AC T01397
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ID T01397
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DT 10.12.1994 (created); ewi.
DT 21.09.2011 (updated); jag.
CO Copyright (C), QIAGEN.
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FA c-Ets-2
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SY c-Ets-2; c-Ets-2 58-64; Ets-2; Ets2; p58-64c-Ets-2.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004761 Ets2.
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CL C0016; ETS.
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SZ 468 AA; 52.8 kDa (cDNA) (calc.), 56 kDa (SDS)
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SQ MNDFGIKNMDQVAPVANSFRGTLKRQPAFDTFDGSLFAVLPSLSEDQTLQEVPTGLDSVS
SQ HDSASCELPLLTPCSKAVMSQALKATFSGFQKEQRRLGIPKNPWLWSEQQVCQWLLWATN
SQ EFSLVNVNLHQFGMNGQMLCNLGKERFLELAPDFVGDILWEHLEQMIKENQEKTEDQYEE
SQ NSHLNAVPHWINSNTLGFSMEQAPYGMQAPNYPKDNLLDSMCPPSATPAALGSELQMLPK
SQ SRLNTVNVNYCSISQDFPSSNVNLLNNNSGKPKDHDSPENGGDSFESSDSLLRSWNSQSS
SQ LLDVQRVPSFESFEEDCSQSLCLSKLTMSFKDYIQERSDPVEQGKPVIPAAVLAGFTGSG
SQ PIQLWQFLLELLSDKSCQSFISWTGDGWEFKLADPDEVARRWGKRKNKPKMNYEKLSRGL
SQ RYYYDKNIIHKTSGKRYVYRFVCDLQNLLGFTPEELHAILGVQPDTED
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SC Swiss-Prot#P15037
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FT 30 393 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 87 170 
PF02198; Sterile alpha motif (SAM)/Pointed domain.
FT 87 170 
SM00251; SAM2_3.
FT 102 168 
POINTED domain of homology [5].
FT 361 444 
PF00178; Ets-domain.
FT 361 446 
SM00413; etsneu2.
FT 362 442 
PS50061; ETS_DOMAIN_3.
FT 364 432 
PS50140; HSF_ETS.
FT 454 468 
repression of DNA-binding [1].
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SF 16 C-terminal AA repress DNA-binding;
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EX brain,,,Theiler Stage 24; low; Northern blot; total RNA; [4].
EX brain,,,adult; detectable; Northern blot; mRNA (poly-A); [4].
EX heart,,,Theiler Stage 23; low; Northern blot; total RNA; [4].
EX heart,,,Theiler Stage 24; low; Northern blot; total RNA; [4].
EX heart,,,adult; detectable; Northern blot; mRNA (poly-A); [4].
EX intestine,,,Theiler Stage 23; low; Northern blot; total RNA; [4].
EX intestine,,,Theiler Stage 24; low; Northern blot; total RNA; [4].
EX intestine,,,adult; detectable; Northern blot; mRNA (poly-A); [4].
EX kidney (right and left),,,Theiler Stage 23; low; Northern blot; total RNA; [4].
EX kidney (right and left),,,Theiler Stage 24; low; Northern blot; total RNA; [4].
EX kidney (right and left),,,adult; detectable; Northern blot; mRNA (poly-A); [4].
EX liver,,,Theiler Stage 24; low; Northern blot; total RNA; [4].
EX liver,,,adult; detectable; Northern blot; mRNA (poly-A); [4].
EX lung,,,Theiler Stage 23; low; Northern blot; total RNA; [4].
EX lung,,,Theiler Stage 24; low; Northern blot; total RNA; [4].
EX lung,,,adult; detectable; Northern blot; mRNA (poly-A); [4].
EX spleen,,,Theiler Stage 23; low; Northern blot; total RNA; [4].
EX spleen,,,Theiler Stage 24; low; Northern blot; total RNA; [4].
EX spleen,,,adult; detectable; Northern blot; mRNA (poly-A); [4].
EX stomach,,,Theiler Stage 23; low; Northern blot; total RNA; [4].
EX stomach,,,Theiler Stage 24; low; Northern blot; total RNA; [4].
EX stomach,,,adult; detectable; Northern blot; mRNA (poly-A); [4].
EX thymus,,,Theiler Stage 23; medium; Northern blot; total RNA; [4].
EX thymus,,,Theiler Stage 24; medium; Northern blot; total RNA; [4].
EX thymus,,,adult; medium; Northern blot; mRNA (poly-A); [4].
EX yolk sac,,,Theiler Stage 12; low; Northern blot; total RNA; [4].
EX yolk sac,,,Theiler Stage 14; low; Northern blot; total RNA; [4].
EX yolk sac,,,Theiler Stage 16; low; Northern blot; total RNA; [4].
EX yolk sac,,,Theiler Stage 18; low; Northern blot; total RNA; [4].
EX yolk sac,,,Theiler Stage 20; low; Northern blot; total RNA; [4].
XX
FF mitogenic and oncogenic activity [2];
FF even a slight overexpression causes skeletal abnormalities [6];
FF the full-length Ets2 does not bind in vitro to a DNA probe containing the two ets sites of the promoter TGFBR2 [7];
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IN T01318 CBP; mouse, Mus musculus.
IN T08499 CBP; mouse, Mus musculus.
IN T23091 p300; Mammalia.
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MX M01989 V$CETS2_01.
MX M07379 V$ETS2_Q4.
MX M01207 V$ETS2_Q6.
MX M08881 V$ETSLIKE_Q4.
MX M00340 V$ETS_B.
MX M00771 V$ETS_Q4.
MX M00971 V$ETS_Q6.
XX
BS R26463.
BS R21799.
BS R12538.
BS R14491.
BS R73990.
BS R21430.
BS R30131.
BS R73955.
BS R16946.
BS R16977.
BS R16978.
BS R14393.
XX
DR TRANSPATH: MO000025645.
DR TRANSCOMPEL: C00086.
DR TRANSCOMPEL: C00136.
DR TRANSCOMPEL: C00185.
DR TRANSCOMPEL: C00238.
DR TRANSCOMPEL: C00264.
DR EMBL: J04103;
DR UniProtKB: P15037;
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RN [1]; RE0002584.
RX PUBMED: 1409581.
RA Hagman J., Grosschedl R.
RT An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of Ets family factors to promoter sequences of the mb-1 gene
RL Proc. Natl. Acad. Sci. USA 89:8889-8893 (1992).
RN [2]; RE0002586.
RX PUBMED: 2813360.
RA Seth A., Watson D. K., Blair D. G., Papas T. S.
RT c-ets-2 protooncogene has mitogenic and oncogenic activity
RL Proc. Natl. Acad. Sci. USA 86:7833-7837 (1989).
RN [3]; RE0005310.
RX PUBMED: 2847145.
RA Watson D. K., McWilliams-Smith M. J., Lapis P., Lautenberger J. A., Schweinfest C. W., Papas T. S.
RT Mammalian ets-1 and ets-2 genes encode highly conserved proteins
RL Proc. Natl. Acad. Sci. USA 85:7862-7866 (1988).
RN [4]; RE0005315.
RX PUBMED: 7689222.
RA Kola I., Brookes S., Green A. R., Garber R., Tymms M., Papas T. S., Setz A.
RT The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation
RL Proc. Natl. Acad. Sci. USA 90:7588-7592 (1993).
RN [5]; RE0005316.
RX PUBMED: 8223245.
RA Klaembt C.
RT The Drosophila gene pointed encodes two ETS-like proteins which are involved in the development of the midline glial cells
RL Development 117:163-176 (1993).
RN [6]; RE0005319.
RX PUBMED: 8596630.
RA Sumarsono S. H., Wilson T. J., Tymms M. J., Venter D. J., Corrick C. M., Kola R., Lahoud M. L., Papas T. S., Seth A., Kola I.
RT Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice
RL Nature 379:534-537 (1996).
RN [7]; RE0034189.
RX PUBMED: 14976186.
RA Kopp J. L., Wilder P. J., Desler M., Kim J. H., Hou J., Nowling T., Rizzino A.
RT Unique and selective effects of five Ets family members, Elf3, Ets1, Ets2, PEA3, and PU.1, on the promoter of the type II transforming growth factor-beta receptor gene.
RL J. Biol. Chem. 279:19407-20 (2004).
RN [8]; RE0048566.
RX PUBMED: 15572696.
RA Foulds C. E., Nelson M. L., Blaszczak A. G., Graves B. J.
RT Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment.
RL Mol. Cell. Biol. 24:10954-10964 (2004).
RN [9]; RE0063266.
RX PUBMED: 19487701.
RA Shi Z., Cai Z., Wen S., Chen C., Gendron C., Sanchez A., Patterson K., Fu S., Yang J., Wildman D. E., Finnell R. H., Zhang D.
RT Transcriptional regulation of the novel toll-like receptor TLR13.
RL J. Biol. Chem. 284:20540-20547 (2009).
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