AC T06586
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ID T06586
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DT 11.07.2005 (created); elf.
DT 25.03.2014 (updated); hna.
CO Copyright (C), QIAGEN.
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FA gfi1b
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SY GFI1B; growth factor independent 1B (potential regulator of CDKN1A, translocated in CML).
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G018219 GFI1B; HGNC: GFI1B.
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CL C0001; CH; 2.3.3.21.2.
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SF six C-terminal C2H2-type zinc finger domains and a characteristic stretch of 20 amino acids, called the SNAG domain, at its N-terminus [2];
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CP high in bone marrow and fetal liver / low in fetal spleen, fetal thymus and testes, precursors of all hematopoietic lineages [4].
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FF transcriptional repressor, SNAG repression domain [2];
FF role in stem cell differentiation [3];
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IN T04074 brca1; human, Homo sapiens.
IN T27532 CENP-B; human, Homo sapiens.
IN T02853 hnRNPK; human, Homo sapiens.
IN T22801 Notch1; human, Homo sapiens.
IN T19338 RFP; human, Homo sapiens.
IN T08956 TAFII250; human, Homo sapiens.
IN T00835 TMF; human, Homo sapiens.
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MX M01058 V$GFI1B_01.
MX M03825 V$GFI1B_Q6.
MX M01067 V$GFI1_Q6.
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BS R38395.
BS R39882.
BS R60956.
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DR TRANSPATH: MO000056184.
DR UniProtKB: Q5VTD9; GFI1B_HUMAN.
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RN [1]; RE0035152.
RX PUBMED: 15718298.
RA Vassen L., Fiolka K., Mahlmann S., Moroy T.
RT Direct transcriptional repression of the genes encoding the zinc-finger proteins Gfi1b and Gfi1 by Gfi1b.
RL Nucleic Acids Res. 33:987-998 (2005).
RN [2]; RE0035156.
RX PUBMED: 15096055.
RA Moreau V. H., da Silva A. C., Siloto R. M., Valente A. P., Leite A., Almeida F. C.
RT The bZIP region of the plant transcription factor opaque-2 forms stable homodimers in solution and retains its helical structure upon subunit dissociation.
RL Biochemistry 43:4862-4868 (2004).
RN [3]; RE0035164.
RX PUBMED: 12721361.
RA Duan Z., Horwitz M.
RT Targets of the transcriptional repressor oncoprotein Gfi-1.
RL Proc. Natl. Acad. Sci. USA 100:5932-5937 (2003).
RN [4]; RE0035175.
RX PUBMED: 9878267.
RA Roedel B., Wagner T., Zoernig M., Niessing J., & Moeroy T.
RT The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases.
RL Genomics 54:580-582 (1998).
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