AC T00880
XX
ID T00880
XX
DT 20.10.1992 (created); ewi.
DT 02.04.2013 (updated); prb.
CO Copyright (C), QIAGEN.
XX
FA Vav
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SY p95vav; Vav; Vav-1; Vav1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004620 VAV1; HGNC: VAV1.
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CL C0013; HLH-ZIP.
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SF SH3 (2x), SH2, acidic region;
SF no basic region;
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CP hematopoietic cells.
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FF Vav cleavage product p76 induces JNK- but not p38-activation, and inhibits IL-2 expression [47];
FF Protooncogene product, loss of HLH activates transforming potential;
XX
IN T02853 hnRNPK; human, Homo sapiens.
IN T08835 Ku70-isoform1; human, Homo sapiens.
IN T05110 Ku70; human, Homo sapiens.
XX
BS R37226.
XX
DR TRANSPATH: MO000019112.
DR UniProtKB: P15498;
XX
RN [1]; RE0001512.
RX PUBMED: 2005887.
RA Katzav S., Cleveland J. L., Heslop H. E., Pulido D.
RT Loss of the amino-terminal helix-loop-helix domain of the vav proto-oncogene activates its transforming potential
RL Mol. Cell. Biol. 11:1912-1920 (1991).
RN [2]; RE0001860.
RX PUBMED: 1311423.
RA Bustelo X. R., Ledbetter J. A., Barbacid M.
RT Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates
RL Nature 356:68-71 (1992).
RN [3]; RE0001861.
RX PUBMED: 1531699.
RA Margolis B., Hu P., Katzav S., Li W., Oliver J. M., Ullrich A., Weiss A., Schlessinger J.
RT Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs
RL Nature 356:71-74 (1992).
RN [4]; RE0017781.
RX PUBMED: 11287617.
RA Kaminuma O., Deckert M., Elly C., Liu Y. C., Altman A.
RT Vav-Rac1-mediated activation of the c-Jun N-terminal kinase/c-Jun/AP-1 pathway plays a major role in stimulation of the distal NFAT site in the interleukin-2 gene promoter.
RL Mol. Cell. Biol. 21:3126-3136 (2001).
RN [5]; RE0017927.
RX PUBMED: 11994417.
RA Houlard M., Arudchandran R., Regnier-Ricard F., Germani A., Gisselbrecht S., Blank U., Rivera J., Varin-Blank N.
RT Vav1 is a component of transcriptionally active complexes.
RL J. Exp. Med. 195:1115-1127 (2002).
RN [6]; RE0023521.
RX PUBMED: 9162069.
RA Shigematsu H., Iwasaki H., Otsuka T., Ohno Y., Arima F., Niho Y.
RT Role of the vav proto-oncogene product (Vav) in erythropoietin-mediated cell proliferation and phosphatidylinositol 3-kinase activity.
RL J. Biol. Chem. 272:14334-14340 (1997).
RN [7]; RE0030376.
RX PUBMED: 9013873.
RA Lee I. S., Liu Y., Narazaki M., Hibi M., Kishimoto T., Taga T.
RT Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6.
RL FEBS Lett. 401:133-7 (1997).
RN [8]; RE0032357.
RX PUBMED: 10360968.
RA Zhang W., Irvin B. J., Trible R. P., Abraham R. T., Samelson L. E.
RT Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.
RL Int. Immunol. 11:943-50 (1999).
RN [9]; RE0033265.
RX PUBMED: 11849313.
RA Bar-Shavit R., Maoz M., Yongjun Y., Groysman M., Dekel I., Katzav S.
RT Signalling pathways induced by protease-activated receptors and integrins in T cells.
RL Immunology 105:35-46 (2002).
RN [10]; RE0034437.
RX PUBMED: 14757747.
RA Zakaria S., Gomez T. S., Savoy D. N., McAdam S., Turner M., Abraham R. T., Billadeau D. D.
RT Differential regulation of TCR-mediated gene transcription by Vav family members.
RL J. Exp. Med. 199:429-34 (2004).
RN [11]; RE0047686.
RX PUBMED: 12386169.
RA Groysman M., Hornstein I., Alcover A., Katzav S.
RT Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways.
RL J. Biol. Chem. 277:50121-50130 (2002).
RN [12]; RE0047691.
RX PUBMED: 8524317.
RA Romero F., Dargemont C., Pozo F., Reeves W. H., Camonis J., Gisselbrecht S., Fischer S.
RT p95vav associates with the nuclear protein Ku-70.
RL Mol. Cell. Biol. 16:37-44 (1996).
RN [13]; RE0047703.
RX PUBMED: 15269224.
RA Jones M. L., Craik J. D., Gibbins J. M., Poole A. W.
RT Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus.
RL J. Biol. Chem. 279:40475-40483 (2004).
RN [14]; RE0047712.
RX PUBMED: 8621483.
RA Smit L., van der Horst G., Borst J.
RT Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and differentially associate with Shc-Grb2, Crk, and Crk-L adaptors.
RL J. Biol. Chem. 271:8564-8569 (1996).
RN [15]; RE0047722.
RX PUBMED: 9488731.
RA Romero F., Germani A., Puvion E., Camonis J., Varin-Blank N., Gisselbrecht S., Fischer S.
RT Vav binding to heterogeneous nuclear ribonucleoprotein (hnRNP) C. Evidence for Vav-hnRNP interactions in an RNA-dependent manner.
RL J. Biol. Chem. 273:5923-5931 (1998).
RN [16]; RE0048802.
RX PUBMED: 9822663.
RA Michel F., Grimaud L., Tuosto L., Acuto O.
RT Fyn and ZAP-70 are required for Vav phosphorylation in T cells stimulated by antigen-presenting cells.
RL J. Biol. Chem. 273:31932-31938 (1998).
RN [17]; RE0048896.
RX PUBMED: 15169881.
RA Chen R., Relouzat F., Roncagalli R., Aoukaty A., Tan R., Latour S., Veillette A.
RT Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors.
RL Mol. Cell. Biol. 24:5144-5156 (2004).
RN [18]; RE0048909.
RX PUBMED: 9269777.
RA Tamma S. M., Chirmule N., Yagura H., Oyaizu N., Kalyanaraman V., Pahwa S.
RT CD4 cross-linking (CD4XL) induces RAS activation and tumor necrosis factor-alpha secretion in CD4+ T cells.
RL Blood 90:1588-1593 (1997).
RN [19]; RE0051437.
RX PUBMED: 16567503.
RA Sanjuan M. A., Rao N., Lai K. T., Gu Y., Sun S., Fuchs A., Fung-Leung W. P., Colonna M., Karlsson L.
RT CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion.
RL J. Cell Biol. 172:1057-1068 (2006).
RN [20]; RE0052353.
RX PUBMED: 8226994.
RA Kiener P. A., Rankin B. M., Burkhardt A. L., Schieven G. L., Gilliland L. K., Rowley R. B., Bolen J. B., Ledbetter J. A.
RT Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase.
RL J. Biol. Chem. 268:24442-24448 (1993).
RN [21]; RE0052391.
RX PUBMED: 9884353.
RA Pan X. Q., Darby C., Indik Z. K., Schreiber A. D.
RT Activation of three classes of nonreceptor tyrosine kinases following Fc gamma receptor crosslinking in human monocytes.
RL Clin. Immunol. 90:55-64 (1999).
RN [22]; RE0053193.
RX PUBMED: 15860232.
RA Jeon H. K., Ahn J. H., Choe J., Park J. H., Lee T. H.
RT Anti-IgM induces up-regulation and tyrosine-phosphorylation of heterogeneous nuclear ribonucleoprotein K proteins (hnRNP K) in a Ramos B cell line.
RL Immunol. Lett. 98:303-310 (2005).
RN [23]; RE0055531.
RX PUBMED: 16920955.
RA Eissmann P., Watzl C.
RT Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells.
RL J. Immunol. 177:3170-3177 (2006).
RN [24]; RE0059681.
RX PUBMED: 15263016.
RA Xavier R., Rabizadeh S., Ishiguro K., Andre N., Ortiz J. B., Wachtel H., Morris D. G., Lopez-Ilasaca M., Shaw A. C., Swat W., Seed B.
RT Discs large (Dlg1) complexes in lymphocyte activation.
RL J. Cell Biol. 166:173-178 (2004).
RN [25]; RE0063531.
RX PUBMED: 10395938.
RA Cichowski K., Orsini M. J., Brass L. F.
RT PAR1 activation initiates integrin engagement and outside-in signalling in megakaryoblastic CHRF-288 cells.
RL Biochim. Biophys. Acta 1450:265-276 (1999).
RN [26]; RE0065731.
RX PUBMED: 16461343.
RA Wu J., Katrekar A., Honigberg L. A., Smith A. M., Conn M. T., Tang J., Jeffery D., Mortara K., Sampang J., Williams S. R., Buggy J., Clark J. M.
RT Identification of substrates of human protein-tyrosine phosphatase PTPN22.
RL J. Biol. Chem. 281:11002-11010 (2006).
RN [27]; RE0066806.
RX PUBMED: 18295596.
RA Schneider H., Rudd C. E.
RT CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription.
RL Biochem. Biophys. Res. Commun. 369:616-621 (2008).
RN [28]; RE0067067.
RX PUBMED: 20388118.
RA Stevens C. N., Simeone A. M., John S., Ahmed Z., Lucherini O. M., Baldari C. T., Ladbury J. E.
RT T-cell receptor early signalling complex activation in response to interferon-alpha receptor stimulation.
RL Biochem. J. 428:429-437 (2010).
RN [29]; RE0067252.
RX PUBMED: 17043143.
RA Dong S., Corre B., Foulon E., Dufour E., Veillette A., Acuto O., Michel F.
RT T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2.
RL J. Exp. Med. 203:2509-2518 (2006).
RN [30]; RE0067441.
RX PUBMED: 15708849.
RA Charvet C., Canonigo A. J., Billadeau D. D., Altman A.
RT Membrane localization and function of Vav3 in T cells depend on its association with the adapter SLP-76.
RL J. Biol. Chem. 280:15289-15299 (2005).
RN [31]; RE0067878.
RX PUBMED: 19412549.
RA Bartelt R. R., Cruz-Orcutt N., Collins M., Houtman J. C.
RT Comparison of T cell receptor-induced proximal signaling and downstream functions in immortalized and primary T cells.
RL PLoS ONE 4:e5430 (2009).
RN [32]; RE0068037.
RX PUBMED: 9846483.
RA Finco T. S., Kadlecek T., Zhang W., Samelson L. E., Weiss A.
RT LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.
RL Immunity 9:617-626 (1998).
RN [33]; RE0068065.
RX PUBMED: 11724779.
RA Teixeiro E., Fuentes P., Galocha B., Alarcon B., Bragado R.
RT T cell receptor-mediated signal transduction controlled by the beta chain transmembrane domain: apoptosis-deficient cells display unbalanced mitogen-activated protein kinases activities upon T cell receptor engagement.
RL J. Biol. Chem. 277:3993-4002 (2002).
RN [34]; RE0068144.
RX PUBMED: 15661896.
RA Dombroski D., Houghtling R. A., Labno C. M., Precht P., Takesono A., Caplen N. J., Billadeau D. D., Wange R. L., Burkhardt J. K., Schwartzberg P. L.
RT Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.
RL J. Immunol. 174:1385-1392 (2005).
RN [35]; RE0068278.
RX PUBMED: 18548611.
RA Haas A., Weckbecker G., Welzenbach K.
RT Intracellular Phospho-Flow cytometry reveals novel insights into TCR proximal signaling events. A comparison with Western blot.
RL Cytometry A 73:799-807 (2008).
RN [36]; RE0068295.
RX PUBMED: 16684890.
RA Tsang J. Y., Camara N. O., Eren E., Schneider H., Rudd C., Lombardi G., Lechler R.
RT Altered proximal T cell receptor (TCR) signaling in human CD4+CD25+ regulatory T cells.
RL J. Leukoc. Biol. 80:145-151 (2006).
RN [37]; RE0068640.
RX PUBMED: 9603925.
RA Pedraza-Alva G., Merida L. B., Burakoff S. J., Rosenstein Y.
RT T cell activation through the CD43 molecule leads to Vav tyrosine phosphorylation and mitogen-activated protein kinase pathway activation.
RL J. Biol. Chem. 273:14218-14224 (1998).
RN [38]; RE0069524.
RX PUBMED: 19880579.
RA Chang J. W., Koike T., Iwashima M.
RT hnRNP-K is a nuclear target of TCR-activated ERK and required for T-cell late activation.
RL Int. Immunol. 21:1351-1361 (2009).
RN [39]; RE0069944.
RX PUBMED: 16782030.
RA Gomez T. S., McCarney S. D., Carrizosa E., Labno C. M., Comiskey E. O., Nolz J. C., Zhu P., Freedman B. D., Clark M. R., Rawlings D. J., Billadeau D. D., Burkhardt J. K.
RT HS1 functions as an essential actin-regulatory adaptor protein at the immune synapse.
RL Immunity 24:741-752 (2006).
RN [40]; RE0070228.
RX PUBMED: 17850179.
RA Cao W., Zhang L., Rosen D. B., Bover L., Watanabe G., Bao M., Lanier L. L., Liu Y. J.
RT BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells.
RL PLoS Biol. 5:e248 (2007).
RN [41]; RE0070254.
RX PUBMED: 20682913.
RA Kwon J., Shatynski K. E., Chen H., Morand S., De Deken X., Miot F., Leto T. L., Williams M. S.
RT The nonphagocytic NADPH oxidase Duox1 mediates a positive feedback loop during T cell receptor signaling.
RL Sci. Signal. 3:ra59 (2010).
RN [42]; RE0070672.
RX PUBMED: 20231423.
RA Robles-Valero J., Martin-Cofreces N. B., Lamana A., Macdonald S., Volkov Y., Sanchez-Madrid F.
RT Integrin and CD3/TCR activation are regulated by the scaffold protein AKAP450.
RL Blood 115:4174-4184 (2010).
RN [43]; RE0070867.
RX PUBMED: 18779373.
RA Martin-Cofreces N. B., Robles-Valero J., Cabrero J. R., Mittelbrunn M., Gordon-Alonso M., Sung C. H., Alarcon B., Vazquez J., Sanchez-Madrid F.
RT MTOC translocation modulates IS formation and controls sustained T cell signaling.
RL J. Cell Biol. 182:951-962 (2008).
RN [44]; RE0071090.
RX PUBMED: 11024037.
RA Pedraza-Alva G., Sawasdikosol S., Liu Y. C., Merida L. B., Cruz-Munoz M. E., Oceguera-Yanez F., Burakoff S. J., Rosenstein Y.
RT Regulation of Cbl molecular interactions by the co-receptor molecule CD43 in human T cells.
RL J. Biol. Chem. 276:729-737 (2001).
RN [45]; RE0071216.
RX PUBMED: 16728400.
RA Wilkinson B., Koenigsknecht-Talboo J., Grommes C., Lee C. Y., Landreth G.
RT Fibrillar beta-amyloid-stimulated intracellular signaling cascades require Vav for induction of respiratory burst and phagocytosis in monocytes and microglia.
RL J. Biol. Chem. 281:20842-20850 (2006).
RN [46]; RE0071441.
RX PUBMED: 17148460.
RA Beach D., Gonen R., Bogin Y., Reischl I. G., Yablonski D.
RT Dual role of SLP-76 in mediating T cell receptor-induced activation of phospholipase C-gamma1.
RL J. Biol. Chem. 282:2937-2946 (2007).
RN [47]; RE0021057.
RX PUBMED: 10713703.
RA Hofmann T. G., Hehner S. P., Droege W., Schmitz M. L.
RT Caspase-dependent cleavage and inactivation of the Vav1 proto-oncogene product during apoptosis prevents IL-2 transcription
RL Oncogene 19:1153-1163 (2000).
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