TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T06586 XX ID T06586 XX DT 11.07.2005 (created); elf. DT 25.03.2014 (updated); hna. CO Copyright (C), QIAGEN. XX FA gfi1b XX SY GFI1B; growth factor independent 1B (potential regulator of CDKN1A, translocated in CML). XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G018219 GFI1B; HGNC: GFI1B. XX CL C0001; CH; XX SF six C-terminal C2H2-type zinc finger domains and a characteristic stretch of 20 amino acids, called the SNAG domain, at its N-terminus [2]; XX CP high in bone marrow and fetal liver / low in fetal spleen, fetal thymus and testes, precursors of all hematopoietic lineages [4]. XX FF transcriptional repressor, SNAG repression domain [2]; FF role in stem cell differentiation [3]; XX IN T04074 brca1; human, Homo sapiens. IN T27532 CENP-B; human, Homo sapiens. IN T02853 hnRNPK; human, Homo sapiens. IN T22801 Notch1; human, Homo sapiens. IN T19338 RFP; human, Homo sapiens. IN T08956 TAFII250; human, Homo sapiens. IN T00835 TMF; human, Homo sapiens. XX MX M01058 V$GFI1B_01. MX M03825 V$GFI1B_Q6. MX M01067 V$GFI1_Q6. XX BS R38395. BS R39882. BS R60956. XX DR TRANSPATH: MO000056184. DR UniProtKB: Q5VTD9; GFI1B_HUMAN. XX RN [1]; RE0035152. RX PUBMED: 15718298. RA Vassen L., Fiolka K., Mahlmann S., Moroy T. RT Direct transcriptional repression of the genes encoding the zinc-finger proteins Gfi1b and Gfi1 by Gfi1b. RL Nucleic Acids Res. 33:987-998 (2005). RN [2]; RE0035156. RX PUBMED: 15096055. RA Moreau V. H., da Silva A. C., Siloto R. M., Valente A. P., Leite A., Almeida F. C. RT The bZIP region of the plant transcription factor opaque-2 forms stable homodimers in solution and retains its helical structure upon subunit dissociation. RL Biochemistry 43:4862-4868 (2004). RN [3]; RE0035164. RX PUBMED: 12721361. RA Duan Z., Horwitz M. RT Targets of the transcriptional repressor oncoprotein Gfi-1. RL Proc. Natl. Acad. Sci. USA 100:5932-5937 (2003). RN [4]; RE0035175. RX PUBMED: 9878267. RA Roedel B., Wagner T., Zoernig M., Niessing J., & Moeroy T. RT The human homologue (GFI1B) of the chicken GFI gene maps to chromosome 9q34.13-A locus frequently altered in hematopoietic diseases. RL Genomics 54:580-582 (1998). XX //