AC T08835
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ID T08835
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DT 19.04.2006 (created); man.
CO Copyright (C), QIAGEN.
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FA Ku70-isoform1
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SY 70 kDa subunit of KU antigen; ATP-dependent DNA helicase II, 70 kDa subunit; CTC box binding factor 75 kDa subunit; CTC75; CTCBF; Ku70; lupus KU autoantigen protein p70; p70 (Ku) lupus autoantigen; thyroid-lupus autoantigen; TLAA.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G008050 XRCC6; HGNC: Xrcc6.
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SZ 609 AA; 69.8 kDa (cDNA) (calc.).
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SQ MSGWESYYKTEGDEEAEEEQEENLEASGDYKYSGRDSLIFLVDASKAMFESQSEDELTPF
SQ DMSIQCIQSVYISKIISSDRDLLAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELD
SQ QFKGQQGQKRFQDMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDS
SQ AKASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISIAEDEDLRVHFEESSKLE
SQ DLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIKLYRETNEPVKTKT
SQ RTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEELKRFDDPGLMLMGFKPLVLLKKHH
SQ YLRPSLFVYPEESLVIGSSTLFSALLIKCLEKEVAALCRYTPRRNIPPYFVALVPQEEEL
SQ DDQKIQVTPPGFQLVFLPFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFEN
SQ PVLQQHFRNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYNPEGKV
SQ TKRKHDNEGSGSKRPKVEYSEEELKTHISKGTLGKFTVPMLKEACRAYGLKSGLKKQELL
SQ EALTKHFQD
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SC translated from EMBL #J04611
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FT 37 256 
PF03731; Ku70/Ku80 N-terminal alpha/beta domain.
FT 261 468 
PF02735; Ku70/Ku80 beta-barrel domain.
FT 308 454 
SM00559; Ku78.
FT 471 559 
PF03730; Ku70/Ku80 C-terminal arm.
FT 573 607 
PF02037; SAP domain.
FT 573 607 
PS50800; SAP.
FT 573 607 
SM00513; sap_9.
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IN T10036 HSF1; human, Homo sapiens.
IN T10782 Smad6; Mammalia.
IN T00880 Vav; human, Homo sapiens.
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DR TRANSPATH: MO000080203.
DR EMBL: J04607;
DR EMBL: J04611;
DR EMBL: M32865;
DR EMBL: S38729;
DR EMBL: Z83840;
DR UniProtKB: P12956;
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RN [1]; RE0044046.
RX PUBMED: 12171929.
RA Ohta S., Shiomi Y., Sugimoto K., Obuse C., Tsurimoto T.
RT A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein
RL J. Biol. Chem. 277:40362-7 (2002).
RN [2]; RE0048036.
RX PUBMED: 11162511.
RA Tang D., Xie Y., Zhao M., Stevenson M. A., Calderwood S. K.
RT Repression of the HSP70B promoter by NFIL6, Ku70, and MAPK involves three complementary mechanisms.
RL Biochem. Biophys. Res. Commun. 280:280-285 (2001).
RN [3]; RE0048301.
RX PUBMED: 15023334.
RA Cohen H. Y., Lavu S., Bitterman K. J., Hekking B., Imahiyerobo T. A., Miller C., Frye R., Ploegh H., Kessler B. M., Sinclair D. A.
RT Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis.
RL Mol. Cell 13:627-638 (2004).
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