (1997). RN [49]; RE0022953. RX PUBMED: 10553096. RA Quinlan K. L., Naik S. M., Cannon G., Armstrong C. A., Bunnett N. W., Ansel J. C., Caughman S. W. RT Substance P activates coincident NF-AT- and NF-kappa B-dependent adhesion molecule gene expression in microvascular endothelial cells through intracellular calcium mobilization. RL J. Immunol. 163:5656-5665 (1999). RN [50]; RE0024015. RX PUBMED: 12403783. RA Hiroi M., Ohmori Y. RT The transcriptional coactivator CREB-binding protein cooperates with STAT1 and NF-kappa B for synergistic transcriptional activation of the CXC ligand 9/monokine induced by interferon-gamma gene. RL J. Biol. Chem. 278:651-660 (2003). RN [51]; RE0052451. RX PUBMED: 16887883. RA Bonofiglio D., Aquila S., Catalano S., Gabriele S., Belmonte M., Middea E., Qi H., Morelli C., Gentile M., Maggiolini M., Ando S. RT Peroxisome proliferator-activated receptor-gamma activates p53 gene promoter binding to the nuclear factor-kappaB sequence in human MCF7 breast cancer cells. RL Mol. Endocrinol. 20:3083-3092 (2006). RN [52]; RE0052543. RX PUBMED: 18243246. RA Das S., Banerji A., Frei E., Chatterjee A. RT Rapid expression and activation of MMP-2 and MMP-9 upon exposure of human breast cancer cells (MCF-7) to fibronectin in serum free medium. RL Life Sci. 82:467-476 (2008). RN [53]; RE0067949. RX PUBMED: 19357230. RA Decker Y., McBean G., Godson C. RT Lipoxin A4 inhibits IL-1beta-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells. RL Am. J. Physiol. Cell Physiol. 296:C1420-7 (2009). RN [54]; RE0068021. RX PUBMED: 20626862. RA Carmona E. M., Lamont J. D., Xue A., Wylam M., Limper A. H. RT Pneumocystis cell wall beta-glucan stimulates calcium-dependent signaling of IL-8 secretion by human airway epithelial cells. RL Respir. Res. 11:95 (2010). RN [55]; RE0068224. RX PUBMED: 20507572. RA Khalaf H., Jass J., Olsson P. E. RT Differential cytokine regulation by NF-kappaB and AP-1 in Jurkat T-cells. RL BMC Immunol. 11:26 (2010). RN [56]; RE0070125. RX PUBMED: 20484576. RA Zhang W., Wang J., Zhang Y., Yuan Y., Guan W., Jin C., Chen H., Wang X., Yang X., He F. RT The scaffold protein TANK/I-TRAF inhibits NF-kappaB activation by recruiting polo-like kinase 1. RL Mol. Biol. Cell 21:2500-2513 (2010). RN [57]; RE0071992. RX PUBMED: 19265123. RA Dai P., Jeong S. Y., Yu Y., Leng T., Wu W., Xie L., Chen X. RT Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins. RL J. Immunol. 182:3450-3460 (2009). RN [58]; RE0072511. RX PUBMED: 21796205. RA Li F. Y., Chaigne-Delalande B., Kanellopoulou C., Davis J. C., Matthews H. F., Douek D. C., Cohen J. I., Uzel G., Su H. C., Lenardo M. J. RT Second messenger role for Mg2+ revealed by human T-cell immunodeficiency. RL Nature 475:471-476 (2011). RN [59]; RE0072608. RX PUBMED: 21455181. RA Ikeda F., Deribe Y. L., Skanland S. S., Stieglitz B., Grabbe C., Franz-Wachtel M., van Wijk S. J., Goswami P., Nagy V., Terzic J., Tokunaga F., Androulidaki A., Nakagawa T., Pasparakis M., Iwai K., Sundberg J. P., Schaefer L., Rittinger K., Macek B., Dikic I. RT SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis. RL Nature 471:637-641 (2011). RN [60]; RE0072635. RX PUBMED: 22288713. RA Sun R., Zhu Z., Su Q., Li T., Song Q. RT Toll-like receptor 4 is involved in bacterial endotoxin-induced endothelial cell injury and SOC-mediated calcium regulation. RL Cell Biol. Int. 36:475-481 (2012). RN [61]; RE0072651. RX PUBMED: 21455180. RA Tokunaga F., Nakagawa T., Nakahara M., Saeki Y., Taniguchi M., Sakata S., Tanaka K., Nakano H., Iwai K. RT SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex. RL Nature 471:633-636 (2011). XX //