AC T02853
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ID T02853
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DT 14.12.1999 (created); mkl.
DT 20.10.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA hnRNPK
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SY heterogenous nuclear ribonucleoprotein complex K.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004016 HNRNPK; HGNC: HNRNPK.
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FF binds preferentially single-stranded DNA [2] [3];
FF may facilitate CNBP recognition of the lower strand of the c-myc gene CT element [3];
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IN T28731 AUF1; human, Homo sapiens.
IN T22877 DeltaNp63alpha; Mammalia.
IN T02734 DSIF-p160; human, Homo sapiens.
IN T06586 gfi1b; human, Homo sapiens.
IN T22942 hnRNPA1; human, Homo sapiens.
IN T02853 hnRNPK; human, Homo sapiens.
IN T24825 HNRPL; human, Homo sapiens.
IN T02186 MO15; human, Homo sapiens.
IN T15720 NF90; human, Homo sapiens.
IN T10416 NFAT5c; human, Homo sapiens.
IN T00671 p53; human, Homo sapiens.
IN T06004 p63-isoform2; human, Homo sapiens.
IN T19717 RHA; human, Homo sapiens.
IN T30231 SIRT1-isoform1; human, Homo sapiens.
IN T34280 TDP43; human, Homo sapiens.
IN T00880 Vav; human, Homo sapiens.
IN T10348 YB-1; human, Homo sapiens.
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BS R32427.
BS R69941.
BS R24521.
BS R37103.
BS R31034.
BS R62261.
BS R04621.
BS R31035.
BS R63992.
BS R32479.
BS R24627.
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DR TRANSPATH: MO000026822.
DR UniProtKB: P61978;
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RN [1]; RE0007508.
RX PUBMED: 8349701.
RA Takimoto M., Tomonaga T., Matunis M., Avigan M., Krutzsch H., Dreyfuss G., Levens D.
RT Specific binding of heterogeneous ribonucleoprotein particle protein K to the human c-myc promoter, in vitro
RL J. Biol. Chem. 268:18249-18258 (1993).
RN [2]; RE0011571.
RX PUBMED: 7876260.
RA Tomonaga T., Levens D.
RT Heterogenous nuclear ribonucleoprotein K is a DNA-binding transactivator
RL J. Biol. Chem. 270:4875-4881 (1995).
RN [3]; RE0012697.
RX PUBMED: 8649373.
RA Michelotti G. A., Michelotti E. F., Pullner A., Duncan R. C., Eick D., Levens D.
RT Multiple single-stranded cis elements are associated with activated chromatin of the human c-myc gene in vivo
RL Mol. Cell. Biol. 16:2656-2669 (1996).
RN [4]; RE0013951.
RX PUBMED: 2690070.
RA Davis T. L., Firulli A. B., Kinniburgh A. J.
RT Ribonucleoprotein and protein factors bind to an H-DNA-forming c-myc DNA element: possible regulators of the c-myc gene
RL Proc. Natl. Acad. Sci. USA 86:9682-9686 (1989).
RN [5]; RE0047722.
RX PUBMED: 9488731.
RA Romero F., Germani A., Puvion E., Camonis J., Varin-Blank N., Gisselbrecht S., Fischer S.
RT Vav binding to heterogeneous nuclear ribonucleoprotein (hnRNP) C. Evidence for Vav-hnRNP interactions in an RNA-dependent manner.
RL J. Biol. Chem. 273:5923-5931 (1998).
RN [6]; RE0049394.
RX PUBMED: 9651361.
RA Hsieh T. Y., Matsumoto M., Chou H. C., Schneider R., Hwang S. B., Lee A. S., Lai M. M.
RT Hepatitis C virus core protein interacts with heterogeneous nuclear ribonucleoprotein K.
RL J. Biol. Chem. 273:17651-17659 (1998).
RN [7]; RE0053172.
RX PUBMED: 16564677.
RA Kwiek N. C., Thacker D. F., Datto M. B., Megosh H. B., Haystead T. A.
RT PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K.
RL Cell. Signal. 18:1769-1778 (2006).
RN [8]; RE0053193.
RX PUBMED: 15860232.
RA Jeon H. K., Ahn J. H., Choe J., Park J. H., Lee T. H.
RT Anti-IgM induces up-regulation and tyrosine-phosphorylation of heterogeneous nuclear ribonucleoprotein K proteins (hnRNP K) in a Ramos B cell line.
RL Immunol. Lett. 98:303-310 (2005).
RN [9]; RE0053646.
RX PUBMED: 18441016.
RA Naarmann I. S., Harnisch C., Flach N., Kremmer E., Kuhn H., Ostareck D. H., Ostareck-Lederer A.
RT mRNA Silencing in Human Erythroid Cell Maturation: HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K CONTROLS THE EXPRESSION OF ITS REGULATOR c-Src.
RL J. Biol. Chem. 283:18461-18472 (2008).
RN [10]; RE0064511.
RX PUBMED: 11231586.
RA Habelhah H., Shah K., Huang L., Ostareck-Lederer A., Burlingame A. L., Shokat K. M., Hentze M. W., Ronai Z.
RT ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation.
RL Nat. Cell Biol. 3:325-330 (2001).
RN [11]; RE0069524.
RX PUBMED: 19880579.
RA Chang J. W., Koike T., Iwashima M.
RT hnRNP-K is a nuclear target of TCR-activated ERK and required for T-cell late activation.
RL Int. Immunol. 21:1351-1361 (2009).
RN [12]; RE0070606.
RX PUBMED: 20082308.
RA Lettau M., Pieper J., Gerneth A., Lengl-Janssen B., Voss M., Linkermann A., Schmidt H., Gelhaus C., Leippe M., Kabelitz D., Janssen O.
RT The adapter protein Nck: role of individual SH3 and SH2 binding modules for protein interactions in T lymphocytes.
RL Protein Sci. 19:658-669 (2010).
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