AC T10416
XX
ID T10416
XX
DT 24.04.2007 (created); apk.
DT 15.01.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA NFAT5c
XX
SY NF-AT5c; NFAT5; OREBP; tone-binding protein; tonebp; tonicity-responsive enhancer-binding protein.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G005535 NFAT5; HGNC: NFAT5.
XX
CL C0052; REL/NFAT; 6.1.3.0.5.3.
XX
SZ 1531 AA; 165.7 kDa (calc.).
XX
SQ MPSDFISLLSADLDLESPKSLYSRESVYDLLPKELQLPPSRETSVASMSQTSGGEAGSPP
SQ PAVVAADASSAPSSSSMGGACSSFTTSSSPTIYSTSVTDSKAMQVESCSSAVGVSNRGVS
SQ EKQLTSNTVQQHPSTPKRHTVLYISPPPEDLLDNSRMSCQDEGCGLESEQSCSMWMEDSP
SQ SNFSNMSTSSYNDNTEVPRKSRKRNPKQRPGVKRRDCEESNMDIFDADSAKAPHYVLSQL
SQ TTDNKGNSKAGNGTLENQKGTGVKKSPMLCGQYPVKSEGKELKIVVQPETQHRARYLTEG
SQ SRGSVKDRTQQGFPTVKLEGHNEPVVLQVFVGNDSGRVKPHGFYQACRVTGRNTTPCKEV
SQ DIEGTTVIEVGLDPSNNMTLAVDCVGILKLRNADVEARIGIAGSKKKSTRARLVFRVNIM
SQ RKDGSTLTLQTPSSPILCTQPAGVPEILKKSLHSCSVKGEEEVFLIGKNFLKGTKVIFQE
SQ NVSDENSWKSEAEIDMELFHQNHLIVKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFT
SQ YTPDPAAAGALNVNVKKEISSPARPCSFEEAMKAMKTTGCNLDKVNIIPNALMTPLIPSS
SQ MIKSEDVTPMEVTAEKRSSTIFKTTKSVGSTQQTLENISNIAGNGSFSSPSSSHLPSENE
SQ KQQQIQPKAYNPETLTTIQTQDISQPGTFPAVSASSQLPNSDALLQQATQFQTRETQSRE
SQ ILQSDGTVVNLSQLTEASQQQQQSPLQEQAQTLQQQISSNIFPSPNSVSQLQNTIQQLQA
SQ GSFTGSTASGSSGSVDLVQQVLEAQQQLSSVLFSAPDGNENVQEQLSADIFQQVSQIQSG
SQ VSPGMFSSTEPTVHTRPDNLLPGRAESVHPQSENTLSNQQQQQQQQQQVMESSAAMVMEM
SQ QQSICQAAAQIQSELFPSTASANGNLQQSPVYQQTSHMMSALSTNEDMQMQCELFSSPPA
SQ VSGNETSTTTTQQVATPGTTMFQTSSSGDGEETGTQAKQIQNSVFQTMVQMQHSGDNQPQ
SQ VNLFSSTKSMMSVQNSGTQQQGNGLFQQGNEMMSLQSGNFLQQSSHSQAQLFHPQNPIAD
SQ AQNLSQETQGSLFHSPNPIVHSQTSTTSSEQMQPPMFHSQSTIAVLQGSSVPQDQQSTNI
SQ FLSQSPMNNLQTNTVAQEAFFAAPNSISPLQSTSNSEQQAAFQQQAPISHIQTPMLSQEQ
SQ AQPPQQGLFQPQVALGSLPPNPMPQSQQGTMFQSQHSIVAMQSNSPSQEQQQQQQQQQQQ
SQ QQQQQQSILFSNQNTMATMASPKQPPPNMIFNPNQNPMANQEQQNQSIFHQQSNMAPMNQ
SQ EQQPMQFQSQSTVSSLQNPGPTQSESSQTPLFHSSPQIQLVQGSPSSQEQQVTLFLSPAS
SQ MSALQTSINQQDMQQSPLYSPQNNMPGIQGATSSPQPQATLFHNTAGGTMNQLQNSPGSS
SQ QQTSGMFLFGIQNNCSQLLTSGPATLPDQLMAISQPGQPQNEGQPPVTTLLSQQMPENSP
SQ LASSINTNQNIEKIDLLVSLQNQGNNLTGSF
XX
SC translated from EMBL #AB020634
XX
FT 26 968 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 264 443 
PS50254; REL_2.
FT 282 439 
PF00554; Rel homology domain (RHD).
FT 444 542 
SM00429; iptmega2.
FT 445 542 
PF01833; IPT/TIG domain.
XX
IN T02853 hnRNPK; human, Homo sapiens.
IN T00992 Hsp90; human, Homo sapiens.
IN T05111 Ku80; human, Homo sapiens.
IN T10416 NFAT5c; human, Homo sapiens.
IN T14055 PARP; human, Homo sapiens.
IN T19717 RHA; human, Homo sapiens.
XX
MX M03556 V$NFAT5_Q5_01.
XX
BS R21231.
BS R08188.
BS R21079.
BS R21082.
XX
DR TRANSPATH: MO000105052.
DR EMBL: AB020634;
DR EMBL: AF089824;
DR EMBL: AF134870;
DR EMBL: AF163836;
DR EMBL: Z97016;
DR UniProtKB: O94916-1;
XX
RN [1]; RE0017300.
RX PUBMED: 10377394.
RA Lopez-Rodriguez C., Aramburu J., Rakeman A. S., Rao A.
RT NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun
RL Proc. Natl. Acad. Sci. USA 96:7214-7219 (1999).
RN [2]; RE0017301.
RX PUBMED: 10051678.
RA Miyakawa H., Woo S. K., Dahl S. C., Handler J. S., Kwon H. M.
RT Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity
RL Proc. Natl. Acad. Sci. USA 96:2538-2542 (1999).
RN [3]; RE0022955.
RX PUBMED: 11485737.
RA Lopez-Rodriguez C., Aramburu J., Jin L., Rakeman A. S., Michino M., Rao A.
RT Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress.
RL Immunity 15:47-58 (2001).
RN [4]; RE0053532.
RX PUBMED: 18411282.
RA Xu S., Wong C. C., Tong E. H., Chung S. S., Yates JR 3. r. d., Yin Y., Ko B. C.
RT Phosphorylation by Casein Kinase 1 Regulates Tonicity-induced Osmotic Response Element-binding Protein/Tonicity Enhancer-binding Protein Nucleocytoplasmic Trafficking.
RL J. Biol. Chem. 283:17624-17634 (2008).
RN [5]; RE0070942.
RX PUBMED: 21209322.
RA Gallazzini M., Heussler G. E., Kunin M., Izumi Y., Burg M. B., Ferraris J. D.
RT High NaCl-induced activation of CDK5 increases phosphorylation of the osmoprotective transcription factor TonEBP/OREBP at threonine 135, which contributes to its rapid nuclear localization.
RL Mol. Biol. Cell 22:703-714 (2011).
XX
//