AC T03960
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ID T03960
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DT 18.10.2000 (created); rio.
DT 06.04.2009 (updated); djp.
CO Copyright (C), QIAGEN.
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FA PMX2A
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SY aristaless homeobox protein homolog; DB1 binding protein; DB1BP; paired mesoderm homeobox protein 2a; Pmx2a.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001940 Phox2a.
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HO Phox2a (mouse) T02090, Pmx2a (human) T03959.
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CL C0006; homeo; 3.1.3.18.1.
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SF highest homeo domain identity to Smox (90%), Aristaless (78%), Pax-3 T00680 (75%), cart1 (75%), Alx3 T03343 (73%), Phox1/Mhox T02966 (72%) and Prd T00699 (70%) [1];
SF N-terminal activation domain interacts with the transcriptional co-activator CBP T01318 [3];
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CP sympathetic ganglia, adrenal gland, dopamine beta-hydroxylase positive tissues, (cell lines:) PC12 cells [1].
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FF involved in regulation of the catecholamine biosynthetic genes [1];
FF can act as activator and repressor [1];
FF synergistic interaction with the cAMP signal transduction system in the regulation of DBH (dopamine beta-hydroxylase) [2];
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IN T01318 CBP; mouse, Mus musculus.
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MX M01444 V$PMX2A_01.
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BS R09472.
BS R09473.
BS R23236.
BS R16167.
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DR TRANSPATH: MO000027870.
DR UniProtKB: Q62782;
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RN [1]; RE0015199.
RX PUBMED: 8613746.
RA Zellmer E., Zhang Z., Greco D., Rhodes J., Cassel S., Lewis E. J.
RT A homeodomain protein selectively expressed in noradrenergic tissue regulates transcription of neurotransmitter biosynthetic genes
RL J. Neurosci. 15:8109-8120 (1995).
RN [2]; RE0015224.
RX PUBMED: 9341190.
RA Swanson D. J., Zellmer E., Lewis E. J.
RT The homeodomain protein Arix interacts synergistically with cyclic AMP to regulate expression of neurotransmitter biosynthetic genes
RL J. Biol. Chem. 272:27382-27392 (1997).
RN [3]; RE0015252.
RX PUBMED: 10644760.
RA Swanson D. J., Adachi M., Lewis E. J.
RT The homeodomain protein Arix promotes protein kinase A-dependent activation of the dopamine beta-hydroxylase promoter through multiple elements and interaction with the coactivator cAMP-response element-binding protein-binding protein
RL J. Biol. Chem. 275:2911-2923 (2000).
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