TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02853 XX ID T02853 XX DT 14.12.1999 (created); mkl. DT 20.10.2014 (updated); yre. CO Copyright (C), QIAGEN. XX FA hnRNPK XX SY heterogenous nuclear ribonucleoprotein complex K. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004016 HNRNPK; HGNC: HNRNPK. XX FF binds preferentially single-stranded DNA [2] [3]; FF may facilitate CNBP recognition of the lower strand of the c-myc gene CT element [3]; XX IN T28731 AUF1; human, Homo sapiens. IN T22877 DeltaNp63alpha; Mammalia. IN T02734 DSIF-p160; human, Homo sapiens. IN T06586 gfi1b; human, Homo sapiens. IN T22942 hnRNPA1; human, Homo sapiens. IN T02853 hnRNPK; human, Homo sapiens. IN T24825 HNRPL; human, Homo sapiens. IN T02186 MO15; human, Homo sapiens. IN T15720 NF90; human, Homo sapiens. IN T10416 NFAT5c; human, Homo sapiens. IN T00671 p53; human, Homo sapiens. IN T06004 p63-isoform2; human, Homo sapiens. IN T19717 RHA; human, Homo sapiens. IN T30231 SIRT1-isoform1; human, Homo sapiens. IN T34280 TDP43; human, Homo sapiens. IN T00880 Vav; human, Homo sapiens. IN T10348 YB-1; human, Homo sapiens. XX BS R32427. BS R69941. BS R24521. BS R37103. BS R31034. BS R62261. BS R04621. BS R31035. BS R63992. BS R32479. BS R24627. XX DR TRANSPATH: MO000026822. DR UniProtKB: P61978; XX RN [1]; RE0007508. RX PUBMED: 8349701. RA Takimoto M., Tomonaga T., Matunis M., Avigan M., Krutzsch H., Dreyfuss G., Levens D. RT Specific binding of heterogeneous ribonucleoprotein particle protein K to the human c-myc promoter, in vitro RL J. Biol. Chem. 268:18249-18258 (1993). RN [2]; RE0011571. RX PUBMED: 7876260. RA Tomonaga T., Levens D. RT Heterogenous nuclear ribonucleoprotein K is a DNA-binding transactivator RL J. Biol. Chem. 270:4875-4881 (1995). RN [3]; RE0012697. RX PUBMED: 8649373. RA Michelotti G. A., Michelotti E. F., Pullner A., Duncan R. C., Eick D., Levens D. RT Multiple single-stranded cis elements are associated with activated chromatin of the human c-myc gene in vivo RL Mol. Cell. Biol. 16:2656-2669 (1996). RN [4]; RE0013951. RX PUBMED: 2690070. RA Davis T. L., Firulli A. B., Kinniburgh A. J. RT Ribonucleoprotein and protein factors bind to an H-DNA-forming c-myc DNA element: possible regulators of the c-myc gene RL Proc. Natl. Acad. Sci. USA 86:9682-9686 (1989). RN [5]; RE0047722. RX PUBMED: 9488731. RA Romero F., Germani A., Puvion E., Camonis J., Varin-Blank N., Gisselbrecht S., Fischer S. RT Vav binding to heterogeneous nuclear ribonucleoprotein (hnRNP) C. Evidence for Vav-hnRNP interactions in an RNA-dependent manner. RL J. Biol. Chem. 273:5923-5931 (1998). RN [6]; RE0049394. RX PUBMED: 9651361. RA Hsieh T. Y., Matsumoto M., Chou H. C., Schneider R., Hwang S. B., Lee A. S., Lai M. M. RT Hepatitis C virus core protein interacts with heterogeneous nuclear ribonucleoprotein K. RL J. Biol. Chem. 273:17651-17659 (1998). RN [7]; RE0053172. RX PUBMED: 16564677. RA Kwiek N. C., Thacker D. F., Datto M. B., Megosh H. B., Haystead T. A. RT PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K. RL Cell. Signal. 18:1769-1778 (2006). RN [8]; RE0053193. RX PUBMED: 15860232. RA Jeon H. K., Ahn J. H., Choe J., Park J. H., Lee T. H. RT Anti-IgM induces up-regulation and tyrosine-phosphorylation of heterogeneous nuclear ribonucleoprotein K proteins (hnRNP K) in a Ramos B cell line. RL Immunol. Lett. 98:303-310 (2005). RN [9]; RE0053646. RX PUBMED: 18441016. RA Naarmann I. S., Harnisch C., Flach N., Kremmer E., Kuhn H., Ostareck D. H., Ostareck-Lederer A. RT mRNA Silencing in Human Erythroid Cell Maturation: HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K CONTROLS THE EXPRESSION OF ITS REGULATOR c-Src. RL J. Biol. Chem. 283:18461-18472 (2008). RN [10]; RE0064511. RX PUBMED: 11231586. RA Habelhah H., Shah K., Huang L., Ostareck-Lederer A., Burlingame A. L., Shokat K. M., Hentze M. W., Ronai Z. RT ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation. RL Nat. Cell Biol. 3:325-330 (2001). RN [11]; RE0069524. RX PUBMED: 19880579. RA Chang J. W., Koike T., Iwashima M. RT hnRNP-K is a nuclear target of TCR-activated ERK and required for T-cell late activation. RL Int. Immunol. 21:1351-1361 (2009). RN [12]; RE0070606. RX PUBMED: 20082308. RA Lettau M., Pieper J., Gerneth A., Lengl-Janssen B., Voss M., Linkermann A., Schmidt H., Gelhaus C., Leippe M., Kabelitz D., Janssen O. RT The adapter protein Nck: role of individual SH3 and SH2 binding modules for protein interactions in T lymphocytes. RL Protein Sci. 19:658-669 (2010). XX //