AC T01686
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ID T01686
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DT 21.02.1996 (created); ewi.
DT 30.06.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA GCN5
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SY hGCN5; YGR252W.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004682 KAT2A; HGNC: KAT2A.
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SF 43% identical and 62.5% similar to yeast GCN5 [1];
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FF adaptor for acidic activators [1];
FF can be functionally replaced by yeast GCN5 [1];
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IN T01685 ADA2; human, Homo sapiens.
IN T05220 Evi-1; human, Homo sapiens.
IN T04106 HDAC1; human, Homo sapiens.
IN T08343 HDAC1; human, Homo sapiens.
IN T04109 hdac2-isoform1; human, Homo sapiens.
IN T30231 SIRT1-isoform1; human, Homo sapiens.
IN T29717 SIRT1; human, Homo sapiens.
IN T21552 SRC-1; Mammalia.
IN T00851 T3R-beta1; human, Homo sapiens.
IN T02482 TIF2; mouse, Mus musculus.
IN T05140 trrap; human, Homo sapiens.
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DR TRANSPATH: MO000025870.
DR UniProtKB: Q92830; GCNL2_HUMAN.
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RN [1]; RE0003820.
RX PUBMED: 8552087.
RA Candau R., Moore P. A., Wang L., Barlev N., Ying C. Y., Rosen C. A., Berger S. L.
RT Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5
RL Mol. Cell. Biol. 16:593-602 (1996).
RN [2]; RE0045374.
RX PUBMED: 15115762.
RA Helmlinger D., Hardy S., Sasorith S., Klein F., Robert F., Weber C., Miguet L., Potier N., Van-Dorsselaer A., Wurtz J. M., Mandel J. L., Tora L., Devys D.
RT Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes
RL Hum. Mol. Genet. 13:1257-65 (2004).
RN [3]; RE0048072.
RX PUBMED: 12529406.
RA Yamagoe S., Kanno T., Kanno Y., Sasaki S., Siegel R. M., Lenardo M. J., Humphrey G., Wang Y., Nakatani Y., Howard B. H., Ozato K.
RT Interaction of histone acetylases and deacetylases in vivo.
RL Mol. Cell. Biol. 23:1025-1033 (2003).
RN [4]; RE0064710.
RX PUBMED: 15932940.
RA Palhan V. B., Chen S., Peng G. H., Tjernberg A., Gamper A. M., Fan Y., Chait B. T., La Spada A. R., Roeder R. G.
RT Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration.
RL Proc. Natl. Acad. Sci. USA 102:8472-8477 (2005).
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