AC T02090
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ID T02090
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DT 29.01.1997 (created); ewi.
DT 04.12.2014 (updated); asv.
CO Copyright (C), QIAGEN.
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FA PMX2A
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SY Aristaless homeobox protein homolog; Arix; paired-like homeobox 2a.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001948 Phox2a.
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HO Pmx2a (human) T03959.
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CL C0006; homeo; 3.1.3.18.1.
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SF most significant similarity with K-2 T02059 and S8 T01483 [1];
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CP CATH.a and PATH.2 cell lines [2].
EX adrenal medulla,,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX adrenal medulla,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX adrenal medulla,,,adult; low; Northern blot; total RNA; [1].
EX aortic paraganglion,,,Theiler Stage 22; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX cervicothoracic ganglion,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX fourth pharyngeal arch,,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX future locus caeruleus,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX ganglion of sympathetic trunk,,,Theiler Stage 21; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX ganglion of sympathetic trunk,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX gastric wall,,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX myelencephalon,,,Theiler Stage 17; low; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX parasympathetic ganglion,,,Theiler Stage 21; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX rhombencephalic isthmus,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX rhombomere 04,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX rhombomere 05,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX rhombomere 06,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX rhombomere 07,,,Theiler Stage 17; detectable; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX superior cervical ganglion,,,Theiler Stage 22; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX trigeminal ganglion [V],,,Theiler Stage 17; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX trigeminal ganglion [V],,,Theiler Stage 21; none; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX vagal ganglion [x],,,Theiler Stage 17; high; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
EX vagal ganglion [x],,,Theiler Stage 21; low; RNA-in situ hybridization (not further specified); RNA (undefined); [1].
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FF antirepressor, relieving repression brought about by Cux T02042 in the NCAM (neural cell adhesion molecule) promoter, but no trans-activation in transfection experiments [1];
FF may be involved in control of differentiation of (nor)adrenergic neurons [1];
FF expressed in sympathetic ganglia of PNS during embryogenesis, also in al other peripheral components of the autonomous nervous system and some of the CNS [1];
FF enhanced levels upon cellular differentiation [1];
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MX M01444 V$PMX2A_01.
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BS R15705.
BS R65136.
BS R16167.
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DR TRANSPATH: MO000026155.
DR UniProtKB: Q62066;
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RN [1]; RE0004999.
RX PUBMED: 7910552.
RA Valarche T. S., Tissier-Seta J. P., Hirsch M. R., Martinez S. F., Goridis C., Brunet J. F.
RT The Mouse homeodomain protein Phox2 regulates NCAM promoter activity in concert with CUX/CDP and is a putative determinant of neurotransmitter phenotype
RL Development 119:881-896 (1993).
RN [2]; RE0051273.
RX PUBMED: 9798905.
RA Yang C., Kim H. S., Seo H., Kim C. H., Brunet J. F., Kim K. S.
RT Paired-like homeodomain proteins, Phox2a and Phox2b, are responsible for noradrenergic cell-specific transcription of the dopamine beta-hydroxylase gene.
RL J. Neurochem 71:1813-1826 (1998).
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