AC T08452
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ID T08452
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DT 23.01.2006 (created); jul.
DT 30.05.2016 (updated); mom.
CO Copyright (C), QIAGEN.
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FA CREB1
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SY ATF-47 (human); cAMP-response element binding protein; CREB; CREB-1; CREB-341; CREB-B; CREB1; CREBalpha; Cyclic AMP Responsive Element Binging factor.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009126 Creb1.
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CL C0008; bZIP; 1.1.7.1.1.
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CP R2C and Granulosa cells [27].
XX
FF treatment with haloperidol induces phosphorylation (on Ser 133) [1];
FF important for c-fos induction in amphetamine treated rat striatum [21];
FF amphetamine (4mg/kg) treatment induces phosphorylation (on Ser 133) which is blocked by pretreatment with SCH23390 (1mg/kg), a dopamine receptor antagonist [21];
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IN T08499 CBP; mouse, Mus musculus.
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MX M07248 V$CREB1_Q3.
MX M03544 V$CREB1_Q6.
MX M00981 V$CREBATF_Q6.
MX M00039 V$CREB_01.
MX M00113 V$CREB_02.
MX M00177 V$CREB_Q2.
MX M00916 V$CREB_Q2_01.
MX M00801 V$CREB_Q3.
MX M00178 V$CREB_Q4.
MX M00917 V$CREB_Q4_01.
MX M00114 V$TAXCREB_01.
MX M00115 V$TAXCREB_02.
XX
BS R21497.
BS R22887.
BS R22912.
BS R23020.
BS R23055.
BS R16162.
BS R61323.
BS R61335.
BS R32283.
BS R34088.
BS R29920.
BS R34477.
BS R28487.
BS R33228.
BS R22888.
BS R42490.
BS R23106.
BS R23115.
BS R31350.
BS R31351.
BS R21737.
BS R72473.
BS R27212.
BS R57705.
BS R34179.
BS R21255.
BS R24986.
BS R23515.
BS R25226.
BS R34476.
BS R32890.
BS R37055.
BS R25565.
BS R57746.
BS R60563.
BS R60252.
BS R24786.
BS R23090.
BS R25569.
BS R33274.
BS R26766.
BS R56223.
BS R37063.
BS R16154.
BS R55863.
BS R21786.
BS R21482.
BS R35580.
BS R41911.
BS R41912.
BS R41913.
BS R25264.
BS R31612.
BS R14822.
BS R60820.
BS R29950.
BS R37236.
BS R20810.
BS R65795.
BS R13066.
BS R24257.
BS R20172.
BS R34632.
BS R16447.
BS R25280.
BS R22891.
BS R63981.
BS R32743.
BS R32744.
BS R32749.
BS R22231.
BS R30482.
BS R26663.
BS R25272.
BS R37059.
BS R24961.
BS R56535.
BS R73701.
BS R26518.
BS R41012.
BS R55965.
BS R29611.
BS R71469.
BS R64798.
BS R56126.
BS R04876.
BS R22964.
BS R37817.
BS R68807.
BS R34666.
BS R27142.
BS R67270.
BS R66223.
BS R66885.
BS R31551.
BS R61869.
BS R61874.
BS R61876.
BS R34500.
BS R01358.
BS R27577.
BS R37060.
BS R09520.
BS R36357.
BS R37065.
XX
DR TRANSPATH: MO000058212.
DR TRANSCOMPEL: C00487.
DR UniProtKB: P15337;
XX
RN [1]; RE0008222.
RX PUBMED: 8346209.
RA Konradi C., Kobierski L. A., Nguyen T. V., Heckers S., Hyman S. E.
RT The cAMP-response-element-binding protein interacts, but Fos protein does not interact, with the proenkephalin enhancer in rat striatum
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RT Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism.
RL Neuron 20:709-726 (1998).
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RA Saini H. S., Gorse K. M., Boxer L. M., Sato-Bigbee C.
RT Neurotrophin-3 and a CREB-mediated signaling pathway regulate Bcl-2 expression in oligodendrocyte progenitor cells.
RL J. Neurochem 89:951-61 (2004).
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RX PUBMED: 11312266.
RA Roux P. P., Bhakar A. L., Kennedy T. E., Barker P. A.
RT The p75 neurotrophin receptor activates Akt (protein kinase B) through a phosphatidylinositol 3-kinase-dependent pathway.
RL J. Biol. Chem. 276:23097-104 (2001).
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RA Ubeda M., Vallejo M., Habener J. F.
RT CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins.
RL Mol. Cell. Biol. 19:7589-7599 (1999).
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RA Chen M. J., Nguyen T. V., Pike C. J., Russo-Neustadt A. A.
RT Norepinephrine induces BDNF and activates the PI-3K and MAPK cascades in embryonic hippocampal neurons.
RL Cell. Signal. 19:114-128 (2007).
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RA Mok S. A., Campenot R. B.
RT A nerve growth factor-induced retrograde survival signal mediated by mechanisms downstream of TrkA.
RL Neuropharmacology 52:270-278 (2007).
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RA Tong L., Balazs R., Thornton P. L., Cotman C. W.
RT Beta-amyloid peptide at sublethal concentrations downregulates brain-derived neurotrophic factor functions in cultured cortical neurons.
RL J. Neurosci. 24:6799-6809 (2004).
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RX PUBMED: 11880483.
RA Ying S. W., Futter M., Rosenblum K., Webber M. J., Hunt S. P., Bliss T. V., Bramham C. R.
RT Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis.
RL J. Neurosci. 22:1532-1540 (2002).
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RX PUBMED: 16877354.
RA Tan J., Shepherd R. K.
RT Aminoglycoside-induced degeneration of adult spiral ganglion neurons involves differential modulation of tyrosine kinase B and p75 neurotrophin receptor signaling.
RL Am. J. Pathol. 169:528-543 (2006).
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RA Rivera C., Voipio J., Thomas-Crusells J., Li H., Emri Z., Sipila S., Payne J. A., Minichiello L., Saarma M., Kaila K.
RT Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2.
RL J. Neurosci. 24:4683-4691 (2004).
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RX PUBMED: 15128846.
RA Arthur J. S., Fong A. L., Dwyer J. M., Davare M., Reese E., Obrietan K., Impey S.
RT Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins.
RL J. Neurosci. 24:4324-4332 (2004).
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RX PUBMED: 11062237.
RA Chandler L. J., Sutton G., Dorairaj N. R., Norwood D.
RT N-methyl D-aspartate receptor-mediated bidirectional control of extracellular signal-regulated kinase activity in cortical neuronal cultures.
RL J. Biol. Chem. 276:2627-2636 (2001).
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RX PUBMED: 18036576.
RA Soiampornkul R., Tong L., Thangnipon W., Balazs R., Cotman C. W.
RT Interleukin-1beta interferes with signal transduction induced by neurotrophin-3 in cortical neurons.
RL Brain Res. 1188:189-197 (2007).
RN [15]; RE0051401.
RX PUBMED: 17467122.
RA Tong L., Balazs R., Soiampornkul R., Thangnipon W., Cotman C. W.
RT Interleukin-1beta impairs brain derived neurotrophic factor-induced signal transduction.
RL Neurobiol. Aging 29:1380-1393 (2007).
RN [16]; RE0051654.
RX PUBMED: 11517234.
RA Iida N., Namikawa K., Kiyama H., Ueno H., Nakamura S., Hattori S.
RT Requirement of Ras for the activation of mitogen-activated protein kinase by calcium influx, cAMP, and neurotrophin in hippocampal neurons.
RL J. Neurosci. 21:6459-6466 (2001).
RN [17]; RE0051728.
RX PUBMED: 17961520.
RA Takeda H., Kitaoka Y., Hayashi Y., Kumai T., Munemasa Y., Fujino H., Kobayashi S., Ueno S.
RT Calcium/calmodulin-dependent protein kinase II regulates the phosphorylation of CREB in NMDA-induced retinal neurotoxicity.
RL Brain Res. 1184:306-315 (2007).
RN [18]; RE0051761.
RX PUBMED: 10804193.
RA Sala C., Rudolph-Correia S., Sheng M.
RT Developmentally regulated NMDA receptor-dependent dephosphorylation of cAMP response element-binding protein (CREB) in hippocampal neurons.
RL J. Neurosci. 20:3529-3536 (2000).
RN [19]; RE0051794.
RX PUBMED: 10825388.
RA Won J. S., Lee J. K., Song D. K., Huh S. O., Jung J. S., Kim Y. H., Choi M. R., Suh H. W.
RT Cycloheximide increases proenkephalin and tyrosine hydroxylase gene expression in rat adrenal medulla.
RL Mol. Pharmacol. 57:1173-1181 (2000).
RN [20]; RE0051809.
RX PUBMED: 11544482.
RA Watson F. L., Heerssen H. M., Bhattacharyya A., Klesse L., Lin M. Z., Segal R. A.
RT Neurotrophins use the Erk5 pathway to mediate a retrograde survival response.
RL Nat. Neurosci. 4:981-988 (2001).
RN [21]; RE0051836.
RX PUBMED: 8083758.
RA Konradi C., Cole R. L., Heckers S., Hyman S. E.
RT Amphetamine regulates gene expression in rat striatum via transcription factor CREB.
RL J. Neurosci. 14:5623-5634 (1994).
RN [22]; RE0051893.
RX PUBMED: 17920195.
RA Lamas M., Lee-Rivera I., Ramirez M., Lopez-Colome A. M.
RT D-serine regulates CREB phosphorylation induced by NMDA receptor activation in Muller glia from the retina.
RL Neurosci. Lett. 427:55-60 (2007).
RN [23]; RE0051928.
RX PUBMED: 14622123.
RA Dudman J. T., Eaton M. E., Rajadhyaksha A., Macias W., Taher M., Barczak A., Kameyama K., Huganir R., Konradi C.
RT Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1.
RL J. Neurochem 87:922-934 (2003).
RN [24]; RE0051940.
RX PUBMED: 12969258.
RA Chartoff E. H., Papadopoulou M., Konradi C., Carlezon WA J. r.
RT Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum.
RL J. Neurochem 87:107-118 (2003).
RN [25]; RE0052224.
RX PUBMED: 8753884.
RA Konradi C., Leveque J. C., Hyman S. E.
RT Amphetamine and dopamine-induced immediate early gene expression in striatal neurons depends on postsynaptic NMDA receptors and calcium.
RL J. Neurosci. 16:4231-4239 (1996).
RN [26]; RE0052570.
RX PUBMED: 16313513.
RA Saini H. S., Coelho R. P., Goparaju S. K., Jolly P. S., Maceyka M., Spiegel S., Sato-Bigbee C.
RT Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors.
RL J. Neurochem 95:1298-1310 (2005).
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RX PUBMED: 7854348.
RA Fitzpatrick S. L., Richards J. S.
RT Identification of a cyclic adenosine 3',5'-monophosphate-response element in the rat aromatase promoter that is required for transcriptional activation in rat granulosa cells and R2C leydig cells.
RL Mol. Endocrinol. 8:1309-1319 (1994).
RN [28]; RE0053577.
RX PUBMED: 16330542.
RA Krones-Herzig A., Mesaros A., Metzger D., Ziegler A., Lemke U., Bruning J. C., Herzig S.
RT Signal-dependent control of gluconeogenic key enzyme genes through coactivator-associated arginine methyltransferase 1.
RL J. Biol. Chem. 281:3025-3029 (2006).
RN [29]; RE0054130.
RX PUBMED: 15470197.
RA Sun L. S., Quamina A.
RT Extracellular receptor kinase and cAMP response element binding protein activation in the neonatal rat heart after perinatal cocaine exposure.
RL Pediatr. Res. 56:947-952 (2004).
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RX PUBMED: 19524026.
RA Katoh-Semba R., Kaneko R., Kitajima S., Tsuzuki M., Ichisaka S., Hata Y., Yamada H., Miyazaki N., Takahashi Y., Kato K.
RT Activation of p38 mitogen-activated protein kinase is required for in vivo brain-derived neurotrophic factor production in the rat hippocampus.
RL Neuroscience 163:352-361 (2009).
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RX PUBMED: 17283241.
RA Chen Y. J., Hsiao P. W., Lee M. T., Mason J. I., Ke F. C., Hwang J. J.
RT Interplay of PI3K and cAMP/PKA signaling, and rapamycin-hypersensitivity in TGFbeta1 enhancement of FSH-stimulated steroidogenesis in rat ovarian granulosa cells.
RL J. Endocrinol. 192:405-419 (2007).
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RX PUBMED: 18063805.
RA Thomson D. M., Herway S. T., Fillmore N., Kim H., Brown J. D., Barrow J. R., Winder W. W.
RT AMP-activated protein kinase phosphorylates transcription factors of the CREB family.
RL J. Appl. Physiol. 104:429-438 (2008).
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RX PUBMED: 18606818.
RA Luo Y., Lathia J., Mughal M., Mattson M. P.
RT SDF1alpha/CXCR4 signaling, via ERKs and the transcription factor Egr1, induces expression of a 67-kDa form of glutamic acid decarboxylase in embryonic hippocampal neurons.
RL J. Biol. Chem. 283:24789-24800 (2008).
RN [34]; RE0072568.
RX PUBMED: 17721610.
RA Dimova E. Y., Jakubowska M. M., Kietzmann T.
RT CREB binding to the hypoxia-inducible factor-1 responsive elements in the plasminogen activator inhibitor-1 promoter mediates the glucagon effect.
RL Thromb. Haemost. 98:296-303 (2007).
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